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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | Biomarkers for the diagnosis of Alzheimer's disease, dementia Lewy body, frontotemporal dementia and vascular dementia显示文摘Background Dementia is a chronic brain disorder classified by four distinct diseases that impact cognition and mental degeneration. Each subgroup exhibits similar brain deficiencies and mutations. This review will focus on four dementia subgroups: Alzheimer's disease, vascular dementia, frontotemporal dementia and dementia Lewy body. Aim The aim of this systematic review is to create a concise overview of unique similarities within dementia used to locate and identify new biomarker methods in diagnosing dementia. Methods 123 300 articles published after 2010 were identified from PubMed, JSTOR, WorldCat Online Computer Library and PALNI (Private Academic Library Network of Indiana) using the following search items (in title or abstract):'Neurodegenerative Diseases' OR 'Biomarkers' OR 'Alzheimer's Disease' OR 'Frontal Temporal Lobe Dementia' OR 'Vascular Dementia, OR 'Dementia Lewy Body' OR 'Cerebral Spinal Fluid' OR 'Mental Cognitive Impairment'. 47 studies were included in the qualitative synthesis. Results Evidence suggested neuroimaging with amyloid positron emission tomography (PET) scanning and newly found PET tracers to be more effective in diagnosing Alzheimer's and amnesiac mental cognitive impairment than carbon-11 Pittsburgh compound-B radioisotope tracer. Newly created methods to make PET scans more accurate and practical in clinical settings signify a major shift in diagnosing dementia and neurodegenerative diseases. Conclusion Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics. Neuroimaging with amyloid PET scanning surpasses what had been considered the dominant method of neuroimaging and MRI. Newly created methods to make PET scans more accurate and practical in clinical settings signify a major shift in diagnosing dementia pathology. Continued research and studies must be conducted to improve current findings and streamline methods to further subcategorise neurodegenerative disorders and diagnosis. | Joshua Marvin Anthony Maclin Tao Wang Shifu Xiao | 2019 | General Psychiatry2019，32，1： | 14 |
| 3 | 甜菜夜蛾体内酶活性对三种棉酚含量棉花的响应显示文摘在室内用3种不同棉酚含量的棉花饲养甜菜夜蛾幼虫,并在不同取食时间测定了甜菜夜蛾幼虫的营养物质、消化酶、保护酶和解毒酶活性的变化.实验结果表明,甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种6h后,体内的游离脂肪酸较取食其他两种低酚含量棉花出现了显著性的降低.甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种24h后,体内的胰蛋白酶较取食1,4,6h后出现了显著性的增加.甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种1,4,6,24h后,体内的过氧化氢酶和总超氧化物歧化酶显著高于取食低酚棉花品种ZMS13和HZ401,但体内显著较低的羧酸酯酶和乙酰胆碱酯酶酶活性显著低于取食低酚棉花品种ZMS13和HZ401.多因素方差分析表明,不同棉酚含量棉花品种除对甜菜夜蛾幼虫体内淀粉酶活性无影响外,对其他消化酶、保护酶和解毒酶活性均有显著性的影响.棉花品种和甜菜夜蛾不同为害时间的交互作用可显著影响甜菜夜蛾幼虫体内的羧酸酯酶和过氧化氢酶活性.测定对甜菜夜蛾不同为害时间体内酶活性对不同棉酚含量的棉花的响应,可有效评估植食性昆虫在植物次生代谢物质压力下的生理反应和抗性变化. | 吴刚 Marvin K.Harris 郭建英 万方浩 | 2009 | 中国科学(C辑)2009，39，11： | 7 |
| 4 | 种子小蜂和空壳果实对生物能源树种黄连木果实和油产量的影响(英文)显示文摘黄连木Pistacia chinensis Bunge因果实含油量高,被作为生物能源树种在我国进行大面积栽培推广和能源开发利用。然而,专性寄生害虫(主要为黄连木广肩小蜂Eurytoma plotnikovi Nikolskaya)的危害及由单性结实和败育所造成的空壳果实可能影响黄连木的果实产量和质量。为了评价种子害虫和空壳果实对黄连木果实产量和质量的影响,我们测定了河南省济源市3个黄连木种群40株结果雌树的果实产量和油产量,同时测定了完好果实、空壳果实和虫蛀果实等3类果实的干重和含油量。结果表明:(1)虫害率和空壳率分别达22.6%和53.0%,且不同个体和种群间均存在显著差异(P<0.05)。(2)空壳果实(30.7mg/果)和虫蛀果实(33.1mg/果)的干重均不到完好果实(67.4mg/果)的一半;空壳果实(3.9%)和虫蛀果实(3.8%)的含油量均显著低于完好果实(39.9%)。(3)实测的果实产量(2.9kg/树)和油产量(0.6kg/树)分别仅为期望产量的50%(4.7kg/树)和33%(1.9kg/树),但在3个种群之间无显著差异。本研究显示小蜂危害和空壳果实对黄连木果实产量和质量能造成严重影响,在将其作为生物能源树种利用时对此应加以克服。 | 刘琼霞 文礼章 周华建 吴倩 Marvin K.HARRIS 肖治术 | 2011 | 昆虫学报2011，54，10： | 5 |
| 5 | Measurements of Acute Cerebral Infarction: A Clinical Examination Scale显示文摘 | Thomas Brott Harold P. Adams Charles P. Olinger John R. Marler William G. Barsan José Biller Judith Spilker Renee Holleran Robert Eberle Vicki Hertzberg Marvin Rorick Charles J. Moomaw Michael Walker | 1989 | Stroke1989，，7： | 2 |
| 6 | Paradoxical Increase in Ventricular Torsion and Systolic Torsion Rate in Type I Diabetic Patients Under Tight Glycemic Control显示文摘 | Jina Chung Paul Abraszewski Xin Yu Wei Liu Andrew J. Krainik Marvin Ashford Shelton D. Caruthers Janet B. McGill Samuel A. Wickline | 2006 | Journal of the American College of Cardiology2006，，2： | 2 |
| 7 | Prognostic Factors Influencing Survival in Gastrointestinal Leiomyosarcomas Implications for Surgical Management and Staging显示文摘 | ENG-HEN NG RAPHAEL E. POLLOCK MARK F. MUNSELL EDWARD N. ATKINSON MARVIN M. ROMSDAHL | 1992 | Annals of Surgery1992，，1： | 2 |
| 8 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 9 | Zinc finger structure-function in Ikaros显示文摘The zinc finger motif was used as a vehicle for the initial discovery of Ikaros in the context of T-cell differentiation and has been central to all subsequent analyses of Ikaros function.The Ikaros gene is alternately spliced to produce several isoforms that confer diversity of function and consequently have complicated analysis of the function of Ikaros in vivo.Key features of Ikaros in vivo function are associated with six C2H2 zinc fingers;four of which are alternately incorporated in the production of the various Ikaros isoforms.Although no complete structures are available for the Ikaros protein or any of its family members,considerable evidence has accumulated about the structure of zinc fingers and the role that this structure plays in the functions of the Ikaros family of proteins.This review summarizes the structural aspects of Ikaros zinc fingers,individually,and in tandem to provide a structural context for Ikaros function and to provide a structural basis to inform the design of future experiments with Ikaros and its family members. | Marvin A Payne | 2011 | World Journal of Biological Chemistry2011，2，6： | 2 |
| 10 | A Reporting System on Patients Evaluated for Coronary Artery Disease显示文摘 | W. GERALD AUSTEN JESSE E. EDWARDS ROBERT L. FRYE GOFFREDO G. GENSINI VINCENT L. GOTT LAWRENCE S. C. GRIFFITH DWIGHT C. MCGOON MARVIN L. MURPHY BENSON B. ROE | 1975 | Circulation1975，，4： | 2 |
| 11 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，14： | 2 |
| 12 | The method of quantitative burn-wound biopsy cultures and its rountine use in the care of burned patient 显示文摘 | Loebl EC Marvin JA Correri PW | 1974 | Am J Clin Pathol1974，61，1： | 1 |
| 13 | A data mining analysis of RTID alarms显示文摘 | STEFANOS M MARVIN C DAN Z | 2000 | Computer Networks2000，34，4： | 1 |
| 14 | Doppler-corrected differential detect ion of mpsk显示文摘 | Marvin K S Dariush D | 1989 | IEEE Trans on Communications1989，37，2： | 1 |
| 15 | Development of replication-defective adenovirus serotype 5 containing the caspid and 3C protease coding regions of Foot-and-Mouth disease virus as a vaccine candinate显示文摘 | Mayr G A Chinsangaram J Marvin J Grubman | 1999 | Virology1999，263，： | 1 |
| 16 | Can cities shape socio - technical transitions and how would we know if they were? 显示文摘 | Hodson M Marvin S | 2010 | Research Policy2010，，4： | 1 |
| 17 | A multiple mode equivalent transmission line method of crosstalk between conductors in shielded environments显示文摘 | Render M C Marvin A C | 1995 | IEEE Transactions on Electromagnetic Compatibility1995，37，3： | 1 |
| 18 | A rapid method for magnetic granulometry with applications to environmental studies显示文摘 | Banerjee S K King J Marvin J | | 0，，04： | 1 |
| 19 | Analytical methods in bioas-say-directed investigations of mutagenicity of air particulatematerial显示文摘 | MARVIN C H HEWITT L M | 2007 | Mutat Res2007，636，13： | 1 |
| 20 | Expression of angiogenic and neurotrophic factors in the human amnion and choriodecidua 显示文摘 | Marvin KW Keelan JA Eykholt RL | 2002 | Am J Obstet Gynecol2002，187，3： | 1 |
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