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| 1 | 2008中西方BNP专家共识显示文摘1.前言
2008年6月,来自中国、美国、欧洲的急诊科、心血管科、实验室及内科临床专家相聚在中国上海。 | Alan Maise Christian Mueller W. Frank Peacock Gerasimos Filippatos Hu Dayi 胡大一(主译) 刘梅颜(主译) 吴寸草(翻译) 王博雅(翻译) 黄睿(翻译) | 2009 | 中国医药导刊2009，11，10： | 76 |
| 2 | Cardiac autonomic neuropathy in patients with diabetes mellitus显示文摘Cardiac autonomic neuropathy(CAN)is an often overlooked and common complication of diabetes mellitus.CAN is associated with increased cardiovascular morbidity and mortality.The pathogenesis of CAN is complex and involves a cascade of pathways activated by hyperglycaemia resulting in neuronal ischaemia and cellular death.In addition,autoimmune and genetic factors are involved in the development of CAN.CAN might be subclinical for several years until the patient develops resting tachycardia,exercise intolerance,postural hypotension,cardiac dysfunction and diabetic cardiomyopathy.During its sub-clinical phase,heart rate variability that is influenced by the balance between parasympathetic and sympathetic tones can help in detecting CAN before the disease is symptomatic.Newer imaging techniques(such as scintigraphy)have allowed earlier detection of CAN in the pre-clinical phase and allowed better assessment of the sympathetic nervous system.One of the main difficulties in CAN research is the lack of a universally accepted definition of CAN;however,the Toronto Consensus Panel on Diabetic Neuropathy has recently issued guidance for the diagnosis and staging of CAN,and also proposed screening for CAN in patients with diabetes mellitus.A major challenge,however,is the lack of specific treatment to slow the progression or prevent the development of CAN.Lifestyle changes,improved metabolic control might prevent or slow the progression of CAN.Reversal will require combination of these treatments with new targeted therapeutic approaches.The aim of this article is to review the latest evidence regarding the epidemiology,pathogenesis,manifestations,diagnosis and treatment for CAN. | Gerasimos Dimitropoulos Abd A Tahrani Martin J Stevens | 2014 | World Journal of Diabetes2014，5，1： | 48 |
| 3 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 4 | Endoscopic extraction of large common bile duct stones:A review article显示文摘Since therapeutic endoscopic retrograde cholangiopancreatography replaced surgery as the first approach in cases of choledocolithiasis,a plethora of endoscopic techniques and devices appeared in order to facilitate rapid,safe and effective bile duct stones extraction.Nowadays,endoscopic sphincterotomy combined with balloon catheters and/or baskets is the routine endoscopic technique for stone extraction in the great majority of patients.Large common bile duct stones are treated conventionally with mechanical lithotripsy,while the most serious complication of the procedure is 'basket and stone impaction' that is predominately resolved surgically.In cases of difficult,impacted,multiple or intrahepatic stones,more sophisticated procedures have been used.Electrohydraulic lithotripsy and laser lithotripsy are performed using conventional mother-baby scope systems,ultra-thin cholangio-scopes,thin endoscopes and ultimately using the novel single use,single operator SpyGlass Direct Visualization System,in order to deliver intracorporeal shock wave energy to fragment the targeted stone,with very good outcomes.Recently,large balloon dilation after endoscopic sphincterotomy confirmed its effectiveness in the extraction of large stones in a plethora of trials.When compared with mechanical lithotripsy or with balloon dilation alone,it proved to be superior.Moreover,dilation is an ideal alternative in cases of altered anatomy where access to the papilla is problematic.Endoscopic sphincterotomy followed by large balloon dilation represents the onset of a new era in large bile duct stone extraction and the management of 'impaction' because it seems that is an effective,inexpensive,less traumatic,safe and easy method that does not require sophisticated apparatus and can be performed widely by skillful endoscopists.When complete extraction of large stones is unsuccessful,the drainage of the common bile duct is mandatory either for bridging to the final therapy or as a curative therapy for very elderly patients with short life expectancy.Placing of more than one plastic endoprostheses is better while the administration of Ursodiol is ineffective.The great majority of patients with large stones can be treated endoscopically.In cases of unsuccessful stone extraction using balloons,baskets,mechanical lithotripsy,electrohydraulic or laser lithotripsy and large balloon dilation,the patient should be referred for extracorporeal shock wave lithotripsy or a percutaneous approach and finally surgery. | Gerasimos Stefanidis Christos Christodoulou Spilios Manolakopoulos Ram Chuttani | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 23 |
| 5 | Steatosis and steatohepatitis in postmortem material from Northwestern Greece显示文摘AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to def ine the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece. | Christos D Zois Gerasimos H Baltayiannis Anna Bekiari Anna Goussia Peter Karayiannis Michalis Doukas Demetrios Demopoulos Antigoni Mitsellou Theodoros Vougiouklakis Vasiliki Mitsi Epameinondas V Tsianos | 2010 | World Journal of Gastroenterology2010，16，31： | 4 |
| 6 | Alternative Transcription Initiation and the AUG Context Configuration Control Dual-Organellar Targeting and Functional Competence of Arabidopsis Lon 1 Protease显示文摘细胞的动态平衡包括女伴和朊酶依靠蛋白质质量控制的部件。在细菌和 eukaryoticorganelles, Lon 朊酶在移开不能挽回地损坏的蛋白质并且从而阻止 accumulationof 起一个关键作用有害降级抵抗的总数。基因表示,实时房间的成像, immunobiochemical,和功能的 complementationapproaches 为对叶绿体和线粒体双指向的 Lon1 提供最后的证据。Dual-organellar depositionof Lon1 isoforms 经由漏的核糖体 scanningfrom 取决于 transcriptional 规定和其他的翻译开始从最佳 Kozak 一致广泛地背离的第一 8 月顺序上下文。在 Arabidopsis lon1-1 异种的部分互补的细胞器特定的 Lon1 targetingresults,而完整的互补被指向的 dual-organellar 完全完成。两最佳并且 non-optimalAUG 顺序上下文在酵母是功能的并且便于漏的核糖体扫描当 mitochondrial presequence 被使用时,补充 pim1 显型。生物信息的搜索与 Lon1 类型双指向的顺序组织识别了一小部分 Arabidopsis 基因。Lon4, Lon1 的 paralog,模糊 presequence 多半从祖先的象 Lon1 一样基因的成双的 presequences 演变,产生单个双目标的蛋白质 isoform。我们要求那 Lon1 和它的 subfunctional paralog Lon4 发展了 transcriptional 和 posttranscriptional 的互补子集对为 dual-organellar targeting.Key 词的 environmentalcues 应答的规章的部件: | Gerasimos Daras Stamatis Rigas Dikran Tsitsekian Hadas Zur Tamir Tuller Polydefkis Hatzopoulos | 2014 | Molecular Plant2014，7，6： | 4 |
| 7 | Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer:Quo vadis?显示文摘Breast cancer(BC) is the most frequent type of non skin cancer among women and a major leading cause of cancer-related deaths in Western countries. It is substantial to discover novel biomarkers with diagnostic, prognostic or predictive usefulness as well as therapeutic value for BC. Micro-RNAs(miR NAs) belong to a novel class of endogenous interfering RNAs that play a crucial role in post transcriptional gene silencing through m RNA targeting and, thus, are involved in many biological processes encompassing apoptosis,cell-cycle control, cell proliferation, DNA repair, immunity, metabolism, stress, aging, etc. Mi RNAs exert their action mainly in a tumor suppressive or oncogenic manner. The specific aberrant expression patterns of miR NAs in BC that are detected with the use of highthroughput technologies reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miR NAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and,at the same time, accumulating evidence has underscored the possible contribution of miR NAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via mi RNA delivery and mi RNA inhibition. The purpose of this review is to explore the ontological role of miR NAs in BC etiopathogenesis as well as to highlight their potential, not only as non-invasive circulating biomarkers with diagnostic and prognostic significance, but also as treatment response predictors and therapeutic targets aiding BC management. | Gerasimos Socrates Christodoulatos Maria Dalamaga | 2014 | World Journal of Clinical Oncology2014，5，2： | 4 |
| 8 | A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulation显示文摘AIM: During endoscopic retrograde cholangiopancreatography (ERCP), selective cannulation of the common bile duct (CBD) is required in most of the cases.METHODS: From June 2001 till December 2002, all patients referred to our unit for ERCP were considered for entry into the study. Selective CBD cannulation was first attempted with a standard catheter with or without the use of a guidewire. In cases, where CBD cannulation was considered unsuccessful, patients were crossed over to a double-lumen sphincterotome and a guidewire. All patients were hospitalized for 24 h after the procedure in order to assess the incidence of post-ERCP complications.RESULTS: The study sample consisted of 158 patients.Selective CBD cannulation using a standard ERCP catheter with or without the assistance of a guidewire, was accomplished in 129 patients (success rate: 81.65%).From the 29 patients who were crossed over to a sphincterotome and a guidewire, selective CBD cannulation was achieved in 24; the overall success rate rising to 96.8%. Meanwhile, the use of this technique did not increase the incidence of post-ERCP complications.CONCLUSION: The use of a sphincterotome and a guidewire increases the success rate of selective bile duct cannulation in cases that this has not been accomplished with a standard catheter. | Georgios Karamanolis Aikaterini Katsikani Nikos Viazis Gerasimos Stefanidis Spilios Manolakopoulos Spiros Sgouros Efthimia Papadopoulou Apostolos Mantides | 2005 | World Journal of Gastroenterology2005，11，11： | 3 |
| 9 | Integrated colloidal quantum dot photodetectors with color-tunable plasmonic nanofocusing lenses显示文摘High-sensitivity photodetection is at the heart of many optoelectronic applications,including spectroscopy,imaging,surveillance,remote sensing and medical diagnostics.Achieving the highest possible sensitivity for a given photodetector technology requires the development of ultra-small-footprint detectors,as the noise sources scale with the area of the detector.This must be accomplished while sacrificing neither the optically active area of the detector nor its responsivity.Currently,such designs are based on diffraction-limited approaches using optical lenses.Here,we employ a plasmonic flat-lens bull’s eye structure(BES)to concentrate and focus light into a nanoscale colloidal quantum dot(CQD)photodetector.The plasmonic lenses function as nanofocusing resonant structures that simultaneously offer color selectivity and enhanced sensitivity.Herein,we demonstrate the first CQD photodetector with a nanoscale footprint,the optically active area of which is determined by the BES;this detector represents an exciting opportunity for high-sensitivity sensing. | Silke L Diedenhofen Dominik Kufer Tania Lasanta Gerasimos Konstantatos | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 10 | Concomitant gastric adenocarcinoma and stromal tumor in a woman with polymyalgia rheumatica显示文摘胃肠的基质肿瘤(大意) 是胃肠道的稀罕的瘤(1%) ,到我们的知识,胃的癌和大意的同步表示的仅仅稀罕的案例在文学被汇报。有胃的腺癌和大意的一个同时的演讲的 72 岁的女性被介绍。而且,由于多肌痛风湿病一病人作为治疗收到了 corticosteroids 最后 3 年。这些瘤的伴随物出现可以包含普通致癌因素,能有有多肌痛的一个协会风湿病任何一个作为帕拉肿瘤的表示或由于它有 corticosteroids 的治疗。 | Panteleimon Kountourakis Niki Arnogiannaki Ilias Stavrinides Nikiforos Apostolikas Gerasimos Rigatos | 2008 | World Journal of Gastroenterology2008，14，43： | 3 |
| 11 | Routine modified D2 lymphadenectomy performance in pT1-T2N0 gastric cancer显示文摘AIM:To evaluate routine modified D2 lymphadenectomy in gastric cancer,based on immunohistochemically detected skip micrometastases in levelⅡlymph nodes. METHODS:Among 95 gastric cancer patients who were routinely submitted to curative modified D2 lymphadenectomy,from January 2004 to December 2008,32 were classified as pN0.All levelⅠlymph nodes of these 32 patients were submitted to immunohistochemistry for micrometastases detection. Patients in whom micrometastases were detected in the levelⅠlymph node stations(n=4)were excluded from further analysis.The levelⅡlymph nodes of the remaining 28 patients were studied immunohistochemically for micrometastases detection and constitute the material of the present study. RESULTS:Skip micrometastases in the levelⅡlymph nodes were detected in 14%(4 out of 28)of the patients. The incidence was further increased to 17%(4 out of24)in the subgroup of T1-2 gastric cancer patients.All micrometastases were detected in the No.7 lymph node station.Thus,the disease was upstaged from stageⅠA toⅠB in one patient and from stageⅠB toⅡin three patients. CONCLUSION:In gastric cancer,true R0 resection may not be achieved without modified D2 lymphadenectomy. Until D2+/D3 lymphadenectomy becomes standard, modified D2 lymphadenectomy should be performed routinely. | John Griniatsos Hara Gakiopoulou Eugenia Yiannakopoulou Nikoletta Dimitriou Gerasimos Douridas Afrodite Nonni Theodoros Liakakos Evangelos Felekouras | 2009 | World Journal of Gastroenterology2009，15，44： | 3 |
| 12 | Covered Wallstents for palliation of malignant biliary obstruction: primary stent placement versus reintervention显示文摘 | Laura C. Ornellas Gerasimos Stefanidis Ram Chuttani Andres Gelrud T. Barry Kelleher Douglas K. Pleskow | 2009 | Gastrointestinal Endoscopy2009，，： | 2 |
| 13 | Efficient differentiation of vascular smooth muscle cells from Wharton's Jelly mesenchymal stromal cells using human platelet lysate: A potential cell source for small blood vessel engineering显示文摘BACKGROUND The development of fully functional small diameter vascular grafts requires both a properly defined vessel conduit and tissue-specific cellular populations.Mesenchymal stromal cells(MSCs) derived from the Wharton's Jelly(WJ) tissue can be used as a source for obtaining vascular smooth muscle cells(VSMCs),while the human umbilical arteries(h UAs) can serve as a scaffold for blood vessel engineering.AIM To develop VSMCs from WJ-MSCs utilizing umbilical cord blood platelet lysate.METHODS WJ-MSCs were isolated and expanded until passage(P) 4. WJ-MSCs were properly defined according to the criteria of the International Society for Cell and Gene Therapy. Then, these cells were differentiated into VSMCs with the use of platelet lysate from umbilical cord blood in combination with ascorbic acid,followed by evaluation at the gene and protein levels. Specifically, gene expression profile analysis of VSMCs for ACTA2, MYH11, TGLN, MYOCD, SOX9,NANOG homeobox, OCT4 and GAPDH, was performed. In addition,immunofluorescence against ACTA2 and MYH11 in combination with DAPI staining was also performed in VSMCs. HUAs were decellularized and served as scaffolds for possible repopulation by VSMCs. Histological and biochemical analyses were performed in repopulated h UAs.RESULTS WJ-MSCs exhibited fibroblastic morphology, successfully differentiating into'osteocytes', 'adipocytes' and 'chondrocytes', and were characterized by positive expression(> 90%) of CD90, CD73 and CD105. In addition, WJ-MSCs were successfully differentiated into VSMCs with the proposed differentiation protocol. VSMCs successfully expressed ACTA2, MYH11, MYOCD, TGLN and SOX9. Immunofluorescence results indicated the expression of ACTA2 and MYH11 in VSMCs. In order to determine the functionality of VSMCs, h UAs were isolated and decellularized. Based on histological analysis, decellularized h UAs were free of any cellular or nuclear materials, while their extracellular matrix retained intact. Then, repopulation of decellularized h UAs with VSMCs was performed for 3 wk. Decellularized h UAs were repopulated efficiently by the VSMCs. Biochemical analysis revealed the increase of total hydroyproline and s GAG contents in repopulated h UAs with VSMCs. Specifically, total hydroxyproline and s GAG content after the 1 st, 2 nd and 3 rd wk was 71 ± 10, 74 ± 9 and 86 ± 8 μg hydroxyproline/mg of dry tissue weight and 2 ± 1, 3 ± 1 and 3 ± 1μg s GAG/mg of dry tissue weight, respectively. Statistically significant differences were observed between all study groups(P<0.05).CONCLUSION VSMCs were successfully obtained from WJ-MSCs with the proposed differentiation protocol. Furthermore, h UAs were efficiently repopulated by VSMCs. Differentiated VSMCs from WJ-MSCs could provide an alternative source of cells for vascular tissue engineering. | Panagiotis Mallis Aggeliki Papapanagiotou Michalis Katsimpoulas Alkiviadis Kostakis Gerasimos Siasos Eva Kassi Catherine Stavropoulos-Giokas Efstathios Michalopoulos | 2020 | World Journal of Stem Cells2020，12，3： | 2 |
| 14 | Effective sleep apnoea treatment improves cardiac function in patients with chronic heart failure显示文摘 | Spiros P. Kourouklis Emmanouil Vagiakis Ioannis A. Paraskevaidis Dimitrios Farmakis Konstantinos Kostikas John T. Parissis Apostolos Katsivas Dimitrios T. Kremastinos Maria Anastasiou-Nana Gerasimos Filippatos | 2012 | International Journal of Cardiology2012，，： | 1 |
| 15 | ESC guidelines for the diagnosis and treatment of acute and chronic heart failure显示文摘 | Kenneth D Alain CS Gerasimos F | | 0，，： | 1 |
| 16 | Nonlinear Kalman Filters and Particle Filters for integrated navigation of unmanned aerial vehicles 显示文摘 | Gerasimos G Rigatos | 2012 | Robotics and Autonomous Systems2012，60，2： | 1 |
| 17 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 18 | Extended Kalman and Particle Filtering for sen- sor fusion in motion control of mobile robots 显示文摘 | Gerasimos G Rigatos | 2010 | Mathematics and Computers in Simulation2010，81，： | 1 |
| 19 | Digoxin Use and Lower 30-day All-cause Readmission for Medicare Beneficiaries Hospitalized for Heart Failure显示文摘 | Ali Ahmed Robert C. Bourge Gregg C. Fonarow Kanan Patel Charity J. Morgan Jerome L. Fleg Inmaculada B. Aban Thomas E. Love Clyde W. Yancy Prakash Deedwania Dirk J. van Veldhuisen Gerasimos S. Filippatos Stefan D. Anker Richard M. Allman | 2014 | The American Journal of Medicine2014，，1： | 1 |
| 20 | Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches显示文摘 | Dimitris Tousoulis Chryssa Simopoulou Nikos Papageorgiou Evangelos Oikonomou George Hatzis Gerasimos Siasos Eleftherios Tsiamis Christodoulos Stefanadis | 2014 | Pharmacology and Therapeutics2014，，3： | 1 |
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