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| 1 | Diagnosis and therapy of ascites in liver cirrhosis显示文摘Ascites is one of the major complications of liver cirrhosis and is associated with a poor prognosis. It is important to distinguish noncirrhotic from cirrhotic causes of ascites to guide therapy in patients with noncirrhotic ascites. Mild to moderate ascites is treated by salt restriction and diuretic therapy. The diuretic of choice is spironolactone. A combination treatment with furosemide might be necessary in patients who do not respond to spironolactone alone. Tense ascites is treated by paracentesis, followed by albumin infusion and diuretic therapy. Treatment options for refractory ascites include repeated paracentesis and transjugular intrahepatic portosystemic shunt placement in patients with a preserved liver function. Potential complications of ascites are spontaneous bacterial peritonitis (SBP) and hepatorenal syndrome (HRS). SBP is diagnosed by an ascitic neutrophil count > 250 cells/mm3 and is treated with antibiotics. Patients who survive a first episode of SBP or with a low protein concentration in the ascitic fluid require an antibiotic prophylaxis. The prognosis of untreated HRS type 1 is grave. Treatment consists of a combination of terlipressin and albumin. Hemodialysis might serve in selected patients as a bridging therapy to liver transplantation. Liver transplantation should be considered in all patients with ascites and liver cirrhosis. | Erwin Biecker | 2011 | World Journal of Gastroenterology2011，17，10： | 70 |
| 2 | Portal hypertension and gastrointestinal bleeding:Diagnosis,prevention and management显示文摘Bleeding from esophageal varices is a life threatening complication of portal hypertension.Primary prevention of bleeding in patients at risk for a first bleeding episode is therefore a major goal.Medical prophylaxis consists of non-selective beta-blockers like propranolol or carvedilol.Variceal endoscopic band ligation is equally effective but procedure related morbidity is a drawback of the method.Therapy of acute bleeding is based on three strategies:vasopressor drugs like terlipressin,antibiotics and endoscopic therapy.In refractory bleeding,self-expandable stents offer an option for bridging to definite treatments like transjugular intrahepatic portosystemic shunt(TIPS).Treatment of bleeding from gastric varices depends on vasopressor drugs and on injection of varices with cyanoacrylate.Strategies for primary or secondary prevention are based on non-selective beta-blockers but data from large clinical trials is lacking.Therapy of refractory bleeding relies on shuntprocedures like TIPS.Bleeding from ectopic varices,portal hypertensive gastropathy and gastric antral vascular ectasia-syndrome is less common.Possible medical and endoscopic treatment options are discussed. | Erwin Biecker | 2013 | World Journal of Gastroenterology2013，19，31： | 47 |
| 3 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 4 | Drought Responses of Leaf Tissues from Wheat Cultivars of Differing Drought Tolerance at the Metabolite Level显示文摘干旱在谷物庄稼的生理学上有严肃的效果。在细胞并且明确地代谢物水平,许多单个混合物被增加提供 osmoprotective 功能,并且减少,阻止酶的分离在房间在场的反应的氧种类的数字。我们使用了一条指向的 GCMS 途径识别在忍耐的不同层次在干旱应力下面描绘到干旱的面包小麦的三不同栽培变种不同的混合物(反曲刀的一种,偏狭;Excalibur 和 RAC875,容忍) 。氨基酸,最尤其是脯氨酸,色氨酸,和分叉的链氨基酸白氨酸,异白氨酸,和缬氨酸的层次在所有栽培变种在干旱应力下面被增加。在二容忍的栽培变种,在很多器官的酸的小减少也是明显的。Excalibur,栽培变种 genotypically 与反曲刀的一种有关,显示出更类似于在浇得好的条件下面的反曲刀的一种的反应的一个模式。在干旱应力下面, Excalibur 和 RAC875 有类似的回答;然而, Excalibur 没有象 RAC875 的反应的一样的大小。这里,结果在以前的工作的上下文被讨论在生理并且在干旱应力下面的这些栽培变种的 proteomic 分析。 | Jairus B. Bowne Tim A. Erwin Juan Juttner Thorsten Schnurbusch Peter Langridge Antony Bacic Ute Roessner | 2012 | Molecular Plant2012，5，2： | 25 |
| 5 | 南海东北部海底沉积物波的形态、粒度特征及物源、成因分析显示文摘在南海东北部广泛发育沉积物波。通过高分辨率多波束数据、地震剖面以及重力柱状样,对沉积物波的形态特征、粒度特征、物源以及形成机制进行了分析。研究表明大致以台湾浅滩南海底峡谷为界,北侧为近北东向展布,南侧为近南北向展布。对其分布规律、地貌和形态特征及重力柱状样粒度分析表明这些沉积物波为浊流成因。沉积物波的发育与新生代晚期研究区的构造活动密切相关,自距今6.5 Ma以来台湾造山运动使台湾岛强烈抬升剥蚀,这些剥蚀物为研究区提供了大量的陆源物质,而在南海东北部陆坡区大量发育的峡谷-冲沟系统为陆缘物质向下陆坡的输送提供了良好的通道。研究区西侧的东沙隆起长期处于抬升剥蚀状态,这种抬升剥蚀也为研究区沉积物波的发育提供了部分物源。随着坡度的减缓,浊流沉积物开始堆积,在台湾浅滩南海底峡谷的北侧形成了展布方向与冲沟垂直的沉积物波,而在南侧由于台湾浅滩南海底峡谷发生转向,浊流从水道中漫溢出来,沉积物堆积下来,形成了与原先水道近于垂直的近南北向的沉积物波。 | 丁巍伟 李家彪 韩喜球 黎明碧 ERWIN Suess | 2010 | 海洋学报2010，32，2： | 23 |
| 6 | 环保型烧结生产新技术——Eposint and MEROS~显示文摘在烧结厂的设计和生产中,环保问题已经成为了决定性的因素。如今,在许多城市地区,新建烧结厂或现有烧结厂扩建,只有在确保严格执行环保排放规定的情况下才能得到批准。采用传统技术往往不可能达到现行排放标准,更不必说排放标准预计会在中短期内变得进一步严格。有鉴于此,作为一家领先的冶金工业设备制造商,西门子奥钢联开发并实施了新技术,能够将烧结生产的环境排放指标降低到前所未有的水平。通过采用与奥钢联钢铁公司联合开发的称之为Eposint的烧结废气选择性循环系统,加上西门子奥钢联开发的MEROS新型废气干法除尘系统,这一目标得以实现。目前,这两种工艺均已在奥钢联钢铁公司第5烧结厂投入运行,环保效果远远好于预期指标。 | Alexander Fleischanderl Christoph Aichinger Erwin Zwittag | 2008 | 中国冶金2008，18，11： | 20 |
| 7 | 南海东沙东北部甲烷缺氧氧化作用的生物标志化合物及其碳同位素组成显示文摘南海东沙东北部碳酸盐岩和泥质沉积物中的生物标志化合物组合及其碳同位素组成分析表明,研究区内甲烷缺氧氧化作用(anaerobic oxidation of methane-AOM)发育。研究区内碳酸盐岩中含丰富的AOM标志化合物,2,6,11,15-四甲基十六烷(Crocetane-Cr.)、2,6,10,15,19-五甲基番茄烷(Pentamethylicosane-PMI)和2,6,10,15,19,23-六甲基二十四烷(Squalane-Sq角鲨烷)的13C亏损强烈(δ13C值介于-74.2‰^-119.0‰PDB之间),表明碳酸盐岩形成于AOM,同时反映该研究区曾发生过强烈、持续的富CH4流体释放活动。柱状泥质沉积物中,AOM生物标志化合物在硫酸岩-甲烷过渡带(SMI—Sulfate-Methane Interface)边界附近相对丰度高,SMI之上样品中含量低,或未检出,表明现代环境在SMI附近有大量嗜甲烷微生物生长,使得深部上升的甲烷被大量消耗,很少有甲烷逸出海底。AOM生物标志化合物可用来指示SMI边界。不同站位、不同岩性AOM生物标志化合物组成(包括碳同位素组成)的差异反映了嗜甲烷古细菌组成的不同。 | 于晓果 韩喜球 李宏亮 金肖兵 龚建明 Erwin SUESS 黄永样 吴能友 苏新 | 2008 | 海洋学报2008，30，3： | 18 |
| 8 | Diagnosis and therapy of non-variceal upper gastrointestinal bleeding显示文摘Non-variceal upper gastrointestinal bleeding(UGIB) is defined as bleeding proximal to the ligament of Treitz in the absence of oesophageal, gastric or duodenal varices. The clinical presentation varies according to the intensity of bleeding from occult bleeding to melena or haematemesis and haemorrhagic shock. Causes of UGIB are peptic ulcers, Mallory-Weiss lesions,erosive gastritis, reflux oesophagitis, Dieulafoy lesions or angiodysplasia. After admission to the hospital a structured approach to the patient with acute UGIB that includes haemodynamic resuscitation and stabilization as well as pre-endoscopic risk stratification has to be done. Endoscopy offers not only the localisation of the bleeding site but also a variety of therapeutic measures like injection therapy, thermocoagulation or endoclips. Endoscopic therapy is facilitated by acid suppression with proton pump inhibitor(PPI) therapy. These drugs are highly effective but the best route of application(oral vs intravenous) and the adequate dosage are still subjects of discussion. Patients with ulcer disease are tested for Helicobacter pylori and eradication therapy should be given if it is present. Non-steroidal antiinflammatory drugs have to be discontinued if possible. If discontinuation is not possible, cyclooxygenase-2 inhibitors in combination with PPI have the lowest bleeding risk but the incidence of cardiovascular events is increased. | Erwin Biecker | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 17 |
| 9 | Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial显示文摘AIM:To evaluate the effect of resistance training(RT)on non alcoholic liver disease(NAFLD)patients.METHODS:A randomized clinical trial enrolling NAFLD patients without secondary liver disease(e.g.,without hepatitis B virus,hepatitis C virus or excessive alcohol consumption).Patients were randomly allocated either to RT,three times weekly,for 3 mo or a control arm consisting of home stretching.The RT included leg press,chest press,seated rowing,latissimus pull down etc.with 8-12 repetitions,3 sets for each exercise,for a total duration of 40 min.Hepatic ultrasound,fasting blood tests,anthropometrics and body composition by dual energy X-ray absorptiometry were assessed.At baseline and follow-up,patients filled out a detailed semi-quantitative food frequency questionnaire reporting their habitual nutritional intake.Steatosis was quantified by the hepatorenal-ultrasound index(HRI)representing the ratio between the brightness level of the liver and the right kidney.The HRI has been previously demonstrated to be highly reproducible and was validated against liver biopsy and proton magnetic resonance spectroscopy.RESULTS:Eighty two patients with primary NAFLD were randomized to receive 3 mo of either RT or stretching.After dropout or exclusion from analysis because of protocol violation(weight change>3 kg),thirty three patients in the RT arm and 31 in the stretching arm completed the study per protocol.All baseline characteristics were similar for the two treatment groups with respect to demographics,anthropometrics and body composition,blood tests and liver steatosis on imaging.HRI score was reduced significantly in the RT arm as compared to the stretching arm(-0.25±0.37 vs-0.05±0.28,P=0.017).The RT arm had a significantly higher reduction in total,trunk and android fat with increase in lean body mass.There was no correlation between the reduction in HRI in the RT arm and weight change during the study,but it was positively correlated with the change in trunk fat(r=0.37,P=0.048).The RT arm had a significant reduction in serum ferritin and total cholesterol.There was no significant difference between arms in dietary changes and these did not correlate with HRI change.CONCLUSION:Three months RT improves hepatic fat content accompanied by favorable changes in body composition and ferritin.RT may serve as a complement to treatment of NAFLD. | Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer Kis Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo Ran Oren Oren Shibolet | 2014 | World Journal of Gastroenterology2014，20，15： | 17 |
| 10 | Environmental mechanism of magnetic susceptibility changes of lacustrine sediments from Lake Hulun, China显示文摘The changes of magnetic susceptibility (κ) are correlated with those of corresponding sedimentological, geochemical, mineralogical and biological results, which verifies that κ can be taken as one of the environmental proxies. However, usually the exact origin of magnetic signal is poorly understood, and is difficult to relate with the environmental evolution. Magnetic properties of material derived from the catchment and sedimentary environment may affect the accumulation, preservation, or authigenesis and diagenesis of magnetic minerals. In the Lake Hulun region in Inner Mongolia, it is found that muddy sediments, deposited during high water level period (corresponding to humid climate), have comparatively high κ values. In contrast, the sandy sediments, deposited during low water level period (corresponding to arid climate), have low κ values. Detailed rock magnetic investigation confirms that detrital magnetite derived from volcanic rocks in the catchment exists in both muddy and sandy | 胡守云 王苏民 Erwin Appel 吉磊 | 2000 | Science China Earth Sciences2000，43，5： | 16 |
| 11 | 临汾市树叶磁性的时空变化特征及其对大气重金属污染的指示显示文摘粉煤灰经工厂废气排放进入大气,对人类健康和生态系统都造成了无法弥补的破坏.本文选取具有高空间分辨率优势的树叶作为收集粉煤灰的载体,对临汾市大气中可吸入颗粒物进行磁学参数和重金属含量监测.结果表明,磁化率最大值出现在工厂污染源附近,磁化率空间分布呈现随污染源距离增加而降低的趋势.工业区收集到的磁性颗粒以低矫顽力、粗粒度的磁铁矿为主.夏季磁性矿物来源单一,主要为人为影响.冬季大气中悬浮的磁性颗粒有部分来自于西北风/北风的自然尘降.同一采样点磁化率随时间变化特征表明,树叶的磁学性质可以灵敏和有效地反映较短时期内大气污染的现状.统计分析表明磁化率和重金属元素(铁,铬,镍,铜,铅,钴)之间存在显著相关性.污染负荷指数用于评估研究区域内重金属各元素综合污染的程度.结果显示,在废弃的旧工业区附近无大气污染指示,但在运营中的工厂集中的地区,大气均受到严重污染.污染负荷指数与表征磁性矿物含量的磁化率呈相关性(r2=0.66),因此树叶的磁性参数可以作为大气重金属污染的替代指标. | 曹丽婉 胡守云 Appel Erwin 师尚礼 尹刚 | 2016 | 地球物理学报2016，59，5： | 12 |
| 12 | 乙型肝炎病毒基本核心启动子及前C区突变与基因型的关系显示文摘目的 探讨乙型肝炎病毒 (HBV)基本核心启动子 (BCP)及前C区突变与基因型之间的关系。方法 随机选取 113例慢性HBV感染者外周血 ,采用INNO LiPA法测定BCPT176 2 A176 4双突变及前C区A1896突变 ,测定HBVS基因序列明确基因型。结果 在C基因型感染者中BCPT176 2 A176 4双突变率明显高于B基因型感染者 ,差异有显著性 (34.2 %∶10 % ,χ2 =6 .74 ,P <0 .0 1) ,而前C区A1896突变率在B基因型和C基因型感染者中差异无显著性 (2 .5 %∶4 .1% ,χ2 =0 .0 0 ,P >0 .0 5 )。结论 与B基因型相比 ,C基因型感染者更易发生BCPT176 2 A176 4双突变。 | 房继莲 魏来 李若冰 丛旭 许军 Erwin Sablon 孙焱 王豪 王宇 | 2004 | 中华微生物学和免疫学杂志2004，24，6： | 11 |
| 13 | 全球大停电的经验教训显示文摘根据国际能源机构的预测,在未来20多年里,发展中国家和新兴国家的耗电量将增加220%,而工业化国家则仅增加37%。现有电力系统负荷的大幅度增加将产生瓶颈效应和可靠性问题。历年发生的欧美州大停电清楚地表明,相邻系统间的紧密电气耦合对于重负荷互联系统而言,可能存在无法控制的级联事故风险。介绍美加大停电和欧洲大停电事件,讨论大停电的经验教训。对避免环流、防止电压崩溃等解决大型电力系统稳定性问题的措施及“防火墙”的实施进行了说明。阐述涉及系统改善的高压直流输电(HVDC)和灵活交流输电(FACTS)技术的优点。 | Gǖnther Beck Dusan Povh Dietmar Retzmann Erwin Tehsch | 2007 | 中国电力2007，40，10： | 11 |
| 14 | 音乐厅响度评价新指标显示文摘响度是评价厅堂音质的最基本的参量之一,然而由于尚缺乏一个公认和可信的评价指标,如何评价厅堂响度的问题至今仍未妥善解决。本文建议将乐队齐奏强音标志乐段的平均声压级LpF作为描述厅堂响度的指标,并给出了预计大厅LpF值分布的计算方法。本文还示出两个厅堂LpF的实测值并将之与预计算值作了比较,证实本计算方法的可行性。本文最后讨论了LpF的优选值和容许值。 | 吴硕贤 李青梅 Erwin Kittinger | 2001 | 声学学报2001，26，3： | 11 |
| 15 | Authigenic gypsum found in gas hydrate-associated sediments from Hydrate Ridge, the eastern North Pacific显示文摘Characteristic gypsum micro-sphere and granular mass were discovered by bin-ocular microscope in the gas hydrate-associated sediments at cores SO143-221 and SO143/TVG40-2A respectively on Hydrate Ridge of Cascadia margin, the eastern North Pacific. XRD patterns and EPA analyses show both micro-sphere and granular mass of the crystals have the typical peaks and the typical main chemical compositions of gypsum, although their weight percents are slightly less than the others in the non-gas hydrate-associated marine regions. SEM pictures show that the gypsum crystals have clear crystal boundaries, planes, edges and cleav-ages of gypsum in form either of single crystal or of twin crystals. In view of the fact that there are meanwhile gas hydrate-associated authigenic carbonates and SO42--rich pore water in the same sediment cores, it could be inferred reasonably that the gypsums formed also authigenically in the gas hydrate-associated environment too, most probably at the interface between the down-ward advecting sulfate-rich seawater and the below gas hydrate, which spilled calcium during its formation on Hydrate Ridge. The two distinct forms of crystal intergrowth, which are the granular mass of series single gypsum crystals at core SO143/TVG40-2A and the microsphere of gypsum crystals accompanied with detrital components at core SO143-221 respectively, indicate that they precipitated most likely in different interstitial water dynamic environments. So, the distinct authigenic gypsums found in gas hydrate-associated sediments on Hydrate Ridge could also be believed as one of the parameters which could be used to indicate the presence of gas hydrate in an unknown marine sediment cores. | Erwin Suess Dirk Rickert | 2004 | Science China Earth Sciences2004，47，3： | 10 |
| 16 | 未来气候变化对鄱阳湖区土地利用变化的影响评估显示文摘为了评估未来气候变化可能对鄱阳湖区土地利用变化产生的影响,本文根据IPCC的建议,利用新近建立的基于主体的土地利用变化模拟模型,详细分析了4种气候变化情景下鄱阳湖区1985-2035年的土地利用变化过程。这4种气候变化情景分别为A1B(经济高速增长模式)、A2(区域经济多样化增长模式)、B1(引进更多清洁能源的经济增长模式)和情景4(无气候变化模式)。在这些气候变化情景中,由于耕地的农业生产潜力差异显著,农户主体的收入和他们对土地利用方式的决策也发生了相应的改变。通过对这一过程的模拟和结果分析,发现气候变化可能有利于鄱阳湖区土地利用变化向着环境友好的方向自我调整。与A1B和A2两种气候变化情景相比,B1情景对土地利用变化的影响更具环境友好性。 | 闫丹 Uwe A.Schneider Erwin Schmid 黄河清 潘理虎 Oliver Dilly | 2013 | 资源科学2013，35，11： | 9 |
| 17 | 光照强度对植物光合作用的影响显示文摘植物通过光合作用来增加体积和干重。提高光合作用效率也就意味着增加开花率、提高植物品质、促进植物的采后活力。而植物光合作用的强度和速率则与光强度、二氧化碳浓度和温度密切相关。 | Jennifer Boldt John Erwin 李平 | 2011 | 中国花卉园艺2011，，12： | 9 |
| 18 | MPTCP与CMT-SCTP多路径传输协议性能分析显示文摘利用终端的多宿主特性实现多路径传输是因特网协议的一个热点研究问题,MPTCP和CMT-SCTP是目前比较成熟而关键的两个多路径传输协议,但在大规模应用前还需要作大量的性能测试分析研究。在本地测试床环境中,对MPTCP和CMT-SCTP多路径传输实际吞吐量的性能进行对比测试与分析。结果表明MPTCP和CMT-SCTP都能获得吞吐量的提高,但传输调度算法仍然不完善,需要进一步改进。 | 符发 周星 杨雄 Hakim Adhari Erwin P.Rathgeb | 2013 | 计算机工程与应用2013，49，21： | 9 |
| 19 | Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification显示文摘AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral hepatitis.All subjects underwent anthropometric measurements and fasting blood tests.Evaluation of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver steatosis.The FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs AUS.FLI < 30 rules out and FLI ≥ 60 rules in fatty liver.RESULTS:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid tests.The prevalence rate of NAFLD was 31.1% according to AUS.The FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good agreement.The sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had S3-S4.The κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate agreement.The sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of FLI for steatosis > 5%,as predicted by SteatoTest,yielded an area under the receiver operating characteristic curve(AUROC) of 0.97(95% CI:0.95-0.98).The diagnostic accuracy of FLI for steatosis> 5%,as predicted by HRI,yielded an AUROC of 0.82(95% CI:0.77-0.87).The κ between diagnosis of fatty liver by AUS and by FLI(≥ 60) was 0.48 for the entire sample.However,after exclusion of all subjects with an intermediate FLI score of 30-60,the κ between diagnosis of fatty liver by AUS and by FLI either ≥ 60 or < 30 was 0.65,representing good agreement.Excluding all the subjects with an intermediate FLI score,the sensitivity of FLI was 80.3% and the specificity 87.3%.Only 8.5% of those with FLI < 30 had fatty liver on AUS,but 27.8% of those with FLI ≥ 60 had normal liver on AUS.CONCLUSION:FLI has striking agreement with SteatoTest and moderate agreements with AUS or HRI.However,if intermediate values are excluded FLI has high diagnostic value vs AUS. | Shira Zelber-Sagi Muriel Webb Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern Ran Oren Erwin Santo | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 20 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
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