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| 1 | Trabeculectomy with Ex-PRESS implant versus Ahmed glaucoma valve implantation-a comparative study显示文摘AIM:To compare the surgical outcomes of trabeculectomy with Ex-PRESS implant and Ahmed glaucoma valve(AGV) implantation. METHODS: Patients who underwent trabeculectomy with Ex-PRESS implants or AGV implantation separately were included in this retrospective chart review.Main outcome measures were surgical failure and complications.Failure was defined as intraocular pressure(IOP) >21 mm Hg or <5 mm Hg on two consecutive visits after 3mo,reoperation for glaucoma,or loss of light perception.Eyes that had not failed were considered as complete success if they did not required supplemental medical therapy.RESULTS: A total of 64 eyes from 57 patients were included: 31 eyes in the Ex-PRESS group and 33 eyes in the AGV group.The mean follow-up time was 2.6 ±1.1y and 3.3±1.6y,respectively.Patients in the AGV group had significantly higher baseline mean IOP(P =0.005),lower baseline mean visual acuity(VA)(P =0.02),and higher proportion of patients with history of previous trabeculectomy(P <0.0001).Crude failure rates were 16.1%,n =5/31 in the Ex-PRESS group and 24.2%,n =8/33 in the AGV group.The cumulative proportion of failure was similar between the groups,P =0.696.The proportion of eyes that experienced postoperative complications was32.3% in the Ex-PRESS group and 60.1% in the AGV group(P =0.0229).CONCLUSION: Trabeculectomy with Ex-PRESS implant and AGV implantation had comparable failure rates.The AGV group had more post-operative complications,but also included more complex cases with higher baselinemean IOP,worse baseline mean VA,and more previous glaucoma surgeries.Therefore,the results are limited to the cohort included in this study. | Michael Waisbourd Naomi Fischer Hadas Shalev Oriel Spierer Elad Ben Artsi Rony Rachmiel Gabi Shemesh Shimon Kurtz | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 6 |
| 2 | Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis显示文摘BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality worldwide.The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics tools.Thrombocytopenia represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor.However,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of cirrhosis.AIM To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver diseases.METHODS A nested case-control study utilizing a large computerized database.Cirrhosis cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:3.All participants had multiple laboratory measurements prior to enrollment.We calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy controls.The association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was investigated.RESULTS The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of HTN.The leading cirrhosis etiologies were viral,alcoholic and fatty liver disease.The mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μL.This trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patients who developed varices and ascites.Compared to controls whose values remained in the normal range,in the cirrhosis group aspartate aminotransferase and alanine aminotransferase,increased from 40 U/L to 75 U/L and FIB-4 increased gradually from 1.3 to 3 prior to cirrhosis diagnosis.In multivariable regression analysis,a decrease of 50 units in PTC was associated with 1.3 times odds of cirrhosis(95%CI 1.25-1.35).CONCLUSION In the preceding years before the diagnosis of cirrhosis,there is a progressive decline in PTC,within the normal range,matched to a gradual increase in fibrosis scores. | Neta Gotlieb Naama Schwartz Shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet | 2020 | World Journal of Gastroenterology2020，26，38： | 3 |
| 3 | Making sense of regulatory T cell suppressive function显示文摘 | Itay Shalev Moritz Schmelzle Simon C. Robson Gary Levy | 2011 | Seminars in Immunology2011，，4： | 2 |
| 4 | Thioredoxin-interacting pro tein is stimulated by glucose through a carbohydrate response element and induces β-cell apoptosis显示文摘 | Minn AH Hafele C Shalev A | 2005 | Endocrinology2005，146，5： | 1 |
| 5 | Making sense of regulatory T cell suppressive function显示文摘 | Shalev I Schmelzle M Robson S C | | 0，，04： | 1 |
| 6 | Heat and moisture transfer trough nonwoven fabrics 显示文摘 | WOO S S SHALEV Itzhak BARKER R L | 1994 | Journal of Textile Research1994，64，3： | 1 |
| 7 | Routine thyroid function tests in infertile women: are they necessary? 显示文摘 | Shalev E Eliyahu S Ziv M | 1994 | Am J Obstet Gynecol1994，171，5： | 1 |
| 8 | Developmental Dyscalculia is a Familial Learning Disability显示文摘 | SHALEV R S MANOR O KEREM B | 2001 | Journal of Learning Disabilities2001，34，1： | 1 |
| 9 | Mortality from neuroleptic malignant syndrome显示文摘 | Shalev A Hermesh H Munitz H | 1989 | J Clin Psychiatry1989，50，1： | 1 |
| 10 | Neurobiology of relapse to heroin and cocaine seeking:a review显示文摘 | Shalev U Grimm JW Shaham Y | | 0，，01： | 1 |
| 11 | Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State显示文摘 | Wenjun Guo Zuzana Keckesova Joana Liu Donaher Tsukasa Shibue Verena Tischler Ferenc Reinhardt Shalev Itzkovitz Aurelia Noske Ursina Zürrer-H?rdi George Bell Wai Leong Tam Sendurai A. Mani Alexander van Oudenaarden Robert A. Weinberg | 2012 | Cell2012，，5： | 1 |
| 12 | Hystvroscopy may be justified after two miscarriages显示文摘 | Weiss A Shalev E Romano S | 2005 | Hum Reprod2005，20，9： | 1 |
| 13 | On the equivalence of weak learn ability and linear reparability: New relaxations and efficient boosting algorithms 显示文摘 | Shalev Shwartz S Singer Y | 2010 | Machine learning2010，80，23： | 1 |
| 14 | Transvaginal sonography as the ult imate diagnosic tool for the management of ectopic pregnancy:experience with 840 cases显示文摘 | Yarom M Peleg D | 1998 | Fertil Steril1998，69，1： | 1 |
| 15 | Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder 显示文摘 | Gilboa A Shalev AY Laor L | 2004 | Biol Psychiatry2004，55，： | 1 |
| 16 | Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutations of the tumor suppressor PTEN/MMAC显示文摘 | Haas Kogan D Shalev N Wong M | 1998 | Curr Biol1998，8，21： | 1 |
| 17 | Multifetal pregnancy reduction in cases of threatened abortion of triplets显示文摘 | Shalev J Meizner I Mashiach R | 1999 | Fertil Steril1999，72，： | 1 |
| 18 | Spontaneous resolution of ectopic tubal pregnancy natural history显示文摘 | Shalev E Romano S Peleg D | 1995 | Fertil Steil1995，63，： | 1 |
| 19 | Hypocholesterolemia in chronic anemias with increased erythropoietic activity显示文摘 | Shalev H Kapelushnik J Moser A | 2007 | Am J Hematol2007，82，3： | 1 |
| 20 | The balance between MMP-9 and MMP-2 and their tissue inhibitor (TIMP)-1 in luteinized granulose cells:comparison between women with PCOS and normal ovulatory women显示文摘 | Shalev E Goldman S Ben-Shlomo I | 2001 | Mol Hum Reprod2001，7，4： | 1 |
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