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| 1 | Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A. Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2005 | Circulation2005，，17： | 7 |
| 2 | 代谢综合征的诊断和治疗——美国心脏协会/国立心肺血液研究所指南概要显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A.Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，4： | 5 |
| 3 | Phase 2 trial of linifanib (ABT‐869) in patients with unresectable or metastatic hepatocellular carcinoma显示文摘 | Han Chong Toh Pei‐Jer Chen Brian I. Carr Jennifer J. Knox Sharlene Gill Peter Ansell Evelyn M. McKeegan Barry Dowell Michelle Pedersen Qin Qin Jiang Qian Frank A. Scappaticci Justin L. Ricker Dawn M. Carlson Wei Peng Yong | 2012 | Cancer2012，，2： | 4 |
| 4 | 血压变化对心肌超声造影评定冠状动脉储备的影响显示文摘目的 探讨高血压对心肌超声造影评定冠状动脉 (冠脉 )储备的影响。方法 对 9只非开胸猪进行心肌超声造影。取乳头肌水平短轴观 ,以 0 .5ml/min的速度连续滴注造影剂BR1。每 15个心动周期进行 1次破泡。破泡后的再充盈时间 -强度关系可用公式y =A(1-e-bt) +c表示 ,依此可得到信号增加率b。以静息时的b参数除滴注腺苷后的b参数所得到的商为冠脉储备 ,并与荧光微球技术测得的心肌血流及冠脉储备进行对照。结果 苯肾上腺素使血压从 12 9/ 10 0mmHg(1mmHg =0 .13 3kPa)增加到 196/153mmHg(P <0 .0 0 1) ,心率由 114次 /min增加到 12 4次 /min(P>0 .0 5)。滴注苯肾上腺素前用两种方法测得的冠脉储备值类似 ,分别为 2 .5和 3 .1。苯肾上腺素导致的血压增高增加静息时的b值 ,降低腺苷扩血管后的b值 ,使冠脉储备明显降低 ,为 1.5(P <0 .0 5) ;用荧光微球技术测量所得的冠脉储备也明显降低 ,为 1.8。 | 杨源 Barry Peters Anthony N. DeMaria | 2003 | 中华超声影像学杂志2003，12，10： | 4 |
| 5 | 新致病基因在颅缝早闭Crouzon综合征中的初步机制研究显示文摘目的研究Rbp4(Retinol binding protein 4)、Gpc3(Glypican family of growth factor binding protein 3)、C1qtnf3(Collagenous repeat-containing sequence of 26 KDa protein)等新致病基因在颅缝早闭症中的发病机制,为疾病非手术治疗奠定理论基础。方法以Crouzon综合征Fgfr2cC342Y/+小鼠为实验模型,应用MicroCT和组织学染色,研究小鼠颅缝闭合模式;以Fgfr2cC342Y/+模型,RT-qPCR研究Rbp4、Gpc3、C1qtnf3等新致病基因的表达差异,初步探讨其在颅缝闭合过程中的调控作用;以体外培养的Fgfr2cC342Y/+小鼠颅缝细胞为模型,研究基因突变动物细胞增殖与代谢改变。结果获得Fgfr2cC342Y/+小鼠后额缝、冠状缝、人字缝、矢状缝等颅缝闭合模式,随颅骨发育、颅缝闭合,OC(Osteocalcin)、ALP(Alkalinephosphatase)表达增加,目的基因Rbp4、Gpc3、C1qtnf3表达下降,Msx2(Muscle segment homeobox gene 2)表达增加,杂合子与野生型小鼠之间均存在显著统计学差异,与前期人颅缝组织Microarray研究结果一致。Gpc1(Glypican family ofgrowth factor binding protein 1)、FliI(Flightless I)在颅缝闭合中的表达较恒定,野生型与杂合子之间未见明显统计学差异。体外培养Fgfr2cC342Y/+小鼠颅缝细胞,CellTiter96 MTS和Quant-iT Picogreen dsDNA细胞增殖与代谢分析结果显示,Fgfr2功能获得性突变可促进冠状缝细胞的增殖,从而导致成骨增加,颅缝早闭。结论 Fgfr2cC342Y/+模型新致病基因表达趋势与前期人颅缝组织Microarray研究结果一致,Rbp4、Gpc3、C1qtnf3可能在颅缝早闭中具重要调控作用。 | 杨娴娴 Jodie T Hatfield Susan J Hinze 穆雄铮 Peter J Anderson Barry C Powell | 2012 | 组织工程与重建外科杂志2012，8，5： | 3 |
| 6 | The European registry of quality outcomes for cataract and refractive surgery(EUREQUO):a database study of trends in volumes,surgical techniques and outcomes of refractive surgery显示文摘Background:A European web-based registry for refractive surgery was established in 2008;The European Registry of Quality Outcomes for Cataract and Refractive Surgery(EUREQUO).The aim of the registry was to improve treatment and standards of care for refractive surgery.Further aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own outcomes.The purpose of this study was to characterize the registry and analyze the data collected during its first decade.Methods:The characteristics of the web-based registry are described.Data collected from February 4^(th) 2004 until June 30th 2014 are included in the analysis.The database is analyzed in terms of surgical technique,indications for surgery,complications,and refractive and visual outcomes.Results:Data have been reported from 47 centers in 14 countries until mid-2014.About 4,000 procedures were reported annually.The most frequent procedure was laser-assisted in-situ keratomileusis(LASIK)with 11697 reported surgeries.Over time in the database,LASIK declined(p<0.001)while photorefractive keratectomy(PRK)and refractive lens exchange(RLE)increased(p<0.001 for both procedures).The indications for surgery,in terms of preoperative refraction and age,were stable over time,for all types of procedures.Surgical complications were reported infrequently and with a well-known relationship to the type of surgical procedure.The reported refractive outcomes were good.The visual outcomes indicate a significant increase of visual acuity after high myopia treatment by phakic intraocular lens in the anterior(phakic IOL AC)and the posterior(phakic IOL PC)chamber and a poorer visual outcome,after both myopia and hyperopia treatment,by epithelial LASIK(Epi-LASIK).Conclusions:We describe the establishment of a European registry for refractive surgery.The database increases at a rate of approximately 4000 refractive procedures per year.The most frequent procedure is LASIK,but both PRK and RLE are an increasing part of the reported procedures.The indications for surgery have been stable over time.Surgical complications and visual outcome vary,depending on the type of surgery. | Mats Lundström Sonia Manning Peter Barry Ulf Stenevi Ype Henry Paul Rosen | 2015 | Eye and Vision2015，2，1： | 3 |
| 7 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 8 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 9 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 10 | The use of 4D-CTA in the diagnostic work-up of brain arteriovenous malformations显示文摘 | Peter W. A. Willems Patamintita Taeshineetanakul Barry Schenk Patrick A. Brouwer Karel G. Terbrugge Timo Krings | 2012 | Neuroradiology2012，，2： | 2 |
| 11 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 12 | Energy and material flow models for the US steel industry显示文摘 | Jan Peter Andersen Barry Hyman | 2001 | Energy2001，，2： | 2 |
| 13 | Long-term Benefit of Sustained-Delivery Fluocinolone Acetonide Vitreous Inserts for Diabetic Macular Edema显示文摘 | Peter A. Campochiaro David M. Brown Andrew Pearson Thomas Ciulla David Boyer Frank G. Holz Michael Tolentino Amod Gupta Lilianne Duarte Steven Madreperla John Gonder Barry Kapik Kathleen Billman Frances E. Kane | 2011 | Ophthalmology2011，，4： | 2 |
| 14 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 15 | Molecular basis of pathogenesis of FMDV显示文摘 | Peter W Mason Marvin J Grubman Barry Baxt | 2002 | Virus Research2002，，1： | 1 |
| 16 | Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery显示文摘 | Jane W. Newburger Richard A. Jonas Janet Soul Barry D. Kussman David C. Bellinger Peter C. Laussen Richard Robertson John E. Mayer Pedro J. del Nido Emile A. Bacha Joseph M. Forbess Frank Pigula Stephen J. Roth Karen J. Visconti Adre J. du Plessis David M | 2007 | The Journal of Thoracic and Cardiovascular Surger2007，，2： | 1 |
| 17 | High-Efficiency utilization of the bovine integrin ανβ3 as a receptor for foot-and-mouth disease virus is dependent on the bovine β3 subunit 显示文摘 | Neff Sherry Peter Mason W Baxt Barry | 2000 | J Virol2000，74，： | 1 |
| 18 | Impact of Obesity on Cardiovascular Disease显示文摘 | Kerstyn C. Zalesin Barry A. Franklin Wendy M. Miller Eric D. Peterson Peter A. McCullough | 2011 | Medical Clinics of North America2011，，5： | 1 |
| 19 | Sustainable futures:policies for global development显示文摘 | Barry B Hughesa Peter D Johnston | 2005 | Futures2005，37，： | 1 |
| 20 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
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