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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 猪乳中一组高分子量蛋白的多态性及其与繁殖性能关系的研究显示文摘采用十二烷基硫酸钠 聚丙烯酰胺凝胶不连续垂直板电泳 (SDS PAGE)对 16 2头二花脸母猪乳中一组高分子量蛋白质 (HMWP)进行了检测 ,计算了该位点的基因型频率、等位基因频率和遗传多样性指数等 ,并运用线性模型统计方法分析了该位点的不同基因型与母猪繁殖性能的关系。结果表明 ,在二花脸猪种群 ,乳中HMWP存在B(M :11480 0± 40 0 )和D(M :10 140 0± 6 0 0 )两种带 ,分别受二个等位基因HB 和HD 控制。BB、BD和DD三种基因型频率分别为 0 6 6 6 7、0 2 716和 0 0 6 17,两个等位基因HB 和HD 频率分别为 0 80 2 5和 0 1975 ,遗传多样性指数为0 3170。在三种HMWP基因型中 ,不同基因型母猪的繁殖性能在活仔数和窝重上存在着显著差异 (P <0 0 5 ) ,但在初生仔猪个体重和 2 0日龄窝重上未达到显著水平 (P >0 0 5 )。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2002 | 畜牧兽医学报2002，33，5： | 9 |
| 3 | A new state of charge determination method for battery management system显示文摘State of Charge (SOC) determination is an increasingly important issue in battery technology. In addition to the immediate display of the remaining battery capacity to the user, precise knowledge of SOC exerts additional control over the charging/discharging process which in turn reduces the risk of over-voltage and gassing, which degrade the chemical composition of the electrolyte and plates. This paper describes a new approach to SOC determination for the lead-acid battery management system by combining Ah-balance with an EMF estimation algorithm, which predicts the battery’s EMF value while it is under load. The EMF estimation algorithm is based on an equivalent-circuit representation of the battery, with the parameters determined from a pulse test performed on the battery and a curve-fitting algorithm by means of least-square regression. The whole battery cycle is classified into seven states where the SOC is estimated with the Ah-balance method and the proposed EMF based algorithm. Laboratory tests and results are described in detail in the paper. | 朱春波 王铁成 HURLEY W G | 2004 | Journal of Harbin Institute of Technology(New Series)2004，11，6： | 4 |
| 4 | Posterior ankle impingement syndrome: A systematic fourstage approach显示文摘Posterior ankle impingement syndrome(PAIS) is a common injury in athletes engaging in repetitive plantarflexion, particularly ballet dancers and soccer players. Despite the increase in popularity of the posterior twoportal hindfoot approach, concerns with the technique remain, including; the technical difficulty, relatively steep learning curve, and difficulty performing simultaneous anterior ankle arthroscopy. The purpose of the current literature review is to provide comprehensive knowledge about PAIS, and to describe a systematic four-stage approach of the posterior two-portal arthroscopy. The etiology, clinical presentation, diagnostic strategies are first introduced followed by options in conservative and surgical management. A detailed systematic approach to posterior hindfoot arthroscopy is then described. This technique allows for systematic review of the anatomic structures and treatment of the bony and/or soft tissue lesions in four regions of interest in the hindfoot(superolateral, superomedial, inferomedial, and inferolateral). The review then discusses biological adjuncts and postoperative rehabilitation and ends with a discussion on the most recent clinical outcomes after posterior hindfoot arthroscopy for PAIS. Although clinical evidence suggests high success rates following posterior hindfoot arthroscopy in the short- and mid-term it may be limited in the pathology that can be addressed due to the technical skills required, but the systematic four-stage approach of the posterior two-portal arthroscopy may improve upon this problem. | Youichi Yasui Charles P Hannon Eoghan Hurley John G Kennedy | 2016 | World Journal of Orthopedics2016，7，10： | 4 |
| 5 | 猪乳中乳成分变化的曲线拟合显示文摘以 10 0头二花脸母猪作为试验动物 ,对猪乳中蛋白质、乳糖、IGF- 、EGF和胰岛素含量在泌乳 1~ 2 1d阶段的变化进行了曲线拟合 ,并分析了这些乳成分的变化规律。结果表明 ,倒数曲线为乳蛋白、IGF- 、EGF和胰岛素随泌乳时间变化的最优拟合曲线。乳蛋白、IGF- 、EGF和胰岛素含量随时间的延续而下降 ,其拟合方程分别为 :y=33.74 4+85 .80 3÷ x(g· L- 1 ) ,y=4 2 .5 94 +2 90 .0 2 3÷ x(μg· L- 1 ) ,y=132 .84 1+6 38.5 98÷ x(ng· L- 1 ) ,y=18.0 73+316 .92 3÷ x(U·m L- 1 ) ,其中 x为泌乳天数。乳糖的最优拟合曲线为对数曲线 ,乳糖含量随时间的延续而上升 ,其拟合方程为 :y=32 .2 2 3+9.6 2 6 lnx(g· L- 1 ) ,x为泌乳天数。猪乳成分变化最为剧烈的是在初乳期 。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2004 | 中国兽医学报2004，24，3： | 4 |
| 6 | 猪乳中一组高分子量蛋白质的表达量与母猪泌乳性能关系的研究显示文摘通过设计的数学模型,分析了162头二花脸母猪和50头大约克母猪乳中一组高分子量蛋白质(HMWP)的基因表达量(HMWP浓度)与母猪泌乳性能的关系。结果表明,初乳和常乳中HMWP的基因表达量与乳中蛋白质和表皮生长因子(EGF)含量存在显著相关(P<0.05或P<0.01),其中常乳中HMWP的基因表达量与乳蛋白存在极显著正向线性相关(P<0.01)。常乳中HMWP基因表达量与乳糖含量也有正向线性相关的趋势(P<0.1),但与类胰岛素样生长因子-1(IGF-I)和胰岛素含量无显著相关性(P>0.1)。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2004 | 畜牧兽医学报2004，35，3： | 3 |
| 7 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 8 | Effects of eutrophication on salmonid communities in oligotrophic lakes显示文摘 | Colby P Spangler G R Hurley D A | 1972 | Journal of the Fisheries Research Board of Canada1972，29，： | 2 |
| 9 | pH 和某些阳离子对乳铁蛋白与肝素结合的影响显示文摘利用酶标板固定乳铁蛋白,用生物素标记肝素,研究 pH 和某些阳离子对乳铁蛋白与肝素结合的影响.结果表明,在100 mmol/L NaCl 时,两者结合的最适 pH 为6.0;无 NaCl 时,为6.5.Na^+和 Ca^+对于乳铁蛋白与肝素的结合有协同的效应,两者的最大结合发生在125mmol/L NaCl 和无 Ca^(2+)或低 Ca^(2+)浓度下;而在低 NaCl 浓度时,Ca^(2+)则促进两者的结合.Zn^(2+)和 Cu^(2+)对乳铁蛋白与肝素的结合有抑制,在100 mmol/L NaCl 时,800μmol/L 的 Cu^2+和900μmol/L 的 Zn^(2+)分别使结合率降低一半。 | 邹思湘 W Hurley | 1992 | 南京农业大学学报1992，15，4： | 2 |
| 10 | A unifying model of cation binding by humic substances显示文摘 | Tipping E and Hurley M A | 1992 | Geochim cosm ochim acta1992，56，： | 2 |
| 11 | 猪乳中一组高分子量蛋白质的多态性及其与泌乳性能的关系显示文摘采用SDS PAGE法对 16 2头二花脸母猪和 5 0头大约克母猪乳中一组高分子量蛋白质 (HMWP)进行了检测 ,计算了该位点基因型频率、等位基因频率和遗传多样性指数 ,并运用线性模型统计方法分析二花脸母猪该位点不同基因型与母猪泌乳性能的关系。结果表明 ,在猪种群中 ,乳中HMWP存在A (相对分子质量 14 6 80 0± 14 0 0 ) ,B ( 114 80 0± 4 0 0 ) ,C ( 10 86 0 0 )和D ( 10 14 0 0± 6 0 0 ) 4种带型 ,分别受 4个等位基因HA、HB、HC 和HD 控制。在二花脸猪乳中HMWP表现出BB、BD和DD 3种基因型 ,其频率分别为 0 6 6 6 7,0 2 716和 0 0 6 17;两个等位基因HB 和HD 频率分别为 0 80 2 5和0 1975 ;遗传多样性指数为 0 3170。大约克猪乳中HMWP表现出BB、AB和BC 3种基因型 ,其频率分别为 0 880 0 ,0 10 0 0和 0 0 2 0 0 ;等位基因HA、HB 和HC 的频率分别为 0 0 5 0 0 ,0 94 0 0和 0 0 10 0 ;遗传多样性指数为 0 1138。在二花脸猪种群中 ,不同HMWP基因型在乳糖浓度上存在显著差异 (P <0 0 5 ) ,但在乳蛋白浓度差异不显著 (P >0 0 5 )。 | 秦宜德 徐银学 邹思湘 Walter L Hurley | 2003 | 南京农业大学学报2003，26，3： | 2 |
| 12 | Effects of induced or delayed parturition and supplemental dietary fat oncolostrum and milk composition in sows显示文摘 | Jackson J R Hurley W L Easter R A | 1995 | J Anim Sci1995，73，： | 2 |
| 13 | Innovativeness: Its antecedents and impact on business performance显示文摘 | HULT GTM HURLEY R F KNIGHT G A | 2004 | Industrial Marketing Management2004，33，5： | 1 |
| 14 | The analytic hierarchy process: Does adjusting a pairwise comparison matrix to improve the consistency ratio help显示文摘 | Finan J S Hurley W J | 1997 | Computers Opserational Research1997，24，8： | 1 |
| 15 | Formation of ultra-fine ferrite in hot rolled strip:potential mechanisms for grain refinement显示文摘 | Hurley P J Hodgson P D | 2001 | Materials Science and Engineering:A2001，302，2： | 1 |
| 16 | Air pollution and daily mortality in the Coachella Valley,California:a study of PM10 dominated by coarse particles显示文摘 | Hurley S Lipsctt MJ | 1999 | Environmental Research Section A1999，81，： | 1 |
| 17 | Male infertility and environmental exposure to lead and cadmium 显示文摘 | BENOFF S JACOB A HURLEY I R | 2000 | Hum Reprod Update2000，6，2： | 1 |
| 18 | Formation of ultrafine ferrite in hot rolled strip: potential mechanisms for grain refinement 显示文摘 | Hurley P J Hodgson P D | 2001 | Materials Science and Engineering A2001，302，： | 1 |
| 19 | Group rings and rings of matrices显示文摘 | HURLEY T | 2006 | Int J Pure Appl Math2006，31，： | 1 |
| 20 | G-quadruplex DNA:a potential target for anti-cancer drug design显示文摘 | HAN H Y HURLEY L H | 2000 | Trends Pharm Sci2000，21，4： | 1 |
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