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| 1 | 胶东矿集区大规模成矿时间和构造环境显示文摘本文全面收集了胶东矿集区矿床和相关岩石的同位素年龄,讨论了该区金矿床大规模成矿的时间和构造背景.数据显示成矿作用发生于中生代,以110~130Ma为高峰;成矿事件同步或略滞后于中生代花岗岩浆活动.铷锶和锆石SHRIMP年龄表明中生代花岗岩类形成于多次热事件,大量继承锆石的存在和较高的ISr值(>0.709)指示花岗岩浆主要源于地壳物质的部分熔融或重熔.矿石和成矿流体的Isr值普遍高于0.709,并略高于中生代花岗岩类,指示成矿流体和物质主要来自地壳内部.讨论显示,中生代华北与华南古板块的碰撞造山作用是导致胶东矿集区形成的主导因素;花岗岩类侵入和大规模成矿作用耦合于碰撞造山带的3阶段地球动力学演化,即早阶段挤压-地壳缩短-隆升,中阶段岩石圈拆沉并转向伸展构造体制,晚阶段伸展;最强烈的成矿作用发生在碰撞造山过程的挤压向伸展转变期;已建立的碰撞造山成岩成矿和流体作用模式可以较好解释胶东矿集区的矿床、花岗岩类的特征. | 陈衍景 Franco PIRAJNO 赖勇 李超 | 2004 | 岩石学报2004，20，4： | 188 |
| 2 | 东北地区浅成低温热液矿床的地质特征和构造背景显示文摘 通过中国东北地区浅成低温热液矿床的综合特征研究,将矿床的分布划分为德尔布干、呼玛、小兴安岭和吉东4个矿集区,根据其矿床地质、地球化学特征初步确定成矿流体主要来自大气降水,部分混有岩浆水;成矿物质主要来自赋矿围岩和成矿岩浆-流体系统;多数矿床形成于中低温、中浅成环境,个别矿床成矿温度高、深度大,显示了斑岩型或造山型与浅成低温溶液型成矿系统之间的连续性;厘定大规模成岩成矿时间为130Ma左右,构造环境是古亚洲洋闭合后陆陆碰撞过程的挤压-伸展转变体制,并以矿集区尺度的CMF模式解释了浅成低温热液矿床岩浆-流体系统的发育机制。 | 祁进平 陈衍景 Franco Pirajno | 2005 | 矿物岩石2005，25，2： | 139 |
| 3 | CMF模式的排他性依据和造山型银矿实例:东秦岭铁炉坪银矿同位素地球化学显示文摘河南熊耳山区的铁炉坪银矿定位于高级变质基底中的NE向断裂带中,是熊耳山脉状造山型金、银、铅锌矿床的重要组成部分。成矿作用包括了早、中、晚3个阶段,分别形成石英-黄铁矿,多金属硫化物和碳酸盐脉3类矿物组合。早阶段成 矿温度大约为373℃左右,成矿流体δD=-90‰,δ^(13)C_(co_2)=2.0‰,δ^(18)O=9‰,来源较深;晚阶段流体温度<203℃,δD=70‰,δ^(13)C_(co_2)=-1.3‰,δ^(18)O=-2‰,属于浅源大气降水热液;中阶段流体均一温度210~249℃,δD=-109‰,δ^(13)C_(co_2)=0.1‰,δ^(18)O=2‰,是深源与浅源流体的混合。对比讨论表明,熊耳山区的早前寒武纪变质基底、熊耳群火山岩和燕山期花岗岩类的三者之一或它们的混合物,均无法提供具有早阶段流体D-O-c同位素组成(高δ^(18)O和δ^(13)C,低δD)的成矿流体,表明早阶段流体来自栾川群和管道口群的碳酸盐-页岩-硅质岩建造的变质脱水作用。矿石硫同位素组成较低,铅同位素比值较高,同样不可能来自熊耳山的主要地质体,更不可能来自其下伏的地幔和下地壳,指示成矿物质和流体应主要来自栾川群和管道口群。尽管栾川群和管道口群地层的同位素地球化学研究尚待补充,铁炉坪银矿的同位素地球化学特征似乎只能借助碰撞造山成岩成矿与流体作用模式才能合理解释。 | 陈衍景 隋颖慧 Franco PIRAJNO | 2003 | 岩石学报2003，19，3： | 129 |
| 4 | 西秦岭地区卡林—类卡林型金矿床及其成矿时间、构造背景和模式显示文摘秦岭造山带是世界第二大卡林—类卡林型金矿省,其地质背景与美国西部卡林—类卡林型金矿省明显不同,位于大陆内部的碰撞造山带,而非活动大陆边缘的盆岭省。秦岭卡林—类卡林型金矿主要赋存于板块缝合带及其前陆冲断带的海西—印支构造层中,以泥盆系和三叠系为主,主要岩性为潟湖—浅海相的含碳细碎屑岩—碳酸盐岩建造,即碳硅泥岩系;成矿元素为 Au—As—Sb—Hg—Ag,缺乏 Tl,共生矿种为 Sb,Hg,Ag,U和重晶石等;成矿温度为160~300℃,流体盐度为4%~10%(NaCl_(eq)),压力为5~50 MPa,深度约0.5~5 km,属于中低温中浅成热液矿床,与内华达卡林—类卡林型金矿一致。成矿流体具有建造水特点,C_2H_6 含量较高,显示了有机流体参与成矿。成矿同位素年龄介于 220~100 Ma之间,以170 Ma 为高峰,地球动力学背景属碰撞造山过程挤压—伸展转变期的减压增温体制,成矿构造模式为碰撞造山成岩成矿和流体作用模式。陆陆碰撞过程中,沿龙门山、阿坝—黑水—平青、若尔盖—文县、玛曲—勉县—略阳、白龙江、双河—公馆、凤县—镇安、安康等大型断裂带的陆内俯冲作用不仅导致了西秦岭地壳缩短增厚隆升,而且使俯冲板片变质脱水、熔融,派生成矿流体和相关熔体,流体和熔体的上升到仰冲板片次级构造带,形成了卡林—类卡林型和造山型? | 陈衍景 张静 张复新 Franco PIRAJNO 李超 | 2004 | 地质论评2004，50，2： | 240 |
| 5 | 天山—阿尔泰东部地区海西晚期后碰撞铜镍硫化物矿床:主要特点及可能与地幔柱的关系显示文摘天山-阿尔泰东部地区是中国重要的铜镍成矿区,近年来针对区内的铜镍矿床和相关岩体的研究不断取得进展,找矿也取得了一系列新突破,已经探明了十几个矿床和矿点。笔者基于以往研究成果,结合目前地质勘查和找矿评价的新进展,比较详细地全面总结了后碰撞铜镍硫化物矿床的基本特点、成矿规律和成矿过程,并建立了描述性成矿模型。这些矿床沿一组平行的走向近东西的深大断裂分布,与成矿有关的镁铁质超镁铁质杂岩体一般不大于5km^2,小的可为一个岩墙。矿化分两种类型:通道型和熔离型。成矿时代为298~270Ma,为中亚成矿带大规模成矿期的组成部分,形成于后碰撞伸展阶段。与这组铜镍硫化物矿床有关的镁铁质-超镁铁质杂岩体可能是早二叠世大面积喷溢岩浆的残留根部或通道部分,可能与地幔柱活动有关。另外,针对区内的地质特征,结合以往找矿的成功经验,对区内进一步的找矿工作提出了一些设想和建议。 | 毛景文 Franco PIRAJNO 张作衡 柴凤梅 杨建民 吴华 陈世平 程松林 张长青 | 2006 | 地质学报2006，80，7： | 79 |
| 6 | Evolution of the Mesozoic Granites in the Xiong'ershan-Waifangshan Region,Western Henan Province,China,and Its Tectonic Implications显示文摘摘要:基于同位素的年龄和 geochemical 分析的新数据,中生代花岗石的三种类型在西方的河南省为 Xiong'ershan-Waifangshan 区域被识别了省:在早阶段(160 妈) 的 high-Ba-Sr 我类型花岗石 emplaced,在中间的阶段(130 妈) 的我类型花岗石和在迟了的阶段(115 妈) 的 anorogenic A 类型花岗石。high-Ba-Sr 我类型花岗石的 Geochemical 特征建议它可能被与闪石和石榴石的主要残余的部分融化从变厚的更低的外壳产生了。异例和 Sr 内容变化反映的否定 Eu 的渐渐的增加这些花岗石从的来源区域的进步 shallowing 对迟了的舞台早。早阶段的 Wuzhangshan 花岗石的新 40Ar/39 Ar 高原年龄(156.0 摮牵摥愠 ? 敬獡 ? 睴? 瑳条獥 ? 桔 ? 慥汲 ? 瑳条 ? 桳畯摬戠 ? 敲慬整 ? 潴琠敨椠瑮畲楳湯漠 ? 桴 ? 慭湩戠摯 ? 景琠敨圠湡硧慩汮湩 ? 牧湡瑩 ? 眠楨档眠獡攠灭慬散 ? 畤楲杮琠敨 ? 摮獯湩慩? 数楲摯眠瑩 ?? 楤条湥瑥捩愠摮洠湩牥污穩摥愠敧漠 ? 有 ? 0 ?????? ?? | NAN Yigui ZHANG Shihong Franco PIRAJNO ZHANG Yuanhou | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 57 |
| 7 | Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma. | Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber | 2010 | World Journal of Gastroenterology2010，16，7： | 43 |
| 8 | 东秦岭上宫金矿流体成矿作用:矿床地质和包裹体研究显示文摘 上宫金矿产于东秦岭熊耳地体的熊耳群火山岩中,属于断控脉状造山型金矿床。上宫金矿赋矿构造由压剪向张剪演化,成矿过程经历了3个阶段:早阶段为黄铁矿-铁白云石-石英脉,脉体和矿物变形、破碎,形成于挤压或压剪环境;中阶段细粒多金属硫化物网脉贯入共轭节理或裂隙,没有遭受变形,形成于张剪环境;晚阶段具梳状构造的石英-碳酸盐细脉形成于伸展引张环境。流体包裹体组合从早阶段富CO2型,经中阶段富CO2型、贫CO2型和纯CO2型组合,向晚阶段贫CO2型演化。3个阶段的流体包裹体均一温度分别为380℃~320℃,300℃~220℃和200℃~120℃;早、中阶段的压力分别为285MPa~200MPa和160MPa~100MPa。中阶段流体离子(如SO42-,Cl-,K+)质量分数高,(K+Na)/(Mg+Ca)比值高,pH值高,Eh值低,属于碱性还原性质的过饱和流体,有利于多金属硫化物、碲化物和Au,Ag,Te等自然元素的快速沉淀。中阶段包裹体可见异相均一现象,具有较低的CO2/H2O比值,表明发生了以CO2逸失为特征的沸腾现象。东秦岭(含熊耳地体)三叠纪-早侏罗世地壳缩短、增厚、隆升,中侏罗世-早白垩世造山带挤压向伸展转折和隆升,白垩纪造山带伸展、断陷。这种区域构造演化的3阶段特征与上宫金矿含矿构造、矿石组构、成矿过程和包裹体组合的3阶段演化特征完全对应。 | 陈衍景 李晶 Franco Pirajno 林治家 王海华 | 2004 | 矿物岩石2004，24，3： | 50 |
| 9 | 东秦岭上宫金矿流体成矿作用:稳定同位素地球化学研究显示文摘 上宫金矿是典型的断控脉状造山型金矿床,成矿过程包括早、中、晚3个阶段。蚀变岩和矿石的δ18O明显高于未蚀变岩石,指示岩石在水岩作用过程中从流体中汲取18O。19件早阶段流体δ18OW变化于4.2‰~13.4‰(平均8.1‰),8件δDW介于-66‰~-88‰之间(平均-78‰),1件δ13C铁白云石=1.5‰,指示流体来源于含碳酸盐地层的变质脱水作用;晚阶段δ18OW为-2.0‰~-0.6‰,1件δDW=-56‰,3件δ13C铁白云石为-1.6‰~-2.2‰,指示流体以大气降水为主要成分;3件中阶段样品δ18OW为1.9‰~4.5‰,δ13为-1.2‰~0.5‰,均介于早、晚阶段之间,指示中阶段为变质热液与大气降水热液的CCO2混合流体作用。大量硫化物沉淀导致中阶段流体(δDW=-113‰~-94‰),显著低于早、晚阶段。28件中阶段硫化物δ34S为显著的负值(-19.2‰~-6.3‰),指示成矿流体系统中存在大量生物硫。理论分析表明,尽管熊耳地体的太华超群、熊耳群、燕山期花岗岩类和下伏地壳、地幔被前人解释为成矿流体的来源,但它们之一或其任意比例的混合物均不可能成为上宫金矿成矿流体的主导性物源,唯一可能是熊耳地体南侧的管道口群-栾川群CSC(含碳质碳酸盐-页岩-硅质岩)建造;在中生代华北与扬子板块的碰撞造山过程中,管道口群-栾川群沿马超营断裂A型俯冲到熊耳地体之? | 陈衍景 林治家 李晶 Franco Pirajno 王海华 | 2004 | 矿物岩石2004，24，3： | 45 |
| 10 | Hepatitis B:Epidemiology and prevention in developing countries显示文摘Hepatitis B virus(HBV)infection is a serious global public health problem.The infection may be transmitted through sexual intercourse,parenteral contact or from an infected mother to the baby at birth and,if contracted early in life,may lead to chronic liver disease,including cirrhosis and hepatocellular carcinoma.On the basis of the HBV carrier rate,the world can be divided in 3 regions of high,medium and low endemicity.The major concern is about high endemicity countries,where the most common route of infection remains vertical transmission from mother to child.Screening of all pregnant women and passive immunization with human hepatitis B immunoglobulin are not affordable for many developing countries.The infection rate can be reduced by modifying behavior,improving individual education,testing all blood donations,assuring asepsis in clinical practice and screening all pregnant women.However,availability of a safe and efficacious vaccine and adoption of appropriate immunization strategies are the most effective means to prevent HBV infection and its consequences.The unsolved problem for poorest countries,where the number of people currently infected is high,is the cost of the vaccine.A future challenge is to overcome the social and economic hurdles of maintaining and improving a prevention policy worldwide to reduce the global burden of the disease. | Elisabetta Franco Barbara Bagnato Maria Giulia Marino Cristina Meleleo Laura Serino Laura Zaratti | 2012 | World Journal of Hepatology2012，4，3： | 39 |
| 11 | A review of mineral systems and associated tectonic settings of northern Xinjiang,NW China显示文摘在这份报纸我们在场在北 Xinjiang 的矿物质系统的评论, NW 中国,集中于 Tianshan,韦斯特和东方 Junggar 和 Altay orogenic 系上带子,所有哪个是更大的中央亚洲 Orogenic 带(CAOB ) 的部分。CAOB 是古老的 microcontinents,岛弧,海洋的 plateaux 和海洋的盘子的复杂大杂烩,它在早 Palaeozoic 被混合并且增大到早二叠的时间。CAOB 大杂烩的建立被罢工滑倒运动跟随并且由 intraplate magmatism 影响了,连接了到披风羽毛活动,最好由 250 个妈西伯利亚的陷井和 280 妈 Tarim 事件例示。在北 Xinjiang,有众多、经济地重要的矿物质系统。在这贡献,我们描述代表性的矿藏的一种选择,包括 subduction 相关的斑岩和 epithermal 沉积物, volcanogenic 巨大的硫醚和 skarn 系统。砍招待地区的 Au 矿脉可能是首先形成了在罢工滑倒期间侵入相关、随后重做变丑。Intraplate magmatism 导致了炮兵阵地同中心地 zoned (阿拉斯加人风格) maficultramafic 侵入,许多哪个主人 orthomagmatic 硫醚沉积物。在 Altay orogen 的伟晶岩的一条巨大的带,局部地招待世界级的稀罕金属沉积物。转动前面,招待沙岩的 U mineralisation 完成北 Xinjiang 岩层的富有的矿物质天赋。 | Franco Pirajno Reimar Seltmann Yongqiang Yang | 2011 | Geoscience Frontiers2011，2，2： | 39 |
| 12 | Third-line rescue therapy for Helicobacter pylori infection显示文摘H pylori 胃的感染是世界范围的最流行的传染病之一。很上面的胃肠的疾病与 H pylori 感染有关能因此与抗菌素被对待的发现是重要医药进展。当前,首要的三倍的治疗被所有一致会议和指南基于质子泵禁止者(PPI ) 或加二抗菌素(clarithromycin 和 amoxicillin 或 nitroimidazole ) 的 ranitidine 枸橼酸铋(RBC ) 推荐。甚至与这药联合的正确使用,感染不能在多达 23% 病人被根除。因此,几第二线治疗被推荐了。7 d 四倍的治疗基于 PPI,铋,四圜素和灭滴灵,更多经常被接受。与第二线的治疗,然而,细菌的根除可以在多达 40% 盒子失败。当 H pylori 根除严格地被显示时,进一步的治疗的选择是争论的。当前,标准第三线的治疗正在缺乏,各种各样的协议被建议了。甚至在二连续失败以后,最近的文学数据证明了 H pylori 根除能在几乎所有病人被完成,甚至当抗菌素危险性没被测试时。实验治疗的不同可能性存在,可得到的第三线的策略此处被考察。 | Rossella Cianci Massimo Montalto Franco Pandolfi Giovan Battista Gasbarrini Giovanni Cammarota | 2006 | World Journal of Gastroenterology2006，12，15： | 31 |
| 13 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 14 | Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma显示文摘AIM:Only a minority of patients carrying a defined viral aetiologic agent develop cirrhosis and ultimately hepatocellular carcinoma (HCC), the mechanism underlying the worsening is still undefined. Experimental infection by Helicobacter hepaticusin mice causes chronic hepatitis and HCC and recently, more Helicobacter species (Helicobacter spp.) have been detected in the liver of patients suffering from cholestatic diseases and HCC arising from non-cirrhotic liver. We investigated whether Helicobacter spp. sequences could be detected in the liver of patients with cirrhosis and HCC compared to subjects with metastasis to liver from colon cancer.METHODS:Twenty-three liver samples from patients operated upon for HCC superimposed on hepatitis C virus (HCV)-related cirrhosis and 6 from patients with resected metastases from colorectal cancer, were tested by polymerase chain reaction for presence of genomic 16S rRNA of Helicobacter genus using specific primers. DNA sequencing and cagA gene analysis were also performed.RESULTS:Genomic sequences of Helicobacter spp. were found in 17 of 20 (85%) liver samples from patients with HCC and in 2 of 6 samples from patients with liver metastasis.In three samples of the first group the result was uncertain.Hpyloriwas revealed in 16 out of 17 positive samples and Helicobacter pullorum in the other.CONCLUSION: Helicobacter spp., carcinogenic in mice,were found at a higher frequency in the liver of patients with HCV-related cirrhosis and HCC than those in patients without primary liver disease. | RinaldoPellicano MarioRizzetto AntonioPonzetto Vincenzo Mazzaferro Walter Franco Grigioni MiguelAngelCutufia SharmilaFagoonee LorenzoSilengo | 2004 | World Journal of Gastroenterology2004，10，4： | 28 |
| 15 | Extraintestinal manifestations in inflammatory bowel disease显示文摘Inflammatory bowel diseases (IBD) can be really considered to be systemic diseases since they are often associated with extraintestinal manifestations,complications, and other autoimmune disorders. Indeed,physicians who care for patients with ulcerative colitis and Crohn's disease, the two major forms of IBD, face a new clinical challenge every day, worsened by the very frequent rate of extraintestinal complications. The goal of this review is to provide an overview and an update on the extraintestinal complications occurring in IBD.Indeed, this paper highlights how virtually almost every organ system can be involved, principally eyes, skin,joints, kidneys, liver and biliary tracts, and vasculature (or vascular system) are the most common sites of systemic IBD and their involvement is dependent on different mechanisms. | Silvio Danese Stefano Semeraro Alfredo Papa Italia Roberto Franco Scaldaferri Giuseppe Fedeli Giovanni Gasbarrini Antonio Gasbarrini | 2005 | World Journal of Gastroenterology2005，11，46： | 24 |
| 16 | Giant appendiceal mucocele: Report of a case and brief review显示文摘Mucocele of the appendix is a rare lesion, characterized by distension of the lumen due to accumulation of mucoid substance. This disease is often asymptomatic and pre-operative diagnosis is rare. If untreated, one type of mucocele may rupture producing a potentially fatal entity known as pseudomyxoma peritonei. The type of surgical treatment is related to the dimensions and to histology of the mucocele. Appendectomy is used for simple mucocele or for cystadenoma. Right hemi-colectomy is recommended for cystadenocarcinoma. In this paper, we report a case of a 51-year-old woman with a mobile, painless mass in the right lower quadrant of abdomen caused by a giant appendiceal mucocele. Imaging showed a large, tubular,cystic structure extending below from the inferior wall of the cecum. Surgery revealed a giant retro-cecal appendix measuring 17 cm in length and 4 cm in diameter. The final pathologic diagnosis was mucocele caused by mucinous cystadenoma. | Bernardino Rampone Franco Roviello Daniele Marrelli Enrico Pinto | 2005 | World Journal of Gastroenterology2005，11，30： | 23 |
| 17 | Low-volume plus ascorbic acid vs high-volume plus simethicone bowel preparation before colonoscopy显示文摘AIM:To investigate the effectiveness of low-volumeplus ascorbic acid [polyethylene glycol plus ascorbicacid(PEG + Asc) ] and high-volume plus simethicone[polyethylene glycol plus simethicone(PEG + Sim) ]bowel preparations.METHODS:A total of one hundred and forty-fourout patients(76 males) ,aged from 20 to 84 years(me-dian age 59.5 years) ,who attended our Department,were divided into two groups,age and sex matched,and underwent colonoscopy. Two questionnaires,onefor patients reporting acceptability and the other forendoscopists evaluating bowel cleansing effectivenes saccording to validated scales,were completed. Indications,timing of examination and endoscopical findings were recorded. Biopsy forceps were used as a measuring tool in order to determine polyp endoscopic sizeestimation. Difficulty in completing the preparation wasrated in a 5-point Likert scale(1 = easy to 5 = un-able) . Adverse experiences(fullness,cramps,nausea,vomiting,ab dominal pain,headache and insomnia) ,number of evacuations and types of activities performed during preparation(walking or resting in bed) were also investigated.RESULTS:Seventy-two patients were selected for eachgroup. The two groups were age and sex matched aswell as being comparable in terms of medical historyand drug therapies taken. Fourteen patients droppedout from the trial because they did not complete the preparation procedure. Ratings of global bowel cleansing examinations were considered to be adequate in91% of PEG + Asc and 88% of PEG + Sim patients.Residual Stool Score indicated similar levels of amountand consistency of residual stool;there was a significant difference in the percentage of bowel wall visuali-zation in favour of PEG + Sim patients. In the PEG +Sim group,12 adenomas ≤ 10 mm diameter(5/left co-lon + 7/right colon) vs 9(8/left colon + 1/right colon) in the PEG + Asc group were diagnosed. Visualization of small lesions seems to be one of the primary advantages of the PEG + Sim preparation.CONCLUSION:PEG + Asc is a good alternative solution as a bowel preparation but more improvements arenecessary in order to achieve the target of a perfect preparation. | Stefano Pontone Rita Angelini Monica Standoli Gregorio Patrizi Franco Culasso Paolo Pontone Adriano Redler | 2011 | World Journal of Gastroenterology2011，17，42： | 22 |
| 18 | Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients显示文摘Hepatocellular carcinoma(HCC) is one of the most frequent neoplasms worldwide and in most cases it is associated with liver cirrhosis.Liver resection is considered the most potentially curative therapy for HCC patients when liver transplantation is not an option or is not immediately accessible.This review is aimed at investigating the current concepts that drive the surgical choice in the treatment of HCC in cirrhotic patients;Eastern and Western perspectives are highlighted.An extensive literature review of the last two decades was performed,on topics covering various aspects of hepatic resection.Early post-operative and long-term outcome measures adopted were firstly analyzed in an attempt to define an optimal standardization useful for research comparison.The need to avoid the development of post-hepatectomy liver failure represents the 'conditio sine qua non' of surgical choice and the role of the current tools available for the assessment of liver function reserve were investigated.Results of hepatic resection in relationship with tumor burden were compared with those of available competing strategies,namely,radiofrequency ablation for early stages,and trans-arterial chemoembolization for intermediate and advanced stages.Finally,the choice for anatomical versus non-anatomical,as well as the role of laparoscopic approach,was overviewed.The literature review suggests that partial hepatectomy for HCC should be considered in the context of multi-disciplinary evaluation of cirrhotic patients.Scientific research on HCC has moved,in recent years,from surgical therapy toward non-surgical approaches and most of the literature regarding topics debated in the present review is represented by observational studies,whereas very few well-designed randomized controlled trials are currently available;thus,no robust recommendations can be derived. | Alessandro Cucchetti Matteo Cescon Franco Trevisani Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，44： | 22 |
| 19 | Effect of the Inclusion of Chestnut in the Finishing Diet on Volatile Compounds of Dry-Cured Ham from Celta Pig Breed显示文摘The effect of the inclusion of chestnut in pigs finishing diet on volatile compounds of dry-cured Celta ham was studied.Twelve hams of each type(from three different pigs finishing diets:concentrate(CO),mixed(MI)and chestnut(CH)) were used.Volatiles were extracted using a purge-and-trap method and analyzed by gas chromatography/mass spectrometry(GC/MS).Thirty-nine volatile compounds were identified in dry-cured Celta ham samples.Most abundant volatiles in ham samples were aldehydes,which represented respectively,53%(CO),51%(MI)and 46%(CH)of the total volatile composition.With the exception of 2-butenal,2-methyl,all aldehydes were affected by feeding system.On the other hand,hydrocarbons n-alkanes were the second major group in the volatile profile of dry-cured Celta hams and represented 28.9,35.7 and 32.4%of the total volatile composition for CO,MI and CH groups,respectively.Ham samples from chestnut group showed a higher content of alcohols and this result could be related with the inclusion of chestnut in the finishing diet of pigs.Principal component analysis showed a good separation among groups.The discriminant analysis selected eight variables(butanoic acid,hexanal,octanal,nonenal(E),decenal(E),tetradecane,decane trimethyl and pyridine 2-methyl) and calculated two discriminating functions to predict if chestnut has been included in the finishing diet.Thus,it was possible to discriminate between groups fed with finishing diets containing chestnuts in their composition(mixed and chestnut group). | José M Lorenzo Javier Carballo Daniel Franco | 2013 | Journal of Integrative Agriculture2013，12，11： | 22 |
| 20 | Robot-assisted laparoscopic vs open gastrectomy for gastric cancer:Systematic review and meta-analysis显示文摘AIM To evaluate the potential effectiveness of robot-assisted gastrectomy(RAG) in comparison to open gastrectomy(OG) for gastric cancer patients.METHODS A comprehensive systematic literature search using PubM ed,EMBASE,and the Cochrane Library was carried out to identify studies comparing RAG and OG in gastric cancer.Participants of any age and sex were considered for inclusion in comparative studies of the two techniques independently from type of gastrectomy.A meta-analysis of short-term perioperative outcomes was performed to evaluate whether RAG is equivalent to OG.The primary outcome measures were set for estimated blood loss,operative time,conversion rate,morbidity,and hospital stay.Secondary among postoperative complications,wound infection,bleeding and anastomotic leakage were also analysed.RESULTS A total of 6 articles,5 retrospective and 1 randomized controlled study,involving 6123 patients overall,with 689(11.3%) cases submitted to RAG and 5434(88.7%) to OG,satisfied the eligibility criteria and were included in the meta-analysis.RAG was associated with longer operation time than OG(weighted mean difference 72.20 min;P < 0.001),but with reduction in blood loss and shorter hospital stay(weighted mean difference-166.83 mL and-1.97 d respectively;P < 0.001).No differences were found with respect to overall postoperative complications(P = 0.65),wound infection(P = 0.35),bleeding(P = 0.65),and anastomotic leakage(P = 0.06).The postoperative mortality rates were similar between the two groups.With respect to oncological outcomes,no statistical differences among the number of harvested lymph nodes were found(weighted mean difference-1.12;P = 0.10).CONCLUSION RAG seems to be a technically valid alternative to OG for performing radical gastrectomy in gastric cancer resulting in safe complications. | Stefano Caruso Alberto Patriti Franco Roviello Lorenzo De Franco Franco Franceschini Graziano Ceccarelli Andrea Coratti | 2017 | World Journal of Clinical Oncology2017，8，3： | 23 |
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