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| 1 | 氧化磷酸化与糖酵解:精子以何种途径获取能量?显示文摘精子为高度特异性的细胞,提供精子重要功能的主要能源一一三磷酸腺苷(ATP)主要通过两种代谢途径形成,即糖酵解和氧化磷酸化(OXPHOS)。ATP除了在精子的头部和鞭毛的主段通过糖酵解的方式产生外,在线粒体主要通过OXPHOS的方式产生。然而,在精子成功受精的过程中主要以何种方式产生ATP具有很大的差异性。与糖酵解相比,线粒体呼吸被认为是一种更有效的ATP合成代谢过程。然而,研究表明ATP从线粒体到精子鞭毛末端的扩散电位不足以支持精子的运动,这表明糖酵解是精子尾部区域主要的获能方式。多项研究表明虽然糖酵解是鞭毛产生ATP的主要方式,但是,精子运动所需要的能量主要还是来自于线粒体的呼吸。有些研究表明当糖酵解受到抑制的时候,精子仍能维持其正常的运动和功能,虽然目前尚未明确这种运动是否能持续足够长的时间,是否能够达到有效受精。本文主要目的是对哺乳动物精子能量的代谢进行综述,分析人类精子在受精的过程中以何种ATP代谢途径作为主要的能量供应方式。 | Stefan S du Plessis Ashok Agarwal Gayatri Mohanty Michelle van der Linde | 2015 | Asian Journal of Andrology2015，17，2： | 19 |
| 2 | Obesity: modern man's fertility nemesis显示文摘肥胖流行成长了到有关最近的年里,不是仅仅在西方的世界上的比例,但是在也开发国家。在男富饶和肥沃的相应减少可以向肥胖在平行被解释,并且肥胖应该被看作男富饶的病原学。研究证明肥胖由减少精液质量贡献不孕,改变精子 proteomes,贡献可勃起的机能障碍,并且导致与肥胖有关的另外的物理问题。为在男不孕上解释肥胖的效果的机制包括睡觉呼吸暂停和增加的阴囊的温度包括反常繁殖荷尔蒙层次,与肥胖联系的脂肪质导出荷尔蒙和 adipokines 的一个增加的版本,和另外的物理问题。最近,为肥胖相关的不孕的基因因素和标记被发现了并且可以解释肥沃的肥胖、不肥沃的肥胖的人之间的差别。处理为与肥胖有关的不孕是可得到的不仅,而且作为为从肥胖产生的另外的 comorbidities 的一个处理。自然重量损失,以及 bariatric 外科是为肥胖的病人的选择并且在恢复富饶和正常神经质的侧面显示出有希望的结果。脂肪质导出荷尔蒙的治疗学的干预包括 aromatase 禁止者,外长的睾丸激素代替治疗和维护和规定,特别地 leptin,可能也能在肥胖的男性恢复富饶。因为在这个区域的研究的相对不知道和缺乏,控制了研究应该被承担,更多的焦点应该作为男不孕的 etiolgy 被给肥胖。 | Stephanie Cabler Ashok Agarwal Margot Flint Stefan S. Du Plessis | 2010 | Asian Journal of Andrology2010，12，4： | 14 |
| 3 | Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production显示文摘瞄准:调查在里面人的精子活动性,生存能力, acrosome 反应和氮的氧化物上的胰岛素和 leptin 的 vitro 效果(没有) 生产。方法:从 normozoospermic 施主的洗的人的精子与胰岛素(10 μIU ) 和 leptin (10 nmol ) 被对待。胰岛素和 leptin 效果被他们的细胞内部的受动器的抑制堵住, phosphotidylinositol 3-kinase (PI3K ) ,由 wortmannin (10 μmol ) ,在胰岛素和 leptin 以前的 30 min 正在被给。帮助计算机的精液分析被用来在孵化的 1, 2 和 3 h 以后估计活动性。生存能力被激活荧光的房间作为一根荧光灯的探针用 propidium 碘化物排序估计。反应 Acrosome 的房间作为一根探针用 fluorescein-isothiocyanate Pisum sativum 凝集素在一台荧光灯的显微镜下面被观察。不在与 4,5-diaminofluorescein-2/diacetate (DAF-2/DA ) 对待精子以后被测量并且由激活荧光的房间排序分析了。结果:显著地增加的胰岛素和 leptin 总计活动性,进步活动性和 acrosome 反应,以及没有生产。结论:这研究出现了在里面 vitro 人的精子上的胰岛素和 leptin 的有益的效果工作。这些荷尔蒙能在提高人的精子的授精能力起一个作用。 | Fanuel Lampiao Stefan S. du Plessis | 2008 | Asian Journal of Andrology2008，10，5： | 13 |
| 4 | Preliminary examination of electrochemical and spectroscopic features of trithiocarbonate collectors for sulfide mineral flotation显示文摘The redox potentials of xanthate/dixanthogen (dithiocarbonate/di dithiocarbonate, DTC/(DTC) 2) and trithiocarbonate/di trithiocarbonate (TTC/(TTC) 2) couples have been measured for the potassium salts. The spectroscopic characteristics of these sulfide mineral collectors were determined by FTIR and UV analysis. Electrochemically controlled contact angle measurements at a pyrite surface provided the basis to analyze the effect of the functional group ( O CS 2 versus S CS 2) on the hydrophobic surface state. Results from this preliminary examination are discussed with respect to the nature of collector adsorption and the pyrite flotation response. | R. Du Plessis 1, J.D. Miller 1, J.C.Davidtz 2 1. Department of Metallurgical Engineering, University of Utah, Salt Lake City, Utah 84102, USA 2. Department of Materials Science and Metallurgical Engineering, University of Pretoria, Pretoria 0002 | 2000 | 中国有色金属学会会刊:英文版2000，10，S1： | 9 |
| 5 | Active explosion barrier performance against methane and coal dust explosions显示文摘 | J. J. L. du Plessis | 2015 | International Journal of Coal Science & Technology2015，2，4： | 8 |
| 6 | New developments of the effect of melatonin on reproduction显示文摘In the past decades, a lot of advances in understanding the biochemistry and physiology of the pineal gland have been made. There is evidence that it interacts with many endocrine as well as non-endocrine tissues to influence their metabolic activity modulating many organs and functions. Melatonin is secreted by the pineal gland in the brain and plays an important role in regulating the neuroendocrine system. This hormone is one of the major role players in the regulation of the circadian sleep-wake cycle. It is normally released from the pineal gland during the night in response to environmental changes in light. Studies have shown that melatonin plays a role in the regulation of many reproductive processes such as puberty, gonadal function, and pregnancy. Beside these, melatonin has been shown to be able to directly neutralize a number of free radicals and reactive oxygen and nitrogen species. The main objective of this review is to provide comprehensive information about the new developments in melatonin research regarding its role in reproduction. A review of international scientific literature was done and a question-and-answer format was used in an attempt to convey comprehensive information in a simple manner. This review discusses evidence currently available relating to the effect of melatonin on reproductive processes. It deliberates the mechanism of action of melatonin, its effect on puberty, testicular and ovafunction, pregnancy, and oxidative stress. A growing body of scientific evidence is suggesting that melatonin plays an important role in reproductive function. It is therefore imperative to highlight the beneficial effects of this hormone in improving the reproductive processes. | Fanuel Lampiao Stefan S Du Plessis | 2013 | World Journal of Obstetrics and Gynecology2013，2，2： | 2 |
| 7 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 8 | The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility显示文摘在这研究,二商业地可得到的 superoxide scavengers , tetrakis ( 1-methyl-4-pyridyl )卟啉( Mn [ III ] TMPyP )并且 superoxide dismutase (草皮),以及红手掌油( RPO ),自然蔬菜油,被用来调查他们的在对人的精子活动性上的 superoxide ( O2 )的有毒的效果的 vitro 效果可能。精液样品从健康志愿者施主在 19 和 23 年之间变老的 12 normozoospermic 被获得。O2 施主 2,3-dimetoxyl-1,4-naphthoquinone (DMNQ )(2.5 摩尔 L-1 鈥 ? 00 摩尔 L-1 ) 当面被加到 normozoospermic post-swim-up 精子或 Mn (III ) TMPyP (50 摩尔 L-1 ) 的缺席,草皮(50 IU ) 或 RPO (0.1% 或 0.5%) 。帮助计算机的精液分析被用来分析各种各样的活动性参数。兴趣的参数是能动房间,进步活动性,快速的房间和静态的房间的百分比。集中高对精子活动性比 25 摩尔 L-1 DMNQ 有害。Mn (III ) TMPyP 能在活动性参数上稀释 O2 的效果。在 vitro,草皮和 RPO 的增加在精子活动性上显示出有害效果。 | Yapo Guillaume Aboua Stefan Stephanus du Plessis Patricia Reichgelt Nicole Brooks | 2009 | Asian Journal of Andrology2009，11，6： | 2 |
| 9 | Molecularpanthology and clinical characteristics of oligodondroglialneoplasms显示文摘 | du Plessis DG Joyce KA | 2005 | Ann Neurol2005，57，6： | 1 |
| 10 | Fuzzy behavior of mechanical systems with uncertain boundary conditions 显示文摘 | Cherki A Plessis G Lallemand B | 2000 | Computer Methods in Applied Mechanics and Engineering2000，189，： | 1 |
| 11 | Lumped Impedance Matc- hing Using a Hybrid Genetic Algorithm 显示文摘 | PLESSIS W P ABRIE P L D | 2003 | IEEE Micro- wave and Optical Technology Letters2003，37，3： | 1 |
| 12 | Comparison of Batho, ETAR and Monte Carlo dose calculation method in CT based patient methods 显示文摘 | du Plessis F C Willemse C A L6tter M G | 2001 | Medical Physics2001，28，4： | 1 |
| 13 | Delayed cortical development in fetuses with complex congenital heart disease显示文摘 | Clouchoux C du Plessis AJ Bouyssi-Kobar M | 2013 | Cereb Cortex2013，23，12： | 1 |
| 14 | Contemporary evidence on the physiological role of reactive oxygen species in human sperm function显示文摘 | Du Plessis SS Agarwal A Halabi J | 2015 | J Assist Reprod Genet2015，32，： | 1 |
| 15 | Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants显示文摘 | du Plessis AJ Jonas RA Wypij D | 1997 | J Thorac Cardiovasc Surg1997，114，6： | 1 |
| 16 | Liposomes as a topical drug delivery system显示文摘 | Plessis J Ramaehandran C Weiner N | 1996 | Int J Pharm1996，127，2： | 1 |
| 17 | Rapid detection of peni-cillin-resistant Streptococcus pneumoniae in cerebrospinal flu- id by a seminested-PCR strategy显示文摘 | Plessis M Smith AM Klugman KP | 1998 | J Clin Microbiol1998，86，2： | 1 |
| 18 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
| 19 | Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery显示文摘 | Jane W. Newburger Richard A. Jonas Janet Soul Barry D. Kussman David C. Bellinger Peter C. Laussen Richard Robertson John E. Mayer Pedro J. del Nido Emile A. Bacha Joseph M. Forbess Frank Pigula Stephen J. Roth Karen J. Visconti Adre J. du Plessis David M | 2007 | The Journal of Thoracic and Cardiovascular Surger2007，，2： | 1 |
| 20 | Biomineralization of metal - containing ores and concentrates 显示文摘 | Douglas E Rawlings David Dew Chris du Plessis | 2003 | Trends in Biotechnology2003，21，1： | 1 |
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