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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | CO2-induced destabilization of pyrite-structured FeO2Hx in the lower mantle显示文摘Volatiles, such as carbon and water, modulate the Earth's mantle rheology, partial melting and redox state,thereby playing a crucial role in the Earth's internal dynamics. We experimentally show the transformation of goethite FeOOH in the presence of CO_2 into a tetrahedral carbonate phase, Fe_4C_3O_(12), at conditions above 107 GPa—2300 K. At temperatures below 2300 K, no interactions are evidenced between goethite and CO_2, and instead a pyrite-structured FeO_2 Hx is formed as recently reported by Hu et al.(2016; 2017)and Nishi et al.(2017). The interpretation is that, above a critical temperature, FeO_2 Hx reacts with CO_2 and H_2, yielding Fe_4C_3O_(12) and H_2 O. Our findings provide strong support for the stability of carbon-oxygen-bearing phases at lower-mantle conditions. In both subducting slabs and lower-mantle lithologies, the tetrahedral carbonate Fe_4C_3O_(12) would replace the pyrite-structured FeO_2 Hx through carbonation of these phases. This reaction provides a new mechanism for hydrogen release as H2 O within the deep lower mantle. Our study shows that the deep carbon and hydrogen cycles may be more complex than previously thought, as they strongly depend on the control exerted by local mineralogical and chemical environments on the CO_2 and H_2 thermodynamic activities. | Eglantine Boulard Francois Guyot Nicolas Menguy Alexandre Corgne Anne-Line Auzende Jean-Philippe Perrillat Guillaume Fiquet | 2018 | National Science Review2018，5，6： | 2 |
| 3 | Linear osmoregulated periplasmic glucans are encoded by the opgGH locus of Pseudomonas aeruginosa 显示文摘 | Yannick L Eglantine R Aurelie D | 2007 | Microbiology2007，153，： | 1 |
| 4 | The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon显示文摘 | Ryan B. MacDonald Jacob N. Pollack Mélanie Debiais-Thibaud Eglantine Heude Jared Coffin Talbot Marc Ekker | 2013 | Developmental Biology2013，，： | 1 |
| 5 | Tensile properties and work hardening behaviors o{ ultrafine grained carbon steel and pure iron processed by warm high pressure torsion显示文摘 | NING J L EGLANTINE C M LILIA K | 2013 | Materials Science and Engineering~ A2013，，： | 1 |
| 6 | Thorium/uranium mixed oxide nanocrystals: Synthesis, structural characterization and magnetic properties显示文摘 | Damien Hudry Jean-Christophe Griveau Christos Apostolidis Olaf Walter Eric Colineau Gert Rasmussen Di wang Venkata Sai Kiran Chakravadhaluna Eglantine Courtois Christian Kubel Daniel Meyer | 2014 | Nano Research2014，7，1： | 0 |
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