|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 2 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 3 | Power Output and Electromyography Activity of the Back Squat Exercise with Cluster Sets显示文摘 | Jordan M. Joy Jonathan M. Oliver Sean A. McCleary Ryan P. Lowery Jacob M. Wilson | 2013 | Journal of Sports Science2013，1，1： | 2 |
| 4 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 5 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 6 | Primary PTCA versus thmmbolytic therapy: An evidence-based summary显示文摘 | Ryan TJ Ryan TJ Jr Jacobs AK | 1999 | Am Heart J1999，138，： | 1 |
| 7 | Gastroschisis: what is the average gestational age of spontaneous delivery?显示文摘 | Andrea Y. Lausman Jacob C. Langer Melissa Tai P. Gareth R. Seaward Rory C. Windrim Edmond N. Kelly Greg Ryan | 2007 | Journal of Pediatric Surgery2007，，11： | 1 |
| 8 | Evaluation of floating treatment wetlands as retrofits to existing stormwater retention ponds显示文摘 | Ryan J. Winston William F. Hunt Shawn G. Kennedy Laura S. Merriman Jacob Chandler David Brown | 2013 | Ecological Engineering2013，，： | 1 |
| 9 | Treatment of chronic fatigue syndrome and fibromyalgia with D-ribose 显示文摘 | Jacob T Janelle J Ryan McGrew | 2012 | Open Pain2012，5，1： | 1 |
| 10 | The case for RAMClouds显示文摘 | John Ousterhout Parag Agrawal David Erickson Christos Kozyrakis Jacob Leverich David Mazières Subhasish Mitra Aravind Narayanan Guru Parulkar Mendel Rosenblum Stephen M. Rumble Eric Stratmann Ryan Stutsman | 2010 | ACM SIGOPS Operating Systems Review2010，，4： | 1 |
| 11 | Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study显示文摘 | Aleksandra Gentry-Maharaj Chloe Karpinskyj Clara Glazer Matthew Burnell Andy Ryan Lindsay Fraser Anne Lanceley Ian Jacobs Myra S. Hunter Usha Menon | 2015 | Menopause2015，，4： | 1 |
| 12 | Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening(UKCTOCS):a randomised controlled trial显示文摘 | Jacobs IJ Menon U Ryan A | 2016 | Lancet2016，387，10022： | 1 |
| 13 | Associations between γ-glutamyltransferase (GGT) and biomarkers of atherosclerosis: The multi-ethnic study of atherosclerosis (MESA)显示文摘 | Ryan D. Bradley Annette L. Fitzpatrick David R. Jacobs Duk-Hee Lee Nancy Swords Jenny David Herrington | 2014 | Atherosclerosis2014，，2： | 1 |
| 14 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，4： | 1 |
| 15 | The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon显示文摘 | Ryan B. MacDonald Jacob N. Pollack Mélanie Debiais-Thibaud Eglantine Heude Jared Coffin Talbot Marc Ekker | 2013 | Developmental Biology2013，，： | 1 |
| 16 | The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study显示文摘 | Jacob M. Wilson Ryan P. Lowery Jordan M. Joy J. C. Andersen Stephanie M. C. Wilson Jeffrey R. Stout Nevine Duncan John C. Fuller Shawn M. Baier Marshall A. Naimo John Rathmacher | 2014 | European Journal of Applied Physiology2014，，6： | 1 |
| 17 | 3D microfluidic gradient generator for combination antimicrobial susceptibility testing显示文摘Microfluidic concentration gradient generators(µ-CGGs)have been utilized to identify optimal drug compositions through antimicrobial susceptibility testing(AST)for the treatment of antimicrobial-resistant(AMR)infections.Conventionalµ-CGGs fabricated via photolithography-based micromachining processes,however,are fundamentally limited to two-dimensional fluidic routing,such that only two distinct antimicrobial drugs can be tested at once.This work addresses this limitation by employing Multijet-3D-printed microchannel networks capable of fluidic routing in three dimensions to generate symmetric multidrug concentration gradients.The three-fluid gradient generation characteristics of the fabricated 3Dµ-CGG prototype were quantified through both theoretical simulations and experimental validations.Furthermore,the antimicrobial effects of three highly clinically relevant antibiotic drugs,tetracycline,ciprofloxacin,and amikacin,were evaluated via experimental single-antibiotic minimum inhibitory concentration(MIC)and pairwise and three-way antibiotic combination drug screening(CDS)studies against model antibiotic-resistant Escherichia coli bacteria.As such,this 3Dµ-CGG platform has great potential to enable expedited combination AST screening for various biomedical and diagnostic applications. | Eric Sweet Brenda Yang Joshua Chen Reed Vickerman Yujui Lin Alison Long Eric Jacobs Tinglin Wu Camille Mercier Ryan Jew Yash Attal Siyang Liu Andrew Chang Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 18 | Incidence and prognostic implications of heart block complicating inferior myocardial infarction treated with thrombolytic therapy: results from TIMI Ⅱ显示文摘 | Berger PB Ryan TJ Jacobs AK | 1992 | J Am Coll Cardiol1992，20，： | 1 |
| 19 | Periodontal Status and A1C Change: Longitudinal results from the Study of Health in Pomerania (SHIP)显示文摘 | Demmer Ryan T Desvarieux Mo?se Holtfreter Birte Jacobs David R Wallaschofski Henri Nauck Matthias V?lzke Henry Kocher Thomas | 2010 | Diabetes Care2010，，5： | 1 |
| 20 | Incidence and prognostic implications of heart block complicating inferior myocardial infarction treated with thrombolytic therapy:results from TIMI Ⅱ显示文摘 | Berger PB Ryan TJ Jacobs AK | 1992 | J Am Coll Cardiol1992，20，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员