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| 1 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 2 | Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease显示文摘AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess. | Indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 3 | 吸烟者肺局部IgA变化及对抗原的免疫应答显示文摘目的 研究吸烟对年轻吸烟者肺局部免疫功能的损害。方法 对 12名健康志愿者 (其中 5名吸烟 )行右肺中叶肺灌洗 (BAL) ,分析肺灌洗 (BALF)中IgA型别、细胞分类计数、白蛋白含量 ,并从左肺舌肺叶内注入钥孔血蓝蛋白抗原 ,观察肺局部抗原免疫后血循环中特异性IgA抗体的免疫应答能力。结果 吸烟者BALF中单体IgA含量、白细胞数、巨噬细胞数显著高于不吸烟者 ,而双体IgA含量未见增加 ;BALF中单体IgA含量与白蛋白含量、白细胞数量呈正相关。肺局部抗原免疫后血清特异性IgA应答表现为抗体出现晚、峰值低、下降早的特点。结论 早期吸烟可引起年轻吸烟者支气管肺泡炎症反应并导致肺局部免疫应答功能损害。 | 黄曙海 黄萍 David N. Weissman | 2000 | 中华预防医学杂志2000，34，5： | 4 |
| 4 | 隐静脉移植血管钙化的发生率、部位、程度及临床相关性:一项血管内超声及血管造影研究 | Castagna M.T. Mintz G.S. Ohlmann P. N.J. Weissman 苏畅 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，9： | 3 |
| 5 | Plasticity of Adult Stem Cells显示文摘 | Amy J Wagers Irving L Weissman | 2004 | Cell2004，，5： | 2 |
| 6 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 7 | Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘Acute pancreatitis is of one the most common gastroenterology-related indications for hospital admissions worldwide.With the widespread reliance on endoscopic retrograde cholangiopancreatography(ERCP)for the management of pancreaticobiliary conditions,post-ERCP pancreatitis(PEP)has come to represent an important etiology of acute pancreatitis.Despite many studies aiming to better understand the pathogenesis and prevention of this iatrogenic disorder,findings have been heterogeneous,and considerable variation in clinical practice exists.Herein,we review the literature regarding PEP with the goal to raise awareness of this entity,discuss recent data,and present evidence-based best practices.We believe this manuscript will be useful for gastrointestinal endoscopists as well as other specialists involved in the management of patients with PEP. | Simcha Weissman Mohamed Ahmed Matthew R Baniqued Dean Ehrlich James H Tabibian | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，6： | 2 |
| 8 | Redefining and Redesigning Hospital Discharge to Enhance Patient Care: A Randomized Controlled Study显示文摘 | Richard B. Balaban Joel S. Weissman Peter A. Samuel Stephanie Woolhandler | 2008 | Journal of General Internal Medicine2008，，8： | 2 |
| 9 | Acute hemodynamic changes during carotid artery stenting显示文摘 | Mendelsohn F O Weissman N J Lederman R J | 1998 | Am J Cardiol1998，82，9： | 2 |
| 10 | 应激的代谢反应:总看法与新进展显示文摘近来,手术应激反应日益受到麻醉医师的关注,因为麻醉技术能调节这些反应。本文就手术操作期间发生的代谢、激素、免疫反应进行了论述。特别是它及时借助了最新免疫学和内分泌学领域的知识。 | Weissman C 张卫 | 1992 | 国外医学(麻醉学与复苏分册)1992，13，1： | 2 |
| 11 | Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights显示文摘The gut microbiome plays an important role in the variation of pharmacologic response.This aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing therapy.The impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of research.Pancreatic adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very limited.Newer studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of PAC.This review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC. | Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman | 2023 | World Journal of Gastroenterology2023，29，25： | 2 |
| 12 | CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis显示文摘 | Siddhartha Jaiswal Catriona H.M. Jamieson Wendy W. Pang Christopher Y. Park Mark P. Chao Ravindra Majeti David Traver Nico van Rooijen Irving L. Weissman | 2009 | Cell2009，，2： | 2 |
| 13 | CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells显示文摘 | Ravindra Majeti Mark P. Chao Ash A. Alizadeh Wendy W. Pang Siddhartha Jaiswal Kenneth D. Gibbs Nico van Rooijen Irving L. Weissman | 2009 | Cell2009，，2： | 2 |
| 14 | Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression显示文摘 | Lei S. Qi Matthew H. Larson Luke A. Gilbert Jennifer A. Doudna Jonathan S. Weissman Adam P. Arkin Wendell A. Lim | 2013 | Cell2013，，： | 2 |
| 15 | Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression显示文摘 | Lei S. Qi Matthew H. Larson Luke A. Gilbert Jennifer A. Doudna Jonathan S. Weissman Adam P. Arkin Wendell A. Lim | 2013 | Cell2013，，： | 2 |
| 16 | CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes显示文摘 | Luke A. Gilbert Matthew H. Larson Leonardo Morsut Zairan Liu Gloria A. Brar Sandra E. Torres Noam Stern-Ginossar Onn Brandman Evan H. Whitehead Jennifer A. Doudna Wendell A. Lim Jonathan S. Weissman Lei S. Qi | 2013 | Cell2013，，2： | 2 |
| 17 | Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart 显示文摘 | Cerqueira MD Weissman N J Dilsizian V | 2002 | Circulation2002，105，4： | 1 |
| 18 | L- selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis 显示文摘 | Qian F Hanahan D Weissman IL | 2001 | Proc Natl Acad Sci USA2001，98，7： | 1 |
| 19 | Lipohemarthtosis of the knee: a review of recent experiences 显示文摘 | Lee JH Weissman BN Nikpoor N | 1989 | Radiology1989，173，1： | 1 |
| 20 | Translating stem and progenitor cell biology to the clinic:barriers and opportunities显示文摘 | | 2000 | J Science2000，287，5457： | 1 |
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