|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 2 | Small intestine bleeding due to multifocal angiosarcoma显示文摘We report a case of an 84-year-old male patient with primary small intestinal angiosarcoma.The patient initially presented with anemia and melena.Consecutive endoscopy revealed no signs of upper or lower active gastrointestinal bleeding.The patient had been diagnosed 3 years previously with an aortic dilation,which was treated with a stent.Computed tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding,leading to operative stent explantation and aortic replacement.However,an aorto-intestinal fistula was not found,and the intestinal bleeding did not arrest postoperatively.The constant need for blood transfusions made an exploratory laparotomy imperative,which showed multiple bleeding sites,predominately in the jejunal wall.A distal loop jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was performed.The histological analysis revealed a lessdifferentiated tumor with characteristic CD31,cytokeratin,and vimentin expression,which led to the diagnosis of small intestinal angiosarcoma.Consequently,the infiltrated part of the jejunum was successfully resected in a subsequent operation,and adjuvant chemotherapy with paclitaxel was planned.Angiosarcoma of the small intestine is an extremely rare malignant neoplasm that presents with bleeding and high mortality.Early diagnosis and treatment are essential to improve outcome.A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity,nonspecific symptoms of altered intestinal function,nonspecific abdominal pain,severe melena,and acute abdominal signs.Therefore,a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim. | Luisa Zacarias Fhrding Arne Macher Stefan Braunstein Wolfram Trudo Knoefel Stefan Andreas Topp | 2012 | World Journal of Gastroenterology2012，18，44： | 4 |
| 3 | Complications and treatment of migrated biliary endoprostheses:A review of the literature显示文摘内视镜的胆汁的斯滕特氏印模膏插入是一个生长得很好的过程。它在对待手术后的胆汁的漏缝是特别成功的,并且可以阻止外科的干预。在 3 瞬间以后的 endoprostheses 的一个平淡的变化是一个普通惯例,但是这能被延长到 6 瞬间。我们向书籍的右页 sigmoid 冒号由于胆汁的斯滕特氏印模膏脱臼和移植汇报了一个结肠的穿孔,并且考察了文学。 | Thomas Namdar Andreas Martin Raffel Stefan Andreas Topp Lisa Namdar Ingo Alldinger Marcus Schmitt Wolfram Trudo Knoefel Claus Ferdinand Eisenberger | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 4 | Relationships between isokinetic core strength and fieldbased athletic performance tests in male collegiate baseballplayers显示文摘 | Clayton M A Trudo C E Laubach L L | 2011 | J E Ponline2011，15，5： | 1 |
| 5 | State-related changes in normal subjects显示文摘 | Trudo F J Gefter WB Welch KC | 1998 | Am J Respir Crit Care Med1998，158，4： | 1 |
| 6 | State-related changes in upper airway caliber and surrounding soft-tissue structures in normal subjects显示文摘 | Trudo Frank J Gefter Warren B Welch Kevin C | | 0，，： | 1 |
| 7 | Prognostic Significance of EpCAM-Positive Disseminated Tumor Cells in Rectal Cancer Patients With Stage I Disease显示文摘 | Sameer Dhayat Sorina Sorescu Daniel Vallb?hmer Sebastian Kraus Stephan Ernst Baldus Alexander Rehders Feride Kr?pil Andreas Krieg Wolfram Trudo Knoefel Nikolas Hendrik Stoecklein | 2012 | The American Journal of Surgical Pathology2012，，12： | 1 |
| 8 | Meat and colorectal cancer:associations and issues显示文摘 | TRUDO S P GALLAHER D D | 2015 | Current Nutrition Reports2015，4，： | 1 |
| 9 | Central cervical lymph nodemetastases in papillary thyroid cancer: a systematic review of imaging-guided and prophylactic removal of the central compartment显示文摘 | Mulla M G Trudo K W Jackie G | 2012 | ClinicalEndocrinology2012，76，1： | 1 |
| 10 | Quantitative evaluation of the upper airway during nasopharyngoscopy with the Muller maneuver 显示文摘 | RITFER C T TRUDO F J GOLDBERG A N | 1999 | Laryngoscope1999，109，6： | 1 |
| 11 | Pleural effusion due to herpes simplex type Ⅱ infection in an immuneocompromised host显示文摘 | Trudo FJ Gopez EV Gupta PK | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 12 | Multimodal Treatment of Hepatocellular Carcinoma显示文摘 | Dirk Graf Daniel Vallb?hmer Wolfram Trudo Knoefel Patric Kr?pil Gerald Antoch Abdurrahaman Sagir Dieter H?ussinger | 2014 | European Journal of Internal Medicine2014，，： | 1 |
| 13 | Quantitative evaluation of the upper airway during nasopharyngoscopy with the Muller maneuver显示文摘 | Ritter CT Trudo FJ Goldberg AN | | 0，，06： | 1 |
| 14 | State related changes in upper airway caliber and surrounding soft-tissue structures in normal subjects显示文摘 | Trudo FJ Gefter WB Welch KC | | 0，，04： | 1 |
| 15 | State-related changes in upper airway caliber and surrounding soft-tissue structures in normal subjects显示文摘 | Trudo FJ Gefter WB Welch KC | 1998 | Am J Respir Crit Care Med1998，158，4： | 1 |
| 16 | Vascular invasion in pancreatic cancer: Tumor biology or tumor topography?显示文摘 | Alexander Rehders Nikolas H. Stoecklein Ayse Güray Rouwen Riediger Andrea Alexander Wolfram Trudo Knoefel | 2012 | Surgery2012，，3： | 1 |
| 17 | State-related changes in upper airway caliber and surrounding soft-tissue structures in normal subjects显示文摘 | Trudo FJ Gefter WB Welch KC | 1998 | Am J Respir Crit Care Med1998，158，4： | 1 |
| 18 | State-related changes in upper airway caliber and surrounding soft-tissue structures in normal subjects显示文摘 | Trudo FJ Gefter WB Welch KC | 1998 | Am J Respir Crit Care Med1998，158，： | 1 |
| 19 | Infusion of CD133+ Bone Marrow–Derived Stem Cells After Selective Portal Vein Embolization Enhances Functional Hepatic Reserves After Extended Right Hepatectomy: A Retrospective Single-Center Study显示文摘 | Jan Schulte am Esch Moritz Schmelzle Günther Fürst Simon C. Robson Andreas Krieg Constanze Duhme Roy Y. Tustas Andrea Alexander Hans M. Klein Stefan A. Topp Johannes G. Bode Dieter H?ussinger Claus F. Eisenberger Wolfram Trudo Knoefel | 2012 | Annals of Surgery2012，，1： | 1 |
| 20 | State related changes in upper airway caliber and surrounding soft tissue structures in normal subjects显示文摘 | TRUDO F J GEFTER W B WELCH K C | 1998 | Am J Respir Crit Care Med1998，158，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员