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| 1 | New Insights into the Shikimate and Aromatic Amino Acids Biosynthesis Pathways in Plants显示文摘在植物的芳香的氨基酸本氨基丙酸,酷氨酸,和色氨酸是蛋白质合成的必要部件不仅,而且为为植物生长以及为人的营养和健康是重要的大量第二等的代谢物用作先锋。芳香的氨基酸经由分叉的芳香的氨基酸生合成小径跟随的 shikimate 小径被综合,与担任一个学生的 chorismate 中间的分支点代谢物。然而,这些氨基酸的合成的规定和协作仍然远非正在被理解。这些小径上的最近的研究与唯一的进化起源识别了很多条其他的跨 regulated 生合成线路。尽管在植物的 Phe 和 Tyr 生合成的主要线路经由中间的代谢物 arogenate 发生,最近的研究建议植物能也综合经由中间的代谢物 phenylpyruvate (PPY ) 的本氨基丙酸,同样到许多微生物。最近的研究也鉴别调整编码 shikimate 和芳香的氨基酸小径以及多重第二等的代谢物的酶的基因的表示的很多个抄写因素在 Arabidopsis 并且在另外的植物种类源于他们。 | Vered Tzin Gad Galili | 2010 | Molecular Plant2010，3，6： | 43 |
| 2 | 专利引证视角下技术轨道演化与技术锁定识别——以光刻技术为例显示文摘本研究结合技术轨道特性界定了技术锁定的内涵与特征,提出一种识别技术锁定的新方法。以光刻技术为例,通过构建专利引文网络识别技术主路径,描绘其技术轨道的动态演化,追溯了不同技术来源在不同阶段的技术贡献,并从技术和地域不同层面分析了技术多样性。研究结果表明:从1980-2010年,光刻技术长期处在锁定状态,然而从2010年之后,技术呈现出多样化的发展方向。光刻技术早期被美国、德国和日本控制,近些年随着技术多样性指数上升,后发国家或地区逐渐兴起,韩国和中国台湾对近期的光刻技术贡献较大,主要集中在光刻胶技术上。中国的光刻技术与发达国家有较大的差距,尚未出现在技术发展主路径中,技术类别涉及范围有限,技术贡献较小。本研究对于探索技术锁定形成,识别技术机会,破解我国“技术锁定”困局具有重大启示。 | 杨武 陈培 Gad David | 2022 | 科学学研究2022，40，2： | 19 |
| 3 | Is aggressive intravenous fluid resuscitation beneficial in acute pancreatitis? A meta-analysis of randomized control trials and cohort studies显示文摘BACKGROUND There is conflincting evidence on the intravenous fluid(IVF)strategy for acute pancreatitis(AP).We perform a metaanalysis of the available evidence.AIM To investigate if aggressive IVF therapy in AP patients is beneficial to decrease mortality and improve outcomes.METHODS Metaanalysis of available randomized controlled trials and cohort studies comparing aggressive IVF vs non-aggressive IVF resuscitation.RESULTS There was no significant difference in mortality between the aggressive(n=1229)and non-aggressive IVF(n=1397)patients.Patients receiving aggressive IVF therapy had higher risk for acute kidney injury and acute respiratory distress syndrome.There also was no significant difference in the overall incidence of systemic inflammatory response syndrome,persistent organ failure,pancreatic necrosis when comparing both study groups.CONCLUSION Early aggressive IVF therapy did not improve mortality.Moreover,aggressive IVF therapy could potentially increase the risk for acute kidney injury and pulmonary edema leading to respiratory failure and mechanical ventilation.Studies are needed to investigate which subset of AP patients could benefit from aggressive IVF therapy. | Mohamed M Gad C.Roberto Simons-Linares | 2020 | World Journal of Gastroenterology2020，26，10： | 18 |
| 4 | Molecular overview of progressive familial intrahepatic cholestasis显示文摘Cholestasis is a clinical condition resulting from the imapairment of bile flow.This condition could be caused by defects of the hepatocytes,which are responsible for the complex process of bile formation and secretion,and/or caused by defects in the secretory machinery of cholangiocytes.Several mutations and pathways that lead to cholestasis have been described.Progressive familial intrahepatic cholestasis(PFIC)is a group of rare diseases caused by autosomal recessive mutations in the genes that encode proteins expressed mainly in the apical membrane of the hepatocytes.PFIC 1,also known as Byler’s disease,is caused by mutations of the ATP8B1 gene,which encodes the familial intrahepatic cholestasis 1 protein.PFIC 2 is characterized by the downregulation or absence of functional bile salt export pump(BSEP)expression via variations in the ABCB11 gene.Mutations of the ABCB4 gene result in lower expression of the multidrug resistance class 3 glycoprotein,leading to the third type of PFIC.Newer variations of this disease have been described.Loss of function of the tight junction protein 2 protein results in PFIC 4,while mutations of the NR1H4 gene,which encodes farnesoid X receptor,an important transcription factor for bile formation,cause PFIC 5.A recently described type of PFIC is associated with a mutation in the MYO5B gene,important for the trafficking of BSEP and hepatocyte membrane polarization.In this review,we provide a brief overview of the molecular mechanisms and clinical features associated with each type of PFIC based on peer reviewed journals published between 1993 and 2020. | Sriram Amirneni Nils Haep Mohammad A Gad Alejandro Soto-Gutierrez James E Squires Rodrigo MFlorentino | 2020 | World Journal of Gastroenterology2020，26，47： | 17 |
| 5 | Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%. | ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab | 2017 | World Journal of Gastroenterology2017，23，38： | 15 |
| 6 | Assessment of KL-6 as a tumor marker in patients with hepatocellular carcinoma显示文摘AIM: To investigate the clinical significance of KL-6 as a tumor marker of HCC in two different ethnic groups with chronic liver disease consecutively encountered at outpatient clinics.METHODS: Serum KL-6 was measured by the sandwich enzyme immunoassay method using the KL-6 antibody (Ab) as both the capture and tracerAb according to the manufacturer's instructions (Eisai, Tokyo, Japan).Assessment of alpha fetoprotein (AFP) and protein induced vitamin K deficiency or absence (PIVKA-Ⅱ) was performed in both groups using commercially available kits.RESULTS: A significantly higher mean serum KL-6(556±467 U/L) was found in HCC in comparison with non-HCC groups either with (391±176 U/L; P<0.001)or without (361±161 U/L; P<0.001) liver cirrhosis (LC).Serum KL-6 level did not correlate with either AFP or PIVKA-Ⅱ serU/Levels. Using receiver operating curve analysis for KL-6 as a predictor for HCC showed that the area under the curve was 0.574 (95%CI = 0.50-0.64)and the KL-6 level that gave the best sensitivity (61%) was found to be 334 U/L but according to the manufacturer's instructions; a cut-off point of 500 U/Lwas used that showed the highest specificity (80%)in comparison with AFP and PIVKA-Ⅱ (78% vs 72%respectively). Combining the values of the three markers improved specificity of AFP for HCC diagnosis from 78%for AFP alone; 93% for AFP plus PIVKA-Ⅱ to 99% for both plus KL-6 value (P<0.001). Mean serum alkaline phosphatase level was significantly higher in KL-6positive (564±475) in comparison with KL-6 negative (505±469) HCC patients (P = 0.021), but such a difference was not found among non-HCC corresponding groups.CONCLUSION: KL-6 is suggested as a tumor for HCC.Its positivity may reflect HCC-associated cholestasis and/or local tumor invasion. | Amal Gad Eiji Tanaka Akihiro Matsumoto Moushira Abd-el Wahab Abd el-Hamid Serwah Fawzy Attia Khalil Ali Howayda Hassouba Abd el-Raoof el-Deeb Tetsuya Ichijyo Takeji Umemura Hidetomo Muto Kaname Yoshizawa Kendo Kiyosawa | 2005 | World Journal of Gastroenterology2005，11，42： | 8 |
| 7 | Vascular Calcification: Current Genetics Underlying This Complex Phenomenon显示文摘 | Nonanzit Perez-Hernandez Gad Aptilon-Duque Ruben Blachman-Braun Gilberto Vargas-Alarcon Adrian Asael Rodriguez-Cortes Shely Azrad-Daniez Rosalinda Posadas-Sanchez Jose Manuel Rodriguez-Perez | 2017 | Chinese Medical Journal2017，，9： | 8 |
| 8 | Combined Transcriptomics and Metabolomics of Arabidopsis thaliana Seedlings Exposed to Exogenous GABA Suggest Its Role in Plants Is Predominantly Metabolic显示文摘 | Albert Batushansky Menny Kirma Nicole Grillich David Toubiana Phuong Anh Pham Ilse Balbo Hillel Fromm Gad Galili Alisdair R. Fernie Aaron Fait | 2014 | Molecular Plant2014，7，6： | 7 |
| 9 | 光刻机产业技术扩散与技术动态演化——对“卡脖子”技术的启示显示文摘在当前中美贸易摩擦升级、“卡脖子”技术频繁出现的背景下,研究光刻技术扩散与动态演化对攻克“卡脖子”技术、突破全局具有重要意义。本文利用专利引证数据构建引文网络,并通过局部向前搜索、局部向后搜索和关键路径3种不同的主路径分析方法来描述光刻技术知识扩散路径,进行对比分析,并对光刻技术动态演化的阶段进行了识别与分析。研究结果表明:美、日、德先发优势明显,光刻技术的扩散由台积电、阿斯麦等大公司主导;技术发展前期,主要侧重器件制造和工艺的改进,而在后期则注重光刻材料的研发,从2015年开始技术扩散方向主要集中在EUV光刻胶材料;与全球范围内光刻技术扩散趋势相比,我国进入光刻领域较晚,技术扩散能力不强且尚未出现在技术扩散主路径中。本研究从技术扩散路径和技术动态演化两个角度揭示了光刻技术扩散的客观规律和特征,丰富了“卡脖子”技术的理论研究,为我国技术路径选择提供企业和技术层面的决策支持与经验依据,以期对突破发达国家的核心技术锁定带来一定的启示。 | 杨武 陈培 Gad David | 2022 | 中国科技论坛2022，，9： | 5 |
| 10 | Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome显示文摘AIM: To compare the predictive power of different endothelial progenitor cell (EPC) phenotypic markers for future cardiovascular events. METHODS: Peripheral blood was collected from 76 consecutive patients with acute coronary syndromes (ACS) who underwent percutaneous coronary intervention in our institute. The various EPC phenotypes of peripheral blood mononuclear cells were CD34+CD133+, CD34+KDR+, and CD 133+KDR+. The outcome endpoint included cardiovascular mortality, recurrent ACS, and hospitalization for decompensated heart failure during a 24-mo follow-up period.RESULTS: CD34+CD133+ cells (P = 0.034), but not CD34+KDR+ (P = 0.35) or CD 133+KDR+ cells (P = 0.19), were found to predict recurrent ACS. We found no correlation between EPCs measured by any of the three phenotypic combinations of accepted CD markers and the total combination of these separate outcomes. CONCLUSION: The EPC CD34+CD133+ phenotype, but not the CD34+KDR+ or the CD 133+KDR+ phenotypes, is predictive of future adverse cardiovascular outcomes. | Shmuel Schwartzenberg Arnon Afek Gideon Charach Ardon Rubinstein Yossi Ben-Shoshan Sarina Kissil Sofia Maisel-Auslender Gad Keren Jacob George | 2010 | World Journal of Cardiology2010，2，9： | 5 |
| 11 | 专利家族视角下技术演化路径依赖研究——以光刻技术为例显示文摘以专利家族为研究视角,阐述技术路径动态演化过程中的路径依赖。专利家族自引会对技术主路径造成干扰,通过对主路径进行调整,提出一种修正技术主路径的新思路。研究发现:光刻技术在“投影对准和曝光系统—浸没式投影物镜—浸没式光刻材料—光刻胶”4个阶段经历了“路径消解—路径产生与路径依赖—路径消解与突破”的动态演化过程。在此过程中,以荷兰阿斯麦、德国蔡司和日本东京电子为代表的专利家族发挥重要作用。其中,以阿斯麦为核心的利益联盟垄断核心技术,强化光刻技术发展的路径依赖作用,占据市场领先地位。研究结论有助于深化对路径依赖理论的认知,通过揭示光刻技术路径演化过程及企业演化格局,为后发国家突破技术路径依赖提供实践启示。 | 杨武 陈培 Gad David | 2022 | 科技进步与对策2022，39，23： | 3 |
| 12 | Whole-Plant Live Imaging of Reactive Oxygen Species显示文摘Reactive oxygen species(ROS)are key regulators of numerous subcellular,cellular,and systemic signals.They function in plants as an integral part of many different hormonal,physiological,and developmental pathways,as well as play a critical role in defense and acclimation responses to different biotic and abiotic conditions.Although many ROS imaging techniques have been developed and utilized in plants,a wholeplant imaging platform for the dynamic detection of ROS in mature plants is lacking.Here we report a robust and straightforward method for the whole-plant live imaging of ROS in mature plants grown in soil.This new method could be used to study local and systemic ROS signals in different genetic variants,conduct phenotyping studies to identify new pathways for ROS signaling,monitor the stress level of different plants and mutants,and unravel novel routes of ROS integration into stress,growth regulation,and development in plants.We demonstrate the utility of this new method for studying systemic ROS signals in different A rabidopsis mutants and wound responses in cereals such as wheat and corn. | Yosef Fichman Gad Miller Ron Mittler | 2019 | Molecular Plant2019，12，9： | 3 |
| 13 | ROS signaling: the new wave?显示文摘 | Ron Mittler Sandy Vanderauwera Nobuhiro Suzuki Gad Miller Vanesa B. Tognetti Klaas Vandepoele Marty Gollery Vladimir Shulaev Frank Van Breusegem | 2011 | Trends in Plant Science2011，，6： | 3 |
| 14 | Small for size syndrome difficult dilemma: Lessons from 10 years single centre experience in living donor liver transplantation显示文摘AIM To analyze the incidence, risk factors, prevention, treatment and outcome of small for size syndrome(SFSS) after living donor liver transplantation(LDLT). METHODS Through-out more than 10 years: During the period from April 2003 to the end of 2013, 174 adult-to-adults LDLT(A-ALDLT) had been performed at National Liver Institute, Menoufiya University, Shibin Elkoom, Egypt. We collected the data of those patients to do this cohort study that is a single-institution retrospective analysis of a prospectively collected database analyzing the incidence, risk factors, prevention, treatment and outcome of SFSS in a period started from the end of 2013 to the end of 2015. The median period of follow-up reached 40.50 m, range(0-144 m). RESULTS SFSS was diagnosed in 20(11.5%) of our recipients. While extra-small graft [small for size graft(SFSG)], portal hypertension, steatosis and left lobe graft were significant predictors of SFSS in univariate analysis(P = 0.00, 0.04, 0.03, and 0.00 respectively); graft size was the only independent predictor of SFSS on multivariate analysis(P = 0.03). On the other hand, there was lower incidence of SFSS in patients with SFSG who underwent splenectomy [4/10(40%) SFSS vs 3/7(42.9%) no SFSS] but without statistical significance, However, there was none significant lower incidence of the syndrome in patients with right lobe(RL) graft when drainage of the right anterior and/or posterior liver sectors by middle hepatic vein, V5, V8, and/or right inferior vein was done [4/10(28.6%) SFSS vs 52/152(34.2%) no SFSS]. The 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients with SFSS were 30%, 30%, 25%, 25%, 25% and 25% respectively, while, the 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients without SFSS were 70.1%, 65.6%, 61.7%, 61%, 59.7%, and 59.7% respectively, with statistical significant difference(P = 0.00). CONCLUSION SFSG is the independent and main factor for occurrence of SFSS after A-ALDLT leading to poor outcome. However, the management of this catastrophe depends upon its prevention(i.e., selecting graft with proper size, splenectomy to decrease portal venous inflow, and improving hepatic vein outflow by reconstructing large draining veins of the graft). | Hany Shoreem Emad Hamdy Gad Hosam Soliman Osama Hegazy Sherif Saleh Hazem Zakaria Eslam Ayoub Yasmin Kamel Kalid Abouelella Tarek Ibrahim Ibrahim Marawan | 2017 | World Journal of Hepatology2017，9，21： | 3 |
| 15 | Prevalence and associated risk factors of recurrent otitis media with effusion in children in Upper Egypt显示文摘Objective:We conducted this study to determine the associations of possible risk factors and prevalence of recurrent otitis media with effusion(OME)in a cohort of children in Upper Egypt.Methods:This was a cross-sectional study undertaken in two tertiary referral centers in Upper Egypt.Associations of possible risk factors with prevalence of recurrent OME were studied.Multi-factor logistic regression analysis was done to recognize the statistically significant risk factors associated with recurrent OME.Results:We collected the data of 2003 pediatric patients,of which 1016 were males(50.7%).A total number of 310 children have OME,including 159 males(51.3%).The prevalence rate of OME in our cohort was 15.5%.Multi-factor logistic regression analysis of the risk factors related to recurrent OME showed it was strongly associated with adenoid hypertrophy(P<0.0001),tonsil hypertrophy(P<0.0001),sinusitis(P<0.0001),posterior nostril polyps(P =0.009),allergic rhinitis(P<0.0001),recurrent URTIs(P=0.029)and gastroesophageal reflux(P=0.031).Conclusions: Our study showed that recurrent OME in children in Upper Egypt is a common multifactorial problem, especially in young age. In our locality, allergic rhinitis, recurrent upper respiratory tract infections, gastroesophageal reflux, adenoid and tonsil hypertrophy were the most important associated factors related to the etiopathogenesis of OME. | Khaled Saad Abobakr Abdelmoghny Yasser F.Abdel-Raheem Eman Fathalla Gad Amira Elhoufey | 2021 | World Journal of Otorhinolaryngology-Head and Neck Surgery2021，7，4： | 2 |
| 16 | Geochemical Stream Sediment Survey in the Wadi Umm Rilan Area,South Eastern Desert,Egypt:A New Occurrence for Gold Mineralization显示文摘The present paper investigates the stream sediment geochemistry,behavior of gold and associated elements,delineates Au-anomalous sites and defines related sources in the Wadi Umm Rilan area.Fifty three major and trace elements were analyzed using ICP-MS and treated applying various statistical and mapping techniques.The results showed a significant difference of mean and median Au and most chemical elements in the three portions of the area,and higher values were recorded in the western portion.Furthermore,Au-anomalous sites appeared in upper and lower parts of the Wadi Umm Rilan,along the tributaries of metavolcanic unit and near granitoid contacts.This indicates the main source of Au mineralization is related to emplacement of granitoid plutons and accompanying hydrothermal solutions.There are significant indications for the presence of more than one mineralization event forming a probable single major episode of mineralization in the area,involving Au,Pb and U mineralizations.Geology,geomorphologic aspects and weathering processes could control stream sediment geochemistry,anomalies of Au and associated elements,elemental association and their dispersion patterns.Therefore,the area is fruitful and regarded as a promising target for Au exploration,using Ag,As,Sb,Cd,Cs,and Tl as pathfinder elements. | Mohamed Abdallah Gad DARWISH | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 2 |
| 17 | Diverse Tumorigenic Pathways in Ovarian Serous Carcinoma显示文摘 | Gad Singer Robert J. Kurman Hsueh-Wei Chang Sarah K.R. Cho Ie-Ming Shih | 2002 | The American Journal of Pathology2002，，4： | 2 |
| 18 | Geochemical and Environmental Evaluation of Um Shashoba Gold Mine Area,Southeastern Desert,Egypt显示文摘元素( Ag Au Ba 双性人 Cd ,公司, Cr , Cu , Ga , Hf , Hg , Mn ,瞬间, Ni , Pb , Rb , Sb , Se , Sr , Te 和 Zn )的一套房,全部的器官的碳( TOC )和 pH 在溪流沉积被分析并且跟踪样品从嗯 Shashoba 区域,被旧采矿活动影响以便评估 Au placer 和沉积。分析结果用统计、图形、印射的方法被检验。尽管有结果,表明在沉积的元素的 Au 和大多数是显著地一般来说在跟踪比那些降低, Au 在形成 Au placer 的 NE 和 SW 部分被集中。它是显著地有 Hg 和 Sb 的 Au 的一个靠近的协会;两个作为为 Au placers 的开拓者元素有用。pH 的值不能控制分析元素的命运 TOC 和 Mn 氧化物和氢氧化物能举起一些元素 Au, Ba,公司, Cr, Hg, Ni,和 Sr。结果也显示沉积被引起的人为的因素污染中等,对关于双性人, Se 和 Te 的很强壮的污染强壮分别地。另外,地球表面形成学的因素能也贡献元素的丰富到排水系统并且引起重要毒性水平。 | Mohamed Abdallah Gad DARWISH | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 2 |
| 19 | 技术轨道延伸与破解技术路径锁定研究——以光刻产业为例显示文摘以光刻为代表的系列产业处于“技术路径锁定”的困局,能否走向更深层次的技术突破和产业变革取决于能否破解“技术路径锁定”。以光刻为例,通过近期科学研究与技术主路径的关联,将技术轨道延伸和扩展至最新研究前沿,揭示可能发生技术改进和技术突破的领域,为后发国家实现技术赶超、破解技术锁定提供了机会。研究发现光刻的技术轨道演化方向为:纳米压印技术、脱模技术、掩膜定位和EUV光刻胶工艺;主路径上光刻技术主要来自发达国家,但通过扩展和延伸,逐渐有大量的中国研究成果出现,在一定程度上技术轨道与科学研究存在关联,但也有差异;关于如何破解技术路径锁定,可以从顺轨创新型路径和技术跨越型路径两个维度采取不同的破解策略。本研究对于发现技术突破窗口,破解发达国家对我国的“技术路径锁定”具有重要的现实意义。 | 杨武 陈培 Gad David 孙世强 | 2023 | 科学学研究2023，41，6： | 2 |
| 20 | The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study显示文摘 | Donald S Silverberg Dov Wexler David Sheps Miriam Blum Gad Keren Ron Baruch Doron Schwartz Tatyana Yachnin Shoshana Steinbruch Itzhak Shapira Shlomo Laniado Adrian Iaina | 2001 | Journal of the American College of Cardiology2001，，7： | 2 |
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