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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘 | Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang | 2013 | Cell Research2013，23，2： | 36 |
| 3 | A retrospective of knowledge graphs显示文摘 | Jihong YAN Chengyu WANG Wenliang CHENG Ming GAO Aoying ZHOU | 2018 | Frontiers of Computer Science2018，12，1： | 25 |
| 4 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 5 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 6 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 7 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 8 | Land subsidence monitoring by D-InSAR technique显示文摘Nowadays, the researches of using Differential Interferometric Synthetic Aperture Radar (D-InSAR) tech- nique to monitor the land subsidence are mainly on how to qualitatively analyze the subsidence areas and values, but the analysis of subsidence process and mechanism are insufficient. In order to resolve these problems, 6 scenes of ERS1/2 images captured during 1995 and 2000 in a certain place of Jiangsu province were selected to obtain the subsidence and velocities in three time segments by ''two-pass'' D- InSAR method. Then the relationships among distributions of pumping wells, exploitation quantity of groundwater, and confined water levels were studied and the subsidence mechanism was systematically analyzed. The results show that using D-InSAR technique to monitor the deformation of large area can obtain high accuracies, the disadvantages of classical observation methods can be remedied and there is a linear relationship among the velocities of land subsidence, the water level and the exploitation quantity. | Fan Hongdong Deng Kazhong Ju Chengyu Zhu Chuanguang Xue Jiqun China | 2011 | Mining Science and Technology2011，21，6： | 15 |
| 9 | Comparison of simple discectomy and instrumented posterior lumbar interbody fusion for treatment of lumbar disc herniation combined with Modic endplate changes显示文摘 | Cao Peng Chen Zhe Zheng Yuehuan Wang Yuren Jiang Leisheng Yang Yaoqi Zhuang Chengyu Liang Yu Zheng Tao Gong Yaocheng Zhang Xingkai Wu Wenjian Qiu Shijing | 2014 | Chinese Medical Journal2014，，15： | 15 |
| 10 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 11 | Dynamic Topology Multi Force Particle Swarm Optimization Algorithm and Its Application显示文摘Particle swarm optimization(PSO) algorithm is an effective bio-inspired algorithm but it has shortage of premature convergence. Researchers have made some improvements especially in force rules and population topologies. However, the current algorithms only consider a single kind of force rules and lack consideration of comprehensive improvement in both multi force rules and population topologies. In this paper, a dynamic topology multi force particle swarm optimization(DTMFPSO) algorithm is proposed in order to get better search performance. First of all, the principle of the presented multi force particle swarm optimization(MFPSO) algorithm is that different force rules are used in different search stages, which can balance the ability of global and local search. Secondly, a fitness-driven edge-changing(FE) topology based on the probability selection mechanism of roulette method is designed to cut and add edges between the particles, and the DTMFPSO algorithm is proposed by combining the FE topology with the MFPSO algorithm through concurrent evolution of both algorithm and structure in order to further improve the search accuracy. Thirdly, Benchmark functions are employed to evaluate the performance of the DTMFPSO algorithm, and test results show that the proposed algorithm is better than the well-known PSO algorithms, such as μPSO, MPSO, and EPSO algorithms. Finally, the proposed algorithm is applied to optimize the process parameters for ultrasonic vibration cutting on Si C wafer, and the surface quality of the Si C wafer is improved by 12.8% compared with the PSO algorithm in Ref. [25]. This research proposes a DTMFPSO algorithm with multi force rules and dynamic population topologies evolved simultaneously, and it has better search performance. | CHEN Dongning ZHANG Ruixing YAO Chengyu ZHAO Zheyu | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 13 |
| 12 | Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse显示文摘Dear Editor,Since the first recognized case of human infection with avian influenza H5N1 virus in 1997,the worldwide spread and re-emergence of this highly pathogenic influenza virus have led to 694 human infection cases.Of these cases,402died from 2003 to 2015(http://gffzz36b398b81f8a4a4chqc60xcu9955p6bqw.ffgz.tsg.suse.edu.cn/influenza/humananimalinterface/ENGIP20150106CumulativeNumber H5N1cases.pdf?ua=1),with a morbidity rate | YAN YiWu LIU Qiang LI Ning DU JianChao LI Xiao LI Chang JIN NingYi JIANG ChengYu | 2015 | Science China(Life Sciences)2015，58，2： | 12 |
| 13 | A survey on pollen dispersal in the western Pacific Ocean and its paleoclimatological significance as a proxy for variation of the Asian winter monsoon显示文摘Pollen grains deposited in marine sediments are transported from land to sea by wind or surface water flows.We analyzed pollen collected from the air and seawater from the coast of the Yellow Sea near China and into the western Pacific Ocean between December 2008 and January 2009 during the cruise 'KX08-973'.Results showed that abundant pollen grains of Artemisia and Chenopodiaceae were probably transported to the continental shelf of the East China Sea,the East Philippine Sea and the equatorial regions of the Pacific Ocean by the winter monsoon.Some pollen may have even traveled over 2000 km from the East Asia continent to the tropical Pacific Ocean.However,a gradual decline of temperate components and an increase in tropical components was observed towards the tropical regions.Fern spores were rare in the air samples,but much more abundant in seawater samples,even though they were collected in nearly the same areas,which indicates that most fern spores were carried to the ocean by flowing water.These results suggest that the winter monsoon may be the major pollen carrier and transporter in the study area during winter. | DAI Lu WENG ChengYu | 2011 | Science China Earth Sciences2011，54，2： | 11 |
| 14 | Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis显示文摘Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed to be mediated by hemagglutinin (HA), a virus surface glycoprotein that can bind terminal sialic acid residues on host cell glycoproteins and glycolipids. In this study, we elucidated the pathways through which H5N1 enters human lung carcinoma cell line A549. We first proved that H5N1 can enter A549 cells via endocytosis, as lysosomotropic agents, such as bafilomycin A1 and chloroquine, can rescue H5N1-induced A549 cell death. By using specific inhibitors, and siRNAs that target the clathrin pathway, we further found that H5N1 could enter A549 cells via clathrin-mediated endocytosis, while inhibitors targeting caveolae-mediated endocytosis could not inhibit H5N1 cell entry. These findings expand our understanding of H5N1 pathogenesis and provide new information for anti-viral drug research. | WANG HongLiang & JIANG ChengYu National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China | 2009 | Science China(Life Sciences)2009，52，5： | 11 |
| 15 | Effects of resolvin D1 on inflammatory responses and oxidative stress of lipopolysaccharide-induced acute lung injury in mice显示文摘 | Yuan Ruixia Wang Lei Yao Chengyue Wu Qingping Marie Christelle Xie Wanli Zhang Xingcai Sun Wei Wang Huiqing Yao Shanglong | 2014 | Chinese Medical Journal2014，，5： | 10 |
| 16 | Chemical and Isotopic Characteristics of the Water and Suspended Particulate Materials in the Yangtze River and Their Geological and Environmental Implications显示文摘The chemical and isotopic characteristics of the water and suspended particulate materials(SPM) in the Yangtze River were investigated on the samples collected from 25 hydrological monitoring stations in the mainsteam and 13 hydrological monitoring stations in the major tributaries during 2003 to 2007. The water samples show a large variation in both δD( 30‰ to 112‰) and δ18O( 3.8‰ to 15.4‰) values. Both δD and δ18O values show a decrease from the river head to the Jinsha Jiang section and then increase downstream to the river mouth. It is found that the oxygen and hydrogen isotopic compositions of the Yangtze water are controlled by meteoric precipitation, evaporation, ice(and snow) melting and dam building. The Yangtze SPM concentrations show a large variation and are well corresponded to the spatial and temporal changes of flow speed, runoff and SPM supply, which are affected by the slope of the river bed, local precipitation rate, weathering intensity, erosion condition and anthropogenic activity. The Yangtze SPM consists of clay minerals, clastic silicate and carbonate minerals, heavy minerals, iron hydroxide and organic compounds. From the upper to lower reaches, the clay and clastic silicate components in SPM increase gradually, but the carbonate components decrease gradually, which may reflect changes of climate and weathering intensity in the drainage area. Compared to those of the upper crust rocks, the Yangtze SPM has lower contents of SiO2, CaO, K2 O and Na2 O and higher contents of TFe2 O3 and trace metals of Co, Ni, Cu, Zn, Pb and Cd. The ΣREE in the Yangtze SPM is also slightly higher than that of the upper crust. From the upper to lower reaches, the CaO and MgO contents in SPM decrease gradually, but the SiO2 content increases gradually, corresponding to the increase of clay minerals and decrease of the carbonates. The δ30SiSPM values( 1.1‰ to 0.3‰) of the Yangtze SPM are similar to those of the average shale, but lower than those of the granite rocks( 0.3‰ to 0.3‰), reflecting the effect of silicon isotope fractionation in silicate weathering process. The δ30SiSPM values of the Yangtze SPM show a decreasing trend from the upper to the middle and lower reaches, responding to the variation of the clay content. The major anions of the river water are HCO 3, SO 4 2, Cl, NO 3, SiO 4 4 and F and the major cations include Ca2+, Na+, Mg2+, K+ and Sr2+. The good correlation between HCO3-content and the content of Ca2+may suggest that carbonate dissolution is the dominate contributor to the total dissolved solid(TDS) of the Yangtze River. Very good correlations are also found among contents of Cl, SO4 2, Na+, Mg2+, K+and Sr2+, indicating the important contribution of evaporite dissolution to the TDS of the Yangtze River. High TDS contents are generally found in the head water, reflecting a strong effect of evaporation in the Qinghai-Tibet Plateau. A small increase of the TDS is generally observed in the river mouth, indicating the influence of tidal intrusion. The F and NO3 contents show a clear increase trend from the upstream to downstream, reflecting the contribution of pesticides and fertilizers in the Chuan Jiang section and the middle and lower reaches. The DSi shows a decrease trend from the upstream to downstream, reflecting the effect of rice and grass growth along the Chuan Jiang section and the middle and lower reaches. The dissolved Cu, Zn and Cd in the Yangtze water are all higher than those in world large rivers, reflecting the effect of intensive mining activity along the Yangtze drainage area. The Yangtze water generally shows similar REE distribution pattern to the global shale. The δ30SiDiss values of the dissolved silicon vary from 0.5‰ to 3.7‰, which is the highest among those of the rivers studied. The δ30SiDiss values of the water in the Yangtze mainsteam show an increase trend from the upper stream to downstream. Its DSi and δ30SiDiss are influenced by multiple processes, such as weathering process, phytolith growth in plants, evaporation, phytolith dissolution, growth of fresh water diatom, adsorption and desorption of aqueous monosilicic acid on iron oxide, precipitation of silcretes and formation of clays coatings in aquifers, and human activity. The δ34SSO4 values of the Yangtze water range from 1.7‰ to 9.0‰. The SO4 in the Yangtze water are mainly from the SO4 in meteoric water, the dissolved sulfate from evaporite, and oxidation of sulfide in rocks, coal and ore deposits. The sulfate reduction and precipitation process can also affect the sulfur isotope composition of the Yangtze water. The87Sr/86Sr ratios of the Yangtze water range from 0.70823 to 0.71590, with an average value of 0.71084. The87Sr/86Sr ratio and Sr concentration are primary controlled by mixing of various sources with different87Sr/86Sr ratios and Sr contents, including the limestone, evaporite and the silicate rocks. The atmospheric precipitation and anthropogenic inputs can also contribute some Sr to the river. The δ11B values of the dissolved B in the Yangtze water range from 2.0‰ to 18.3‰, which is affected by multifactors, such as silicate weathering, carbonate weathering, evaporite dissolution, atmospheric deposition, and anthropogenic inputs. | DING Tiping GAO Jianfei TIAN Shihong SHI Guoyu CHEN Feng WANG Chengyu LUO Xurong HAN Dan | 2014 | Acta Geologica Sinica(English Edition)2014，88，1： | 10 |
| 17 | Expression and subcellular localization of mechano-growth factor in osteoblasts under mechanical stretch显示文摘Mechano-growth factor (MGF) is a stretch sensitive factor in myocytes, and it might also be produced by other mechanocytes under mechanical stimulation. In this study, both the mRNA and protein expression of MGF were detected in stretched osteoblasts. Quantitative analysis showed that a cyclic stretching stimulation caused a quick and sharp increase of MGF mRNA and protein expression from a low basal level under no stretch; the mRNA and protein levels respectively peaked in 6 and 12 h to 5 and 5.2 fold over the basal level and returned to normal by 24 h. The subcellular distribution of MGF protein was revealed by immunofluorescence analysis to be restricted to the nucleus. We concluded that cyclic stretching stimulation could induce MGF expression in osteoblasts in a pulsing fashion; and the nuclear distribution of MGF suggested that MGF might act in mechanocytes as an autocrine growth factor. | ZHANG BingBing, XIAN ChengYu, LUO YanFeng & WANG YuanLiang Research Center of Bioinspired Materials Science and Engineering, Bioengineering College, Chongqing University, Chongqing 400030, China | 2009 | Science China(Life Sciences)2009，52，10： | 10 |
| 18 | Avian influenza H5N1:an update on molecular pathogenesis显示文摘Avian influenza A virus constitutes a large threat to human health. Recent outbreaks of highly pathogenic avian influenza H5N1 virus in poultry and in humans have raised concerns that an influenza pandemic will occur in the near future. Transmission from avian species to humans remains sporadic, but the mortality associated with human infection is very high (about 62%). To date, there are no effective therapeutic drugs or a prophylactic vaccines available, which means that there is still a long way to go before we can eradicate or cure avian influenza. This review focuses on the molecular pathogenesis of avian influenza H5N1 virus infection. An understanding of the viral pathogenesis may facilitate the development of novel treatments or effective eradication of this fatal disease. | WANG HongLiang & JIANG ChengYu National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China | 2009 | Science China(Life Sciences)2009，52，5： | 9 |
| 19 | Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX显示文摘在 BCL-2 家庭蛋白质之间的相互作用决定房间的命运生活或死。他们怎么与对方一起交往调整 apoptosis,作为一个未解决的中央问题留下。到目前为止, antiapoptotic BCL-2 蛋白质被认为微弱地与 BAX 交往,但是这个相互作用的生理的意义是含糊的。此处,我们证明 recombinant BCL-2 和 BCL-w 与 3 包含域的肽从 BAX 导出的 BCL-2 相同(BH ) potently 交往,分别地展出 15 和 23 nM 的分离常数。为这个强壮的相互作用澄清基础,我们与跨越它的 BH3 领域的 BAX 肽决定了 BCL-2 的建筑群的三维的结构。它表明他们在正规 BH3 领域以外扩大并且包含了三 nonconserved 的相互作用控告了 BAX 的残余。新奇 BAX 变体,包含这三残余的丙氨酸替换,极大地为 BCL-2 和 BCL-w 损害了亲密关系,但是与野类型的 BAX 另外难区分。极其, BAX 变体的 apoptotic 活动不能被 BCL-2 和 BCL-w 制止,指观察紧密的相互作用为调整 BAX 激活是批评的。我们包括地也确定了与三 BCL-2 亚科蛋白质的有约束力的亲密关系。一起,数据表演由于为 BCL-2 , BCL-w 和 A1 的 BAX 的高亲密关系,并且为 BCL-XL , MCL-1 和 A1 的 BAK ,仅仅一个子集BH3仅仅蛋白质,通常包括的 BIM ,出价和美洲狮,能从 antiapoptotic BCL-2 蛋白质被期望到免费 BAX 或 BAK 得到 apoptosis 。 | Bonsu Ku Chengyu Liang Jae U Jung Byung-Ha Oh | 2011 | Cell Research2011，21，4： | 9 |
| 20 | Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis显示文摘 | Delong Jiao Zhenyu Cai Swati Choksi Dan Ma Moran Choe Hyung-Joon Kwon Jin Young Balk Brian G. Rowan Chengyu Liu Zheng-gang Liu | 2018 | Cell Research2018，28，8： | 9 |
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