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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | 过一硫酸盐羊毛表面改性的红外光谱研究显示文摘应用FTIR(ATR)分析技术和二次微分谱图处理方法,跟踪分析过一硫酸盐羊毛表面改性技术中的各道工艺对羊毛表面胱氨酸二硫键结构的影响,定性定量地分析胱氨酸的最终氧化产物及其氧化中间产物的形成和变化,并探讨这些氧化成分与羊毛防毡缩性的关系。 | 邵建中 刘今强 郑今欢 Christopher M Carr | 2001 | 纺织学报2001，22，5： | 32 |
| 3 | Occult hepatitis C virus infection: A new form of hepatitis C显示文摘Occult hepatitis C virus (HCV) infection is a new recently characterized entity. This occult infection can be present in two different clinical situations: in anti-HCV negative, serum HCV-RNA negative patients with abnormal liver function tests and in anti-HCV positive subjects with normal values of liver enzymes and without serum HCV- RNA. This review describes recent studies of occult HCV infection in both kinds of patients. | Vicente Carreo | 2006 | World Journal of Gastroenterology2006，12，43： | 10 |
| 4 | 用于羊毛表面改性的氧化剂性能研究显示文摘应用电位法和碘量法测定氧化剂的氧化电位和有效成分,探讨氧化剂在不同条件下的氧化性、稳定性及与羊毛的反应性,研究各种工艺因素对氧化剂性能的影响。建立了分析、评价和优选无AOX污染的羊毛表面改性氧化剂和确定其相应工艺条件的新途径。 | 邵建中 胡朝明 刘今强 陈雁 Christopher M Carr | 2001 | 纺织学报2001，22，4： | 9 |
| 5 | 蚕丝丝素的表面结构与活性染料染色性能的关系显示文摘应用FTIR(ATR)分析技术和二次微分谱图处理方法研究高温、日晒、蛋白酶处理对丝素微细结构和酪氨酸含量的影响;应用氨基酸分析技术研究上述外界因素对丝素蛋白中具有亲核基团的氨基酸剩基的影响。结果表明:蚕丝纤维经高温、日晒或蛋白酶处理后,活性染料的上染率、固着率、总固着效率有不同程度下降,染色物的表面颜色深度和得色的丰满性也均下降。酪氨酸含量的减少和丝蛋白微细结构的变化是导致活性染料染色性能下降的内在原因。 | 邵建中 王东升 郑今欢 刘今强 Christopher M Carr | 2003 | 染整技术2003，25，5： | 8 |
| 6 | pTC-1 observation of ion high-speed flow reversal in the near-Earth plasma sheet during substorm显示文摘Based on measurements of FGM and HIA on board TC-1 at its apogee on Septem-ber 14, 2004, we analyzed the ion high-speed flows in the near-Earth plasma sheet observed during the substorm expansion phase. Strong tailward high-speed flows (Vx ~ -350 km/s) were first seen at about X ~ -13.2 RE in near-Earth magnetotail, one minute later the flows reversed from tailward to earthward. The reversal process occurred quickly after the substorm expansion onset. The near-Earth magnetotail plasma sheet was one of key regions for substorm onset. Our analysis showed that the ion flow reversal from tailward to earthward was likely to be in close relation with the substorm expansion initiation and might play an important role in trigger-ing the substorm expansion onset. | H. RME I. DANDOURAS C. M. CARR | 2008 | Science China(Technological Sciences)2008，51，10： | 6 |
| 7 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 8 | Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC. | Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami | 2014 | World Journal of Gastroenterology2014，20，38： | 6 |
| 9 | 雌二醇和催产素对乏情期绵羊子宫肌电活动性的影响显示文摘用微电极技术研究了4只乏情期绵羊自发性和激素诱导性子宫肌电图(EMG),并同时测定了血浆17β-雌二醇(E_2β)和孕酮(P_4)的水平。自发性子宫肌电图呈节率性静、动复合波丛的基础图型,平均峰电位频率为682次/小时,幅度190μV,子宫运动比率(MR)7.3%。催产素(OXT)可激发频率达1725次/小时,维持1小时,使基础波丛变为活动性单一波丛,MR=8.4%(P<0.05)。苯甲酸雌二醇(E_2)则对基础波丛呈抑制/兴奋双向作用,即先抑制约7小时后,再使幅度(925μV)和频率(2500次/小时)都增加长达3日之久的兴奋作用,MR=64.7%(P<0.01)。应用E_2后10小时血浆E_2β水平达22.50pg/ml,明显高于基础水平(10.50pg/ml)(P<0.01),而P_4基础水平均为0.3625ng/ml,其它各阶段E_2β、P_4浓度变化都不明显。在E_2兴奋阶段OXT可使其频率于数秒内即测得持续约45分钟的进一步高度触发(6000次/小时),EMG呈极强活性(MR=150%),与单独使用OXT和E_2相比差异极显著。结论:E_2和OXT在临床上配合应用能较强兴奋子宫。 | 李跃民 Fielden E.D. Carr D.H. | 1993 | 畜牧兽医学报1993，24，6： | 6 |
| 10 | 通过业余时间运动的中老年的运动心电图:100次运动试验足以确定一个无症状心肌缺血的心脏事件风险显示文摘运动心电图在预防运动员心脏事件方面的重要性一直存在争议。为了确定运动心电图中无症状心肌缺血(silent myocardial ischemia,SMI)的频率及运动心电图与冠状动脉造影评估结果和潜在可预防的心脏事件的关系。Hupin等纳入2011-2014年就诊于Saint-Etienne大学医院运动医学科年龄≥35岁的无症状业余运动员,进行前瞻性队列研究。 | 刘青 叶鹏 Hupin D Edouard P Oriol M Laukkanen J Abraham P Doutreleau S Guy JM CarréF Barthélémy JC Roche F Chatard JC | 2018 | 中华高血压杂志2018，26，4： | 6 |
| 11 | 羊毛表面改性对染色性能的作用显示文摘比较过一硫酸盐氧化表面改性和DCCA氯化表面改性对羊毛染色性能的作用效果,探讨弱酸性染料、中性染料和毛用活性染料在不同改性羊毛织物上的上染率和上染速率。结果表明:羊毛的表面改性能够削弱染料的扩散壁垒,改善各种染料在羊毛纤维上的染色性能。 | 邵建中 陈冬芝 刘今强 C M Carr | 2003 | 纺织学报2003，24，2： | 6 |
| 12 | Dynamic expression of Slit1–3 and Robo1–2 in the mouse peripheral nervous system after injury显示文摘The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors.Although we previously reported that Slit1–3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system,how this expression changes after injury has not been well studied.Herein,we constructed a peripheral nerve injury mouse model by transecting the right sciatic nerve.At 14 days after injury,quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1–3 and Robo1–2 in L4–5 spinal cord and dorsal root ganglia,as well as the sciatic nerve.Immunohistochemical analysis was performed to examine Slit1–3,Robo1–2,neurofilament heavy chain,F4/80,and vimentin in L4–5 spinal cord,L4 dorsal root ganglia,and the sciatic nerve.Co-expression of Slit1–3 and Robo1–2 in L4 dorsal root ganglia was detected by in situ hybridization.In addition,Slit1–3 and Robo1–2 protein expression in L4–5 spinal cord,L4 dorsal root ganglia,and sciatic nerve were detected by western blot assay.The results showed no significant changes of Slit1–3 or Robo1–2 mRNA expression in the spinal cord within 14 days after injury.In the dorsal root ganglion,Slit1–3 and Robo1–2 mRNA expression were initially downregulated within 4 days after injury;however,Robo1–2 mRNA expression returned to the control level,while Slit1–3 mRNA expression remained upregulated during regeneration from 4–14 days after injury.In the sciatic nerve,Slit1–3 and their receptors Robo1–2 were all expressed in the proximal nerve stump;however,Slit1,Slit2,and Robo2 were barely detectable in the nerve bridge and distal nerve stump within 14 days after injury.Slit3 was highly ex-pressed in macrophages surrounding the nerve bridge and slightly downregulated in the distal nerve stump within 14 days after injury.Robo1 was upregulated in vimentin-positive cells and migrating Schwann cells inside the nerve bridge.Robo1 was also upregulated in Schwann cells of the distal nerve stump within 14 days after injury.Our findings indicate that Slit3 is the major ligand expressed in the nerve bridge and distal nerve stump during peripheral nerve regeneration,and Slit3/Robo signaling could play a key role in peripheral nerve repair after injury.This study was approved by Plymouth University Animal Welfare Ethical Review Board (approval No.30/3203) on April 12,2014. | Bing Chen Lauren Carr Xin-Peng Dun | 2020 | Neural Regeneration Research2020，15，5： | 6 |
| 13 | 蚕丝丝素表面结构与活性染料染色(一)显示文摘对蚕丝织物进行高温、日晒、蛋白酶处理,测定处理前后活性染料的上染率、固着率、总固着效率及染色物的表面颜色深度。结果表明:蚕丝纤维经高温、日晒或蛋白酶处理后,活性染料染色性能有所下降,主要原因在于酪氨酸含量的减少和丝蛋白微细结构的变化而致。 | 邵建中 王东升 郑今欢 刘今强 Christopher M Carr | 2002 | 纺织学报2002，23，5： | 6 |
| 14 | Convective high-speed flow and field-aligned high-speed flows explored by TC-1显示文摘From June 1, 2004 to October 31, 2006, a total 465 high-speed flow events are observed by the TC-1 satellite in the near-Earth region (?13 RE < x < ?9 RE, |Y |<10 RE, |Z|<5 RE). Based on the angle between the flow and the magnetic field, the high-speed flow events are further divided into two types, that is, field-aligned high-speed flow (FAHF) in the plasma sheet boundary and convective bursty bulk flow (BBF) in the center plasma sheet. Among the total 465 high-speed flow events, there are 371 FAHFs, and 94 BBFs. The CHF are mainly concentrated in the plasma sheet, the intersection angle between the flow and the magnetic field is larger, the magnetic field intensity is relatively weak. The FHF are mainly distributed near the boundary layer of the plasma sheet, the intersection angle between the flow and magnetic field is smaller, and the magnetic field intensity is relatively strong. The convective BBFs have an important effect on the substorm. | ZHANG LingQian LIU ZhenXing MA ZhiWei W. BAUMJOHANN M.W. DUNLOP WANG GuangJun WANG Xiao H. REME C. CARR | 2008 | Chinese Science Bulletin2008，53，15： | 5 |
| 15 | 基于岗位胜任力的塔夫茨大学医学院生理学教学改革显示文摘医学生理学是一门重要的基础医学课程,如何在以岗位胜任力为导向的课程模式中调整生理学的教学内容和方法,培养优秀的医学人才,是当下基础医学教育改革的关键。美国塔夫茨大学医学院(Tufts University School of Medicine)近十几年来进行了两次重要的基础医学教育改革,生理学的教学内容已经与临床相关知识充分整合,了解其生理学教学改革的过程,将为我国高等院校今后进行生理学及麻醉生理学教学改革提供借鉴。 | 张咏梅 刘苏 Ylisabyth Bradshaw Daniel Carr 曹君利 | 2019 | 基础医学教育2019，21，11： | 5 |
| 16 | Surveys on magnetospheric plasmas based on the Double Star Project (DSP) exploration显示文摘The equatorial and polar satellites of the Double Star Project (DSP) were launched successfully on December 29, 2003 and July 25, 2004, respectively, and both of them are operating smoothly. The DSP provides a good opportunity for investigat-ing the structure of the magnetosphere. Based on the DSP data collected during 2004, we have surveyed the distribution of the magnetic fields and plasmas in the magnetosphere. It is found that: (1) Near the Earth’s equatorial plane within geo-centric distances of less than 7 RE, the Earth’s magnetic field is dipolar. In the vi-cinity of the magnetopause, the magnetic field is enhanced by a factor of about 1.5, and on the nightside, the magnetic field can vary significantly from the Earth’s di-pole field, likely caused by the presence of the near-Earth tail current sheet. (2) In the day-side magnetosheath, the electron and ion densities are usually both in the range of 10―30 cm?3; the ion and electron temperatures are usually about 200 and 50 eV, respectively. The flow pattern is usually smooth, with a low velocity in the subsolar region and with significantly higher velocities in the dawn and dusk flanks. (3) In the region between the magnetopause and plasmasphere the density is low, approximately 0.5―5 cm?3, and the temperature is high, about 1―10 keV for ions and 0.1―5 keV for electrons. The ion temperature has an apparent anisotropy, with the ratio of the perpendicular and parallel temperatures being about 1.0―1.3 for the night- and dusk-side magnetosphere and about 1.3―2.0 for the day- and dawn-side magnetosphere. There is an evident sunward convection of about 50 km/s in the magnetosphere. On the dawn side, the flow becomes somewhat turbulent, and in the vicinity of the night-noon meridian plane, the convection is rather slow. (4) The high-energy electrons with energies higher than 2 MeV are mainly located in the regions with 3 < L < 4.5; the size of the high-energy electrons area varies with time, it may expand and shrink occasionally according to different solar wind conditions and magnetic activities. | C. P. ESCOUBET C. M. CARR H. RME A. FAZAKERLEY H. LAAKSO I. DANDOURAS M. DUNLOP | 2008 | Science China(Technological Sciences)2008，51，10： | 5 |
| 17 | Pretreatment methods to improve sludge anaerobic degradability: A review显示文摘 | H. Carrère C. Dumas A. Battimelli D.J. Batstone J.P. Delgenès J.P. Steyer I. Ferrer | 2010 | Journal of Hazardous Materials2010，，1： | 5 |
| 18 | New perspectives in occult hepatitis C virus infection显示文摘Occult hepatitis C virus (HCV) infection, defined as the presence of HCV RNA in liver and in peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard assays, can be found in anti-HCV positive patients with normal serum levels of liver enzymes and in anti-HCV negative patients with persistently elevated liver enzymes of unknown etiology. Occult HCV infection is distributed worldwide and all HCV genotypes seem to be involved in this infection. Occult hepatitis C has been found not only in anti-HCV positive subjects with normal values of liver enzymes or in chronic hepatitis of unknown origin but also in several groups at risk for HCV infection such as hemodialysis patients or family members of patients with occult HCV. This occult infection has been reported also in healthy populations without evidence of liver disease. Occult HCV infection seems to be less aggressive than chronic hepatitis C although patients affected by occult HCV may develop liver cirrhosis and even hepatocellular carcinoma. Thus, anti-HCV negative patients with occult HCV may benefit from antiviral therapy with pegylated-interferon plus ribavirin. The persistence of very low levels of HCV RNA in serum and in PBMCs, along with the maintenance of specific T-cell responses against HCV-antigens observed during a long-term follow-up of patients with occult hepatitis C, indicate that occult HCV is a persistent infection that is not spontaneously eradicated. This is an updated report on diagnosis, epidemiology and clinical implications of occult HCV with special emphasis on anti-HCV negative cases. | Vicente Carreño Javier Bartolomé Inmaculada Castillo Juan Antonio Quiroga | 2012 | World Journal of Gastroenterology2012，18，23： | 5 |
| 19 | Phase 2 trial of linifanib (ABT‐869) in patients with unresectable or metastatic hepatocellular carcinoma显示文摘 | Han Chong Toh Pei‐Jer Chen Brian I. Carr Jennifer J. Knox Sharlene Gill Peter Ansell Evelyn M. McKeegan Barry Dowell Michelle Pedersen Qin Qin Jiang Qian Frank A. Scappaticci Justin L. Ricker Dawn M. Carlson Wei Peng Yong | 2012 | Cancer2012，，2： | 4 |
| 20 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
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