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| 1 | Epidemiology of pancreatic cancer显示文摘Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11^(th) most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world. A known cause of pancreatic cancer is tobacco smoking. This risk factor is likely to explain some of the international variations and gender differences. The overall five-year survival rate is about 6%(ranges from 2% to 9%), but this vary very small between developed and developing countries. To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as smoking, obesity, genetics, diabetes, diet, inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease. | Milena Ilic Irena Ilic | 2016 | World Journal of Gastroenterology2016，22，44： | 95 |
| 2 | Hepatitis C and HIV co-infection:a review显示文摘Co-infection with hepatitis C virus and humanimmunodeficiency virus is common in certainpopulations. Among HCV(+) persons, 10 % are alsoHIV (+), and among HIV (+) persons, 25 % are alsoHCV(+). Many studies have shown that in intravenousdrug users, co-infection prevalence can be as high as90-95 %. There is increasing evidence supporting theconcept that people infected with HIV have a muchmore rapid course of their hepatitis C infection.Treatment of co-infection is often challenging becausehighly active anti-retroviral therapy (HAART) therapyis frequently hepatotoxic, especially in the presence ofHCV. The purpose of this review is to describe theeffects that HIV has on hepatitis C, the effects thathepatitis C has on HIV, and the treatment options inthis challenging population. | Irena Maier George Y. Wu | 2002 | World Journal of Gastroenterology2002，8，4： | 25 |
| 3 | Epidemiology of stomach cancer显示文摘Despite a decline in incidence and mortality during the last decades,stomach cancer is one of the main health challenges worldwide.According to the GLOBOCAN 2020 estimates,stomach cancer caused approximately 800000 deaths(accounting for 7.7%of all cancer deaths),and ranks as the fourth leading cause of cancer deaths in both genders combined.About 1.1 million new cases of stomach cancer were diagnosed in 2020(accounting for 5.6%of all cancer cases).About 75%of all new cases and all deaths from stomach cancer are reported in Asia.Stomach cancer is one of the most lethal malignant tumors,with a five-year survival rate of around 20%.There are some well-established risk factors for stomach cancer:Helicobacter pylori infection,dietary factors,tobacco,obesity,and radiation.To date,the most important way of preventing stomach cancer is reduced exposure to risk factors,as well as screening and early detection.Further research on risk factors can help identify various opportunities for more effective prevention.Screening programs for stomach cancer have been implemented in a few countries,either as a national or opportunistic screening of high-risk individuals only.Generally,due to its high aggressiveness and heterogeneity,stomach cancer still remains a severe global health problem. | Milena Ilic Irena Ilic | 2022 | World Journal of Gastroenterology2022，28，12： | 24 |
| 4 | Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy显示文摘Cell-based regenerative medicine is of growing interest in biomedical research. The role of stem cells in this context is under intense scrutiny and may help to define principles of organ regeneration and develop innovative therapeutics for organ failure. Utilizing stem and progenitor cells for organ replacement has been conducted for many years when performing hematopoietic stem cell transplantation. Since the first successful transplantation of umbilical cord blood to treat hematological malignancies, non-hematopoietic stem and progenitor cell populations have recently been identified within umbilical cord blood and other perinatal and fetal tissues. A cell population entitled mesenchymal stromal cells (MSCs) emerged as one of the most intensely studied as it subsumes a variety of capacities: MSCs can differentiate into various subtypes of the mesodermal lineage, they secrete a large array of trophic factors suitable of recruiting endogenous repair processes and they are immunomodulatory.Focusing on perinatal tissues to isolate MSCs, we will discuss some of the challenges associated with these cell types concentrating on concepts of isolation and expansion, the comparison with cells derived from other tissue sources, regarding phenotype and differentiation capacity and finally their therapeutic potential. | Karen Bieback Irena Brinkmann | 2010 | World Journal of Stem Cells2010，2，4： | 15 |
| 5 | Nonalcoholic fatty liver disease and liver transplantation-Where do we stand?显示文摘Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis(NAFLD/NASH) is a challenging and multisystem disease that has a high socioeconomic impact. NAFLD/NASH is a main cause of macrovesicular steatosis and has multiple impacts on liver transplantation(LT), on patients on the waiting list for transplant, on posttransplant setting as well as on organ donors. Current data indicate new trends in the area of chronic liver disease. Due to the increased incidence of metabolic syndrome(Met S) and its components, NASH cirrhosis and hepatocellular carcinoma caused by NASH will soon become a major indication for LT. Furthermore, due to an increasing incidence of Met S and, consequently, NAFLD, there will be more steatotic donor livers and less high quality organs available for LT, in addition to a lack of available liver allografts. Patients who have NASH and are candidates for LT have multiple comorbidities and are unique LT candidates. Finally, we discuss long-term grafts and patient survival after LT, the recurrence of NASH and NASH appearing de novo after transplantation. In addition, we suggest topics and areas that require more research for improving the health care of this increasing patient population. | Ivana Mikolasevic Tajana Filipec-Kanizaj Maja Mijic Ivan Jakopcic Sandra Milic Irena Hrstic Nikola Sobocan Davor Stimac Patrizia Burra | 2018 | World Journal of Gastroenterology2018，24，14： | 14 |
| 6 | Immunobiology of congenital cytomegalovirus infection of the central nervous system--the murine cytomegalovirus model显示文摘 | Irena Slavuljica Daria Kvestak Peter Csaba Huszthy Kate Kosmac William J Britt Stipan Jonjic | 2015 | Cellular & Molecular Immunology2015，12，2： | 10 |
| 7 | Nitrogen removal from wastewater and bacterial diversity in activated sludge at different COD/N ratios and dissolved oxygen concentrations显示文摘The impact of the organic carbon to nitrogen ratio (chemical oxygen demand (COD)/N) in wastewater and dissolved oxygen (DO) concentration on carbon and nitrogen removal efficiency,and total bacteria and ammonia-oxidizing bacteria (AOB) communities in activated sludge in constantly aerated sequencing batch reactors (SBRs) was determined.At DO of 0.5 and 1.5 mg O2 /L during the aeration phase,the efficiency of ammonia oxidation exceeded 90%,with nitrates as the main product.Nitrification and denitrification achieved under the same operating conditions suggested the simultaneous course of these processes.The most effective nitrogen elimination (above 50%) was obtained at the COD/N ratio of 6.8 and DO of 0.5 mg O2 /L.Total bacterial diversity was similar in all experimental series,however,for both COD/N ratios of 6.8 and 0.7,higher values were observed at DO of 0.5 mg O2 /L.The diversity and abundance of AOB were higher in the reactors with the COD/N ratio of 0.7 in comparison with the reactors with the COD/N of 6.8.For both COD/N ratios applied,the AOB population was not affected by oxygen concentration.Amplicons with sequences indicating membership of the genus Nitrosospira were the determinants of variable technological conditions. | Magdalena Zielińska Katarzyna Bernat Agnieszka Cydzik-Kwiatkowska Joanna Sobolewska Irena Wojnowska-Baryla | 2012 | Journal of Environmental Sciences2012，24，6： | 9 |
| 8 | 新冠肺炎疫情影响下区域产业网络风险传导效应研究显示文摘新冠肺炎疫情的突发和快速蔓延,使我国区域产业经济面临严峻挑战。疫情导致部份产业供给中断和需求下滑,并通过产业链扩散蔓延至整个网络,极易引发系统性风险。为模拟疫情影响下区域产业供应链的风险传导效应,该文通过构建我国区域产业网络,引入网络级联失效模型,模拟湖北产业供给中断、需求下滑以及不同产业产能受限和需求下降的情况下,停产和流动性风险的传导效应。结果显示,风险的扩散呈现突变态势,存在临界时间点。临界点前风险扩散较为缓慢平稳,一旦突破临界点,则加速蔓延使整个产业网络在短时期内陷入瘫痪。不同产业在供给侧和需求端的冲击影响下,对系统性风险水平的影响具有异质性。 | 张欣 郁佳亮 IRENA Vodenska | 2020 | 电子科技大学学报2020，49，3： | 8 |
| 9 | Cancer mortality in Serbia, 1991-2015: an age-period-cohort and joinpoint regression analysis显示文摘Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health problems.The aim of this study was to assess cancer mortality trends in Serbia.Methods:This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using offi-cial data.The age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by Segi.The average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression analysis.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal trends.Results:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in Serbia.Overall cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both sexes.For almost all major cancers except stomach cancer,cancer mortality in Serbia demonstrated upward trends during the study period.The largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in Serbia.Despite this,these rates place Serbia among the countries with the highest cancer mortality in the world. | Milena Ilic Irena Ilic | 2018 | Cancer Communications2018，38，1： | 7 |
| 10 | 眼小叶蝉属和东半球眼小叶蝉族评述(头喙亚目,叶蝉科,小叶蝉亚科)(英文)显示文摘本文首先根据眼小叶蝉族Alebrini讨论翅的命名,接着是眼小叶蝉属Alebra Fieb.和东半球眼小叶蝉族各属的评论。Homa elongata Kato移入属AsialebraDwor.,Shaddai distanti Dwor.是S.typicus Dist.的异名。描述了6个新种,即Sobralacapreola,S.clara,Orientalebra drawidana,Afralebra melichari,A.youngi,A.paolii. 本文引言部分讨论小叶蝉亚科Typhlocybinae翅的形态学,正文为分类部分。 在描述内部构造以及端节、头、和胸部背面时,使用习惯术语。 新种模式标本系列保存于下列博物馆中;正模的保管者在有关描述中最先提到: SMTD——德国得累斯顿,国家动物学博物馆。 BMNH——英国伦敦,英国自然历史博物馆。 USNM——美国华盛顿,美国国家博物馆。 MM——捷克斯洛伐克Brno,Moravian博物馆。 | Irena DWORAKOWSKA | 1993 | Entomotaxonomia1993，15，2： | 5 |
| 11 | Colonic duplication in an adult who presented with chronic constipation attributed to hypothyroidism显示文摘Gastrointestinal duplications are an uncommon congenital abnormality that manifest before the age of two in 80% of cases. Ileal duplication is the most common while colonic duplication,either cystic or tubular,occurs in 10%-15% of cases and remains asymptomatic and undiagnosed in most cases. Mostly occurring in pediatric patients,colonic duplication is encountered in adults in only a few cases. The most common clinical manifestations are abdominal pain and intestinal obstruction. Rarely,duplications present with signs of acute abdomen or acute bleeding. This study reports a case of colonic duplication in an adult who presented with chronic constipation. Complete diagnostic workup was made on several occasions during the previous eight year period,but no pathology was found and chronic constipation was attributed to hypothyroidism caused by long standing Hashimoto thyroiditis. Multislice CT,performed because of abdominal distension,defined colonic pathology but the definite diagnosis of duplication of the transversal colon was made at operation. The cystic duplication and the adjacent part of the ascending and transversal colon were excised en-block. This study implies that colonic duplication,though uncommon,should be included in the differential diagnosis of chronic constipation even when precipitating factors for constipation,such as hypothyroidism are present. | Tihomir Kekez Goran Augustin Irena Hrstic Dubravko Smud Mate Majerovic Zeljko Jelincic Emil Kinda | 2008 | World Journal of Gastroenterology2008，14，4： | 5 |
| 12 | Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis显示文摘Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress.Dubin-Johnson syndrome is a rare,autosomal recessive,inherited disorder characterized by biphasic,predominantly conjugatedhyperbilirubinemia with no progression to end-stage liver disease.The molecular basis in Dubin-Johnson syndrome is absence or deficiency of human canalicular multispecific organic anion transporter MRP2/cMOAT caused by homozygous or compound heterozygous mutation(s) in ABCC2 located on chromosome 10q24.Clinical onset of the syndrome is most often seen in the late teens or early adulthood.In this report,we describe a case of previously unrecognized Dubin-Johnson syndrome caused by two novel pathogenic mutations (c.2360_2366delCCCTGTC and c.3258+1G>A),coinciding with cholestatic liver disease in an 82-year-old male patient.The patient,suffering from advanced atherosclerosis with serious involvement of coronary arteries,developed colorectal cancer with nodal metastases.The subsequent findings do not support the protective role of Dubin-Johnson type hyperbilirubinemia. | Eva Sticova Milan Elleder Helena Hulkova Ondrej Luksan Martin Sauer Irena Wunschova-Moudra Jan Novotny Milan Jirsa | 2013 | World Journal of Gastroenterology2013，19，6： | 4 |
| 13 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 14 | Prevalence of glaucoma in the Israeli Arab population显示文摘We describe the prevalence and treatment of glaucoma in a Muslim Arab population in Israel. Based on the medical records of 15 122 persons, the overall prevalence of glaucoma was 3.9%. Prevalence rates of primary open angle glaucoma(POAG) and primary angle-closure glaucoma(PACG) were 3.0% and 0.42%, respectively. Prevalence rates of women were 135% that of men considering all types of glaucoma, 143% for POAG, and 96% for PACG. Prostaglandin analogs and beta blockers, alone or combined with carbonic anhydrase inhibitors, were the preferred medications. Of 68 patients who underwent trabeculectomy, 27(39.7%) required medications, postoperatively, for treatment of glaucoma; following Ex-Press shunt surgery, 3/11(27.3%) required medications. During the last three years, 16(1.3%) individuals with POAG were recorded as legally blind as a result of glaucoma. | Otzem Chassid Irena Epstein Adi Sharabi-Nov Joseph Pikkel | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 3 |
| 15 | Colorectal cancer mortality trends in Serbia during 1991–2010:an age-period-cohort analysis and a joinpoint regression analysis显示文摘Background: For both men and women worldwide, colorectal cancer is among the leading causes of cancer-related death. This study aimed to assess the mortality trends of colorectal cancer in Serbia between 1991 and 2010, prior to the introduction of population-based screening.Methods: Joinpoint regression analysis was used to estimate average annual percent change(AAPC) with the corresponding 95% confidence interval(CI). Furthermore, age-period-cohort analysis was performed to examine the effects of birth cohort and calendar period on the observed temporal trends.Results: We observed a significantly increased trend in colorectal cancer mortality in Serbia during the study period(AAPC = 1.6%, 95% CI 1.3%–1.8%). Colorectal cancer showed an increased mortality trend in both men(AAPC –2.2%) and women(AAPC rend of colorectal cancer mo= 2.0%, 95% CI 1.7%= 1.0%, 95% CI 0.6%–1.4%). The temporal trtality was significantly affected by birth cohort(P < 0.05), whereas the study period did not significantly affect the trend(P = 0.072). Colorectal cancer mortality increased for the first several birth cohorts in Serbia(from 1916 to 1955), followed by downward flexion for people born after the 1960 s. According to comparability test, overall mortality trends for colon cancer and rectal and anal cancer were not parallel(the final selected model rejected parallelism, P < 0.05).Conclusions: We found that colorectal cancer mortality in Serbia increased considerably over the past two decades. Mortality increased particularly in men, but the trends were different according to age group and subsite. In Serbia, interventions to reduce colorectal cancer burden, especially the implementation of a national screening program, as well as treatment improvements and measures to encourage the adoption of a healthy lifestyle, are needed. | Milena Ilic Irena Ilic | 2016 | Chinese Journal of Cancer2016，35，10： | 2 |
| 16 | Frequency-modulated second elements of two-element alarm calls do not enhance discrimination of callers in three Eura- sian ground squirrels显示文摘 | Irena SCHNEIDEROVA | 2012 | Current Zoology2012，58，5： | 2 |
| 17 | Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects显示文摘与导致药的肝疾病的增加的发生,正在被尝试更好在这些经常危及生活的反应后面理解机制。止痛剂和反煽动性的药是展出 hepatotoxicity 的一个主要的组。我们考察关于这些反应的研究,集中于极端结构的调查结果,它可以贡献理解和导致药的肝疾病的可能的回避。我们也在与抗氧化剂 N-acetylcysteine 或 P-glycoprotein 禁止者 verapamil 独自或在联合暴露于 acetaminophen 的临床的材料和有教养的房间上介绍一些原来的观察。 | Irena MANOV Helen MOTANIS Idan FRUMIN Theodore C IANCU | 2006 | Acta Pharmacologica Sinica2006，27，3： | 2 |
| 18 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 19 | Monitoring of atrazine in milk using a rapid tube-based ELISA and validation with HPLC显示文摘 | Hanna Barchanska Elzbieta Jodo Robert Graham Price Irena Baranowska Ramadan Abuknesha | 2012 | Chemosphere2012，，11： | 2 |
| 20 | Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma显示文摘AIM:To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS:The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls.Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal,hepatic and splenic veins were examined.Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS:In the majority of patients,hepatomegaly was observed.Lesions were mostly hypoechoic and mixed,solitary or multiple.Some of the patients presented with dilated splenic veins and hepatofugal blood flow.A pulse wave was registered in the centre and at the margins of lymphoma.The average velocity of the pulse wave was higher at the margins (P>0.05).A continuous venous wave was found only at the margins of lymphoma.There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r=390,P<0.01).HPI was significantly lower in patients with lymphomas than in controls (P<0.05),pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION:Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity.Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. | Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
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