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| 1 | BRCA1和BRCA2在前列腺癌中的作用显示文摘前列腺癌中最大的风险因素之一就是家族遗传史。BRCA2生殖细胞系突变是迄今为止已知的导致前列腺癌的最大遗传性风险因子(65岁以上男性的风险比其他高8.6倍)。尽管BRCA2和BRCA1在前列腺癌形成中的作用还不太清楚,但这两个基因的破坏性突变往往会产生严重癌症表现以及不理想的临床结果。随着全世界前列腺癌发生率的上升,我们需要新的预测前列腺癌以及筛查具有潜在致死性前列腺癌病人的方法。我们这里所探讨的BRCA生殖细胞系突变(主要指BRCA2生殖细胞系突变),就是这样的一种预测方法。我们还将探讨这些突变在前列腺癌治疗方面的作用,并且针对具有相似特征的零散病例的治疗方案提出假设。 | Elena Castro Rosalind Eeles | 2012 | Asian Journal of Andrology2012，14，3： | 11 |
| 2 | 基层医疗卫生服务质量评估及其影响因素探讨显示文摘目的:测评基层医疗卫生服务的质量,并探讨影响其服务质量的因素。方法:采用约翰霍普金斯大学的基层医疗卫生服务患者评估量表(简化版)对福州市区1所三级综合医院、3所社区卫生服务中心及3所社区卫生服务站的242名就诊者进行调查,同时采取半结构式访谈方法探求8位卫生行业管理者对服务质量及其影响因素的观点。结果:社区卫生服务中心的综合得分最高,在两种计分方式中分别得到14.38和15.93;满意度为93.5%;在影响基层医疗卫生服务质量的五类因素中,卫技人员的因素得到了8位受访者的共同认可。结论:通过对卫技人员的投入、培养和双向转诊系统的完善,有助于改善基层医疗卫生服务的质量。 | 陈烈平 唐程翔 郑锦焕 Rosalind McCollum | 2011 | 中国农村卫生事业管理2011，31，2： | 6 |
| 3 | A living foundry for Synthetic Biological Materials:A synthetic biology roadmap to new advanced materials显示文摘Society is on the cusp of harnessing recent advances in synthetic biology to discover new bio-based products and routes to their affordable and sustainable manufacture.This is no more evident than in the discovery and manufacture of Synthetic Biological Materials,where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological materials.These will encompass novel,smart,functionalised and hybrid materials for diverse applications whose discovery and routes to bio-production will be stimulated by the fusion of new technologies positioned across physical,digital and biological spheres.This article,which developed from an international workshop held in Manchester,United Kingdom,in 2017[1],sets out to identify opportunities in the new materials from biology era.It considers requirements,early understanding and foresight of the challenges faced in delivering a Discovery to Manufacturing Pipeline for synthetic biological materials using synthetic biology approaches.This challenge spans the complete production cycle from intelligent and predictive design,fabrication,evaluation and production of synthetic biological materials to new ways of bringing these products to market.Pathway opportunities are identified that will help foster expertise sharing and infrastructure development to accelerate the delivery of a new generation of synthetic biological materials and the leveraging of existing investments in synthetic biology and advanced materials research to achieve this goal. | Rosalind A.Le Feuvre Nigel S.Scrutton | 2018 | Synthetic and Systems Biotechnology2018，3，2： | 6 |
| 4 | Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression显示文摘AIM: To establish stable tetracycline-inducible pancreatic cancer cell lines. METHODS: Suit-2, MiaPaca-2, and Panc-1 cells were transfected with a second generation reverse tetracycline-controlled transactivator protein (rtTA2S-M2), under the control of either a cytomegalovirus (CMV) or a chicken β-actin promoter, and the resulting clones were characterised.RESULTS: Use of the chicken (β-actin) promoter proved superior for both the production and maintenance of doxycycline-inducible cell lines. The system proved versatile, enabling transient inducible expression of a variety of genes, including GST-P, CYP2E1, S100A6, and the actin capping protein, CapG. To determine the physiological utility of this system in pancreatic cancer cells, stable inducible CapG expressors were established. Overexpressed CapG was localised to the cytoplasm and the nuclear membrane, but was not observed in the nucleus. High CapG levels were associated with enhanced motility, but not with changes to the cell cycle, or cellular proliferation. In CapG-overexpressing cells, the levels and phosphorylation status of other actin-moduating proteins (Cofilin and Ezrin/Radixin) were not altered. However, preliminary analyses suggest that the levels of other cellular proteins, such as ornithine aminotransferase and enolase, are altered upon CapG induction. CONCLUSION: We have generated pancreatic-cancer derived cell lines in which gene expression is fully controllable. | Sarah Tonack Sabina Patel Mehdi Jalali Taoufik Nedjadi Rosalind E Jenkins Christopher Goldring John Neoptolemos Eithne Costello | 2011 | World Journal of Gastroenterology2011，17，15： | 4 |
| 5 | 重症监护室内患者睡眠的自评和护士评估:一项探索性描述研究显示文摘目的:描述ICU患者的睡眠自评报告,检测患者的睡眠自评报告和床旁护士的睡眠评估报告之间的关系;描述患者建议的促进睡眠的对策。方法:对2014-2015年间连续纳入的能进行交流的成年患者,进行了探索性描述研究。患者睡眠情况采用理查兹-坎贝尔(Richards-Campbell)睡眠问卷(评分范围为0~100 mm;得分越高,表明睡眠质量越好)进行自评,同时护士以5级递进形式记录患者睡眠情况,进行评估。要求患者每日描述辅助或妨碍睡眠的因素。研究已获得伦理委员会批准。进行描述性统计分析[中位数(四分位间距)];用Spearman等级相关分析相关关系,用Kruskal-Wallis检验进行差异检验;P<0.05时,认为差异有显著性。结果:151名受试者纳入研究,年龄为60(46~71)岁,ICU停留时间为4(2~9)天,完成了356份睡眠自评报告。自我感知的睡眠质量为46(26~65)mm。睡眠的患者自评和护士评估之间存在中度相关(Spearman等级相关系数为0.39~0.50;P<0.001)。经患者认可的改善睡眠的对策包括适当的止痛和镇静药物,平和舒适的环境,以及集群护理、耳塞等物理措施。结论:患者在ICU期间,完成睡眠自评的中位数为2(1~3)日,表明常规使用自评是可行的。自评报告显示患者的睡眠质量低。在患者自评的多种辅助或妨碍睡眠的因素中,环境因素和影响患者舒适度的因素是最常见的。应实施针对这些因素的干预,以改善患者睡眠状况。 | Leanne M.Aitken Rosalind Elliott Marion Mitchell Chelsea Davis Bonnie Macfarlane Amanda Ullman Krista Wetzig Ashika Datt Sharon McKinley | 2017 | 中国护理管理2017，17，4： | 3 |
| 6 | Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show显示文摘 | Rosalind F Robertst Edward A Fon | 2016 | Cell Research2016，26，11： | 3 |
| 7 | KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer显示文摘 | Stefan Boeck Andreas Jung Rüdiger P. Laubender Jens Neumann Rosalind Egg Clara Goritschan Steffen Ormanns Michael Haas Dominik P. Modest Thomas Kirchner Volker Heinemann | 2013 | Journal of Gastroenterology2013，，4： | 2 |
| 8 | Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and in Situ Models: Relationship to Absorption in Humans显示文摘 | Barbra H. Stewart O. Helen Chan Rosalind H. Lu Eric L. Reyner Heidi L. Schmid Harriet W. Hamilton Bruce A. Steinbaugh Michael D. Taylor | 1995 | Pharmaceutical Research1995，，5： | 2 |
| 9 | Colorectal Cancer in Patients Under Close Colonoscopic Surveillance显示文摘 | Douglas J. Robertson E. Robert Greenberg Michael Beach Robert S. Sandler Dennis Ahnen Robert W. Haile Carol A. Burke Dale C. Snover Robert S. Bresalier Gail McKeown-Eyssen Jack S. Mandel John H. Bond Rosalind U. van Stolk Robert W. Summers Richard Rothste | 2005 | Gastroenterology2005，，1： | 2 |
| 10 | Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity显示文摘 | Daniel J. Antoine Rosalind E. Jenkins James W. Dear Dominic P. Williams Mitchell R. McGill Matthew R. Sharpe Darren G. Craig Kenneth J. Simpson Hartmut Jaeschke B. Kevin Park | 2012 | Journal of Hepatology2012，，5： | 2 |
| 11 | 规划师与经济师之间有关土地市场政策的争论显示文摘为了进一步探讨在经济学家和规划师之间长期以来就对土地市场能否实现广泛的社会目标等问题而存在的争论,林肯学院组织研讨会对相关问题进行讨论和交流,并特别关注了政治在规划和决策中所起到的作用。 | Paul Cheshire Rosalind Greenstein Stephen C.Sheppard | 2003 | 国外城市规划2003，18，4： | 2 |
| 12 | Global spread of dengue virus types: mapping the 70-year history显示文摘 | Jane P. Messina Oliver J. Brady Thomas W. Scott Chenting Zou David M. Pigott Kirsten Duda Samir Bhatt Leah Katzelnick Rosalind E. Howes Katherine E. Battle Cameron P. Simmons Simon I. Hay | 2013 | Trends in Microbiology2013，，： | 2 |
| 13 | Isolation and identification of the first C-17 limonin epimer, epilimonin 显示文摘 | Andrew P B Klaus D Rosalind Y W | 2008 | J Agric Food Chem2008，56，14： | 1 |
| 14 | Treatment Modality and Vasospasm After Aneurysmal Subarachnoid Hemorrhage显示文摘 | Gross BA Rosalind Lai PM Frerichs KU | | 0，，13： | 1 |
| 15 | From Paratext to Epitext: Mapping the Authorial Apparatus in Early Modem Women' s Writing 显示文摘 | PENDER PATRICIA SMITH ROSALIND | 2012 | Parergon2012，，2： | 1 |
| 16 | Immunological response of the Indian major carps to Areomonas hydrophila vaccine显示文摘 | ROSALIND G | 1991 | Fish Diseases1991，14，3： | 1 |
| 17 | Recovering from stillbirth: the effects of making and sharing memories on maternal mental health显示文摘 | Rosalind Crawley Samantha Lomax Susan Ayers | 2013 | Journal of Reproductive & Infant Psychology2013，31，2： | 1 |
| 18 | Li 2 MnSiO 4 cathodes modified by phosphorous substitution and the structural consequences显示文摘 | Rosalind J. Gummow Guihong Han Neeraj Sharma Yinghe He | 2014 | Solid State Ionics2014，，： | 1 |
| 19 | Intracellular signaling pathways activated by neurotrophic factors显示文摘 | Rosalind AS Michael EG | 1996 | Annu Rev Neurosci1996，19，： | 1 |
| 20 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
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