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185篇 您的检索式:作者名="Moad"
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1Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers.Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer 2015World Journal of Stem Cells2015,7,2:5
2Radical addition–fragmentation chemistry in polymer synthesis显示文摘Graeme Moad Ezio Rizzardo San H. Thang 2007Polymer2007,,5:3
3Radical addition–fragmentation chemistry in polymer synthesis显示文摘Graeme Moad Ezio Rizzardo San H. Thang 2007Polymer2007,,5:2
4Living Free Radical Polymerization with Reversible Addition-Fragmentation Chain Transfer (the life of RAFT) 显示文摘Moad G Chiefari J Chong Y K 2000Polymer International2000,49,9:1
5Living radical polymerization by the RAFT process显示文摘Moad G Rizzardo E Thang S H 2005Aust J Chem2005,58,:1
6Selectivity of the reaction of free radicals with styrene显示文摘Moad G Rizzardo E Solomon D H 1982Mneromol Sci-Chem1982,17,:1
7查看详情显示文摘Chiefari J Chong Y.K Ercole F Krstina J. Jeffery J. Le T.P.T. Mayadunne R.T.A. Meijs G.F. Moad C.L. Moad G 0,,:1
8Non-ionic, poly (ethylene oxide)-based surfactants asintereala- nts/dispersants/exfoliants for poly (propyl- ene) -clay nanocomposites 显示文摘Moad G DeanK Edmond L 2006Macromol Ma- ter Eng2006,291,1:1
9A more versatile route to block copolymers and other polymers of complex architecture by living radical polymerization : the RAFT process 显示文摘Chong Y K le P T Moad G 1999Macromolecules1999,32,6:1
10Synthesis of novel architectures by radical polymerization with reversible addition fragmentation chain transfer(RAFT polymerization)显示文摘MOAD G MAYADUNNE R T A RIZZARDO E 2003Macromol Symp2003,192,:1
11Relief for slow storage systems显示文摘MOAD J 1990Datamatton1990,36,17:1
12Living Free Radical Polymerization With Reversible Addition-Fragmentation Chain Transfer (the Life of RAFT)显示文摘Moad G Chiefari J Chong Y K 2000Polym Int2000,49,9:1
13Imidazolidinone nitroxide-mediated polymerization显示文摘 Ercole F Moad G 1999Macromolecules1999,32,:1
14Living radical polymeri- zation by the RANI' process显示文摘Moad G Rizzardo E Thang S H 2005Aust J Chem2005,58,6:1
15The synthesis of polyolefin graft copolymers by reactive e xtrusion显示文摘 1999Progress Polymer Science1999,24,:1
16Controlled growth free radical polymerization of methacrylate esters- reversible chain transfer显示文摘Moad G Ercole F Johnson C H 1997Acs Symp Ser1997,685,:1
17Living radical polymeri- zation by the RAFT process显示文摘Moad G Rizzardo E Thang S H 2005Au:tra J Chem2005,58,6:1
18The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals 显示文摘Tan HK Moad AI Tan ML 2014Asian Pac J Cancer Prev2014,15,:1
19Living free-radical polymeriza- tion by reversible addition-fragmentation chain transfer: the RAFT process 显示文摘Chiefari J Chong YK Ereole F Krstina J Jeffery J Le TPT Mayadunne RTA Meijs GF Moad CL Moad G Rizzardo E Thang SH 1998Macromolecules1998,31,:1
20Thiocarbon- ylthio end group removal from RAFT-synthesized poly- mers by radical-induced reduction 显示文摘CHONG Y K MOAD G RIZZARDO E 2007Macromolecules2007,40,13:1
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