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| 1 | 减少急性冠状动脉综合征和卒中患者求医的延误——美国心脏协会心血管护理委员会和卒中委员会的科学声明显示文摘在寻求急性冠状动脉综合征和卒中症状的治疗方面,患者延误是限制提供这些疾病的确定性治疗的主要因素。尽管数十年来的研究和公众教育活动一直旨在缩短患者延误时间,但大多数患者仍然不能及时求医。在本科学声明中,我们总结了以下证据:(1)证明早期治疗的益处;(2)描述患者延误问题的程度;(3)确定与患者延误及时求医有关的因素;(4)揭示当前减少患者延误措施的不足。最后,提出临床实践和今后研究的建议。 | Debra K. Moser Laura P. Kimble Mark J. Alberts Angelo Alonzo Janet B. Croft Kathleen Dracup Kelly R. Evenson Alan S. Go Mary M. Hand Rashmi U. Kothari George A. Mensah Dexter L. Morris Arthur M. Pancioli Barbara Riegel Julie Johnson Zerwic 李宏建 曲东锋 | 2006 | 国际脑血管病杂志2006，14，10： | 39 |
| 2 | 中国两栖动物保护需求总述显示文摘通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少的铃蟾科、隐腮鲵科、小鲵科和蝾螈科显示出了高的受胁倾向.像世界其它地方一样,高海拔地区溪流繁殖的森林物种受胁程度更高.对中国两栖动物而言,生境丧失、污染和过度捕捉是最主要的致危因素.过度捕捉虽然影响不如生境丧失深远,但它更可能导致一个物种种群的快速衰落.针对5个方面的保护挑战,提出了优先研究领域和保护行动方面的建议. | 谢锋 刘惠宁 Simon N Stuart Janice S Chanson Neil A Cox Debra L Fischman | 2006 | 中国科学(C辑)2006，36，6： | 28 |
| 3 | 移动医疗在慢性病管理中的应用研究进展显示文摘慢性病已经成为全球社会医疗的巨大负担,是死亡和残疾的主要原因。美国有一半的人口至少有1种最常见的慢性病(如高血压、心血管疾病、卒中、糖尿病、癌症、关节炎、肝炎、肾功能不全、哮喘、肺气肿),超过1/4的人口有2种以上的慢性病。据美国疾病控制中心报告,在10种最常见的死亡病因中,7种是慢性病, | 蔡素销 Debra Bakerjian | 2016 | 中华护理教育2016，0，8： | 26 |
| 4 | Conservation needs of amphibians in China: A review显示文摘The conservation status of all the amphibians in China is analyzed,and the country is shown to be a global priority for conservation in comparison to many other countries of the world.Three Chinese regions are particularly rich in amphibian diversity:Hengduan,Nanling,and Wuyi mountains.Sala-manders are more threatened than frogs and toads.Several smaller families show a high propensity to become seriously threatened:Bombinatoridae,Cryptobranchidae,Hynobiidae and Salamandridae.Like other parts of the world,stream-breeding,high-elevation forest amphibians have a much higher likeli-hood of being seriously threatened.Habitat loss,pollution,and over-harvesting are the most serious threats to Chinese amphibians.Over-harvesting is a less pervasive threat than habitat loss,but it is more likely to drive a species into rapid decline.Five conservation challenges are mentioned with recommendations for the highest priority research and conservation actions. | Michael Wai Neng LAU Simon N STUART Janice S CHANSON Neil A COX Debra L FISCHMAN | 2007 | Science China(Life Sciences)2007，50，2： | 12 |
| 5 | 美国护理文化在中国的适应性研究显示文摘目的 :探讨美国本科护理教育课程纲要在中国的文化适用性。探索建立适用于全球的本科护理教育课程模式的可能性。方法 :对中国 11所护理学院进行问卷调查。结果 :由于中美两国国情、道德观念及文化传统等方面的差异 ,导致双方在护理教育体制上既具有一致性又具有差异性。结论 :在把美国的护理课程纲要引入和实施到中国的护理教育过程中 ,要注重学习和借鉴 ,同时要结合中国的国情 ,使之适合本国文化的要求 。 | 徐照珉 徐俞 Debra C.Davis | 2003 | 中华护理杂志2003，38，12： | 7 |
| 6 | Glycogenic hepatopathy:A narrative review显示文摘Glycogenic hepatopathy(GH) is a rare complication of the poorly controlled diabetes mellitus characterized by the transient liver dysfunction with elevated liver enzymes and associated hepatomegaly caused by the reversible accumulation of excess glycogen in the hepatocytes. It is predominantly seen in patients with longstanding type 1 diabetes mellitus and rarely reported in association with type 2 diabetes mellitus. Although it was first observed in the pediatric population, since then, it has been reported in adolescents and adults with or without ketoacidosis. The association of GH with hyperglycemia in diabetes has not been well established. One of the essential elements in the pathophysiology of development of GH is the wide fluctuation in both glucose and insulin levels. GH and non-alcoholic fatty liver disease(NAFLD) are clinically indistinguishable, and latter is more prevalent in diabetic patients and can progress to advanced liver disease and cirrhosis. Gradient dual-echo MRI can distinguish GH from NAFLD; however, GH can reliably be diagnosed only by liver biopsy. Adequate glycemic control can result in complete remission of clinical, laboratory and histological abnormalities. There has been a recent report of varying degree of liver fibrosis identified in patients with GH. Future studies are required to understand the biochemical defects underlying GH, noninvasive, rapid diagnostic tests for GH, and to assess the consequence of the fibrosis identified as severe fibrosis may progress to cirrhosis. Awareness of this entity in the medical community including specialists is low. Here we briefly reviewed the English literature on pathogenesis involved, recent progress in the evaluation, differential diagnosis, and management. | Jagannath M Sherigar Joline De Castro Yong Mei Yin Debra Guss Smruti R Mohanty | 2018 | World Journal of Hepatology2018，10，2： | 7 |
| 7 | 三核苷酸重复的检测在脊髓小脑型共济失调的应用研究显示文摘目的建立中国人遗传性脊髓小脑型共济失调(SCA)患者的SCA1、SCA2、SCA3/MJD、SCA6型的CAG三核苷酸重复(CAG)n频率的检测方法并探讨其诊断意义。方法应用聚合酶链式反应(PCR)和6%变性聚丙烯酰胺凝胶电泳技术,检测了30例正常人和6例临床诊断为SCA患者上述4型的(CAG)n重复数。结果30例正常人(CAG)n的重复数目分别为SCA16~40次,SCA222~29次,SCA313~36次,SCA64~16次。6例SCA患者中2例有SCA3异常,(CAG)n重复数分别为67和75,而SCA1、SCA2、SCA6型(CAG)n重复数均在正常范围内。结论研究三核苷酸重复频率的检测为SCA患者提供了准确可靠的诊断方法和标准。 | 丁新生 程虹 李晨 姚娟 邓晓萱 DEBRA LEONARD | 1999 | 临床神经病学杂志1999，12，1： | 7 |
| 8 | 单倍型测序确认HLA新等位基因A~* 9217显示文摘目的用单倍型测续方法判定骨髓库HLA分型检测中出现的模棱两可结果,以发现新的HLA基因序列。方法用DNA测序的方法确认HLA分型结果,用单倍型测序的方法分析常规测序方法无法确认的杂合子的新基因序列。结果9个常规SSO流式荧光微珠HLA分型方法无法确认的结果中,有8个可以用常规测序方法得到确切分型结果(该8个结果均为近期报告的新的HLA等位基因),1个标本被确认为新的基因序列A*9217,已经在GENBANK注册(注册号:EF526712),并向HLA因子命名委员会进行新基因申报(申报号:WHS10004629),得到WHO HLA因子命名委员会的正式命名。结论DNA测序的方法是解决HLA分型的最直接方法;在遇到杂合子等位基因时,采用单倍型测续的方法简单有效。 | 张伯伟 杜广有 赵磊 Baiba Poorer Debra Kukuruga | 2007 | 中国卫生工程学2007，6，3： | 6 |
| 9 | Arabidopsis thaliana T-DNA Mutants Implicate GAUT Genes in the Biosynthesis of Pectin and Xylan in Cell Walls and Seed Testa显示文摘Galacturonosyltransferase 1 (GAUT1 ) 是从 uridine 5-diphosphogalacturonic 酸转移 galacturonic 酸到果胶的多糖 homogalacturonan 上的 1,4-D-galacturonosyltransferase (斯特林等, 2006 ) 。25 成员 Arabidopsis thaliana GAUT1 相关的基因家庭编码 15 GAUT 和 10 象 GAUT 一样(GATL ) 蛋白质与,分别地 5684 和 4253% 氨基酸顺序类似到 GAUT1。AtGAUTs 的以前的种系发生的分析显示了三 clades:通过 C 的 A。Arabidopsis,白杨和米饭 GAUT 家庭的比较种系发生的分析有亚 classified GAUT 进七 clades:clade A-1 (GAUT 1 ~ 3 ) ;A-2 (GAUT4 ) ;A-3 (GAUT 5 和 6 ) ;A-4 (GAUT7 ) ;B-1 (GAUT 8 和 9 ) ;B-2 (GAUT 10 和 11 ) ;并且 clade C (GAUT 12 ~ 15 ) 。Arabidopsis GAUT 有比得上白杨 orthologs 的分布,与 GAUT2 的例外,它在白杨是不在的。然而,瑞斯没有 GAUT 的 orthologs 2 和 12 并且有 GAUT 的多重明显的 orthologs 1, 4,和 7 与 Arabidopsis 或白杨相比。为 15 Arabidopsis GAUT 基因中的 13 个的 26 同型结合的 T-DNA 插入异种的房间墙 glycosyl 残余作文显著地并且 reproducibly 在 6, 8, 9, 10, 11, 12, 13,和 14 从野类型的 Arabidopsis 的围的 gaut 异种的特定的纸巾揭示不同房间墙。果胶和木聚糖多糖被 GAUT 功能的损失影响,由改变的 galacturonic 酸示威了不同 gaut 异种的木糖, rhamnose,半乳糖,和 arabinose 作文围。墙 glycosyl 残余在 gaut 异种之中观察的组合显型建议在果胶或木聚糖的至少六个不同 biosynthetic 连接被损害在这些 GAUT 基因影响。证据也被介绍在种子粘液扩大并且在种子墙和粘液作文中为 GAUT11 支持一个角色。 | Kerry H. Caffall Sivakumar Pattathil Sarah E. Phillips Michael G. Hahn Debra Mohnen | 2009 | Molecular Plant2009，2，5： | 5 |
| 10 | Analysis of Open Access Landscape显示文摘This paper is created by bounding 5 editorials of Public Library of Science (PLoS ) which have written on various aspects of open access. It covers wide range topics of important open access issues, such as from paying for open access to copyright to open access as a public issue, which may be more or less of interest of our audience. | Helen Doyle Andy Gass Debra Lappin Rebecea Kennison | 2005 | 图书情报工作2005，49，12： | 4 |
| 11 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 12 | Cdx 2 ectopic expression induces gastric intestinal metaplasia in transgenic mice显示文摘 | Debra G. Silberg Jessica Sullivan Eugene Kang Gary P. Swain Jennifer Moffett Newman J. Sund Sara D. Sackett Klaus H. Kaestner | 2002 | Gastroenterology2002，，3： | 3 |
| 13 | Safe acupuncture and dry needling during pregnancy:New Zealand physiotherapists' opinion and practice显示文摘Objective: Acupuncture guidelines have advised caution when treating women during pregnancy,because historical ‘‘forbidden' acupuncture points are believed to stimulate miscarriage or early labor.Despite recent research demonstrating that acupuncture is a useful and safe treatment tool for pregnancy-related low-back pain(LBP) and pelvic girdle pain(PGP), it is postulated that fear of miscarriage and subsequent blame by association, restricts its provision. More recently, an increase in dry needling(DN) courses for physiotherapists has potentiated the rapid growth in DN practice in New Zealand(NZ). Many dry needlers do not consider DN to be a form of acupuncture; it is unknown if they have similar safety concerns.Methods: NZ registered physiotherapists practicing acupuncture and/or DN were invited to participate in an electronic survey to examine their practice and level of understanding in regard to safe needling during pregnancy.Results: Of 124 respondents, only 60(48%) would needle pregnant women, with a further 66% of those still expressing safety concerns. NZ physiotherapists practicing DN only, were more likely to needle areas related to ‘‘forbidden' points in all trimesters. However, overall, NZ physiotherapists were less likely to needle ‘‘forbidden' points than their UK peers.Conclusion: Conflicting literature and a ‘‘fear of blame' influences NZ physiotherapists' decisions to offer needling(both acupuncture and DN) during pregnancy. Further training in this field is recommended to ensure safe practice and adequate provision of acupuncture treatment options for pregnant women suffering musculoskeletal pain, such as LBP and PGP. Further research, particularly into DN, for women during pregnancy, is warranted. | Jillian Marie McDowell Susan Heather Kohut Debra Betts | 2019 | Journal of Integrative Medicine2019，17，1： | 3 |
| 14 | White grapes arose through the mutation of two similar and adjacent regulatory genes显示文摘 | Amanda R.Walker ElizabethLee JochenBogs Debra A. J.McDavid Mark R.Thomas Simon P.Robinson | 2007 | The Plant Journal2007，，5： | 3 |
| 15 | BCL-2 FAMILY: Regulators of Cell Death显示文摘 | Debra T. Chao Stanley J. Korsmeyer | 1998 | Annual Review of Immunology1998，，： | 3 |
| 16 | Modern SEM-based mineral liberation analysis显示文摘 | Rolf Fandrich Ying Gu Debra Burrows Kurt Moeller | 2006 | International Journal of Mineral Processing2006，，1： | 2 |
| 17 | Advances in cellulose ester performance and application显示文摘 | Kevin J Edgar Charles M Buchanan John S Debenham Paul A Rundquist Brian D Seiler Michael C Shelton Debra Tindall | 2001 | Progress in Polymer Science2001，，9： | 2 |
| 18 | Effect of CC Chemokine Receptor 2 CCR2 Blockade on Serum C-Reactive Protein in Individuals at Atherosclerotic Risk and With a Single Nucleotide Polymorphism of the Monocyte Chemoattractant Protein-1 Promoter Region显示文摘 | Jim Gilbert Julie Lekstrom-Himes Debra Donaldson Yih Lee Mingxiu Hu Jing Xu Tim Wyant Michael Davidson | 2011 | The American Journal of Cardiology2011，，6： | 2 |
| 19 | Functional conservation of the grapevine candidate gene INNER NO OUTER for ovule development and seed formation显示文摘Seedlessness represents a highly appreciated trait in table grapes.Based on an interesting case of seedless fruit production described in the crop species Annona squamosa,we focused on the Vitis vinifera INNER NO OUTER(INO)gene as a candidate.This gene encodes a transcription factor belonging to the YABBY family involved in the determination of abaxial identity in several organs.In Arabidopsis thaliana,this gene was shown to be essential for the formation and asymmetric growth of the ovule outer integument and its mutation leads to a phenotypic defect of ovules and failure in seed formation.In this study,we identified in silico the V.vinifera orthologue and investigated its phylogenetic relationship to INO genes from other species and its expression in different organs in seeded and seedless varieties.Applying cross-species complementation,we have tested its functionality in the Arabidopsis ino-1 mutant.We show that the V.vinifera INO successfully rescues the ovule outer integument growth and seeds set and also partially complements the outer integument asymmetric growth in the Arabidopsis mutant,differently from orthologues from other species.These data demonstrate that VviINO retains similar activity and protein targets in grapevine as in Arabidopsis.Potential implications for grapevine breeding are discussed. | Valentina di Rienzo Zahra Imanifard Isabella Mascio Charles SGasser Debra JSkinner Ciro Leonardo Pierri Martina Marini Valentina Fanelli Wilma Sabetta Cinzia Montemurro Diana Bellin | 2021 | Horticulture Research2021，8，1： | 2 |
| 20 | Classification of α1-adrenoceptor subtypes显示文摘 | Martin C. Michel Barry Kenny Debra A. Schwinn | 1995 | Naunyn - Schmiedeberg’s Archives of Pharmacology1995，，1： | 2 |
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