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| 1 | 陶瓷装甲显示文摘陶瓷的脆性断裂行为往往限制了它的使用,其主要应用之一是装甲系统构件。陶瓷装甲可以防护高速弹丸,其重量仅为普通钢装甲的二分之一左右。本文介绍了在装甲系统中使用的陶瓷材料性能,并对比了它们的优缺点。 | Gary Savage 依公焯 | 1991 | 兵器材料科学与工程1991，14，4： | 10 |
| 2 | Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A. Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2005 | Circulation2005，，17： | 7 |
| 3 | 复发性口疮患者静止期与溃疡期T抑制细胞功能比较研究显示文摘目的 :本研究旨在比较RAU患者溃疡期和静止期外周血淋巴细胞抑制活性 ,探索T抑制细胞在RAU发病学中的作用。方法 :应用刀豆碱 (ConA)激活产生的淋巴细胞抑制检测方法探测了 12位RAU患者溃疡期和静止期外周血淋巴细胞抑制活性。结果 :溃疡期患者的T淋巴细胞抑制率明显低于正常组 (P <0 .0 5 ) ;而患者静止期的抑制率与正常组无显著性差异 (P >0 .0 5 )。结论 :RAU患者外周血T抑制细胞功能在溃疡期降低 。 | 胡雁 Neil W Savage Phil B Sugerman Greg J Sey mour | 2001 | 口腔医学纵横2001，17，1： | 7 |
| 4 | 代谢综合征的诊断和治疗——美国心脏协会/国立心肺血液研究所指南概要显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A.Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，4： | 5 |
| 5 | SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress显示文摘 | Hyun-Seok Kim Krish Patel Kristi Muldoon-Jacobs Kheem S. Bisht Nukhet Aykin-Burns J. Daniel Pennington Riet van der Meer Phuongmai Nguyen Jason Savage Kjerstin M. Owens Athanassios Vassilopoulos Ozkan Ozden Seong-Hoon Park Keshav K. Singh Sarki A. Abdulka | 2010 | Cancer Cell2010，，1： | 3 |
| 6 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 7 | Intra-growth retardation and postnatal growth failure associated deletion of the insulin-like growth factor I gene 显示文摘 | Woods KA Camacho-Hubner C Savage MO | 1996 | A Engl J1996，335，： | 2 |
| 8 | Regional landslide-hazard assessment for Seattle, Washington, USA显示文摘 | Rex L. Baum Jeffery A. Coe Jonathan W. Godt Edwin L. Harp Mark E. Reid William Z. Savage William H. Schulz Dianne L. Brien Alan F. Chleborad Jonathan P. McKenna John A. Michael | 2005 | Landslides2005，，4： | 2 |
| 9 | Chronic nitrogen additions reduce total soil respiration and microbial respiration in temperate forest soils at the Harvard Forest显示文摘 | Richard D Bowden Eric Davidson Kathleen Savage Chris Arabia Paul Steudler | 2004 | Forest Ecology and Management2004，，1： | 2 |
| 10 | Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients:Six case reports显示文摘BACKGROUND Epstein-Barr virus associated smooth muscle tumor(EBV-SMT)is a rare oncological entity.However,there is an increasing incidence of EBV-SMTs,as the frequency of organ transplantation and immunosuppression grows.EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder(PTLD).There is no clear consensus on the treatment of EBV-SMTs.However,surgical resection,chemotherapy,radiation therapy,and immunosuppression reduction have been explored with varying degrees of success.CASE SUMMARY Our case series includes six cases of EBV-SMTs across different age groups,with different treatment modalities,adding to the limited existing literature on this rare tumor.The median latency time between immunosuppression and disease diagnosis is four years.EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals. | Afshin A Khan Bassam N Estfan Anirudh Yalamanchali Djibril Niang Erica C Savage Clifton G Fulmer Hailey L Gosnell Jamak Modaresi Esfeh | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 11 | Theory of heat transfer and air gap formation in continuous casting moulds 显示文摘 | Savage J A | 1962 | J Iron Steel Inst1962，，1： | 2 |
| 12 | Seed dormancy and the control of germination显示文摘 | William E.Finch‐Savage GerhardLeubner‐Metzger | 2006 | New Phytologist2006，，3： | 2 |
| 13 | 利用稳定氮同位素跟踪污水氮对沿海生态系统的影响显示文摘本文评价了稳定氮同位素(δ^(15)N)用于阐述污水氮对沿海生态系统的影响,重点描述波罗的海希默兰湾个案的情况,该海湾接纳主要以溶解的无机氮(DIN)形式排泄的富含^(15)N的三级处理过的污水。巨藻(Fucus vesiculosus)和表层沉积物的δ^(15)N梯度变化曲线示踪到距排泄口24km污水衍生氮的情况。但是高δ^(15)N值(>7‰)说明污水在10km的范围内影响最大。强化的三级处理前后巨藻δ^(15)N值的比较研究表明,从距排泄口约24km到12km范围内污水氮的空间影响是减弱的,而且对于最近生长的组织中的较高的海洋δ^(15)N值来说也是下降的。沉积物中δ^(15)N的记载表明,在污水氮含量最大的年份里随着沉积物中δ^(15)N的急剧增加污水对该湾有机物的生产已造成重大的影响。当污水氮将明显的同位素特征引入系统时以及当它对有机物质的生产已产生主导影响时,生物群和沉积物中的δ^(15)N值可用来跟踪污水氮在水生生态系统中的时空影响。 | Candida Savage 高战朝 | 2005 | AMBIO-人类环境杂志2005，34，2： | 2 |
| 14 | Emerging Role of PD-1 in the Central Nervous System and Brain Diseases显示文摘Programmed cell death protein 1(PD-1)is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated remarkable efficacy in cancer treatment.Accumulating evidence suggests an important role of PD-1 in the central nervous system(CNS).PD-1 has been implicated in CNS disorders such as brain tumors,Alzheimer’s disease,ischemic stroke,spinal cord injury,multiple sclerosis,cognitive function,and pain.PD-1 signaling suppresses the CNS immune response via resident microglia and infiltrating peripheral immune cells.Notably,PD-1 is also widely expressed in neurons and suppresses neuronal activity via downstream Src homology 2 domain-containing protein tyrosine phosphatase 1 and modulation of ion channel function.An improved understanding of PD-1 signaling in the cross-talk between glial cells,neurons,and peripheral immune cells in the CNS will shed light on immunomodulation,neuromodulation,and novel strategies for treating brain diseases. | Junli Zhao Alexus Roberts Zilong Wang Justin Savage Ru-Rong Ji | 2021 | Neuroscience Bulletin2021，37，8： | 2 |
| 15 | Human metabolic sydrome resulting from dominant-negative mutation in the nuclear receptor peroxisome proliferator-activated recepter-gamma显示文摘 | Savage DB Tan GD Acerini CL | 2003 | Diabetes2003，52，4： | 1 |
| 16 | Differential splintage for flexor tendon rehabilitation:an experimental study of its effect on strength显示文摘 | Savage R Pritchard M G Thomas M | 2005 | J Hand Surg Br2005，30，2： | 1 |
| 17 | Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study 显示文摘 | Levy D Garrison R J Savage DD et at | 1990 | N Engl J Med1990，322，22： | 1 |
| 18 | Contributions to the theory of rank order statistics-the two-sample case显示文摘 | SAVAGE I R | 1956 | Ann Math Statistics1956，27，2： | 1 |
| 19 | Strapdown inertial navigation integration algorithm design--Part 2: velocity and position algorithms显示文摘 | Savage P | 1998 | Journal of Guidance Control and Dynamics1998，21，2： | 1 |
| 20 | The Utility Analysis of Choice Involving Risk显示文摘 | Friedman M Savage L J | 1948 | Journal of Political Economy1948，56，27： | 1 |
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