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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Power Output and Electromyography Activity of the Back Squat Exercise with Cluster Sets显示文摘 | Jordan M. Joy Jonathan M. Oliver Sean A. McCleary Ryan P. Lowery Jacob M. Wilson | 2013 | Journal of Sports Science2013，1，1： | 2 |
| 3 | Performance of optical OFDM in ultralong-haul WDM lightwave systems显示文摘 | LOWERY J DU L ARMSTRONG J | 2007 | J of Lightwave Technol2007，25，1： | 1 |
| 4 | Posterior percutaneous spine instrumentation 显示文摘 | Lowery GL Kulkarni SS | 2000 | Eur Spine J2000，9，1： | 1 |
| 5 | Rejection of an MHC class II negative tumor following induction of murine syngeneic graft-versus-host disease显示文摘 | Bryson JS Jennings CD Lowery DM | 1999 | Bone Marrow Transplant1999，23，4： | 1 |
| 6 | Self-Reflexivity:A Place for Religion and Spirituality in Public Administration显示文摘 | LOWERY D | 2005 | Public Administration Review2005，，3： | 1 |
| 7 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 8 | Inhibition of aphid (Homoptera: Aphididae) reproduction by neem seed oil and azadirachtin 显示文摘 | LOWERY D T ISMAN M B | 1996 | J Econ Entomol1996，89，3： | 1 |
| 9 | OUM- A180 nm nonvolatile memory cell element technology for stand- alone and embedded applications 显示文摘 | Lai S Lowery T | 2001 | IEEE IEDM Technical Digest2001，5，： | 1 |
| 10 | Experi- mental Demonstrations of Electronic Dispersion Com- pensation for Long-Haul Transmission Using Direct- Detection Optical OFDM 显示文摘 | Schmidt B J C Lowery A J Armstrong J | 2008 | Journal of Lightwave Technology2008，26，1： | 1 |
| 11 | Dysregulated miRNA- 183 inhibits migration in breast cancer cells显示文摘 | Lowery A J Miller N Dwyer RM | 2010 | BMC Cancer2010，10，： | 1 |
| 12 | Protein measurement with the Folin phenol reagent 显示文摘 | Lowery OH Rosebrough NJ Farr AL | 1951 | Biol Chem1951，193，： | 1 |
| 13 | Posterior percutaneous spine instrumentation显示文摘 | Lowery GL Kulkarni SS | 2000 | Eur Spine2000，9，1： | 1 |
| 14 | Rejection of an MHC class Ⅱ negative tumor following induction of murine syngeneic graft-versus-host disease 显示文摘 | Bryson JS Jennings CD Lowery DM | 1999 | Bone Marrow Transplant1999，23，4： | 1 |
| 15 | Thyroid lymphoma:recent advances in diagnosis and optimal management strategies显示文摘 | Walsh S Lowery AJ Evoy D | 2013 | Oncologist2013，18，9： | 1 |
| 16 | Etiologic factors associated with patellofemoral pain in runners显示文摘 | Messier SP Davis SE Curl WW Lowery RB Pack RJ | | 0，，： | 1 |
| 17 | Changing practices in the surgical management of hyperparathyroidism-a 10-year review 显示文摘 | Mc Veigh T Lowery AJ Quill DS | 2012 | Surgeon2012，10，6： | 1 |
| 18 | physical properties of selected soil by erosion clss显示文摘 | Lowery B Swan J Schumacher T | 1995 | Soil and Water Cons1995，50，3： | 1 |
| 19 | Positional synthetic cloning and functional characterization of the mammadian circadian mutation tau显示文摘 | Lowery PL Shimonura K Antoch MP | 2000 | Science2000，288，5465： | 1 |
| 20 | The use of titanium surgical mesh-bone graft composite in the anterior thoracic or lumbar spine after complete or partial corpectomy显示文摘 | Bhat AL Lowery GL Sei A | 1999 | Eur Spine J1999，8，4： | 1 |
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