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| 1 | Identifying the relationship between suspension parameters of underframe equipment and carbody modal frequency显示文摘As a critical component of the railway vehicle,underframe equipment has a great influence on the ride comfort of railway vehicles due to their big mass and active vibration. Therefore, study on the relationship between suspension parameters of underframe equipment and the modal frequency of carbody is extremely crucial for controlling the ride quality of railway vehicles. In this paper, a finite element model of the carbody was developed to investigate the effects of the suspension location, the mass of the suspension equipment, and the suspension frequency on the mode of the carbody. Then, the matching relationship between the suspension parameters and the modal frequency of the carbody was studied through the transfer function. In addition, roller rig tests were performed to verify the numerical simulation model of the carbody. The results show that the suspension parameters of the underframe equipment have a great influence on the mode of the carbody, especially for the frequency of the first bending mode. To improve the frequency of carbody high-frequency bending and reduce energy transfer, equipment with a large mass should be suspended toward the middle of the carbody. The weight of the equipment strongly affects the first bending frequency and energy transfer of the carbody. The frequency of heavy suspended equipment should be sufficiently low to increase the transmissibility of high frequencies and improve the vibration characteristics of the carbody. Although the bending frequency of the carbody can be improved effectively by increasing the suspension stiffness of thesuspension equipment, in order to reduce carbody vibration effectively, the suspension frequency of the equipment should be slightly lower than the carbody bending frequency. | Guangbing Luo Jing Zeng Qunsheng Wang | 2014 | Journal of Modern Transportation2014，22，4： | 10 |
| 2 | The role and clinical implications of microRNAs in hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis. | ZHAO Xue YANG Zhen LI GuangBing LI DongKai ZHAO Yi WU Yan ROBSON Simon C. HE Lian XU YiYao MIAO R-uoYu ZHAO HaiTao | 2012 | Science China(Life Sciences)2012，55，10： | 6 |
| 3 | A novel PTEN gene promoter mutation and untypical Cowden syndrome显示文摘Cowden syndrome (CS), an autosomal dominant disorder, is one of a spectrum of clinical disorders that have been linked to germline mutations in the phosphatase and tensin homolog (PTEN) gene. Although 70-80% of patients with CS have an identifiable germline PTEN mutation, the clinical diagnosis presents many challenges because of the phenotypic and genotypic variations. In the present study, we sequenced the exons and the promoter of PTEN gene, mutations and variations in the promoter and exons were identified, and a PTEN protein expression negative region was determined by immunohistochemistry (IHC). In conclusion, a novel promoter mutation we found in PTEN gene may turn off PTEN protein expression occasionally, leading to the disorder of PTEN and untypical CS manifestations. | Chen Liu Guangbing Li Rongrong Chen Xiaobo Yang Xue Zhao Haitao Zhao | 2013 | Chinese Journal of Cancer Research2013，25，3： | 5 |
| 4 | Prognostic significance of preoperative Naples prognostic score on short-and long-term outcomes after pancreatoduodenectomy for ampullary carcinoma显示文摘Background:The Naples prognostic score(NPS)is an effective and objective tool to assess the immune-nutritional status of patients with malignant tumors.The aim of this study was to investigate the clinical significance of preoperative NPS on short-and long-term outcomes after pancreatoduodenectomy(PD)for ampullary carcinoma.Methods:We retrospectively analyzed 404 consecutive patients with ampullary carcinoma who underwent PD between January 2012 and June 2018.Preoperative NPS was calculated from serum albumin and total cholesterol concentrations,and the neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio(LMR).Patients were then divided into three groups according to their NPS.Clinicopathological variables,postoperative outcomes,and survival data were compared between the three groups.Univariate and multivariate Cox analysis of overall survival(OS)and recurrence-free survival(RFS)were also conducted,and time-dependent receiver operating characteristic(ROC)curves were created to evaluate the discriminatory ability of the prognostic scoring systems.Results:Patients with higher NPS had worse prognosis,and significant OS difference(group 0 vs.1,P=0.02;group 1 vs.2,P<0.001;group 0 vs.2,P<0.001)and RFS difference(group 0 vs.1,P=0.088;group 1 vs.2,P<0.001;group 0 vs.2,P<0.001).Multivariate analysis revealed that NPS was an independent significant predictor of OS(grade 2 vs.grade 1 or 0,hazard ratio:3.067;P<0.001)and RFS(grade 2 vs.grade 1 or 0,hazard ratio:2.732;P<0.001).The time-dependent receiver operating curve analysis showed that NPS had better prognostic performance for OS and RFS than other prognostic models.Additionally,significant differences in the incidence of postoperative morbidity were observed between the three groups,and the NPS was an independent risk factor of overall postoperative complications(grade 2 vs.grade 1 or 0,odds ratio:1.692;P=0.02).Conclusions:The NPS was an independent predictor of overall-and RFS in patients undergoing PD for ampullary carcinoma,and was independently associated with the incidence of postoperative complications. | Jikuan Jin Hebin Wang Feng Peng Xiaoxiang Wang Min Wang Feng Zhu Guangbing Xiong Renyi Qin | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 5 |
| 5 | Exchange-coupling interaction and effective anisotropy in nanocomposite permanent materials显示文摘Taking Nd2Fe14B/α-Fe as example, the exchange-coupling interactions between magnetically soft and hard grains in nanocomposite permanent materials and their effects on the effective anisotropy of materials were investigated. The calculation results expressed that the exchange-coupling interactions are enhanced with the reduction of grain size, and the effective anisotropy of materials decreases with the reduction of gram size and the increase of magnetically soft phase component. The remanence and the effective anisotropy of materials possess the opposite variation trend with the change of grain size and phase ratio. The mean grain size should be in the range of 10-15 nm and the ratio of soft phase should be less than 50% for getting the magnet with high energy product. | Ruwei Gao Weicun Feng Wei Chen Biao Wang Guangbing Han Peng Zhang | 2002 | Chinese Science Bulletin2002，47，14： | 5 |
| 6 | Observations and analysis of environment and acoustic field changed by the passage of typhoon Damrey in the Yellow Sea in 2012显示文摘In order to investigate the environment and acoustic filed change induced by typhoon in shallow sea, we conducted two experiments just before and after the passage of typhoon Damrey, which is the strongest to affect the area north of the Yangtze River since 1949, in the Yellow sea in 2012. The data show that the temperature of the whole water column increases dramatically except the sea surface layer after the passage of Damrey while the salinity decreases obviously. The thermocline deepens and weakens, which leads to a change of internal wave activity. The transmission losses(TL) of the two experiments show that the environment change induced by typhoon can increase the TL as large as 8 d B at a distance of 9.2 km and depth of 15 m. The scintillation index(SI) of the sound intensity is simulated to estimate the change of the effect of internal wave activity on acoustic field showing that the SI decreases to a half after the typhoon's passage. The normal mode structures of the two experiments are also significantly different due to the thermocline changes. In addition, the signal arrives earlier after the typhoon's passage due to the water temperature increase. | YANG GuangBing Lü LianGang YUAN YeLi JIANG Ying LIU ZongWei YANG ChunMei LIU HongNing CHEN Zhao | 2015 | Science China Earth Sciences2015，58，12： | 3 |
| 7 | Mooring observed mode-2 internal solitary waves in the northern South China Sea显示文摘The mode-2 internal solitary waves(ISWs)generated by mode-2 internal tide(IT)are identified by mooring observations in the northern South China Sea(SCS)from 2016 to 2017.Two mode-2 ISWs with a re-appearance period of 24.9 h observed on 29 and 30 July 2016 are characterized by type-b ISWs.They occurred when the isotherms compressed obviously in the vertical direction.Modal decomposition of IT horizontal currents shows that the vertical compression of the isotherms is mainly caused by diurnal mode-2 IT.The analysis of the role of the density stratification reveals that a deeper and thinner pycnocline is favorable for generation of mode-2 ISWs rather than pycnocline intensity.By comparing the mode-2 nonlinear,dispersion coefficients and the Ursell numbers calculated based on the stratification associated with different kinds of ITs with the observation results,it is shown that the diurnal mode-2 IT plays a crucial role in the generation of the mode-2 ISWs.When the diurnal mode-2 IT interacts with the semidiurnal IT and causes a deeper and thinner pycnocline,the mode-2 ISWs are easily excited. | Liang Chen Xuejun Xiong Quanan Zheng Yeli Yuan Long Yu Yanliang Guo Guangbing Yang Xia Ju Jia Sun Zhenli Hui | 2020 | Acta Oceanologica Sinica2020，39，11： | 3 |
| 8 | Impact of warm mesoscale eddy on tropical cyclone intensity显示文摘The spatial-temporal patterns of tropical cyclone(TC) intensity changes caused by the warm ocean mesoscale eddy(WOME) distribution are evaluated using two sets of idealized numerical experiments. The results show that the TC was intensified and weakened when a WOME was close to and far away from the TC center, respectively.The area where the WOME enhanced(weakened) TC intensity is called the inner(outer) area in this study.Amplitudes of the enhancement and weakening caused by the WOME in the inner and outer area decreased and increased over time, while the ranges of the inner and outer area diminished and expanded, respectively. The WOME in the inner area strengthened the secondary circulation of the TC, increased heat fluxes, strengthened the symmetry, and weakened the outer spiral rainband, which enhanced TC intensity. The effect was opposite if the WOME was in the outer area, and it weakened the TC intensity. The idealized simulation employed a stationary TC, and thus the results may only be applied to TCs with slow propagation. These findings can improve our understanding of the interactions between TC and the WOME and are helpful for improving TC intensity forecasting by considering the effect of the WOME in the outer areas. | Jia Sun Guihua Wang Xuejun Xiong Zhenli Hui Xiaomin Hu Zheng Ling Long Yu Guangbing Yang Yanliang Guo Xia Ju Liang Chen | 2020 | Acta Oceanologica Sinica2020，39，8： | 3 |
| 9 | Principal-component estimates of the Kuroshio Current axis and path based on the mathematical verification between satellite altimeter and drifting buoy data显示文摘We used satellite altimetry data to investigate the Kuroshio Current because of the higher resolution and wider range of observations. In previous studies, satellite absolute geostrophic velocities were used to study the spatiotemporal variability of the sea surface velocity field along the current, and extraction methods were employed to detect the Kuroshio axes and paths. However, sea surface absolute geostrophic velocity estimated from absolute dynamic topography should be regarded as the geostrophic component of the actual surface velocity, which cannot represent a sea surface current accurately. In this study, mathematical verification between the climatic absolute geostrophic and bin-averaged drifting buoy velocity was established and then adopted to correct the satellite absolute geostrophic velocities. There were some differences in the characteristics between satellite geostrophic and drifting buoy velocities. As a result, the corrected satellite absolute geostrophic velocities were used to detect the Kuroshio axis and path based on a principal-component detection scheme. The results showed that the detection of the Kuroshio axes and paths from corrected absolute geostrophic velocities performed better than those from satellite absolute geostrophic velocities and surface current estimations. The corrected satellite absolute geostrophic velocity may therefore contribute to more precise day-to-day detection of the Kuroshio Current axis and path. | Zhanpeng Zhuang Zhenli Hui Guangbing Yang Xinhua Zhao Yeli Yuan | 2020 | Acta Oceanologica Sinica2020，39，1： | 2 |
| 10 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 11 | Effect of microstructure on the coercivity of HDDR Nd-Fe-B permanent magnetic alloy显示文摘The effect of the grain boundary microstructure on the anisotropy and coercivity was investigated in an HDDR Nd-Fe-B permanent magnetic alloy. Considering the special microstructure of its magnetic powder grain, an anisotropic theoretical model influenced simultaneously by the structure defect at the grain boundary and the exchange coupling interaction was put forward. The variations of the structure defect factors based on the nucleation and pinning mechanism with 2r0/lex (where r0 and lex are the defect thickness and the length of exchange coupling, respec-tively) were calculated. The results show that the coercivity mechanism of an HDDR Nd-Fe-B permanent magnetic alloy is greatly related to its microstructure defect at the grain boundary. For a fixed lex, when 2r0/lex < 1.67, the coercivity is controlled by the pinning mechanism; when 2r0/lex > 1.67, it is determined by the nucleation mechanism. The coercivity reaches the maximum when 2r0/lex = 1.67. The calcula-tion result is consistent well with the experimental result given by Morimoto et al. | LIU Min SUN Yan HAN GuangBing YANG Wu GAO RuWei | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 2 |
| 12 | Progression and prospects of translational medicine in China显示文摘Translational medicine is a new discipline aiming to eliminate the barrier between preclinical and clinical medicine [1]. It converts promising laboratory discoveries into clinical applications and elucidates clinical questions | LI GuangBing MIAO RuoYu ZHAO HaiTao | 2012 | Science China(Life Sciences)2012，55，11： | 1 |
| 13 | Effective anisotropy and coercivity in nanocrystalline single-phase NdFeB permanent magnetic materials 显示文摘 | Han Guangbing Gao Ruwei Feng Weicun | 2003 | Science in China (G)2003，46，4： | 1 |
| 14 | Effective anisotropy and coercivity in nanocrystalline single-phase NdFeB permanent magnetic material显示文摘 | Guangbing Han Ruwei Gao Weicun Feng Hanqiang Liu Biao Wang Peng Zhang Wei Chen Wei Li Yongquan Guo | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，4： | 1 |
| 15 | Effective anisotropy and coercivity in nanocrystalline single-phase NdFeB permanent magnetic material显示文摘 | Guangbing Han Ruwei Gao Weicun Feng Hanqiang Liu Biao Wang Peng Zhang Wei Chen Wei Li Yongquan Guo | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，4： | 1 |
| 16 | Dependence of magnetic properties of HDDR Nd-Fe-B bonded magnet on intergranular phase显示文摘用在谷物边界的建议不同 anisotropy 表情 K 1′(r) 和 K 1″(r) ,我们调查效果内部平均 anisotropy 〈K 1〉 上的小粒的阶段(IP )谷物边界和 coercivity H HDDR (加氢, disproportionation,解吸附作用和再结合) 的 c Nd-Fe-B 结合了磁铁。当 IP 的厚度 d 是零时,结果显示那, 〈K 1〉并且 H c 基于 K 1″(r) 基于 K 1′(r) 等于相应的。当 d 拿非零价值时, 〈K 1〉并且 H 分别地, c 与增加 d 更快基于 K 1″(r) 掉落并且升起。当 d 是 1 nm,结构缺点厚度 r 0 接近域墙(∼4 nm ) 的厚度时,计算 coercivity 与 avaiable 一致很好试验性的数据。 | LIU Min GAO RuWei HAN GuangBing YANG Wu | 2009 | Chinese Science Bulletin2009，54，18： | 0 |
| 17 | Magnetic rotation in Rubidium-84显示文摘High-spin states in 84 Rb have been studied by using the 70Zn(18O, p3n)84Rb reaction at beam energy of 75MeV. Three regular magnetic dipole bands including strong M1 and weak E2 transitions have been observed in this nucleus which shows the characteristic feature of magnetic rotation. These bands are interpreted in the projected shell model for the first time on the basis of the four-quasiparticle configuration of the type π(fp)π(g29/2)v(g9/2). It is shown that the calculated sequence lies roughly in the same energy range as the experimental one but the interval between neighboring levels is larger than the corresponding experimental value. We believe that a 4-quasiparticle band crossing with the 2-quasiparticle band will depress the energies of the states. | SHEN Shuifa HAN Guangbing WEN Shuxian YAN Yupeng WU Xiaoguang ZHU Lihua HE Chuangye LI Guangsheng | 2013 | Nuclear Science and Techniques2013，24，3： | 0 |
| 18 | Exchange-coupling interaction, effective anisotropy and magnetic property of nano-magnetic materials显示文摘在在 nanocrystalline 的谷物之间的联合交换的相互作用的理论和模型磁性的材料这里被介绍。他们的不足和区别 frcrn 试验性的结果被削尖 out' 和一些修订被做。阶段部件 ratio' 的效果在 nanocomposite peimanent 材料和改进模型的有效 anistropy 和磁性上的谷物尺寸和 microstnjcture 详细被讨论。 | SUN Yan GAO Ruwei HAN Baiping LIU Min HAN Guangbing FENG Weicun | 2007 | Progress in Natural Science:Materials International2007，17，2： | 0 |
| 19 | Subthermocline eddies carrying the Indonesian Throughflow water observed in the southeastern tropical Indian Ocean显示文摘We observed a subthermocline eddy(STE)with a cold and fresh core during an observation cruise along a transect of 10°S in the southeastern tropical Indian Ocean(SETIO)in December 2017.The vertical scale,speed radius,and maximum swirl velocity of the STE were about 200 m,55 km,and 0.5 m/s,respectively.The mean Rossby number and Burger number of the STE were then estimated to be about−0.7 and 2.4,indicating the STE was a submesoscale coherent vortex.The STE core water had characteristics of the Indonesian Throughflow(ITF)water and was distinct from that of surrounding areas.By examining Argo float data,another STE was well captured by five successive profiles of the same Argo float.Both STEs showed significant temperature and salinity anomalies at theσ0=26.0-26.5 kg/m3 surfaces.With the assumption that the low-salinity ITF water parcels could be carried only by surface eddies and the STEs,the Argo profiles,which detected low-salinity ITF water and were located outside a surface eddy,were believed to be inside an STE and were used to analyze the distribution,origin,and generation mechanism of the STE.The results suggested that the STEs carrying ITF water may be generated under topography-current interaction at the eastern coastal waters or under front-induced subduction in the area away from coastal waters.Those STEs may be widely distributed in the SETIO and may play a role in ITF water parcel transport. | Guangbing Yang Quanan Zheng Xuejun Xiong | 2023 | Acta Oceanologica Sinica2023，42，5： | 0 |
| 20 | Boron promoted Fe^(3+)/peracetic acid process for sulfamethazine degradation:Efficiency,role of boron,and identification of the reactive species显示文摘In this work,boron(B)was used to promote Fe^(3+)/peracetic acid(Fe^(3+)/PAA)for the degradation of sulfamethazine(SMT).An SMT degradation efficiency of 9.1%was observed in the Fe^(3+)/PAA system over 60 min,which was significantly increased to 99.3%in the B/Fe^(3+)/PAA system over 10 min.The B/Fe^(3+)/PAA process also exhibited superior resistance to natural substances,excellent adaptability to different harmful substances,and good removal of antibiotics in natural fresh water samples.The mechanism of action of boron for Fe^(3+)reduction was determined using scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared(FT-IR)spectroscopy,density functional theory(DFT)calculations,and electrochemical tests.The dominant role of^(·)OH was confirmed using quenching experiments,electron spin resonance(EPR)spectroscopy,and quantitative tests.Organic radicals(R-O^(·))and Fe(IV)also significantly contribute to the removal of SMT.DFT calculations on the reaction between Fe^(2+)and the PAA were conducted to further determine the contribution from ^(·)OH,R-O^(·),and Fe(IV)from the perspective of thermodynamics and the reaction pathways.Different boron dosages,Fe^(3+)dosages,and initial pH values were also investigated in the B/Fe^(3+)/PAA system to study their effect of SMT removal and the production of the reactive species.Fe(IV)production determined the k_(R-O·+Fe(IV))value suggesting that Fe(IV)may play a more important role than R-O^(·).A comparison of the results with other processes has also proved that the procedure described in this study(B/Fe^(3+)/PAA)is an effective method for the degradation of antibiotics. | Yanhong Zhang Guangbing Liu Yuzhu Xue Lichun Fu Yawei Qian Minhui Hou Xiang Li Chen Ling Ying Zhang Yuwei Pan | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
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