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| 1 | Defining and predicting deep remission in patients with perianal fistulizing Crohn's disease on anti-tumor necrosis factor therapy显示文摘Perianal fistulas can occur to up to one-third of patients with Crohn's disease(CD) leading to significant disabling disease and morbidity. Fistulising perianal CD treatment often necessitates a combined pharmacological and surgical approach. Anti-tumor necrosis factor(anti-TNF) therapy, particularly infliximab, has been shown to be very effective for both perianal and internal fistulising CD. Nevertheless, current data suggest that sustained remission and long-term complete fistula healing can be achieved in only 30% to 50% of patients. Moreover, these percentages refer mostly to clinical rather than deep remission, defined as endoscopic and radiologic remission, which is quickly emerging as the preferred goal of therapy. Unfortunately, the therapeutic options for perianal fistulising CD are still limited. As such, it would be of great value to be able to predict, and more importantly, prevent treatment failure in these patients by early and continued optimization of antiTNF therapy. Similar to ulcerative colitis and luminal CD, recent data demonstrate that higher infliximab concentrations are associated with better clinical outcomes in patients with perianal fistulising CD. This suggests that therapeutic drug monitoring and a treatto-trough therapeutic approach may emerge as the new standard of care for optimizing anti-TNF therapy in patients with perianal fistulising CD. | konstantinos papamichael adam s cheifetz | 2017 | World Journal of Gastroenterology2017，23，34： | 2 |
| 2 | The Crohn’s disease activity index (CDAI) is similarly elevated in patients with Crohn’s disease and in patients with irritable bowel syndrome显示文摘 | C. Lahiff P. Safaie A. Awais M. Akbari L. Gashin S. Sheth A. Lembo D. Leffler A. C. Moss A. S. Cheifetz | 2013 | Aliment Pharmacol Ther2013，，8： | 2 |
| 3 | Varicella zoster virus infection in inflammatory bowel disease显示文摘 | Garret Cullen Rachel P. Baden Adam S. Cheifetz | 2012 | Inflamm Bowel Dis2012，，12： | 2 |
| 4 | Comparative cost‐effectiveness of strategies to prevent postoperative clinical recurrence of Crohn’s disease显示文摘 | Glen A. Doherty Rebecca A. Miksad Adam S. Cheifetz Alan C. Moss | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 5 | The incidence and management of infusion reactions to infliximab : a large center experience显示文摘 | Cheifetz A Smedley M Martin S | 2003 | Am J Gastroenterol2003，98，6： | 1 |
| 6 | Capsule endoscopy for small-bowel evaluation in Crohn’s disease显示文摘 | Glen A. Doherty Alan C. Moss Adam S. Cheifetz | 2011 | Gastrointestinal Endoscopy2011，，1： | 1 |
| 7 | Management of acute lung injury:sharing databetween adults and children显示文摘 | Cheifetz IM | 2011 | Respir Care2011，56，9： | 1 |
| 8 | Cardiac nurses coping with stress显示文摘 | Ehrenfeld M Cheifetz FR | 1990 | J Adv Nurs1990，15，9： | 1 |
| 9 | Serum lactates correlate with mortality after operations for complex congenital heart disease显示文摘 | Cheifetz IM Kern FH Schulman SR | 1997 | Ann Thorac Surg1997，64，3： | 1 |
| 10 | Structure and expression of the membrane proteoglycan betaglycan,acomponent of the TGF-βreceptor system显示文摘 | Fernando López-Casillas Sela Cheifetz Jacqueline Doody | 1991 | Cell1991，67，4： | 1 |
| 11 | Human cell surface glycoprotein related to cell proliferation is the receptor for transform显示文摘 | Cheifetz S Hemandez H Laiho M | 1990 | Journal of Biology Chemistry1990，265，20： | 1 |
| 12 | transforming growth factor-beta显示文摘 | Cheifetzs S Laihao M | 1992 | Cabeer Surveyes1992，12，： | 1 |
| 13 | Can cytology accurately predict benign follicular nodules显示文摘 | SMITH J CHEIFETZ R E SCHNEIDEREIT N | 2005 | Am J Surg2005，189，5： | 1 |
| 14 | Invasive and noninvasive pediatric mechanical ventilation显示文摘 | Cheifetz I M | 2003 | Respir Care2003，48，4： | 1 |
| 15 | The incidence and management of infusion reactions to infliximab:a large center experience 显示文摘 | Cheifetz A Smedley M Martin S | 2003 | Am J Gastroenterol2003，98，6： | 1 |
| 16 | Meta-analysis:targeting the intestinal microbiota in prophylaxis for post-operative Crohn's disease显示文摘 | Doherty GA Bennett GC Cheifetz AS | 2010 | Aliment Pharmacol Ther2010，31，8： | 1 |
| 17 | Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells显示文摘 | Bellon T Cales C | 1992 | Biol Chem1992，267，19： | 1 |
| 18 | Angular momentum of primary products formed in the spontaneous fission of 252Cf显示文摘 | WILHELMY J B CHEIFETZ E JARAD R C | 1972 | Physical Review1972，5，： | 1 |
| 19 | The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors显示文摘 | Cheifetz S Weatherbee J A Tsang M L | 1987 | Cell1987，48，3： | 1 |
| 20 | Transforming growth factor-beta receptors and binding proteoglycans显示文摘 | Boyd FT Cheifetz S Andres J | 1990 | J Cell Sci Suppl1990，13，： | 1 |
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