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| 1 | CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products: An updated review显示文摘The disinfection of drinking water is an important public health service that generates high quality, safe and palatable tap water. The disinfection of drinking water to reduce waterborne disease was an outstanding public health achievement of the 20 th century.An unintended consequence is the reaction of disinfectants with natural organic matter,anthropogenic contaminants and bromide/iodide to form disinfection by-products(DBPs).A large number of DBPs are cytotoxic, neurotoxic, mutagenic, genotoxic, carcinogenic and teratogenic. Epidemiological studies demonstrated low but significant associations between disinfected drinking water and adverse health effects. The distribution of DBPs in disinfected waters has been well defined by advances in high precision analytical chemistry. Progress in the analytical biology and toxicology of DBPs has been forthcoming.The objective of this review was to provide a detailed presentation of the methodology for the quantitative, comparative analyses on the induction of cytotoxicity and genotoxicity of103 DBPs using an identical analytical biological platform and endpoints. A single Chinese hamster ovary cell line was employed in the assays. The data presented are derived from papers published in the literature as well as additional new data and represent the largest direct quantitative comparison on the toxic potency of both regulated and emerging DBPs.These data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better. | Elizabeth D.Wagner Michael J.Plewa | 2017 | Journal of Environmental Sciences2017，29，8： | 70 |
| 2 | Overexpression of a Potato Sucrose Synthase Gene in Cotton Accelerates Leaf Expansion, Reduces Seed Abortion, and Enhances Fiber Production显示文摘蔗糖 synthase (怀疑) 是在蔗糖的故障的关键酶并且为水池力量被认为一个生物化学的标记特别在庄稼种类,基于 mutational 和基因,抑制学习。它留下逃犯,然而是否,或到什么程度,的增加怀疑活动可以提高水池开发。我们由表示一个土豆瞄准了这个问题到地址在怀疑表达式的棉花怀疑基因以前被显示了为正常批评种子和纤维开发。那增加了的在产生在揭示的同型结合的子孙线由研究跟随了的 T1 的分离分析在提高的棉花(1 ) 怀疑活动有从从射击顶出现的年轻叶子明显的效果的叶扩大;(2 ) 早改善了种子开发,减少了种子流产,因此提高了种子集合,并且(3 ) 支持的纤维延伸。在年轻叶子怀疑 overexpressing 线,果糖而,集中显著地被增加,在伸长纤维,果糖并且葡萄糖层次被增加。自从 hexoses,在叶子贡献很少到 osmolality,与开发纤维相对照,高怀疑活动,这被结束独立于渗透的规定支持叶开发,可能通过糖发信号。分析也证明在 0-d 棉花种子加倍 Sus 活动增加了他们的新鲜重量大约 30% 。然而,进一步增加在怀疑活动没更进一步在种子重量导致增加,为 Sus overexpression 效果显示上面的限制。最后,从增加的纤维长度和种子数字基于纤维上的观察添加剂效果让步,新策略被建议由总体上,而非完全改进种子开发增加棉花纤维产量集中于操作纤维生长。 | Shou-Min Xu Elizabeth Brill Danny J. Llewellyn Robert T. Furbank Yong-Ling Ruan | 2012 | Molecular Plant2012，5，2： | 35 |
| 3 | 中国1型糖尿病的社会成见:请停止对这种可控慢性病患者的歧视显示文摘社会成见(也称'污名化')是阻碍1型糖尿病患者得到更好医疗保障的顽固壁垒。这篇述评描述了目前中国存在的针对1型糖尿病患者的社会成见现象。在中国,社会成见给1型糖尿病患者带来歧视和对个体的贬低。1型糖尿病患者因社会成见在择偶、升学、就业中遭受的不公正待遇迫使很多患者隐瞒他们的疾病。社会成见给1型糖尿病患者带来的耻辱感、恐惧感和负罪感会妨碍他们应用能更好地控制血糖的胰岛素泵或每日多次皮下注射胰岛素来管理血糖,因为运用这些治疗方法会要求患者在学校或工作单位进行餐前胰岛素注射和血糖监测。同时,社会成见也使他们不愿参加与1型糖尿病相关的科研活动,或那些可能让他们获益的健康促进活动。目前亟需多方面、多层次的行动来改变这种社会成见。这包括:提高公众对于1型糖尿病的认识和理解;医疗工作者从整体医疗而不是仅从生物医学角度出发来管理1型糖尿病;辅导患者发展积极应对的技能;考虑到中国现实的社会心理环境,扩展1型糖尿病研究的范围。近期,在中国全国播出的一部关于1型糖尿病的纪录片,正是朝向这正确方向迈进的重要一步。我们相信,通过协调各相关方的行动,终会给1型糖尿病的治疗带来重要的改善、提高这些身患慢性但可控疾病患者的身心健康。 | 刘蔚 纪立农 苏夜阳 Lindsay M.Jaacks Elizabeth J.Mayer-Davis | 2015 | 中国糖尿病杂志2015，23，3： | 31 |
| 4 | “坐月子”对产后抑郁症的影响显示文摘目的 :调查产后抑郁症及其相关因素 ,了解“坐月子”以及家庭和社会支持等社会心理因素对产后抑郁症的影响。方法 :产后 4 2 d,使用自编社会心理因素及传统风俗调查表、明尼苏达多项个性量表 (MMPI)调查 199例产后妇女。结果 :本研究中产后抑郁症的发生率为 2 6 .9% ;产后抑郁症的发生与丈夫的作用、家庭经济收入、婆婆的参与以及亲友的支持有显著联系 (P<0 .0 5 ) ;“坐月子”相关因素与产后抑郁症之间没有发现显著联系 (P >0 .0 5 )。结论 :坐月子似乎对女性的产后经历有积极和消极两方面的作用。计划怀孕、预先做好“坐月子”时间和经济支出的安排将可能对产后抑郁症的发生具有保护作用。家庭。 | 关宏岩 戴耀华 Elizabeth Dziadik 孙二妹 | 2002 | 中国妇幼保健2002，17，8： | 34 |
| 5 | Using nuclear gene data for plant phylogenetics: Progress and prospects II. Next-gen approaches显示文摘原子基因提供的单个、低的拷贝很多,并且更快演变,比叶绿体和原子 ribosomal 基因序列,那统治了的人物迄今为止种种系发生的研究。直到最近,仅仅或一些低拷贝原子基因标记在如此的研究被包括。现在, “next 产生 sequencing” 的快速的采纳(NGS ) 更简单、更便宜的技术提议存取到几百,并且不仅仅中的十个,编码并且 noncoding DNA 区域。在这评论,我们描述为存取原子基因可得到的最使用得通常的 NGS 方法并且讨论在最后二~三年里被出版了的许多 NGS 案例研究。这些途径包括整个染色体定序指向 microsatellites,定序的 transcriptome,定序的告知 Exon 的 Intron 十字路口(史诗) ,指向的丰富(或顺序俘获) ,定序的 RAD (RAD-Seq,包括 genotyping-by-sequencing 或 GBS ) ,并且掠过的染色体。我们也讨论一些对的挑战,并且摆姿势由, NGS 途径。 | Elizabeth A. Zimmer Jun Wen | 2015 | Journal of Systematics and Evolution2015，53，5： | 31 |
| 6 | 卫生经济学评价报告标准共识2022(CHEERS 2022):卫生经济学评价报告指导意见更新版显示文摘卫生经济学评价是对备选行动方案的成本和结果的比较分析。2013年发表的《卫生经济学评价报告标准共识》(CHEERS)提出了卫生经济学评价的特点,确保结果正确阐释,以支持决策制订。2013版CHEERS旨在指导研究报告撰写者准确报告卫生干预和对照措施、背景、过程、结果等评价细节,使审稿人理解文章内容,帮助读者使用研究结果。本版共识将取代2013版共识,其更加适用于各类卫生经济学评价,结合学科发展和方法更新的需要,更注重患者、公众等相关利益方的参与。本共识适用多种个体或人群健康干预措施(简单或复杂)在不同政策场景的应用分析,包括医疗服务、公共卫生、教育、社会服务等。本文概要介绍了CHEERS 2022共识中包含的28个检查项及每一个检查项的相关建议。CHEERS 2022共识主要用于指导研究人员撰写拟投递同行评议学术期刊的卫生经济学评价文章,亦可用于期刊编辑和审稿专家对待发表文章的评价。熟悉了解本共识要求,还有助于研究人员规划评价研究。随着决策透明度要求提高,本共识可支持卫生技术评估机构建立评价报告标准。 | Don Husereau Michael Drummond Federico Augustovski Esther de Bekker-Grob Andrew H Briggs Chris Carswell Lisa Caulley Nathorn Chaiyakunapruk Dan Greenberg Elizabeth Loder Josephine Mauskopf C Daniel Mullins Stavros Petrou Raoh-Fang Pwu Sophie Staniszewska on behalf of CHEERSISPOR Good Research Practices Task Force 肖月(译) 邱英鹏(译) 史黎炜(译) 张治国(译) 张歆(译) 王海银(译) 翟铁民(译) | 2022 | 英国医学杂志中文版2022，25，8： | 31 |
| 7 | Expression, Imprinting, and Evolution of Rice Homologs of the Polycomb Group Genes显示文摘Polycomb 组蛋白质(PcG ) 在基因表示的 epigenetic 规定起重要作用。一些核心 PcG 蛋白质例如 Zeste (E (z)) 的 Enhancer, Zeste (12 ) 的 Suppressor (苏(z) 12 ) ,并且额外的性梳子(转换字符) ,在植物被保存。米饭染色体包含象基因, OsiEZ1 和 OsCLF 一样的二 E (z) ,苏(z) 的二个相当或相同的事物 12, OsEMF2a 和 OsEMF2b,和二像转换字符的基因, OsFIE1 和 OsFIE2。OsFIE1 仅仅在内乳被表示;当父亲的拷贝不是活跃的时,母亲的拷贝被表示。另外的米饭 PcG 基因在大量纸巾被表示并且没在内乳被印。象基因一样的二 E (z) 看起来以前复制了 dicots 和 monocots 的分离;12 可能在 Gramineae 和二像转换字符的基因的进化期间复制了的苏(z) 的二个相当或相同的事物是可能的在草的祖先复制了。Arabidopsis 表示种子的 PcG 基因 MEA 和 FIS2 的相当或相同的事物都没在米饭染色体被识别。我们在三 PcG 基因的米饭相当或相同的事物孤立 T-DNA 插入线。在这些 T-DNA 插入线没有自治内乳发展。有在 OsEMF2b 的 T-DNA 插入的一根线包括改变的 flowering 时间和反常的花机关显示多种的显型,建议在为这基因的米饭开发的重要角色。 | Ming Luo Damien Platten Abed Chaudhury W.J. Peacock Elizabeth S. Dennis | 2009 | Molecular Plant2009，2，4： | 25 |
| 8 | 塞来昔布治疗疼痛及炎症临床前期及临床研究显示文摘塞来昔布是一个环氧化酶 2 (COX 2 )特异性抑制剂 ,是治疗骨关节炎和类风湿关节炎的抗炎镇痛药 ,而伴随治疗的不良作用则是由于其对COX 1的抑制作用。临床试验表明 :塞来昔布较安慰剂明显有效 ,且与传统NSAID的萘普生疗效相当 ,安全且耐受性好 ,不影响血小板聚集 ,也未出现胃肠道溃疡。 | Elizabeth Tindall | 2000 | 中国新药杂志2000，9，8： | 26 |
| 9 | 期刊与学术会议论文摘要中报告随机对照试验的CONSORT声明:说明与详述显示文摘背景:对于与随机对照试验(randomized controlled trial,RCT)有关的学术会议论文或期刊中发表的文章来说,清楚、明了、信息量充足的摘要是十分重要的,因为读者经常仅仅根据报告的摘要对一个临床试验作出评价。为此,我们需要对'临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)声明'进行扩充,制定一个期刊与学术会议论文摘要中报告RCT的必备条目清单。今后在任何期刊发表的论文或学术会议论文摘要中,作者对RCT结果的报告都要包含这些内容。方法与结果:我们根据现有的质量评价工具和基于经验的证据总结出一个条目清单。运用三轮修正式德尔菲法(modified-Delphi process)进行条目筛选。邀请共计109人参与电子网络调查,反馈率为61%。调查结果于2007年1月在加拿大蒙特贝罗举行的CONSORT小组会议中公布,与会的26人中有临床试验实施人员、统计学家、流行病学家以及生物医学编辑。经过讨论最终确定条目,随后对其进行修订以保证这些条目体现了会议期间以及会后的讨论思路。摘要CONSORT建议RCT报告的摘要需要有一个结构化的格式,其中应该包括具体的试验目的、试验设计(随机分配的方法、盲法或遮蔽等)、研究对象(对象描述、随机分组的样本量以及用于分析的样本量)、每组实施的干预、实施的干预对主要疗效结果的影响及其危害、试验结论、试验注册名称和编号以及资金来源。本文对每一条能够找到例子的纳入条目都配有良好报告范例、基本原理以及证据等,十分明了易懂,因此我们建议与清单同时使用。结论:摘要CONSORT旨在改善期刊与学术会议中发表的论文摘要的质量,这将有助于摘要提供详尽清晰的信息,这些信息能够帮助读者对试验的有效性和试验结果的适用性做出正确的评价。 | Sally Hopewell Mike Clarke David Moher Elizabeth Wager Philippa Middleton Douglas G.Altman Kenneth F.Schulz the CONSORT Group 李迅 刘建平 | 2008 | 中西医结合学报2008，6，3： | 23 |
| 10 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 11 | 基于嵌入式互联网的远程智能喷雾控制系统设计显示文摘为提高设施农业植保作业智能管控能力,该文提出一种基于STM32F101和STM32F103嵌入式技术,结合4G互联网、局域WIFI通信技术及超声波靶标检测算法,能够便捷地对设施作业装备远程视频与控制的方案,达到人机分离与精准施药的目的。该系统在Eclipse和Keil-uvision4开发环境下采用Socket和多线程技术实现双向通信,以TCP通讯协议为媒介,Android端和客户端通过互联网或无线网卡转接移动路由实现远程智能喷雾控制。试验结果表明:1)Android端能够在LAN或Internet中实现智能喷雾装备的近远程控制,软件界面回传状态无卡顿、延时发生,能够准确发射控制指令,实现了对靶标间歇性施药管控;2)系统建立的双向心跳包能够在通信故障情况下迫使喷雾装备处于休眠状态,经测试,心跳包设定时间与喷雾装备休眠响应时间平均相对误差不超过5.50%;3)采用视频帧对冠层中线定位,借助超声检测算法确定风送距离参数且建立冠层体积模型。试验发现,冠层密度对体积测量结果有显著影响,但总体测量准确度可达94.67%。该研究对其他农机装备的智能化管控研究有参考意义。 | 吴亚垒 祁力钧 张豪 程浈浈 刘婠婠 谢德盛 Elizabeth Musiu | 2018 | 农业工程学报2018，34，20： | 21 |
| 12 | Prognostic significance of red blood cell distribution width in gastrointestinal disorders显示文摘The red blood cell distribution width(RDW) is a routinely measured and automatically reported blood parameter,which reflects the degree of anisocytosis. Recently,the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases,sepsis,cancers,leukemia,renal dysfunction and respiratory diseases. A myriad of factors,most of which ill-defined,have an impact on the red cell population dynamics(i.e.,production,maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review,we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data,RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers(i.e.,C reactive protein,erythrocyte sedimentation rate,and platelet count) and current disease severity indices used in clinical practice. | Hemant Goyal Giuseppe Lippi Altin Gjymishka Bijo John Rajiv Chhabra Elizabeth May | 2017 | World Journal of Gastroenterology2017，23，27： | 20 |
| 13 | ^(18)F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值显示文摘背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。 | 王国慧 Eddie W. F. Lau Ramdave Shakher David S. Binns Annette Hogg Elizabeth Drummond Rodney J. Hicks | 2007 | 癌症2007，26，6： | 19 |
| 14 | Intestinal antigen-presenting cells in mucosal immune homeostasis:Crosstalk between dendritic cells,macrophages and B-cells显示文摘The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota.Inflammatory bowel disease(IBD)involves a breakdown in tolerance towards the microbiota.Dendritic cells(DC),macrophages(MΦ)and B-cells are known as professional antigen-presenting cells(APC)due to their specialization in presenting processed antigen to T-cells,and in turn shaping types of T-cell responses generated.Intestinal DC are migratory cells,unique in their ability to generate primary T-cell responses in mesenteric lymph nodes or Peyer’s patches,whilst MΦand B-cells contribute to polarization and differentiation of secondary T-cell responses in the gut lamina propria.The antigen-sampling function of gut DC and MΦenables them to sample bacterial antigens from the gut lumen to determine types of T-cell responses generated.The primary function of intestinal B-cells involves their secretion of large amounts of immunoglobulin A,which in turn contributes to epithelial barrier function and limits immune responses towards to microbiota.Here,we review the role of all three types of APC in intestinal immunity,both in the steady state and in inflammation,and how these cells interact with one another,as well as with the intestinal microenvironment,to shape mucosal immune responses.We describe mechanisms of maintaining intestinal immune tolerance in the steady state but also inappropriate responses of APC to components of the gut microbiota that contribute to pathology in IBD. | Elizabeth R Mann Xuhang Li | 2014 | World Journal of Gastroenterology2014，20，29： | 19 |
| 15 | Developing integrative systematics in the informatics and genomic era, and calling for a global Biodiversity Cyberbank显示文摘Systematics 是发现的科学,组织并且解释所有生活有机体的差异。在 genomics 和生物多样性信息科学的最近的开发正在转变 systematics 并且开创了许多新机会。在生物多样性信息科学的主要 digitization 努力和开发帮助了 systematics 社区探索方法在组织提高效率,出版,并且利用系统的信息。同时, genomics 很快正在便于生活的树的建设,改进分类分类,并且解开复杂进化历史。在信息科学和 genomics 时代, systematics 有一个不可思议的能力为发现以及与其它一起与计算、探索的平台集成,当在生物集合和形态学维持它的核心力量时,联系了学科。我们要求将作为生物多样性数据的许多类型的主要仓库工作保证系统的数据的广阔、成长的数量的长期的可持续性的新全球 cyberinfrastructure 或生物多样性 Cyberbank 的建立。这生物多样性 Cyberbank 将为 systematics 研究包含新、有效的分析管道,特别为高效地产生分类处理(修订,电子书和植物群) 。综合 systematics 要求训练下一代的组织主义者与分类, phylogenomic 和信息科学技巧到关于生物多样性和它的集会探讨宏大问题并且继续开发生物多样性 Cyberbank。综合 systematics 必须积极地也为探讨 Anthropocene 的生物多样性危机在 systematics 和集合的重要性上教育公众和政策制造者,并且生物多样性 Cyberbank 可以代表一个强大的工具为超出。 | Jun Wen AJ Harris Stefanie M. Ickert-Bond Rebecca Dikow Kenneth Wurdack Elizabeth A. Zimmer | 2017 | Journal of Systematics and Evolution2017，55，4： | 18 |
| 16 | 护士排班方式概述与思考显示文摘本文通过详细介绍护士每班工作时长、轮班模式、休息时间安排以及加班等护士排班重要组成部分及相关研究,以期为我国护士排班的探索与研究提供借鉴与参考。 | 邓敏娉 陈伟菊 Elizabeth Roe | 2017 | 中国护理管理2017，17，1： | 18 |
| 17 | Histopathology of nonalcoholic fatty liver disease显示文摘Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease(NAFLD) are measured.Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD,i.e.nonalcoholic steatohepatitis(NASH) and fibrosis.Included in the lesions of NAFLD are steatosis,lobular and portal inflammation,hepatocyte injury in the forms of ballooning and apoptosis,and fibrosis.However,patterns of these lesions are as distinguishing as the lesions themselves.Liver injury in adults and children due to NAFLD may have different histological patterns.In this review,the rationale for liver biopsy,as well as the histopathological lesions,the microscopically observable patterns of injury,and the differential diagnoses of NAFLD and NASH are discussed. | Elizabeth M Brunt Dina G Tiniakos | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 18 | Epidemiology of Hepatitis B and Associated Liver Diseases in China显示文摘Hepatitis B virus (HBV) infection has long been a critical public health challenge in China. National surveys revealed a prevalence of approximate 10% for chronic HBV infection in general population. HBV has been the leading cause of chronic hepatitis, cirrhosis, and liver cancers in Chinese population and a common pathogen of acute viral hepatitis. Meanwhile, the epidemic provided important opportunities to research the natural history, public health impact, and therapeutic and preventive interventions for HBV in China. In this review, we summarized the selected key epidemiological studies since 1970s regarding HBV infection and its associated liver diseases in China, and provided considerations for future research, prevention and treatment of HBV. | Yao Zhang Hua Zhang Au Elizabeth Xiao-qing Liu | 2012 | Chinese Medical Sciences Journal2012，27，4： | 16 |
| 19 | Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases显示文摘Helicobacter pylori(H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases. Since a microorganism resembling H. pylori was detected in samples from patients with hepatobiliary disorders, several reports have been discussed the possible role of bacteria in hepatic diseases as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis. Additionally, studies have reported the possible association between H. pylori infection and pancreatic diseases, especially because it has been suggested that this infection could change the pancreatic physiology. Some of them have related a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been suggested to play a role in the acute and chronic pancreatitis pathogenesis, autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. Considering that association of H. pylori to liver and pancreas diseases needs further clarification, our work offers a review about the results of some investigations related to the potential pathogenicity of H. pylori in these extragastric diseases. | Elizabeth MA Rabelo-Goncalves Bruna M Roesler Jose MR Zeitune | 2015 | World Journal of Hepatology2015，7，30： | 16 |
| 20 | 无人机果树施药旋翼下洗气流场分布特征研究显示文摘植保无人机悬停果树施药时的旋翼下洗气流场分布对雾滴空间运动和在冠层内部的附着、穿透有重要影响。该文基于计算流体动力学(computational fluid dynamic,CFD)方法,结合RNGκ–ε湍流模型、多孔介质模型和滑移网格技术,通过构建虚拟果园,对六旋翼植保无人机悬停果树施药时的下洗气流流场进行数值模拟,分析在无人机不同悬停高度、不同果树生长阶段和不同自然风速下的气流场分布特征,并进行标记点下洗气流速度测试试验。研究结果表明:1)自然风速大于3m/s时,旋翼下洗气流速度已淹没于环境自然风速中,不再满足植保无人机悬停施药作业条件;2)自然风破坏了旋翼下洗气流的中心对称状态,向下风方向出现后扬,且随着自然风速和悬停高度的增大,后扬距离随之增大;3)与无自然风状态比较,果树生长时期对其喷头处速度分布影响不显著,主要受自然风影响,且竖直向下的z向气流占主体地位,对雾滴的对靶运输起主导作用,应将喷头安装于可使雾滴获得较大z向速度的旋翼正下方0.2m处附近;4)无人机悬停位置沿逆风方向调整后,冠层内部上、中、下层气流平均速度较调整前分别由1.36、0.80、0.81m/s增大至3.04、2.37、1.63m/s;上、下层速度分布变异系数分别由74.26%、35.80%降至45.39%和22.70%,中层略有增大,总体利于实现对靶喷雾。试验结果表明,标记点下洗气流速度测量值和模拟值之间具有较好的一致性。该文可为动态环境条件下植保无人机悬停果树施药的对靶喷雾自适应控制技术研究提供参考。 | 张豪 祁力钧 吴亚垒 程浈浈 刘婠婠 Elizabeth Musiu 肖雨 杨泽鹏 | 2019 | 农业工程学报2019，35，18： | 16 |
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