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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | Ocular drug delivery systems:An overview显示文摘The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed. | Ashaben Patel Kishore Cholkar Vibhuti Agrahari Ashim K Mitra | 2013 | World Journal of Pharmacology2013，2，2： | 18 |
| 3 | Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells显示文摘基础切除修理(BER ) 是为由消除损坏的几打维持 genomic 完整的 evolutionarily 保存的进程(氧化或烷基 ated ) 或内长地被产生或由 genotoxicants 导致了的不恰当的库,主要反应的氧种类(ROS ) 。BER 包含由脱氧核糖核酸 glycosylase 以基础切除开始的 4-5 步骤,由通常包含 AP-endonuclease (无尾猿) 产生 3' 的一条普通小径列在后面哦在损坏地点的终点,与由脱氧核糖核酸连接酶封上的 DNA 和刻痕由修复合成列在后面。这条小径也负责修理脱氧核糖核酸单个海滨与 ROS 直接产生的堵住的终点决裂。将近所有 glycosylases,比他们特别地为氧化的底的底层损害少得多,宽广、重叠的底层变化,并且能用作备份酶体内。相反,哺乳动物的房间编码仅仅一无尾猿, APE1,不同于在更低的有机体的二无尾猿。尽管有全面类似,有在哺乳动物的不同潜水艇小径的 BER 比在 E 更复杂。关口 i。glycosylases 与下游的蛋白质形成建筑群经由不同潜水艇小径执行有效修理哪个之一,负责因为海滨的修理与 NEIL 家庭 glycosylases 或由 ROS 产生的 3' 磷酸盐终点决裂,要求多核苷酸 kinase 的磷酸酶活动而不是 APE1。不同建筑群可以利用不同 DNA 和 ligases。哺乳动物的 glycosylases 非在终点之一保存了延期、为酶的活动非必需却为和另外的 BER 并且非的相互作用需要 -- 为指向的复杂形成和细胞器的 BER 蛋白质。哺乳动物的酶 covalently 有时被修改它可以影响活动和复杂形成。这评论的焦点在在为氧化损坏的哺乳动物的 BER 的早步上。 | Muralidhar L Hegde Tapas K Hazra Sankar Mitra | 2008 | Cell Research2008，18，1： | 15 |
| 4 | Smart scaffolds in bone tissue engineering: A systematic review of literature显示文摘AIM: To improve osteogenic differentiation and attachment of cells.METHODS: An electronic search was conducted inPub Med from January 2004 to December 2013. Studies which performed smart modifications on conventional bone scaffold materials were included. Scaffolds with controlled release or encapsulation of bioactive molecules were not included. Experiments which did not investigate response of cells toward the scaffold(cell attachment, proliferation or osteoblastic differentiation) were excluded. RESULTS: Among 1458 studies, 38 met the inclusion and exclusion criteria. The main scaffold varied extensively among the included studies. Smart modifications included addition of growth factors(group Ⅰ-11 studies), extracellular matrix-like molecules(group Ⅱ-13 studies) and nanoparticles(nano-HA)(group Ⅲ-17 studies). In all groups, surface coating was the most commonly applied approach for smart modification of scaffolds. In group I, bone morphogenetic proteins were mainly used as growth factor stabilized on polycaprolactone(PCL). In group Ⅱ, collagen 1 in combination with PCL, hydroxyapatite(HA) and tricalcium phosphate were the most frequent scaffolds used. In the third group, nano-HA with PCL and chitosan were used the most. As variable methods were used, a thorough and comprehensible compare between the results and approaches was unattainable.CONCLUSION: Regarding the variability in methodology of these in vitro studies it was demonstrated that smart modification of scaffolds can improve tissue properties. | Saeed Reza Motamedian Sepanta Hosseinpour Mitra Ghazizadeh Ahsaie Arash Khojasteh | 2015 | World Journal of Stem Cells2015，7，3： | 15 |
| 5 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 6 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 7 | Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome显示文摘瞄准:与 Klinefelter 的症候群(KFS ) 在 azoospermic 病人学习 Y 微删除的出现。方法:血和精液样品与 KFS 从 azoospermic 病人被收集(n = 14 ) 并且证明富饶的人的一个控制组(n = 13 ) 。精液分析根据世界卫生组织被做() 指南。血样品为 karyotyping,荧光灯的原位杂交(鱼) 和由放射性免疫测定刺激荷尔蒙(FSH ) 的血浆滤泡的测量被处理。决定 Y 微删除, 16 顺序的聚合酶链反应(PCR ) 标注了地点(圣) ,三基因(DFFRY, XKRY 和 RBM1Y ) 在孤立的 genomic DNA 上被执行。阴囊的好针渴望细胞学(FNAC ) 在选择情况中被做。结果:跨越一个 and AZFb 部位与 KFS 在 14 个 azoospermic 病人中的四个被发现的精子缺乏因素(AZF ) 的 Y 微删除。染色质组型和鱼分析表明显示出 Y 微删除的四个盒子,三个盒子有一 47, XXY/46, XY 染色体的模式和一个盒子有一 46, XY/47, XXY/48, XXXY/48, XXYY 染色体的模式。有 Y 微删除的一件样品的阴囊的 FNAC 揭示了形态学的 Sertoli 房间唯一的类型。然而,没有 Y 微删除在任何 13 个肥沃的人被观察。有 KFS 的所有病人提高了血浆 FSH 层次。结论:有 KFS 的病人可以怀有 Y 微删除并且为这些屏蔽应该是他们的诊断病情的检查的部分,特别地在那些考虑帮助了繁殖技术。 | Anurag Mitra Rima Dada Rajeev Kumar Narmada Prasad Gupta Kiran Kucheria Satish Kumar Gupta | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 8 | Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran显示文摘AIM: To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection.METHODS: This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples.All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers.RESULTS: The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively).Twelve (11%) of all family members were HBsAg positive.Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination.CONCLUSION: The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies.More attention should be paid to HBV vaccination and risk-lowering activities. | Amir Houshang Mohammad Alizadeh Mitra Ranjbar Shahin Ansari Seyed Moayed Alavian Hamid Mohaghegh Shalmani Leila Hekmat Mohammad Reza Zali | 2005 | World Journal of Gastroenterology2005，11，31： | 8 |
| 9 | Effects of Gibberellic Acid on Primary Terpenoids and △^9 -Tetrahydrocannabinol in Cannabis sativa at Flowering Stage显示文摘Plants synthesize an astonishing diversity of isoprenoids,some of which play essential roles in photosynthesis,respiration,and the regulation of growth and development.Two independent pathways for the biosynthesis of isoprenoid precursors coexist within the plant cell: the cytosolic mevalonic acid (MVA) pathway and the plastidial methylerythritol phosphate (MEP) pathway.However,little is known about the effects of plant hormones on the regulation of these pathways.In the present study we investigated the effect of gibberellic acid (GA3) on changes in the amounts of many produced terpenoids and the activity of the key enzymes,1-deoxy-D-xylulose 5-phosphate synthase (DXS) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR),in these pathways.Our results showed GA3 caused a decrease in DXS activity in both sexes that it was accompanied by a decrease in chlorophylls,carotenoids and 9-tetrahydrocannabinol (THC) contents and an increase in α-tocopherol content.The treated plants with GA3 showed an increase in HMGR activity.This increase in HMGR activity was followed by accumulation of stigmasterol and β-sitosterol in male and female plants and campestrol in male plants.The pattern of the changes in the amounts of sterols was exactly similar to the changes in the HMGR activity.These data suggest that GA3 can probably influence the MEP and MVA pathways oppositely,with stimulatory and inhibitory effects on the produced primary terpenoids in MVA and DXS pathways,respectively. | Hakimeh Mansouri Zahra Asrar Mitra Mehrabani | 2009 | Journal of Integrative Plant Biology2009，51，6： | 8 |
| 10 | 软熔过程中烧结矿和块矿的交互作用显示文摘为更好地明晰块矿的软熔行为并优化其在高炉内的使用,以烧结矿和澳大利亚纽曼混合块矿为研究对象,分别就两者在软熔过程中的物理和化学交互作用进行了试验研究。通过使用中子CT扫描软熔试验试样,发现1 450℃时烧结矿与纽曼混合块矿的混合炉料孔隙度要高于两者单一炉料,即两者间存在着物理交互作用;通过采用扫描电镜和电子探针分析发现,1 200~1 300℃温度范围内烧结矿中钙和镁扩散到了块矿中,两者发生了明显的化学交互作用。在物理和化学交互共同作用下,配加约20%纽曼混合块矿的混合炉料软熔行为得到了明显改善,且其性能相似或略好于同碱度的单一烧结矿炉料,这表明块矿和烧结矿混合后能在高炉内形成温度区间更窄、位置更低、透气性更好的软熔带。 | 刘新亮 HONEYANDS Tom O′DEA Damien MITRA Subhasish CHEN Jeff 邱光君 | 2019 | 钢铁2019，54，12： | 7 |
| 11 | 开放式基金在上升市场与下降市场中选时与选股能力的实证研究显示文摘选取我国10只开放式基金作为样本,根据它们的收益情况并联系市场背景,对它们基金管理人的选时与选股能力进行的实证研究表明,不同基金在市场上升和市场下降过程中所表现出来的选时能力指标和选股能力指标与整体指标并不相同。这一结论可用于基金整体性指标研究。 | 杨湘豫 吴许文 Gautam Mitra | 2007 | 财经理论与实践2007，28，5： | 7 |
| 12 | Incidence and risk factors of retinopathy of prematurity and utility of the national screening criteria in a tertiary center in Iran显示文摘AIM: To determine the incidence and risk factors of retinopathy of prematurity(ROP) and the sensitivity of current screening criteria in a tertiary eye center in Tehran, Iran. METHODS: In a cross-sectional observational study, neonates weighing ≤2000 grams at birth or born <34 wk gestational age(GA) and all other infants at risk of ROP admitted to the neonatal intensive care unit(NICU) or referred to our ROP clinic were investigated. The incidence of ROP and severe ROP(i.e. patients needing treatment) were determined. The associations between risk factors and the development and severity of ROP were assessed. We also examined the sensitivity of the current national screening guideline in Iran. RESULTS: Among 207 infants, the incidence of ROP and severe ROP was 33.3% and 11.1%, respectively. Mean GA and birth weight(BW) were significantly lower in ROP vs non-ROP infants(29±2 wk vs 33±3 wk, P<0.001;1274±489 g vs 1916±550 g, P<0.001, respectively). Univariate analysis displayed significant association between ROP incidence and GA, BW, NICU admission period, blood transfusion, surfactant usage, sepsis, intraventricular hemorrhage and patent ductus arteriosus(P<0.05 for all). BW [relative risk(RR): 0.857(0.711-0.873), P<0.001], GA [RR: 0.788(0.711-0.873), P<0.001] and blood transfusion [RR: 1.888(0.995-3.583), P=0.052] were independent ROP risk factors. The sensitivity of country-specific screening guidelines was 95.7% and 100% for overall and severe ROP detection, respectively. CONCLUSION: ROP incidence is relatively high in Iran. Identifying ROP risk factors results in more accurate screening and reduces the risk of irreversible vision loss. The ROP screening criteria utilized in Iran are efficient at the present time. | Milad Khorshidifar Homayoun Nikkhah Alireza Ramezani Morteza Entezari NarsisDaftarian Hamid Norouzi Mansoor Shahiari Mitra Radfar Ramin Norinia Saeed Karimi | 2019 | International Journal of Ophthalmology(English edition)2019，12，8： | 6 |
| 13 | Novel ternary g-C_3N_4/Fe_3O_4/MnWO_4 nanocomposites: Synthesis,characterization, and visible-light photocatalytic performance for environmental purposes显示文摘The g-C_3 N_4/Fe_3 O_4/MnWO_4 nanocomposites were prepared by a refluxing-calcination procedure. Visiblelight-induced photocatalytic experiments showed that the g-C_3 N_4/Fe_3 O_4/MnWO_4(10%) nanocomposite has excellent ability to degrade a range of contaminants including rhodamine B, methylene blue, methyl orange, and fuchsine, which is about 7, 10, 25, and 31 times of the g-C_3 N_4 photocatalyst, respectively.Reactive species trapping experiments revealed that superoxide anion radicals play major role in the photodegradation reaction of rhodamine B(RhB). After the treatment process, the utilized photocatalyst was magnetically recovered and reused with negligible loss in the photocatalytic activity, which is vital in the photocatalytic processes. Finally, a mechanism was proposed for the enhanced interfacial carrier separation and transfer and the improved photocatalytic performance. | Mitra Mousavi Aziz Habibi-Yangjeh Davod Seifzadeh | 2018 | Journal of Materials Science & Technology2018，34，9： | 6 |
| 14 | Analysis of decorrelator-based receivers for multirate DS/CDMA communications显示文摘 | Chen Jiangxin Urbashi Mitra | 1999 | IEEE Trans Vehicular Technology1999，，4： | 5 |
| 15 | Conf irmation of endotracheal tube placement using disposable f iberoptic bronchoscopy in the emergent setting显示文摘BACKGROUND:Patients intubated in the prehospital setting require quick and definitive confirmation of endotracheal (ET) tube placement upon arrival to the emergency department (ED).Direct and adjunct strategies exist,but each has limitations and there is no definitive gold standard.The utility of bronchoscopy in ED intubation has been studied,but scant literature exists on its use for ET tube confirmation.This study aims to assess effectiveness,ease and speed with which ET tube placement can be confirmed with disposable fiberoptic bronchoscopy.METHODS:Emergency medicine residents recruited from a 3-year urban residency program received 5 minutes of active learning on a simulation mannequin using a disposable,flexible Ambu aScope interfaced with a monitor.With residents blinded,the researcher randomly placed the ET tube in the trachea,esophagus or right mainstem.Residents identified ET tube position by threading the bronchoscope through the tube and viewing distal anatomy.Each resident underwent 4 trials.Accuracy,speed and perceptions of difficulty were measured.RESULTS:Residents accurately identified the location of the ET tube in 88 out of 92 trials (95.7%).The median time-to-guess was 7.0 seconds,IQR (5.0-10.0).Average perceived difficulty was 1.6 on a scale from 1-5 (1 being very easy and 5 being very difficult).No tubes were damaged or dislodged.CONCLUSION:While simulation cannot completely replicate the live experience,fiberoptic bronchoscopy appears to be a quick and accurate method for ET tube confirmation.Further studies directly comparing this novel approach to established practices on actual patients are warranted. | Avir Mitra Asaf Gave Kelsey Coolahan Thomas Nguyen | 2019 | World Journal of Emergency Medicine2019，10，4： | 5 |
| 16 | Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract显示文摘Objective:To evaluate the wound healing and antimicrobial activity of root extracts of Ixora coccinea(I.coccinea).Methods:To investigate the wound healing efficacy of root extract of I.coccinea Linn,five groups of animals were divided each containing six animals.Two wound models including incision and excision wound models were used in this study.The parameters studied were tensile strength on incision wound model and in terms of wound contraction for excision wound model were compared with standard Nitrofurazone(NFZ) ointment(0.2%w/w). Six extracts(ethanol.aqueous,petroleum ether,benzene,chloroform and ethyl acetate ) of I. coccinea were screened for in vitro growth inhibiting activity against different bacterial strains riz. Staphylococcia aureus.Bacillus pumilius,Enterococcus facialis.Escherichia coli,Salmonella typhi and Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger were compared with the standard drugs ciprofloxacin and chloramphenicol for antibacterial and griscofulvin for antifungal screening.The serial dilution and cup(or) well plate methods were used for the antimicrobial study and MIC was determined.Results:The ethanolic extract showed significant (P<0.001) wound healing activity when compared to standard drug NFZ with respect to normal control group.Amongst all.ethanolic extract showed highly significant antibacterial activity against all bacterial strains used in this study when compared to standard.The aqueous extract showed moderate significant inhibition against all bacterial strains when compared to standard. All the extracts were shown negligible activity against the fungal strains used in this study. Conclusions:The ethanolic root extract of I.coccinea showed pronounced wound healing and antibacterial activity.The probable reason to heal the wound was that the external application of the extract prevented the microbes to invade through the wound thus the protection of wound occurs against the infection of the various organisms. | Nagaraj Selvaraj Baskar Lakshmanan Papiya Mitra Mazumder Muthukumar Karuppasamy Simon Santosh Jena Ashok Kumar Pattnaik | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 5 |
| 17 | Multimodality management of gallbladder cancer can lead to a better outcome:Experience from a tertiary care oncology centre in North India显示文摘BACKGROUND Surgical resection is a treatment of choice for gallbladder cancer(GBC)patients but only 10%of patients have a resectable disease at presentation.Even after surgical resection,overall survival(OS)has been poor due to high rates of recurrence.Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.AIM To summarize our single-center experience with multimodality management of resectable GBC patients.METHODS Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database.Information extracted included demographics,operative and perioperative details,histopathology,neoadjuvant/adjuvant therapy,follow-up,and recurrence.To know the factors associated with recurrence and OS,univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables,respectively.Multivariate analysis was done using multiple regression analysis.RESULTS Of 274 patients with GBC taken up for surgical resection,172(62.7%)were female and the median age was 56 years.On exploration,102 patients were found to have a metastatic or unresectable disease(distant metastasis in 66 and locally unresectable in 34).Of 172 patients who finally underwent surgery,93(54%)underwent wedge resection followed by anatomical segment IVb/V resection in 66(38.4%)and modified extended right hepatectomy in 12(7%)patients.The postoperative mortality at 90 d was 4.6%.During a median follow-up period of 20 mo,71(41.2%)patients developed recurrence.Estimated 1-,3-,and 5-years OS rates were 86.5%,56%,and 43.5%,respectively.Estimated 1-and 3-year disease free survival(DFS)rates were 75%and 49.2%,respectively.On multivariate analysis,inferior OS was seen with pT3/T4 tumor(P=0.0001),perineural invasion(P=0.0096),and R+resection(P=0.0125).However,only pT3/T4 tumors were associated with a poor DFS(P<0.0001).CONCLUSION Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%.R+resection,higher T stage,and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes.Multimodality treatment of GBC has potential to improve the survival of GBC patients. | Shaifali Goel Abhishek Aggarwal Assif Iqbal Vineet Talwar Swarupa Mitra Shivendra Singh | 2021 | World Journal of Gastroenterology2021，27，45： | 5 |
| 18 | Investigations for the assessment of adult patients presenting to the emergency department with supraventricular tachycardia显示文摘Dear editor,Patients with supraventricular tachycardia(SVT)commonly present to the emergency department(ED).Current guidelines[1,2]do not recommend routine pathology testing and a report on the topic has questioned their role.A systematic review concluded that troponin testing is commonly performed with a high proportion of positive fi ndings,but these results were not associated with major adverse cardiac events.[3]The conclusions of this review were limited by paucity of data and heterogeneity among studies. | Harith Fernando Nicholas Adams Biswadev Mitra | 2020 | World Journal of Emergency Medicine2020，11，1： | 4 |
| 19 | Development of flexible zinc–air battery with nanocomposite electrodes and a novel separator显示文摘In this paper, we present the development of flexible zinc–air battery. Multiwalled carbon nanotubes(MWCNTs) were added into electrodes to improve their performance. It was found that MWCNTs were effective conductive additive in anode as they bridged the zinc particles. Poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS) was applied as a co-binder to enhance both the conductivity and flexibility. A poly(acrylic acid)(PAA) and polyvinyl alcohol(PVA) coated paper separator was used to enhance the battery performance where the PVP–PAA layer facilitated electrolyte storage. The batteries remained functional under bending conditions and after bending. Multiple design optimizations were also carried out for storage and performance purposes. | Zhiqian Wang Xianyang Meng Zheqiong Wu Somenath Mitra | 2017 | Journal of Energy Chemistry2017，26，1： | 4 |
| 20 | Heterojunction DDR THz IMPATT diodes based on Al_xGa_(1-x)N/Ga N material system显示文摘Simulation studies are made on the large-signal RF performance and avalanche noise properties of heterojunction double-drift region(DDR) impact avalanche transit time(IMPATT) diodes based on Alx Ga1 xN/Ga N material system designed to operate at 1.0 THz frequency. Two different heterojunction DDR structures such as n-Al0:4Ga0:6N/p-Ga N and n-Ga N/p-Al0:4Ga0:6N are proposed in this study. The large-signal output power, conversion efficiency and noise properties of the heterojunction DDR IMPATTs are compared with homojunction DDR IMPATT devices based on Ga N and Al0:4Ga0:6N. The results show that the n-Al0:4Ga0:6N/p-Ga N heterojunction DDR device not only surpasses the n-Ga N/p-Al0:4Ga0:6N DDR device but also homojunction DDR IMPATTs based on Ga N and Al0:4Ga0:6N as regards large-signal conversion efficiency, power output and avalanche noise performance at 1.0 THz. | Suranjana Banerjee Monojit Mitra | 2015 | Journal of Semiconductors2015，36，6： | 4 |
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