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| 1 | 灌区水资源合理配置研究进展显示文摘灌区水资源合理配置是提高灌区水资源利用效率及保障粮食安全的重要途径,也是实现灌区水资源可持续利用的有效调控措施。从灌区水资源管理政策、水资源循环转化规律、水资源优化配置模型与方法和水文生态4个方面,对国内外该领域的研究现状进行了对比分析。研究发现,国内灌区水资源配置主要存在4个方面的问题:水资源合理配置与保护政策落实不到位、水资源的统一管理机制不健全、水资源优化配置模型实用性不强和水资源优化配置基础条件较为薄弱。建议加强灌区水资源的统一管理政策与机制、变化环境下水资源循环转化规律、水资源承载力基础理论与评价新方法、水文生态调控技术、水资源实时风险调度与智能化管理技术以及水资源优化配置耦合技术研究。 | 齐学斌 黄仲冬 乔冬梅 张现超 李平 Mathias N Andersen | 2015 | 水科学进展2015，26，2： | 66 |
| 2 | 中欧高压直流电网技术论坛综述显示文摘高压柔性直流输电和直流电网技术是解决可再生能源并网和大规模远距离传输最有效的方案之一。2015年9月7日和8日,在CIGRE(国际大电网会议)和中国电机工程学会的大力支持下和柏诚集团英国分公司(WSP|Parsons Brinckerhoff)的协助下,全球能源互联网研究院在英国伯明翰举行了为期两天的高压柔性直流输电和直流电网高峰技术论坛,邀请了欧洲和中国学术界、工业界直流输电和直流电网领域的40余位资深科研专家和决策者。本次论坛旨在通过对话,交流和探讨本领域的关键性问题、前沿技术以及未来发展方向。论坛期间,与会者展示了各自相关项目的实施、最新进展和成果。与此同时还对该领域现存的技术挑战和未来研究方向进行了广泛的讨论。该文从技术角度概述了与会者在高压柔性直流输电和直流电网技术领域的最新进展和成果,综述了本次论坛在柔性直流输电和直流电网领域所讨论的一些主要技术,介绍了参会的部分国际著名直流输电设备主要生产商的研发动态,根据论坛的讨论环节总结归纳了在高压柔性直流输电和直流电网领域所存在的挑战。 | 安婷 Bjarne Andersen Norman MacLeod 王伟男 | 2017 | 电网技术2017，41，8： | 40 |
| 3 | 属间体细胞杂交创建甘蓝型油菜细胞质雄性不育系及其鉴定显示文摘利用原生质体融合技,获得了甘蓝型油菜品种中双4号与新疆野生油菜野油18的对称性体细胞杂种。杂种当代建成的6株植株中有2株雄性不育株。用中双4号做轮回亲本与不育株回交,不育株率随回交代数增加而升高,至BC3代大部分株系的不育株率接近100%,到BC4代不育性稳定,群体中无育性分离现象。用波里马CMS的恢复系和保持系与其测交,6个甘蓝型油菜品系均可保持该不育系的不育性,表明该雄性不育胞质与Pol不育胞质不同。 | 胡琼 李云昌 梅德圣 方小平 Lise N. Hansen Sven B. Andersen | 2004 | 中国农业科学2004，37，3： | 40 |
| 4 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 5 | Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease显示文摘AIM To investigate the effect of a low-FODMAP diet on irritable bowel syndrome(IBS)-like symptoms in patients with inflammatory bowel disease(IBD).METHODS This was a randomised controlled open-label trial of patients with IBD in remission or with mild-to-moderate disease and coexisting IBS-like symptoms(Rome III) randomly assigned to a Low-FODMAP diet(LFD) or a normal diet(ND) for 6 wk between June 2012 andDecember 2013. Patients completed the IBS symptom severity system(IBS-SSS) and short IBD quality of life questionnaire(SIBDQ) at weeks 0 and 6. The primary end-point was response rates(at least 50-point reduction) in IBS-SSS at week 6 between groups; secondary end-point was the impact on quality of life. RESULTS Eighty-nine patients, 67(75%) women, median age 40, range 20-70 years were randomised: 44 to LFD group and 45 to ND, from which 78 patients completed the study period and were included in the final analysis(37 LFD and 41 ND). There was a significantly larger proportion of responders in the LFD group(n = 30, 81%) than in the ND group(n = 19, 46%);(OR = 5.30; 95%CI: 1.81-15.55, P < 0.01). At week 6, the LFD group showed a significantly lower median IBSSSS(median 115; inter-quartile range [IQR] 33-169) than ND group(median 170, IQR 91-288), P = 0.02. Furthermore, the LFD group had a significantly greater increase in SIBDQ(median 60, IQR 51-65) than the ND group(median 50, IQR 39-60), P < 0.01.CONCLUSION In a prospective study, a low-FODMAP diet reduced IBS-like symptoms and increased quality of life in patients with IBD in remission. | Natalia Pedersen Dorit Vedel Ankersen Maria Felding Henrik Wachmann Zsuzsanna Végh Line Molzen Johan Burisch Jens Rikardt Andersen Pia Munkholm | 2017 | World Journal of Gastroenterology2017，23，18： | 15 |
| 6 | 北欧湖泊的重金属调查:浓度、地理模式及与临界界限的关系显示文摘1995年秋天,北欧各国同时对本国的湖泊进行了调查,包括俄罗斯西北的科拉半岛。在大约3000个湖泊中,被调查的11种金属(铅、镉、砷、锌、铜、镍、钴、铁、锰、铬、钒)一般浓度较低,并具有明确的地理模式。对于铅、镉、锌和一定程度上钴的分布,远程迁移的空气污染带来的直接和间接影响是最重要的因素。湖中总有机碳(TOC)浓度对于铁和锰,并在一定程度上对于砷、铬和钒是重要的。对于铜和镍,基岩地质概况是最重要的控制因素,但在科拉半岛很多冶炼厂周围地区是个例外,在那里由于当地空气传播的污染,湖泊中铜和镍的浓度很高。基岩和地表的地质概况对于控制砷、钴、铬和钒的浓度也是重要的因素。调查结果表明在北欧国家湖泊中重金属污染在区域尺度上是一个较轻微的生态问题。 | Brit Lisa Skjelkvle Tom Andersen Eirik Fjeld Jaakko Mannio Anders Wilander Kjell Johansson Jens Peder Jensen Tatyana Moiseenko 孙学飞 | 2001 | AMBIO-人类环境杂志2001，30，1： | 11 |
| 7 | Endovascular treatment of nonvariceal acute arterial upper gastrointestinal bleeding显示文摘Transcatheter arterial embolization as treatment of upper nonvariceal gastrointestinal bleeding is increasingly being used after failed primary endoscopic treatment.The results after embolization have become better and surgery still has a high mortality.Embolization is a safe and effective procedure,but its use is has been limited because of relatively high rates of rebleeding and high mortality,both of which are associated with gastrointestinal bleeding and non-gastrointestinal related mortality causes.Transcatheter arterial embolization is a valuable minimal invasive method in the treatment of early rebleeding and does not involve a high risk of treatment associated complications.A multidisciplinary approach is necessary in the treatment of these patients and should comprise gastroenterologists,interventional radiologists,anaesthesiologists,and surgeons to achieve the best possible results. | Poul Erik Andersen Stevo Duvnjak | 2010 | World Journal of Radiology2010，2，7： | 11 |
| 8 | 射血分数保留的心力衰竭患者动脉硬化与运动的相关性显示文摘人类衰老以主动脉僵硬度增加为特征,通过降低动脉顺应性和增强收缩期波反射造成收缩期高血压。老年、高血压和肥胖是射血分数保留的心力衰竭(heart failure with preserved ejection fraction, HFpEF)发生发展最大的影响因素. | Reddy YNV Andersen MJ Obokata M Koepp KE Kane GC Melenovsky V Olson TP Borlaug BA 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 10 |
| 9 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 10 | Risk of infections associated with biological treatment in inflammatory bowel disease显示文摘Tumor necrosis factor-α(TNF-α)inhibitors are biological agents introduced in the late 1990s for the treatment of different immune-mediated diseases as inflammatory bowel disease,rheumatoid arthritis and psoriasis.The most commonly used TNF-αantagonists are infliximab,adalimumab,and certolizumab pegol,and though highly effective in lowering inflammation,the efficacy must be weighed against the potential for adverse events.The treatment-induced immunosuppression is suspected to increase the risk of infections,including the risk of reactivation of latent tuberculosis,as the TNF-αcytokine plays an important role in the immune function.In this topic highlight a short overview of the infection risk associated with TNF-αinhibiter therapy is outlined with a focus on the overall risk of serious infections,mycobacterial infection and latent viral infections. | Nynne Nyboe Andersen Tine Jess | 2014 | World Journal of Gastroenterology2014，20，43： | 9 |
| 11 | Biomarkers in inflammatory bowel diseases:Current status and proteomics identification strategies显示文摘Unambiguous diagnosis of the two main forms of inflammatory bowel diseases(IBD):Ulcerative colitis(UC)and Crohn’s disease(CD),represents a challenge in the early stages of the diseases.The diagnosis may be established several years after the debut of symptoms.Hence,protein biomarkers for early and accurate diagnostic could help clinicians improve treatment of the individual patients.Moreover,the biomarkers could aid physicians to predict disease courses and in this way,identify patients in need of intensive treatment.Patients with low risk of disease flares may avoid treatment with medications with the concomitant risk of adverse events.In addition,identification of disease and course specific biomarker profiles can be used to identify biological pathways involved in the disease development and treatment.Knowledge of disease mechanisms in general can lead to improved future development of preventive and treatment strategies.Thus,the clinical use of a panel of biomarkers represents a diagnostic and prognostic tool of potentially great value.The technological development in recent years within proteomic research(determination and quantification of the complete protein content)has made the discovery of novel biomarkers feasible.Several IBD-associated protein biomarkers are known,but none have been successfully implemented in daily use to distinguish CD and UC patients.The intestinal tissue remains an obvious place to search for novel biomarkers,which blood,urine or stool later can be screened for.When considering the protein complexity encountered in intestinal biopsysamples and the recent development within the field of mass spectrometry driven quantitative proteomics,a more thorough and accurate biomarker discovery endeavor could today be performed than ever before.In this review,we report the current status of the proteomics IBD biomarkers and discuss various emerging proteomic strategies for identifying and characterizing novel biomarkers,as well as suggesting future targets for analysis. | Tue Bennike Svend Birkelund Allan Stensballe Vibeke Andersen | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 12 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 13 | Has the risk of colorectal cancer in inflammatory bowel disease decreased?显示文摘The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intestine in combination with a genetic predisposition.The magnitude of the risk of CRC in IBD remains a continuing subject of debate.The early,high risk estimates for CRC in IBD were most likely overestimated due to selected patient populations originating from tertiary referral centers with a disproportional high percentage of patients with severe disease.Later population-based studies calculating risk estimates from a broad spectrum of IBD patients have found the risk to be significantly lower.At present,there is evidence that IBD patients with longstanding and extensive disease with uncontrolled inflammation are those at increased risk.Additional,other recognized risk factors include early age at onset,family history of CRC,and concomitant primary sclerosing cholangitis.A significant amount of effort is put into identifying potential preventive factors of CRC in IBD,including surveillance programs and chemopreventive agents but the individual effect of these remains uncertain.Interestingly,recent studies have reported a decline in risk of CRC over time.Surveillance programs and the new treatment strategies,particular biological treatment might be part of the reason for the observed decline in risk of CRC in IBD over time but future studies will have investigate this assumption. | Nynne Nyboe Andersen Tine Jess | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 14 | Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet显示文摘In the present study we report on changes in irritable bowel syndrome-severity scoring system(IBS-SSS)and irritable bowel syndrome-quality of life(IBS-QoL)in 19 IBS patients,aged 18 to 74 years(F/M:14/5),during 12 wk registering their symptoms on the webapplication(www.ibs.constant-care.dk).During a control period of the first 6-wk patients were asked to register their IBS-SSS and IBS-QoL on the web-application weekly without receiving any intervention.Thereafter,low fermentable oligo-,di-,mono-saccharides and polyols(FODMAP)diet(LFD)was introduced for the next6 wk while continuing the registration.Though a small sample size a significant improvement in disease activity(IBS-SSS)was observed during both the control period,median:278(range:122-377),P=0.02,and subsequently during the LFD period,median:151(range:29-334),P<0.01.The IBS-QoL solely changed significantly during the LFD period,median:67(37-120),P<0.01.The significant reduction in disease activity during the control period shows a positive effect of the web-application on IBS symptoms when presented as a'traffic light'.However adding the diet reduced IBSSSS to<150,inactive to mild symptoms.In the future results from larger scale trials are awaited. | Natalia Pedersen Zsuzsanna Vegh Johan Burisch Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Nynne Nyboe Andersen Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，21： | 7 |
| 15 | Effects of reclaimed water irrigation and nitrogen fertilization on the chemical properties and microbial community of soil显示文摘The ecological effect of reclaimed water irrigation and fertilizer application on the soil environment is receiving more attention.Soil microbial activity and nitrogen(N)levels are important indicators of the effect of reclaimed water irrigation on environment.This study evaluated soil physicochemical properties and microbial community structure in soils irrigated with reclaimed water and receiving varied amounts of N fertilizer.The results indicated that the reclaimed water irrigation increased soil electrical conductivity(EC)and soil water content(SWC).The N treatment has highly significant effect on the ACE,Chao,Shannon(H)and Coverage indices.Based on a 16S ribosomal RNA(16S rRNA)sequence analysis,the Proteobacteria,Gemmatimonadetes and Bacteroidetes were more abundant in soil irrigated with reclaimed water than in soil irrigated with clean water.Stronger clustering of microbial communities using either clean or reclaimed water for irrigation indicated that the type of irrigation water may have a greater influence on the structure of soil microbial community than N fertilizer treatment.Based on a canonical correspondence analysis(CCA)between the species of soil microbes and the chemical properties of the soil,which indicated that nitrate N(NO_3~–-N)and total phosphorus(TP)had significant impact on abundance of Verrucomicrobia and Gemmatimonadetes,meanwhile the p H and organic matter(OM)had impact on abundance of Firmicutes and Actinobacteria significantly.It was beneficial to the improvement of soil bacterial activity and fertility under 120 mg kg^(–1) N with reclaimed water irrigation. | GUO Wei Mathias N Andersen QI Xue-bin LI Ping LI Zhong-yang FAN Xiang-yang ZHOU Yuan | 2017 | Journal of Integrative Agriculture2017，16，3： | 7 |
| 16 | WONCA研究论文摘要汇编——肿瘤坏死因子α抑制剂与炎症性肠炎患者严重感染风险的关系:丹麦全国性队列研究显示文摘目的探讨肿瘤坏死因子α(TNF-α)抑制剂是否会增加严重感染风险。设计以全国登记资料为基础的倾向分数匹配队列研究。地点丹麦,2002年12月。参与者获得匹配资格的背景队列包含52392例炎症性肠炎患者,年龄15—75岁,其中4300例接受TNF—α抑制剂治疗。为了避免混淆,使用两个阶段匹配法:首先匹配年龄、性别、病程、炎症性肠炎亚型;之后匹配倾向分数(1:1比例)。最后将接受TNF—d抑制剂治疗的1543例患者与未接受TNF一0【抑制剂治疗的1543例患者纳入研究。主要结果指标主要结果指标是严重感染,即确诊为入院造成的感染。进行Cox比例风险回归分析,计算两个高危时期(TNF-α抑制剂治疗90d后和365d后)的风险率。特定位点严重感染的风险率只在356d获取。结果在90d,51例接受TNF—α抑制荆治疗的患者发生感染(发生率14/100人年),33例未接受TNF—α抑制剂治疗的患者发生感染(9/100人年),风险率为1.63[95%CI(1.01,2.63)]。在365d,风险率为1.27[95%CI(0.92,1.75)]。特定位点感染分析中,多个亚组的风险率超过2.00,有皮肤和软组织感染者风险率为2.51[95%[(1.23,5.12)]。结论这项全国性倾向分数匹配队列研究证明,开始治疗90d内使用TNF—d抑制剂会增加严重感染风险,后期风险率会降低。建议临床工作加强对炎症性肠炎患者潜在感染并发症的重视,尤其是在治疗早期。 | Nyboe Andersen N Pasternak B Friis-Mφller N 本刊编辑部 | 2015 | 中国全科医学2015，18，24： | 6 |
| 17 | Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA显示文摘除了明确的脱氧核糖核酸修理小径,所有生活有机体发展了机制避免复制叉倒塌在复制由于脱氧核糖核酸的造成分裂的共有原子价修正被堵住的一个地点引起的细胞死亡。术语脱氧核糖核酸损坏忍耐(DDT ) 泛泛地被采用了包括房间由熬过堵住复制的损害与或没有联系 genomic 不稳定性的许多机制。最近的基因分析在优核质显示那 DDT,从酵母到人,与是无差错的和另外一个由二条平行小径组成高度诱变。在开始发育的酵母,有趣地,这二条小径被增殖的房间的顺序的修正调停由二 ubiquitination 建筑群 Rad6-Rad18 和 Mms2-Ubc13-Rad5 的原子抗原(PCNA ) 。由 Rad6-Rad18 的 PCNA 的导致损坏的 monoubiquitination 与增加的傻瓜发育不全支持 translesion 合成(TLS ) ,当在由 Mms2-Ubc13-Rad5 的一样的 K164 残余的 PCNA 的随后的 polyubiquitination 支持无差错的损害时绕过。从最近的研究获得的数据建议上述机制在更高的优核质被保存。特别地,哺乳动物包含多重专业化 TLS 聚合酶。在 TLS 聚合酶之一的缺点被连接了到 genomic 不稳定性和癌症。 | Parker L Andersen Fang Xu Wei Xiao | 2008 | Cell Research2008，18，1： | 6 |
| 18 | A simple interpretation of the surface temperature/vegetation index space for assessment of surface moisture status显示文摘 | Inge Sandholt Kjeld Rasmussen Jens Andersen | 2001 | Remote Sensing of Environment2001，，2： | 5 |
| 19 | Bone mineral density in lifelong trained male football players compared with young and elderly untrained men显示文摘Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched men.Methods: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were measured.Results: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to UY.Conclusion: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despite an age difference of 47 years. | Marie Hagman Eva Wulff Helge Therese Hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 20 | An ingredient for the elixir of youth显示文摘 | Rebecca E Andersen | 2014 | Cell Research2014，24，12： | 5 |
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