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| 1 | 卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。 | Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 | 2014 | 国际脑血管病杂志2014，22，10： | 80 |
| 2 | 胰腺导管腺癌放射学报告模板:腹部放射协会和美国胰腺协会的共识声明显示文摘胰腺导管腺癌(PDA)是一种具有侵袭性、死亡率高的恶性肿瘤。在肿瘤分期时,通过影像学分析,合理判定肿瘤的范围,是患者治疗措施中最重要的步骤之一。考虑到不同医生在专业知识水平和疾病严重程度的判定有所差异,以及在放射学检查时经常缺乏相关影像学表现的完整报道,有必要采用标准化的影像学报告模板以及大家一致接受和认可的胰腺实性肿瘤术语。在腹部放射协会和美国胰腺协会的共同资助下,胰腺导管腺癌(PDA)多机构专家组(包括放射学专家、胃肠病学和肝胆胰外科学专家)共同发起了一份描述标准化报告模板的共识声明。采用这种标准化的影像学报告模板将能改进PDA患者的治疗决策过程,并可通过提供一份完整、相关、精准的疾病分期报告以优化治疗方案。通过对可行手术切除的患者恰当、一致的分期,标准化报告模板有助于促进临床和科研实验设计,从而实现在不同机构之间的实验结果的比较。 | Mahmoud M.Al-Hawary Isaac R.Francis Suresh T.Chari Elliot K.Fishman David M.Hough David S.Lu Michael Macari Alec J.Megibow Frank H.Miller Dushyant V.Sahani Diane M.Simeone 黄翔 孙灿辉 | 2014 | 影像诊断与介入放射学2014，23，4： | 52 |
| 3 | Current oncologic applications of radiofrequency ablation therapies显示文摘Radiofrequency ablation (RFA) uses high frequency alternating current to heat a volume of tissue around a needle electrode to induce focal coagulative necrosis with minimal injury to surrounding tissues. RFA can be performed via an open, laparoscopic, or image guided percutaneous approach and be performed under general or local anesthesia. Advances in delivery mechanisms, electrode designs, and higher power generators have increased the maximum volume that can be ablated, while maximizing oncological outcomes. In general, RFA is used to control local tumor growth, prevent recurrence, palliate symptoms, and improve survival in a subset of patients that are not candidates for surgical resection. It's equivalence to surgical resection has yet to be proven in large randomized control trials. Currently, the use of RFA has been well described as a primary or adjuvant treatment modality of limited but unresectable hepatocellular carcinoma, liver metastasis, especially colorectal cancer metastases, primary lung tumors, renal cell carcinoma, boney metastasis and osteoid osteomas. The role of RFA in the primary treatment of early stage breast cancer is still evolving. This review will discuss the general features of RFA and outline its role in commonly encountered solid tumors. | Dhruvil R Shah Sari Green Angelina Elliot John P McGahan Vijay P Khatri | 2013 | World Journal of Gastrointestinal Oncology2013，5，4： | 33 |
| 4 | 电动自行车交通发展的主要趋势——近10年文献综述显示文摘电动自行车是交通市场增长最快的领域之一,2012年总销售量超过3 100万辆。相关研究的数量不断上升,鉴于此,对过去蓬勃发展的与电动自行车最相关的主题进行综合分析。将研究重点放在电动自行车交通及需要注意的最关键的研究缺口方面,而非休闲娱乐。中国的电动自行车销量在世界占领先地位,荷兰、德国紧随其后。电动自行车能够以较少能耗保持一定速度,也有研究发现电动自行车能增加自行车使用率。电动自行车有潜力取代传统机动交通方式(内燃式),但在取代传统自行车方面所扮演的角色仍存在争议。电动自行车不仅有益身体健康,并且相同行驶里程下,碳排放水平显著低于小汽车。在某些地区,安全问题上升到政策层面,目前电动自行车的数量已经足以搜集到丰富的安全数据。尽管如此,关于电动自行车的研究目前仍处于萌芽阶段。随着电动自行车数量的不断上升,为了向政策制定者以及整个行业提供必要的数据,相关领域的进一步研究需求也日益增长。 | Elliot Fishman Christopher Cherry 秦维 | 2016 | 城市交通2016，14，2： | 27 |
| 5 | 老年糖尿病患者合并衰弱的相关研究进展显示文摘衰弱(frailty)是指由于个体脆弱性增加及保持自我内在平衡能力下降而出现的临床综合征,是独立于疾病、年龄等因素的多个生理系统损害的累积,极易导致不良事件的发生。最新数据显示.我国约有1.14亿糖尿病患者,他们有加速老化的趋势,在更小的年龄有更大风险出现衰弱状况。国外对老年糖尿病合并衰弱的研究[4-5]较为深入。 | 贾文文 戴付敏 Julie Elliot 韦伟 段贯英 李博 | 2017 | 中华护理杂志2017，52，6： | 27 |
| 6 | 公共自行车文献综述显示文摘对公共自行车系统进行总体概述,并针对相关文献进行批判性检验。基于以往同行评议文献及灰色文献,对与公共自行车系统影响相关的认知缺陷进行分析。当前亟须针对全球公共自行车研究进行评估,该综述旨在更好地了解及加强当前和未来公共自行车系统的实施效率。越来越多的研究聚焦于公共自行车系统,主要议题集中在以下方面。首先,公共自行车使用者认为方便性和低支出是注册并使用该系统的重要原因。其次,与固有观念相反,公共自行车系统用户比非用户更倾向于拥有和使用私人自行车。第三,当法律强制要求佩戴头盔时,公共自行车使用者比私人自行车使用者更不愿佩戴头盔。最后,从更重要的可持续交通角度而言,大量公共自行车系统使用者选择该方式取代可持续交通方式而非小汽车出行方式。 | Elliot Fishman Simon Washington Narelle Haworth 张晓为(译) | 2014 | 城市交通2014，12，2： | 26 |
| 7 | 公共自行车近期文献综述显示文摘提供公共自行车服务的城市数量快速发展,从20世纪90年代末屈指可数发展到如今超过800个。通过综述近期公共自行车文献,总结公共自行车研究领域的若干议题。便捷性是出行者使用公共自行车的主要动机。省钱是促使低收入群体使用的原因,与停放站间距离是预测会员数量的重要指标。在一些国家,只有不到半数会员每月使用率少于一次。男性使用率高于女性,但性别失衡情况并未如私人自行车那样显著(至少在自行车使用率低的国家)。年会员最普遍的出行目的是通勤。与私人自行车使用者相比,公共自行车使用者不常佩戴头盔,但在法律强制佩戴头盔的国家,其使用水平则受到影响。公共自行车使用者相比私人自行车使用者不易受伤。未来发展方向包括电动自行车集成、GPS全球定位系统、无停放站系统和改进的公共交通一体化。指出应开展更多研究量化公共自行车在出行方式选择、尾气排放、拥堵和健康方面的影响。 | Elliot Fishman 魏贺 | 2015 | 城市交通2015，13，6： | 20 |
| 8 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 9 | Osteoporosis in primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an autoimmune cholestatic liver disease with multiple debilitating complications. Osteoporosis is a common complication of PBC resulting in frequent fractures and leading to significant morbidity in this population, yet evidence for effective therapy is lacking. We sought to summarize our current understanding of the pathophysiology of osteoporosis in PBC, as well as current and emerging therapies in order to guide future research directions. A complete search with a comprehensive literature review was performed with studies from Pub Med, EMBASE, Web of Science, Cochrane database, and the Countway Library. Osteoporosis in PBC is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Despite this fundamental difference, current treatment recommendations are based primarily on experience with postmenopausal osteoporosis. Trials specific to PBC-related osteoporosis are small and have not consistently demonstrated a benefit in this population. As it stands, prevention of osteoporosis in PBC relies on the mitigation of risk factors such as smoking and alcohol use, as well as encouraging a healthy diet and weight-bearing exercise. The primary medical intervention for the treatment of osteoporosis in PBC remains bisphosphonates though a benefit in terms of fracture reduction has never been shown. This review outlines what is known regarding the pathogenesis of bone disease in PBC and summarizes current and emerging therapies. | Christopher J Danford Hirsh D Trivedi Konstantinos Papamichael Elliot B Tapper Alan Bonder | 2018 | World Journal of Gastroenterology2018，24，31： | 13 |
| 10 | 3-D bioprinting technologies in tissue engineering and regenerative medicine:Current and future trends显示文摘Advances in three-dimensional(3D)printing have increased feasibility towards the synthesis of living tissues.Known as 3D bioprinting,this technology involves the precise layering of cells,biologic scaffolds,and growth factors with the goal of creating bioidentical tissue for a variety of uses.Early successes have demonstrated distinct advantages over conventional tissue engineering strategies.Not surprisingly,there are current challenges to address before 3D bioprinting becomes clinically relevant.Here we provide an overview of 3D bioprinting technology and discuss key advances,clinical applications,and current limitations.While 3D bioprinting is a relatively novel tissue engineering strategy,it holds great potential to play a key role in personalized medicine. | Elliot S.Bishop Sami Mostafa Mikhail Pakvasa Hue H.Luu Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2017 | Genes & Diseases2017，4，4： | 10 |
| 11 | Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes显示文摘Gastrointestinal tract involvement by neurofi bromatous lesions is rare and occurs most frequently as one of the systemic manifestations of generalized neurofibromatosis type 1 (NF1). In this setting, the lesions may manifest as focal scattered neurofi bromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis. Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease. Rarely, cases of isolated neurofi bromatosis of the large bowel with no prior or subsequent evidence of generalized neurofi bromatosis have been documented. We present the case of a 52 year-old female with abdominal pain and alternating bowel habits. Colonoscopic evaluation revealed multiple small polyps in the cecum and the presence of nodular mucosa in the colon and rectum. Pathologic evaluation of the biopsies from the cecum, descending colon, sigmoid colon, and rectum revealed tangled fascicles of spindle cells expanding the lamina propia leading to separation of the intestinal crypts. Immunohistochemical stains helped confirm the diagnosis of diffuse intestinal neurofibromatosis. A thorough clinical evaluation failed to reveal any stigmata of generalized neurofibromatosis. This case represents a rare presentation of isolated intestinal neurofi bromatosis in a patient without classic systemic manifestations of generalized neurofibromatosis and highlights the need in such cases for close clinical follow-up to exclude neurofibromatosis type Ⅰ or multiple endocrine neoplasia type Ⅱ. | J Elliot Carter Javier A Laurini | 2008 | World Journal of Gastroenterology2008，14，42： | 9 |
| 12 | Recent progress in pancreatic cancer显示文摘 | Christopher L. Wolfgang Joseph M. Herman Daniel A. Laheru Alison P. Klein Michael A. Erdek Elliot K. Fishman Ralph H. Hruban | 2013 | CA A Cancer Journal for Clinicians2013，，5： | 7 |
| 13 | 中国某省降低艾滋病流行危害干预项目的成本效果分析显示文摘目的:开展成本效果分析,研究美沙酮维持治疗、针具交换以及针对暗娼人群的干预对G省艾滋病流行的影响。方法:采用UNAIDS和PANCEA项目提供的标准工具收集3类干预的成本,通过文献检索了解3类干预对行为改变的效果,利用PANCEA开发的多重干预、多重流行的成本效果模型预测3类干预对G省艾滋病流行的影响。结果:2005年,在高、低流行地区,针具交换最具成本效果,每避免1例新发艾滋病感染的成本分别为892美元和1801美元;美沙酮维持治疗项目每避免1例新发感染的成本分别为2687美元和5101美元;而针对暗娼人群的干预避免1例新发感染的成本分别为3029美元和6429美元。本研究还揭示对艾滋病干预长期投入的必要性。此外,为跟踪干预效果和预测其对艾滋病流行的影响,必须重视行为学、经济学资料的收集。 | 白玥 王世勇 EMIKO MASAKI ELLIOT MARSEILLE | 2010 | 医学与社会2010，23，6： | 7 |
| 14 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 15 | 否思“后真相”:基于李普曼舆论学视角显示文摘当前西方后真相研究涵盖哲学、政治学、传播学、舆论学等学科,触及当代哲学中有关“真理”“客观事实”等诸多理论讨论。“后真相”的定义强调“客观事实”在舆论形成过程中的作用被大大削弱了,但“舆论”作为这个定义中的关键词却没有引起西方学界的足够重视。借鉴李普曼的舆论学理论视角对后真相的定义进行批判性反思发现:舆论形成的最大动因是“虚构”,而不是“客观事实”;并且,基于李普曼对人类语言主观性的思考,有必要指出“客观事实”和“事实的客观性”的区别。研究认为西方的价值观、偏见及思维方式使得后真相研究的局限性十分突出。后真相研究需要从客观事实回到完整的人,他们不是为某种假定的“真相”所制约的人,而是在解蔽过程中不断开放的人。 | Elliot O’Donnell 刘学蔚 | 2020 | 新闻与传播评论2020，73，3： | 6 |
| 16 | Epidural electrical stimulation for spinal cord injury显示文摘A long-standing goal of spinal cord injury research is to develop effective repair strategies,which can restore motor and sensory functions to near-normal levels.Recent advances in clinical management of spinal cord injury have significantly improved the prognosis,survival rate and quality of life in patients with spinal cord injury.In addition,a significant progress in basic science research has unraveled the underlying cellular and molecular events of spinal cord injury.Such efforts enabled the development of pharmacologic agents,biomaterials and stem-cell based therapy.Despite these efforts,there is still no standard care to regenerate axons or restore function of silent axons in the injured spinal cord.These challenges led to an increased focus on another therapeutic approach,namely neuromodulation.In multiple animal models of spinal cord injury,epidural electrical stimulation of the spinal cord has demonstrated a recovery of motor function.Emerging evidence regarding the efficacy of epidural electrical stimulation has further expanded the potential of epidural electrical stimulation for treating patients with spinal cord injury.However,most clinical studies were conducted on a very small number of patients with a wide range of spinal cord injury.Thus,subsequent studies are essential to evaluate the therapeutic potential of epidural electrical stimulation for spinal cord injury and to optimize stimulation parameters.Here,we discuss cellular and molecular events that continue to damage the injured spinal cord and impede neurological recovery following spinal cord injury.We also discuss and summarize the animal and human studies that evaluated epidural electrical stimulation in spinal cord injury. | Elliot H.Choi Sandra Gattas Nolan J.Brown John D.Hong Joshua N.Limbo Alvin Y.Chan Michael Y.Oh | 2021 | Neural Regeneration Research2021，16，12： | 5 |
| 17 | Prevalence of unsuspected thyroid nodules in adults on contrast enhanced 16-and 64-MDCT of the chest显示文摘AIM: To determine the prevalence of unsuspected thyroid nodules on contrast enhanced 16and 64-modified discrete cosine transform (MDCT) of the chest, in a population of adult outpatients imaged for indications other than thyroid disease. METHODS: This retrospective study involved review of intravascular contrast-enhanced MDCT scans of the chest from 3077 consecutive adult outpatients, to identify unsuspected thyroid nodules. Exclusion criteria included history of thyroid cancer, known thyroid nodules or thyroid disease and risk factors for thyroid cancer, as evidenced by their medical records. One of 9 radiologists recorded number of nodules, location and bidirectional measurement of largest nodule, as well as amount of thyroid visualized on the chest computed tomography (CT). Presence of nodule was correlated with age, gender, race and percentage of thyroid imaged. RESULTS: A total of 2510 (2510/3077 or 81.6%) study subjects were included in the data analysis; among them,one or more nodules were identified in 629 subjects (629/2510 or 25.1%), with 242 (242/629 or 38.5%) having multiple nodules. Patients with nodule(s) were significantly older than those without (64 ± 13 years vs 58 ± 14 years, P < 0.0001), and female gender was associated with presence of nodule(s) (373/1222 or 30.5% vs 256/1288 or 19.9%, P < 0.0001). Women were also more likely having multiple nodules (167/373 or 44.8%) compared to men (75/256 or 29.3%, P < 0.0001). The majority of nodules (427/629 or 67.9%) were less than 1 cm. CONCLUSION: This retrospective review revealed a prevalence of 25.1% for unsuspected thyroid nodules on contrast-enhanced chest CT. | Sameer Ahmed Pamela T Johnson Karen M Horton Atif Zaheer Saline Tsai Elliot K Fishman | 2012 | World Journal of Radiology2012，4，7： | 4 |
| 18 | Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement显示文摘 | Mark P. Callery MD Kenneth J. Chang MD Elliot K. Fishman MD Mark S. Talamonti MD L. William Traverso MD David C. Linehan MD | 2009 | Annals of Surgical Oncology2009，，7： | 3 |
| 19 | 照顾者虐待老年人行为评估及影响因素的研究进展显示文摘随着老年人数增长,长期照护负担加重,老年人虐待事件发生率逐渐上升,已引起广泛关注。本文大量查阅国内外文献,汇集各国照顾者虐待老年人的行为评估工具,并分析照顾者虐待老年人相关影响因素,以指导我国研制本土化评估工具,预警老年人虐待事件发生可能性,制定有效可行的干预措施,将预防的关口前移,营造和谐照护氛围,提高老年人生存质量。 | 王丽君 戴付敏 Julie Elliot 陈瑞云 刘广芝 | 2017 | 中国护理管理2017，17，2： | 3 |
| 20 | Potential mechanisms promoting restenosis in diabetic patients显示文摘 | Doron Aronson Zachary Bloomgarden Elliot J. Rayfield | 1996 | Journal of the American College of Cardiology1996，，3： | 2 |
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