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| 1 | 卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。 | Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 | 2014 | 国际脑血管病杂志2014，22，10： | 80 |
| 2 | Law, finance, and economic growth in China显示文摘 | Franklin Allen Jun Qian Meijun Qian | 2005 | Journal of Financial Economics2005，，1： | 35 |
| 3 | 新发舒张期和收缩期高血压的预测因素:Framing-han心脏研究 | Franklin S.S. Pio J.R. Wong N.D. 苏畅 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，9： | 24 |
| 4 | 巴山木竹发笋和大熊猫取食的时空格局及相关性分析显示文摘巴山木竹(Bashania fargesii)是秦岭大熊猫冬季和春季主要食物来源。秦岭地区巴山木竹的更新是保护大熊猫和评价其生境质量的一个重要因子,而发笋是巴山木竹更新的主要方式。揭示巴山木竹发笋和大熊猫取食的时空格局以及二者空间和数量上的相关性对保护和恢复大熊猫栖息地具有重要意义。运用单变量和双变量Ripley K函数点格局方法,对秦岭南坡佛坪国家级自然保护区40×40m永久样地竹子发笋和大熊猫取食情况连续6年(2002-2008年,2007年除外)研究表明,由于自身克隆生长、资源异质性、大熊猫取食和践踏等因素,巴山木竹发笋呈现聚集分布格局;而大熊猫取食的聚集格局可能归因于食物聚集分布、自身取食习惯和取食地段小地形特征。大熊猫取食和巴山木竹发笋空间上呈现正相关,显示出巴山木竹为秦岭大熊猫食物主要来源。同时,线性回归结果显示,大熊猫取食强度与巴山木竹发笋产量之间相关性不显著,说明该地区还存在其他竹子提供食物来源,大熊猫对巴山木竹不是完全依赖。 | 卢志军 王巍 张文辉 李红 曹庆 党高弟 何东 Scott Franklin | 2009 | 生物多样性2009，17，1： | 18 |
| 5 | 203例农村有偿献血感染HIV患者抑郁障碍及生活质量调查显示文摘目的:调查通过献血途径感染人类免疫缺陷病毒(HIV)的203例患者的情绪状况及生活质量。方法:采用贝克抑郁问卷、复合性国际诊断用检查提纲和SF-36对203例通过献血途径感染HIV的患者(HIV阳性组)及年龄、性别和受教育年限相匹配的198例HIV阴性献血者进行调查。结果:①HIV阳性组献血次数多于HIV阴性组(52.2±95.4/13.2±23.9,P<0.001),已婚者少于HIV阴性组(88.6%/ 95.5%,P=0.020),丧偶者多于HIV阴性组(10.9%/4.5%,P=0.020),失业率高于HIV阴性组(21.7%/4.0%,P<0.001),前一年全年工作时间少于HIV阴性组(5.0±3.5/7.5±3.0,P<0.001),家庭月收入低于HIV阴性组(476.3±412.7/709.9±513.7,P<0.001)。②HIV阳性组被诊断为获得性免疫缺陷综合征(AIDS)者占56.6%。HIV阳性组抑郁症的终生患病率为13.8%,HIV阴性组的终生患病率为5.1%。HIV阳性组的抑郁总分(11.3±11.3/6.6±9.6)、躯体(3.3±2.9/2.0±2.6)和非躯体因子分(8.0±8.8/4.6±7.4)均高于HIV阴性组(P<0.001)。HIV阳性组达轻度抑郁以上者占40.4%。HIV阳性组已制定自杀计划者高于HIV阴性组(8.4%/3.0%,P<0.05)。HIV阳性组总体生理健康(48.3±9.7/ 55.5±7.0)和心理健康(48.8±8.9/55.1±7.8)得分均低于HIV阴性组(P<0.001)。③HIV阳性组的贝克抑郁问卷总分与T细胞亚群CD4细胞计数无显著相关,与总体生理健康及心理健康呈显著负相关(r=- 0.46~0.68,P<0.001)。结论:HIV阳性患者生存状况较差。对HIV阳性感染者而言,抑郁给患者生活质量造成全面的影响,抑郁和自杀风险仍然是需要干预和处理的问题。 | 宁南义 石川 于欣 陈玉芳 吴尊友 Jin Hua Vigil O Cysique LA Franklin DR Grant I Heaton RK | 2008 | 中国心理卫生杂志2008，22，7： | 14 |
| 6 | Large animal ischemic stroke models: replicating human stroke pathophysiology显示文摘The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions.Although promising therapeutics have been identified using these animal models,with most undergoing significant testing in rodent models,the vast majority of these interventions have failed in human clinical trials.This failure of preclinical translation highlights the critical need for better therapeutic assessment in more clinically relevant ischemic stroke animal models.Large animal models such as non-human primates,sheep,pigs,and dogs are likely more predictive of human responses and outcomes due to brain anatomy and physiology that are more similar to humans-potentially making large animal testing a key step in the stroke therapy translational pipeline.The objective of this review is to highlight key characteristics that potentially make these gyrencephalic,large animal ischemic stroke models more predictive by comparing pathophysiological responses,tissue-level changes,and model limitations. | Erin E.Kaiser Franklin D.West | 2020 | Neural Regeneration Research2020，15，8： | 11 |
| 7 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 8 | Advancing antimicrobial strategies for managing oral biofilm infections显示文摘Effective control of oral biofilm infectious diseases represents a major global challenge.Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells.The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly over the past 5 years.Antimicrobial dental materials based on antimicrobial agent release,contact-killing and multi-functional strategies have been designed and synthesized for the prevention of initial bacterial attachment and subsequent biofilm formation on the tooth and material surface.Among the therapeutic approaches for managing biofilms in clinical practice,antimicrobial photodynamic therapy has emerged as an alternative to antimicrobial regimes and mechanical removal of biofilms,and cold atmospheric plasma shows significant advantages over conventional antimicrobial approaches.Nevertheless,more preclinical studies and appropriately designed and well-structured multi-center clinical trials are critically needed to obtain reliable comparative data.The acquired information will be helpful in identifying the most effective antibacterial solutions and the most optimal circumstances to utilize these strategies. | Yang Jiao Franklin RTay Li-na Niu Ji-hua Chen | 2019 | International Journal of Oral Science2019，11，4： | 10 |
| 9 | Childhood achalasia: A comprehensive review of disease, diagnosis and therapeutic management显示文摘Achalasia is an esophageal motility disorder character-ized by failure of lower esophageal sphincter(LES) relaxation and is rare in children. The most common symptoms are vomiting, dysphagia, regurgitation, and weight loss. Definitive diagnosis is made with barium swallow study and esophageal manometry. In adults, endoscopic biopsy is recommended to exclude malig-nancy however; it is not as often indicated in children. Medical management often fails resulting in recurrent symptoms and the ultimate definitive treatment is sur-gical. Laparoscopic Heller myotomy with or without an anti-reflux procedure is the treatment of choice and has become standard of care for children with achala-sia. Peroral endoscopic myotomy is a novel therapy uti-lized with increasing frequency for achalasia treatment in adults. More experience is needed to determine the safety, efficacy, and feasibility of peroral endoscopic myotomy in children. | Ashanti L Franklin Mikael Petrosyan Timothy D Kane | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 9 |
| 10 | Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A. Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2005 | Circulation2005，，17： | 7 |
| 11 | The pig as a preclinical traumatic brain injury model:current models,functional outcome measures,and translational detection strategies显示文摘Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions. | Holly A.Kinder Emily W.Baker Franklin D.West | 2019 | Neural Regeneration Research2019，14，3： | 7 |
| 12 | 全球溺水负担:GBD 2017全球疾病负担死亡率的估计研究显示文摘世界卫生组织已将溺水确定为公共卫生优先事项。溺水指因淹没或者浸没于液体中而出现呼吸障碍的过程,其结果分为死亡、受伤和不受伤。致命性溺水是世界范围内导致非故意伤害相关死亡的主要原因,全球每年约有30万人溺水死亡。中低收入国家非故意溺水发生尤为严重。此外,男性和儿童是非故意溺水的高危人群。伤害预防工作者掌握准确和及时的数据将有助于合理分配公共卫生资源和评价干预措施的效果。 | 黄锦裕 佘宇航(摘译) 李丽萍(审校) Franklin R C Peden A E Hamilton E B | 2020 | 伤害医学(电子版)2020，9，4： | 6 |
| 13 | Pre-recorded instructional audio vs. dispatchers' conversational assistance in telephone cardiopulmonary resuscitation: A randomized controlled simulation study显示文摘BACKGROUND:To assess the effectiveness of the telephone chest-compression-only cardiopulmonary resuscitation(CPR)guided by a pre-recorded instructional audio when compared with dispatcher-assisted resuscitation.METHODS:It was a prospective,blind,randomised controlled study involving 109 medical students without previous CPR training.In a standardized mannequin scenario,after the step of dispatcher-assisted cardiac arrest recognition,the participants performed compression-only resuscitation guided over the telephone by either:(1)the pre-recorded instructional audio(n=57);or(2)verbal dispatcher assistance(n=52).The simulation video records were reviewed to assess the CPR performance using a 13-item checklist.The interval from call reception to the first compression,total number and rate of compressions,total number and duration of pauses after the first compression were also recorded.RESULTS:There were no significant differences between the recording-assisted and dispatcher-assisted groups based on the overall performance score(5.6±2.2 vs.5.1±1.9,P>0.05)or individual criteria of the CPR performance checklist.The recording-assisted group demonstrated provided(170.2±48.0 vs.156.2±60.7).CONCLUSION:When provided by untrained persons in the simulated settings,the compression-only resuscitation guided by the pre-recorded instructional audio is no less efficient than dispatcher-assisted CPR.Future studies are warranted to further assess feasibility of using instructional audio aid as a potential alternative to dispatcher assistance. | Alexei Birkun Maksim Glotov Herman Franklin Ndjamen Esther Alaiyex Esther Alaiye Temidara Adeleke Sergey Samarin | 2018 | World Journal of Emergency Medicine2018，9，3： | 6 |
| 14 | Biomaterials from the sea:Future building blocks for biomedical applications显示文摘Marine resources have tremendous potential for developing high-value biomaterials.The last decade has seen an increasing number of biomaterials that originate from marine organisms.This field is rapidly evolving.Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials.The latter are represented by chitin and chitosan,marine-derived collagen,and composites of different organisms of marine origin.The diversity of marine natural products,their properties and applications are discussed thoroughly in the present review.These materials are easily available and possess excellent biocompatibility,biodegradability and potent bioactive characteristics.Important applications of marine biomaterials include medical applications,antimicrobial agents,drug delivery agents,anticoagulants,rehabilitation of diseases such as cardiovascular diseases,bone diseases and diabetes,as well as comestible,cosmetic and industrial applications. | Mei-chen Wan Wen Qin Chen Lei Qi-hong Li Meng Meng Ming Fang Wen Song Ji-hua Chen Franklin Tay Li-na Niu | 2021 | Bioactive Materials2021，6，12： | 4 |
| 15 | Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improve in-situ bone regeneration显示文摘Sensory nerves promote osteogenesis through the release of neuropeptides.However,the potential application and mechanism in which sensory nerves promote healing of bone defects in the presence of biomaterials remain elusive.The present study identified that new bone formation was more abundantly produced after implantation of silicified collagen scaffolds into defects created in the distal femur of rats.The wound sites were accompanied by extensive nerve innervation and angiogenesis.Sensory nerve dysfunction by capsaicin injection resulted in significant inhibition of silicon-induced osteogenesis in the aforementioned rodent model.Application of extracellular silicon in vitro induced axon outgrowth and increased expression of semaphorin 3 A(Sema3A)and semaphorin 4D(Sema4D)in the dorsal root ganglion(DRG),as detected by the upregulation of signaling molecules.Culture medium derived from silicon-stimulated DRG cells promoted proliferation and differentiation of bone marrow mesenchymal stem cells and endothelial progenitor cells.These effects were inhibited by the use of Sema3A neutralizing antibodies but not by Sema4D neutralizing antibodies.Knockdown of Sema3A in DRG blocked silicon-induced osteogenesis and angiogenesis almost completely in a femoral defect rat model,whereas overexpression of Sema3A promoted the silicon-induced phenomena.Activation of“mechanistic target of rapamycin”(mTOR)pathway and increase of Sema3A production were identified in the DRG of rats that were implanted with silicified collagen scaffolds.These findings support the role of silicon in inducing Sema3A production by sensory nerves,which,in turn,stimulates osteogenesis and angiogenesis.Taken together,silicon has therapeutic potential in orthopedic rehabilitation. | Yu-Xuan Ma Kai Jiao Qian-Qian Wan Jing Li Ming-Yi Liu Zi-Bin Zhang Wen Qin Kai-Yan Wang Ya-zhou Wang Franklin R.Tay Li-Na Niu | 2022 | Bioactive Materials2022，7，3： | 4 |
| 16 | Law, finance, and economic growth in China显示文摘 | Franklin Allen Jun Qian Meijun Qian | 2005 | Journal of Financial Economics2005，，1： | 4 |
| 17 | Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model显示文摘Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(MRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant MRI biomarkers and predict functional outcomes using MRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric MRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the MRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if MRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant MRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia Institutional Animal Care and Use Committee(AUP: A2015 11-001) on December 22, 2015. | Hongzhi Wang Emily W.Baker Abhyuday Mandal Ramana M.Pidaparti Franklin D.West Holly A.Kinder | 2021 | Neural Regeneration Research2021，16，2： | 4 |
| 18 | Research on flexible display at Ulsan National Institute of Science and Technology显示文摘Displays represent information visually,so they have become the fundamental building block to visualize the data of current electronics including smartphones.Recently,electronics have been advanced toward flexible and wearable electronics that can be bent,folded,or stretched while maintaining their performance under various deformations.Here,recent advances in research to demonstrate flexible and wearable displays are reviewed.We introduce these results by dividing them into several categories according to the components of the display:active-matrix backplane,touch screen panel,light sources,integrated circuit for fingerprint touch screen panel,and characterization tests;and we also present mechanical tests in nano-meter scale and visual ergonomics research. | Jihun Park Sanghyun Heo Kibog Park Myoung Hoon Song Ju-Young Kim Gyouhyung Kyung Rodney Scott Ruoff Jang-Ung Park Franklin Bien | 2017 | npj Flexible Electronics2017，1，1： | 3 |
| 19 | Advances in Conceptual Electronic Nanodevices based on 0D and 1D Nanomaterials显示文摘Nanoelectronic devices are being extensively developed in these years with a large variety of potential applications. In this article, some recent developments in nanoelectronic devices, including their principles, structures and potential applications are reviewed. As nanodevices work in nanometer dimensions, they consume much less power and function much faster than conventional microelectronic devices. Nanoelectronic devices can operate in different principles so that they can be further grouped into field emission devices,molecular devices, quantum devices, etc. Nanodevices can function as sensors, diodes, transistors, photovoltaic and light emitting devices, etc. Recent advances in both theoretical simulation and fabrication technologies expedite the development process from device design to prototype demonstration. Practical applications with a great market value from nanoelectronic devices are expected in near future. | Yafei Zhang Li Franklin Duan Yaozhong Zhang Jian Wang Huijuan Geng Qing Zhang | 2014 | Nano-Micro Letters2014，6，1： | 3 |
| 20 | A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione显示文摘The Food and Drug Administration (FDA) has issued a warning on numerous herbal drugs, including many popular products at General Nutrition Centers (GNC), regarding unstudied hepatotoxicity. There have been recent reports of GNC products such as hydroxycut and herbalife, causing drug-induced hepatitis. Herbal medications are over-the-counter products and are not investigated thoroughly by the FDA. Given that the mostcommon outpatient laboratory abnormality is elevated liver transaminases, a sign of hepatocellular toxicity; it is not surprising that some of these products end up causing hepatic dysfunction, especially when taken in large volume. There are numerous herbal supplements that are hepatotoxic, however, these medications have a much more significant effect in human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome patients, which is secondary to depleted glutathione. We present a rare case of drug induced hepatitis secondary to herbal medications used to treat HIV and elucidate the role of glutathione depletion in immunocompromised patients. | Viplove Senadhi Deepika Arora Manish Arora Franklin Marsh | 2012 | World Journal of Hepatology2012，4，8： | 3 |
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