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| 1 | Functional dyspepsia:The role of visceral hypersensitivity in its pathogenesis显示文摘功能,或非溃疡,消化不良(FD ) 是为到胃的肠学的工作分派的最普通的原因之一。它与重要病态被联系并且损害了生命的质量。许多当局相信那机能性消化不良和急躁的肠症候群代表一样的疾病过程的光谱的部分。FD 的病理生理学仍然保持不清楚但是几个理论包括内脏的超敏性,胃的马达机能障碍, Helicobacter pylori 感染和精神分析被建议了社会因素。在这评论,迄今为止,我们在 FD 的原因论为内脏的超敏性的角色看证据。 | John Keohane Eamonn M M Quigley | 2006 | World Journal of Gastroenterology2006，12，17： | 35 |
| 2 | 2010—2020年世界范围内青光眼患者数量的评估研究显示文摘Aim: To estimate the number of peoplewith open angle (OAG)-and angle closure glaucoma (ACG) in 2010 and 2020. Methods: A review of published data with use of prevalence models. Data from population based studies of age specific prevalence of OAG and ACG that satisfied standard definitions were used to construct prevalence models for OAG and ACG by age,sex,and ethnicity,weighting data proportional to sample size of each study. Models were combined with UN world population projections for 2010 and 2020 to derive the estimated number with glaucoma. Results: There will be 60.5million people with OAG and ACG in 2010,increasing to 79.6million by 2020,and of these,74% will have OAG. Women will comprise 55% of OAG,70% of ACG,and 59% of all glaucoma in 2010. Asians will represent 47% of those with glaucoma and 87% of those with ACG. Bilateral blindness will be present in 4.5 million people with OAG and 3.9 million people with ACG in 2010,rising to 5.9 and 5.3 million people in 2020,respectively. Conclusions: Glaucoma is the second leading cause of blindness worldwide,disproportionately affecting women and Asians. | Quigley H. Broman A. T. 王文军(译) | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，6： | 34 |
| 3 | 阿片类药物在癌痛治疗中的作用显示文摘ColumbaQuigley是颐养关怀治疗领域中的一位专家,她为一个以医院为基础的支持团队(ahospitalbasedsupportteam)工作。同时她还服务于一所颐养关怀社团和一所临终关怀医院;在那里,患者得到临终护理,延续生命并控制症状。癌症患者特别是晚期癌症患者常常伴发疼痛。此外,疼痛还是癌症患者最令人恐惧的症状。适当应用镇痛药物(特别是阿片类药物)可以有效控制绝大多数患者的癌痛。 | Columba Quigley 王静捷(译) 黄宇光(校) | 2006 | 英国医学杂志中文版2006，9，1： | 27 |
| 4 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 5 | Gastroenterology in developing countries:Issues and advances显示文摘Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments,lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori . Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of 'cascades' are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries. | Kate L Mandeville Justus Krabshuis Nimzing Gwamzhi Ladep Chris JJ Mulder Eamonn MM Quigley Shahid A Khan | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 6 | Changing face of irritable bowel syndrome显示文摘最近的年在我们急躁的肠症候群(IBS ) 的理解见证巨大的进步。这是在个人并且为折磨的个人的社会工作与重要症状和缺陷联系的真正全球的疾病,是明显的。在我们内脏 flora-mucosal 相互作用,伤寒神经系统和大脑勇气轴的理解的进展至少在 IBS 在症状的致病导致了实质的进步并且向这混乱的基本病原学提供了一些提示,在一些潜水艇人口。我们盼望治疗将针对病理生理学并且也许的一时间,甚至到主要病原学。同时,一个模型基于为肠的发炎的一个主要角色服役集成各种各样的海滨,它贡献 IBS 的演讲。 | Eamonn MM Quigley | 2006 | World Journal of Gastroenterology2006，12，1： | 6 |
| 7 | Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses显示文摘 | Siobhain M. O’Mahony Julian R. Marchesi Paul Scully Caroline Codling Anne-Marie Ceolho Eamonn M.M. Quigley John F. Cryan Timothy G. Dinan | 2009 | Biological Psychiatry2009，，3： | 4 |
| 8 | A Global Perspective on Irritable Bowel Syndrome: A Consensus Statement of the World Gastroenterology Organisation Summit Task Force on Irritable Bowel Syndrome显示文摘 | Eamonn M. M. Quigley Hussein Abdel-Hamid Giovanni Barbara Shobna J. Bhatia Guy Boeckxstaens Roberto De Giorgio Michel Delvaux Douglas A. Drossman Amy E. Foxx-Orenstein Francisco Guarner Kok-Ann Gwee Lucinda A. Harris A. Pali S. Hungin Richard H. Hunt John | 2012 | Journal of Clinical Gastroenterology2012，，5： | 4 |
| 9 | Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?显示文摘 | Timothy G. Dinan Eamonn M.M. Quigley Salah M.M. Ahmed Paul Scully Sinead O’Brien Liam O’Mahony Siobhan O’Mahony Fergus Shanahan P.W. Napoleon Keeling | 2006 | Gastroenterology2006，，2： | 3 |
| 10 | ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents显示文摘 | Deepak L. Bhatt James Scheiman Neena S. Abraham Elliott M. Antman Francis K.L. Chan Curt D. Furberg David A. Johnson Kenneth W. Mahaffey Eamonn M. Quigley Robert A. Harrington Eric R. Bates Charles R. Bridges Mark J. Eisenberg Victor A. Ferrari Mark A. Hl | 2008 | Circulation2008，，18： | 3 |
| 11 | 肠易激综合征中下丘脑-垂体-肠腺轴调节失调:血浆细胞因子是否为潜在的生物标记显示文摘Background & Aims: Irritable bowel syndrome (IBS) is a functional disorder with an etiology that has been linked to both psychological stress and infection. The primary aim of this study was to examine the hypothalamic-pituitary-adrenal axis in patients with IBS and to relate such response to plasma cytokine profiles. Methods: A total of 151 subjects, 76 patients and 75 controls, were recruited. The patients with IBS were diagnosed according to Rome II criteria. Forty-nine patients and 48 matched controls had cytokine levels measured, and a subset of 21 patients and 21 controls also underwent a corticotropin-releasing hormone (CRH) stimulation test with plasma levels of adrenocorticotropic hormone (ACTH) and cortisol measured. The remaining 27 patients and 27 controls underwent a dexamethasone (1 mg) challenge. Results: Cortisol and the proinflammatory cytokines interleukin (IL)- 6 (together with its soluble receptor) and IL-8 were elevated in all IBS subgroups (diarrhea predominant, constipated, and alternators), although the elevation was most marked in the constipated subgroup. There was no alteration in the anti-inflammatory cytokine IL- 10. Following CRH infusion, an exaggerated release of both ACTH and cortisol was observed in patients with IBS. There was a significant correlation between the ACTH response (δ ACTH) and the IL- 6 levels. A similar relationship existed between the δ ACTH/δ cortisol ratio and the IL- 6 levels. Dexamethasone suppression of cortisol was similar in patients and controls. Conclusions: IBS is characterized by an overactivation of the hypothalamic-pituitary-adrenal axis and a proinflammat ory cytokine increase. | Dinan T.G. Quigley E.M.M. Ahmed S.M.M. 赵天智 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 3 |
| 12 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 3 |
| 13 | Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies显示文摘 | Fergus Shanahan Eamonn M.M. Quigley | 2014 | Gastroenterology2014，，： | 3 |
| 14 | A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome显示文摘 | Caroline Codling Liam O’Mahony Fergus Shanahan Eamonn M. M. Quigley Julian R. Marchesi | 2010 | Digestive Diseases and Sciences2010，，2： | 3 |
| 15 | Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease显示文摘 | Kevin Whelan Eamonn M.M. Quigley | 2013 | Current Opinion in Gastroenterology2013，，2： | 3 |
| 16 | TUNEL-positive gangline cells in human primary open-angle glaucoma 显示文摘 | Kerrigan LA Zack DJ Quigley HA | 1997 | Arch Ophthalmol1997，115，： | 2 |
| 17 | Gut microbiota and gastrointestinal health: current concepts and future directions显示文摘 | Q. Aziz J. Doré A. Emmanuel F. Guarner E. M. M. Quigley | 2012 | Neurogastroenterology & Motility2012，，1： | 2 |
| 18 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 19 | A rapid boiling method for the preparation of bacterial plasmids 显示文摘 | Holmes DS Quigley M | 1981 | Anal Biochem1981，114，： | 2 |
| 20 | The Gut Microbiota and the Liver Pathophysiological and Clinical Implications显示文摘 | Eamonn M .M. Quigley Catherine Stanton Eileen F. Murphy | 2012 | Journal of Hepatology2012，，： | 2 |
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