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| 1 | Antibiotic Resistance Genes in the Human-Impacted Environment:A One Health Perspective显示文摘Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains. | James M. TIEDJE WANG Fang Celia M. MANAIA Marko VIRTA SHENG Hongjie MA Liping ZHANG Tong Edward TOPP | 2019 | Pedosphere2019，29，3： | 11 |
| 2 | Intrahepatic endometriosis as differential diagnosis: Case report and literature review显示文摘Intrahepatic endometriosis is one of the rarest forms of atypical endometriosis; only eighteen cases have been reported in the English literature. We describe the case of a 32-year-old woman, who presented with persistent, non-cyclical upper right quadrant abdominal pain, a central liver cyst, and no history of endometriosis. Three years previous, she was diagnosed with an intrahepatic cyst. The lesion progressed and two laparoscopic deroofing-operations were performed, yet the diagnosis of intrahepatic endometriosis was never reached. She presented in our clinic with further progress of the cyst as well as obstruction of the intrahepatic biliary system. The magnetic resonance imaging showed a 9.5 cm × 12 cm, lobulated intrahepatic cyst. We performed an ultrasonic pericystectomy. Immunostaining confirmed intrahepatic endometriosis. Only one of the previously described eighteen patients with intrahepatic endometriosis presented with cyclical pain in the upper right abdominal quadrant accompanying menstruation. This lack of a 'typical' clinic makes it challenging to diagnose extragonadal endometriosis without histopathology. A previous history of endometriosis was described in only twelve cases, thus the diagnosis of this condition should not be limited to patients with a known history of endometriosis. Six of 18 patients were postmenopausal, demonstrating this condition is not limited to women of reproductive age. A preoperative diagnosis was only reached in seven of the previously described cases, highlighting the importance of preoperative biopsies. Yet due to the potential adverse effects, a transhepatic biopsy must be discussed individually. Although rare, intrahepatic endometriosis should always be considered as a differential diagnosis in women with recurrent hepatic cysts, regardless of age or previous medical history. In such cases, histology is essential and a pericystectomy should be performed as standard of care. | Georg Fluegen Frank Jankowiak Luisa Zacarias Foehrding Feride Kroepil Wolfram T Knoefel Stefan A Topp | 2013 | World Journal of Gastroenterology2013，19，29： | 9 |
| 3 | Small intestine bleeding due to multifocal angiosarcoma显示文摘We report a case of an 84-year-old male patient with primary small intestinal angiosarcoma.The patient initially presented with anemia and melena.Consecutive endoscopy revealed no signs of upper or lower active gastrointestinal bleeding.The patient had been diagnosed 3 years previously with an aortic dilation,which was treated with a stent.Computed tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding,leading to operative stent explantation and aortic replacement.However,an aorto-intestinal fistula was not found,and the intestinal bleeding did not arrest postoperatively.The constant need for blood transfusions made an exploratory laparotomy imperative,which showed multiple bleeding sites,predominately in the jejunal wall.A distal loop jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was performed.The histological analysis revealed a lessdifferentiated tumor with characteristic CD31,cytokeratin,and vimentin expression,which led to the diagnosis of small intestinal angiosarcoma.Consequently,the infiltrated part of the jejunum was successfully resected in a subsequent operation,and adjuvant chemotherapy with paclitaxel was planned.Angiosarcoma of the small intestine is an extremely rare malignant neoplasm that presents with bleeding and high mortality.Early diagnosis and treatment are essential to improve outcome.A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity,nonspecific symptoms of altered intestinal function,nonspecific abdominal pain,severe melena,and acute abdominal signs.Therefore,a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim. | Luisa Zacarias Fhrding Arne Macher Stefan Braunstein Wolfram Trudo Knoefel Stefan Andreas Topp | 2012 | World Journal of Gastroenterology2012，18，44： | 4 |
| 4 | 豆科灌木和乔木作家畜饲料的潜力、组成和利用显示文摘本文论述了大量豆科灌木和乔木种是有效的家畜饲料。通过非常有名的种,对其作为动物细饲料的潜力、组成和利用作出了评价。在不同的气候带,特别是年降雨量≤400mm地区,豆科灌木和乔木的幼嫩枝叶(枝叶饲料),通常是饲料的主要来源。某些豆科灌木和乔木饲料可以给多数动物提供大量有用的非降解蛋白质及钙等少量无机矿物质。豆科灌木及乔木含有抗营养因子,喂养家畜时,最实际的方法是添加适当的混合物减轻豆科植物此种作用的影响。为了安全偶尔饲喂两种或多种豆科植物。这种饲料饲喂似乎可提高动物饲料的摄食和消化率,将促进动物生产力的提高。 | 赵勇斌 J. H. Topps | 1993 | 国外畜牧学(草原与牧草)1993，，1： | 3 |
| 5 | Complications and treatment of migrated biliary endoprostheses:A review of the literature显示文摘内视镜的胆汁的斯滕特氏印模膏插入是一个生长得很好的过程。它在对待手术后的胆汁的漏缝是特别成功的,并且可以阻止外科的干预。在 3 瞬间以后的 endoprostheses 的一个平淡的变化是一个普通惯例,但是这能被延长到 6 瞬间。我们向书籍的右页 sigmoid 冒号由于胆汁的斯滕特氏印模膏脱臼和移植汇报了一个结肠的穿孔,并且考察了文学。 | Thomas Namdar Andreas Martin Raffel Stefan Andreas Topp Lisa Namdar Ingo Alldinger Marcus Schmitt Wolfram Trudo Knoefel Claus Ferdinand Eisenberger | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 6 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 7 | In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two‐stage liver resection显示文摘 | W. T. Knoefel I. Gabor A. Rehders A. Alexander M. Krausch J. Schulte am Esch G. Fürst S. A. Topp | 2012 | Br J Surg2012，，3： | 2 |
| 8 | Electromagnetic determination of soil water content: measurement in coaxial transmission lines显示文摘 | Topp G C Davis J L Annan A P | 1980 | Water Resources Research1980，16，3： | 1 |
| 9 | Soil-water hysteresis: The domain theory extended to pore interaction conditions显示文摘 | TOPP G C | 1972 | Soil Science Society of America Journal1972，35，： | 1 |
| 10 | Prehabilitation before total knee arthroplasty increases strength and function in older adults with severe osteoarthritis显示文摘 | Swank AM Kachelman JB Bibeau W Quesada PM Nyland J Malkani A Topp RV | 2011 | journal of strength and conditioning research2011，25，2： | 1 |
| 11 | State of the art of measuring soil water content显示文摘 | Topp G C | 2003 | Hydrological Processes2003，17，： | 1 |
| 12 | Targeted therapy with theT-cell-engaging antibody blinaturaomab of chemotherapy-refractoryminimal residual disease in B-lineage acute lymphoblastic leukemiapatients results in high response rate and prolonged leukemia-freesurvival 显示文摘 | Topp MS Kufer P Gokbuget N | 2011 | J Clin Oncol2011，29，： | 1 |
| 13 | Phase II trial of the anti - CD19 bispecific T cell - engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B - precursor acute lymphoblas- tic leukemia 显示文摘 | Topp M Gokbuget N Zugmaier G | 2014 | J Clin Oncol2014，32，36： | 1 |
| 14 | Detellnination of Electricl Conductivity Using Time Domain Reflectometry Soil and Water Experimentsineoaxiallines 显示文摘 | TOPP G G YANUKA M ZEBCHUK W D ZEGELIN S | 1988 | WaterResour Res1988，24，： | 1 |
| 15 | Spatial variability of soil microbial biomass measured by the fumigation extraction method, and KEC as affected by depth and manure application显示文摘 | TESSIER L GREGORICH E G TOPP E | 1998 | Soil Biology and Biochemistry1998，30，： | 1 |
| 16 | Electromagnetic determination of soil water content:measurements in coaxial transmission lines显示文摘 | TOPP G C DAVIS J L ANNAN A P | 1980 | Water Resources Research1980，16，3： | 1 |
| 17 | Prehabilitation before knee arthroplasty increases postsurgical function:a case study显示文摘 | Jaggers JR Simpson CD Frost KL Quesada PM Topp RV Swank AM Nyland JA | 2007 | journal of strength and conditioning research2007，21，2： | 1 |
| 18 | Next-generation wireless communications concepts and technologies 显示文摘 | Berezdivin R Breinig R Topp R | 2002 | Communications Magazine IEEE2002，40，3： | 1 |
| 19 | Combination cone penetration resistance/water content instrumentation to evaluate cone penetration-water content relationships in tillage research显示文摘 | Lapen D R Topp G C Edwards M E | 2004 | Soil and Tillage Research2004，79，1： | 1 |
| 20 | Rapid mineralization of the endocrine-disrupting chemical 4-nonylphenol in soil显示文摘 | Topp E Starratt A | | 0，，02： | 1 |
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