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| 1 | Lipoprotein metabolism in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD),an escalating health problem worldwide,covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages,with potential progression to liver inflammation,fibrosis,and failure.A close,yet poorly understood link exists between NAFLD and dyslipidemia,a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins.Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins;they not only play an extracellular role in lipid transport between vital organs through circulation,but also play an important intracellular role in hepatic lipoprotein assembly and secretion.The liver functions as the central hub for lipoprotein metabolism,as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance.Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis,potential diagnosis,and treatment of NAFLD. | Zhenghui Gordon Jiang Simon C. Robson Zemin Yao | 2013 | The Journal of Biomedical Research2013，27，1： | 8 |
| 2 | The role and clinical implications of microRNAs in hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis. | ZHAO Xue YANG Zhen LI GuangBing LI DongKai ZHAO Yi WU Yan ROBSON Simon C. HE Lian XU YiYao MIAO R-uoYu ZHAO HaiTao | 2012 | Science China(Life Sciences)2012，55，10： | 6 |
| 3 | Making sense of regulatory T cell suppressive function显示文摘 | Itay Shalev Moritz Schmelzle Simon C. Robson Gary Levy | 2011 | Seminars in Immunology2011，，4： | 2 |
| 4 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Dysfunctional CD39POS regulatory T cells and aberrant control of T‐helper type 17 cells in autoimmune hepatitis显示文摘 | Charlotte R. Grant Rodrigo Liberal Beth S. Holder John Cardone Yun Ma Simon C. Robson Giorgina Mieli‐Vergani Diego Vergani Maria Serena Longhi | 2014 | Hepatology2014，，： | 1 |
| 6 | Vitamin D Levels in Adults with Crohn?s Disease Are Responsive to Disease Activity and Treatment显示文摘 | Maggie Ham Maria S. Longhi Conor Lahiff Adam Cheifetz Simon Robson Alan C. Moss | 2014 | Inflammatory Bowel Diseases2014，，5： | 1 |
| 7 | Transgenic swine: Expression of human CD39 protects against myocardial injury显示文摘 | Debra G. Wheeler Matthew E. Joseph Shouvik D. Mahamud William L. Aurand Peter J. Mohler Vincent J. Pompili Karen M. Dwyer Mark B. Nottle Sharon J. Harrison Anthony J.F. d’Apice Simon C. Robson Peter J. Cowan Richard J. Gumina | 2012 | Journal of Molecular and Cellular Cardiology2012，，5： | 1 |
| 8 | Ectonucleotidases as Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity显示文摘 | Silvia Deaglio Simon C. Robson | 2011 | Advances in Pharmacology2011，，： | 1 |
| 9 | CD39/ENTPD1 Expression by CD4 + Foxp3 + Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice显示文摘 | Xiaofeng Sun Yan Wu Wenda Gao Keiichi Enjyoji Eva Csizmadia Christa E. Müller Takashi Murakami Simon C. Robson | 2010 | Gastroenterology2010，，3： | 1 |
| 10 | The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance显示文摘 | Simon C. Robson Jean Sévigny Herbert Zimmermann | 2006 | Purinergic Signalling2006，，2： | 1 |
| 11 | Inhibition of Interleukin-17 Promotes Differentiation of CD25 – Cells Into Stable T Regulatory Cells in Patients With Autoimmune Hepatitis显示文摘 | Maria Serena Longhi Rodrigo Liberal Beth Holder Simon C. Robson Yun Ma Giorgina Mieli–Vergani Diego Vergani | 2012 | Gastroenterology2012，，7： | 1 |
| 12 | Mo1228 Fecal Microbiota Transplantation Induces Early Improvement in Symptoms in Patients With Active Crohn’s Disease显示文摘 | Byron P. Vaughn Dirk Gevers Amanda Ting Joshua R. Korzenik Simon C. Robson Alan C. Moss | 2014 | Gastroenterology2014，，： | 1 |
| 13 | The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver显示文摘 | Jonathan A. Dranoff Emma A. Kruglov Simon C. Robson Norbert Braun Herbert Zimmermann Jean Sévigny | 2002 | Hepatology2002，，5： | 1 |
| 14 | Infusion of CD133+ Bone Marrow–Derived Stem Cells After Selective Portal Vein Embolization Enhances Functional Hepatic Reserves After Extended Right Hepatectomy: A Retrospective Single-Center Study显示文摘 | Jan Schulte am Esch Moritz Schmelzle Günther Fürst Simon C. Robson Andreas Krieg Constanze Duhme Roy Y. Tustas Andrea Alexander Hans M. Klein Stefan A. Topp Johannes G. Bode Dieter H?ussinger Claus F. Eisenberger Wolfram Trudo Knoefel | 2012 | Annals of Surgery2012，，1： | 1 |
| 15 | Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury显示文摘 | Ming Cai Zachary M. Huttinger Heng He Weizhi Zhang Feng Li Lauren A. Goodman Debra G. Wheeler Lawrence J. Druhan Jay L. Zweier Karen M. Dwyer Guanglong He Anthony J.F. d’Apice Simon C. Robson Peter J. Cowan Richard J. Gumina | 2011 | Journal of Molecular and Cellular Cardiology2011，，6： | 1 |
| 16 | Purinergic signalling in the liver in health and disease显示文摘 | Geoffrey Burnstock Byron Vaughn Simon C. Robson | 2014 | Purinergic Signalling2014，，1： | 1 |
| 17 | Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea显示文摘 | Mary G. O’Keeffe Peter R. Thorne Gary D. Housley Simon C. Robson Srdjan M. Vlajkovic | 2010 | Histochemistry and Cell Biology2010，，4： | 1 |
| 18 | Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice显示文摘 | Guido Beldi Yara Banz Alexander Kroemer Xiaofeng Sun Yan Wu Nadine Graubardt Alyssa Rellstab Martina Nowak Keiichi Enjyoji Xian Li Wolfgang G. Junger Daniel Candinas Simon C. Robson | 2010 | Hepatology2010，，5： | 1 |
| 19 | Coagulopathy in cirrhosis – The role of the platelet in hemostasis显示文摘 | Elliot B. Tapper Simon C. Robson Raza Malik | 2013 | Journal of Hepatology2013，，4： | 1 |
| 20 | A Novel Model of Urinary Tract Differentiation, Tissue Regeneration, and Disease: Reprogramming Human Prostate and Bladder Cells into Induced Pluripotent Stem Cells显示文摘 | Mohammad Moad Deepali Pal Anastasia C. Hepburn Stuart C. Williamson Laura Wilson Majlinda Lako Lyle Armstrong Simon W. Hayward Omar E. Franco Justin M. Cates Sarah E. Fordham Stefan Przyborski Jane Carr-Wilkinson Craig N. Robson Rakesh Heer | 2013 | European Urology2013，，： | 1 |
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