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| 1 | 慢性心力衰竭大鼠转化生长因子-β—Smads信号传导通路的调节异常显示文摘目的 探讨慢性缺血性心力衰竭大鼠转化生长因子 (transforminggrowthfactorTGF β) 信号传导蛋白 (Smads)的信号传导通路的变化 ,及与心肌梗死 (MI)后心力衰竭心脏重塑过程的关系。方法 大鼠经冠状动脉结扎 ,5d后经有创性血流动力学监测 ,试验分组 :(1)慢性心力衰竭组 (CHF) :左室舒张末压 (LVEDP)≥ 15mmHg (1mmHg =0 .133kPa) ,n =6 ;(2 )Sham组 :无冠状动脉结扎的手术对照组 ,n =6。 6周末 ,行逆行心脏体外灌流 ,应用胶原酶灌流心脏。分离活的心肌细胞和非心肌细胞。应用Westernblot测定TGF β1、β3 、Smad 2 /3、Smad 6蛋白表达水平。结果 非心肌细胞 :CHF组TGF β1明显增高 (P <0 .0 2 ) ,而TGF β3 明显减少 (P <0 .0 1) ,Smad 6明显下调 ;而Smad 3明显上调 (P <0 .0 2 ) ;心肌细胞 :CHF组TGF β3 明显减少 ,TGF β1明显增高 (P <0 .0 1) ;伴有Smad 2 /3明显下调 (P <0 .0 1) ;而Smad 6明显上调 (P <0 .0 5 )。结论 本研究首次证明了CHF大鼠心肌细胞和非心肌细胞的TGF β1、β3 和它们的信号转导通路特异性调节变化 ,TGF β | 高连如 John Teerlink Joel Karliner | 2001 | 中华心血管病杂志2001，29，3： | 23 |
| 2 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 3 | Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure显示文摘 | Maria Rosa Costanzo Maya E. Guglin Mitchell T. Saltzberg Mariell L. Jessup Bradley A. Bart John R. Teerlink Brian E. Jaski James C. Fang Erika D. Feller Garrie J. Haas Allen S. Anderson Michael P. Schollmeyer Paul A. Sobotka | 2007 | Journal of the American College of Cardiology2007，，6： | 2 |
| 4 | Overview of randomized clinical trials in acute heart failure syndromes显示文摘 | Teerlink JR | | 0，，6： | 1 |
| 5 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 6 | Endothelins: pathophysiology and treatment implications in chronic heart failure显示文摘 | Teerlink J R | 2005 | Curt Heart Fail Rep2005，2，4： | 1 |
| 7 | Serelaxin,recombinant human relaxin-2,for treatment of acute heart failure(RELAX-AHF):a randomised,placebo-controlled trial显示文摘 | TEERLINK J R COTTER G DAVISON B A | 2013 | Lancet2013，381，： | 1 |
| 8 | Progressive ventricular remodeling in response to diffuse isoproterenol -induced myocardial necrosis in rats显示文摘 | Teerlink JR Pfeffer JM Pfeffer MA | 1994 | Cire Res1994，75，： | 1 |
| 9 | Medical therapy for chronic heart failure 显示文摘 | Krum H Teerlink J R | 2011 | Lancet2011，378，9792： | 1 |
| 10 | Tezosentan in patients with acute heart failure:design of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Study(VERITAS)显示文摘 | Teerlink JR McMurray JJ Bourge RC | 2005 | 1Am Heart J2005，150，1： | 1 |
| 11 | Beta - adrenergic blocker mortality trials in congestive heart failure 显示文摘 | Teerlink JR Marie BM | 1999 | Am J Cardiol1999，84，9： | 1 |
| 12 | The role of beta-blockers in preven- ting sudden death in heart failure显示文摘 | Teerlink JR Massie BM | 2000 | J Card Fail2000，6，21： | 1 |
| 13 | A genealogi- cal assessment of heritable predisposition to asthma mortality显示文摘 | Teerlink CC Hegewald MJ Cannon-Albright LA | 2007 | American Journal of Respiratory & Critical Care Medicine2007，176，9： | 1 |
| 14 | L-Homoarginine and L-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study显示文摘 | Leonard P. van der Zwan Mariska Davids Peter G. Scheffer Jacqueline M. Dekker Coen D.A. Stehouwer Tom Teerlink | 2013 | Journal of Hypertension2013，，6： | 1 |
| 15 | Progressive ventricular remodeling in response to diffuse isoproterenol-induced necrosis inrats显示文摘 | Teerlink JR Pfeffer JM Pfeffer MA | 1994 | Circ Res1994，75，1： | 1 |
| 16 | Asymmetrical dimethylarginine(ADMA) in critically ill patients:high plasma ADMA concentration is an independent risk factor of ICU mortality显示文摘 | Nijveldt RJ Teerlink T Van Der Hoven B | 2003 | Clin Nutr2003，22，11： | 1 |
| 17 | Asymmetrical dimethylarginine (ADMA) in critically ill patients:high plasma ADMA concentration is an independent risk factor of ICU mortality显示文摘 | Nijveldt RJ Teerlink T van der Hoven B | 2003 | Clin Nutr2003，22，1： | 1 |
| 18 | Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes显示文摘 | Tarnow L Hovind P Teerlink T | 2004 | Diabetes Care2004，27，3： | 1 |
| 19 | Relaxin for the treatment of patients with acute heart failure(Pre-RELAX-AHF):a multicentre,randomised,placebo-controlled,parallel-group,dose-ifnding phase IIb study显示文摘 | Teerlink JR Metra M Felker GM | | 0，，9673： | 1 |
| 20 | Progressive ventricular remodeling in response to diffuse isoproterenol-indueed myocardial necrosis in rats显示文摘 | Teerlink J R Pfeffer J M Pfeffer M A | 1994 | Circ Res1994，75，1： | 1 |
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