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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | 面向未来的电驱动技术显示文摘效率是未来技术最重要的考量要素之一,车辆的续驶里程由电池的容量和车辆的能耗决定。增加电池容量会进一步提高重量和成本,因此节能是非常重要的。本文中采埃孚对未来电驱动技术作出了展望,包括电动脱开装置、800V与碳化硅及如何设计800V电驱系统等。 | Stephan Demmerer | 2020 | 汽车制造业2020，，11： | 2 |
| 3 | Periodontal microbiota and carotid intima-media thickness:the oral infections and vascular disease epidemiology study (INVEST)显示文摘 | Dasvarieux M Demmer RT Rundek T | 2005 | Circulation2005，111，5： | 1 |
| 4 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom 显示文摘 | Demmers T GM Phillips V R Short L S | 2001 | Journal of Agricultural Engineering Research2001，79，1： | 1 |
| 5 | Relationship Between Periodontal Disease , Tooth Loss, and Carotid Ariery Plaque : Infections and Vascular Disease Epideiology Study 显示文摘 | Desvarieux M Demmer RT Tatjana R | 2003 | Stroke2003，34，9： | 1 |
| 6 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom显示文摘 | Demmers T G M Phillips VR Short L S | 2001 | Journal of Agricultural Engineering Research2001，，： | 1 |
| 7 | Trophoblast interferon and pregnancy显示文摘 | Demmers K J Derecka K Flint A | 2001 | Journals of Reproduction and Fertility2001，121，： | 1 |
| 8 | The case for technology for developing regions显示文摘 | Brewer E Demmer M Du B | 2005 | IEEE Computer2005，38，6： | 1 |
| 9 | The influ- ence of type 1 and type 2 diabetes on periodontal disease progression: prospective results from the Study of Health in Pomerania显示文摘 | Demmer RT Holtfreter B Desvarieux M | 2012 | Diabetes Care2012，35，10： | 1 |
| 10 | Spherical organelles, analogous to seed protein bodies, fluctuate seasonally in parenchymatous cells of hard woods显示文摘 | Wetzel S Demmers C Greewood J S | 1989 | Canada Journal of Botany1989，67，： | 1 |
| 11 | Relationship between periodontal disease, tooth loss, and carotid artery plaque:the Oral infections and Vascular Disease Epidemiology Study ( INVEST ) 显示文摘 | Desvarieux M Demmer R Rundek T | 2003 | Stroke2003，34，9： | 1 |
| 12 | Cloning and expressionof the transferring and ferrin genes in a marsupial,the brushtail (trichosurus wlpecula) 显示文摘 | Demmer J Stasiuk S J Adamski F M | 1999 | Biochimacaet BiophysicaActa1999，14，： | 1 |
| 13 | Relationship between periodontal disease,tooth loss,and carotid artery plaque:the Oral Infections and Vascular Disease Epidemiology Study (INVEST)显示文摘 | Desvarieux M Demmer RT Rundek T | 2003 | Stroke2003，34，9： | 1 |
| 14 | Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity显示文摘 | Jacek Jaworski Lukas C. Kapitein Susana Montenegro Gouveia Bjorn R. Dortland Phebe S. Wulf Ilya Grigoriev Paola Camera Samantha A. Spangler Paola Di Stefano Jeroen Demmers Harm Krugers Paola Defilippi Anna Akhmanova Casper C. Hoogenraad | | Neuron0，，： | 1 |
| 15 | The relationship between periodontal disease,tooth loss,and carotid artery plaque:the Oral Infections and Vasular Disease Eepidmiology Study(INCEST)显示文摘 | Desvarieux M Demmer RT Rundek T | | 0，，： | 1 |
| 16 | Periodontal infections and cardiovascular disease: the heart of the matter显示文摘 | Demmer RT Desvarieux M | 2006 | J Am Dent Assoc2006，，： | 1 |
| 17 | Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST) 显示文摘 | Desvarieux M Demmer RT Rundek T | 2005 | Circulation2005，111，5： | 1 |
| 18 | Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy显示文摘 | Pushpakumara PG Robinson RS Demmers KJ | 2002 | Reproduction2002，123，6： | 1 |
| 19 | Bioinfornatics techniques in microarray research:applied microarray data analysis using R and SAS software显示文摘 | Demmer RT Pavlidis P Papapanou PN | 2010 | Methods Mol Biol2010，666，： | 1 |
| 20 | An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells显示文摘 | Debbie L.C. van den Berg Tim Snoek Nick P. Mullin Adam Yates Karel Bezstarosti Jeroen Demmers Ian Chambers Raymond A. Poot | 2010 | Cell Stem Cell2010，，4： | 1 |
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