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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Dysregulation of the miR-146a-Smad4 axis impairs osteogenesis of bone mesenchymal stem cells under inflammation显示文摘Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population.Although inflammation contributes significantly to osteoporosis, the underlying mechanism is unclear. In this study, we found that tumor necrosis factor(TNF)-α, an inflammatory environment mimic, inhibits osteogenesis of bone mesenchymal stem cells(BMSCs), induces mi R-146 a and decreases Smad4. Moreover,overexpression of mi R-146 a inhibited the osteogenic ability of BMSCs, whereas blocking mi R-146 a partially rescued the osteogenesis deficiency under TNF-α treatment. Molecularly, mi R-146 a decreased Smad4 expression at the protein level by binding to an element located in the Smad4 30-untranslated region, and restoration of Smad4 reversed the inhibitory effects of mi R-146 a on osteogenesis. Together, our results showed that the inflammatory environment mimic TNF-α inhibits osteogenesis via upregulation of mi R-146 a and subsequent downregulation of Smad4, thus suggesting that therapeutic manipulation of mi R-146 a maybe a potential strategy to improve osteogenesis in the context of osteoporosis. | Wei Kuang Liwei Zheng Xin Xu Yao Lin Jiong Lin Jiahua Wu Jiali Tan | 2017 | Bone Research2017，5，4： | 13 |
| 4 | IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome显示文摘Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development. | Xiang Lin Xiaohui Wang Fan Xiao Kongyang Ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 13 |
| 5 | PMAC-based Tracking Control System for 8-axis Automated Tape-laying Machine显示文摘为实现自动铺带工艺的特殊要求,搭建了铺带专用开放式数控系统;为实现超声切割运动子系统与铺带头主运动实时联动,采用PMAC的随动模式与时基控制方式将两者的运动有机衔接。该系统以PMAC运动控制卡为核心,以工控机为上位机,且与多数字I/O板卡(PCL-725,PCL-730)并行控制的方式,为提高5轴铺带主运动与3轴超声切割子系统运动的实时同步性,采用PMAC卡中的时基随动功能实现各种切割情况。为实现了数控系统软件中的运动控制及其与开关动作量之间的协调联动的任务,采用WINDOW2000操作系统平台,并完成了各控制器的驱动程序、用户图形界面和数控代码编译模块的设计。该系统能很好解决铺带机多轴运动控制精度要求较高、运动量与较多动作量联动实时性等设计难点。 | Liu Lin Li Yong Wen Liwei Xiao Jun | 2009 | Chinese Journal of Aeronautics2009，22，5： | 11 |
| 6 | Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis显示文摘最近的研究在嗅觉的薄板 propria 作为居民干细胞的一种新类型识别了嗅觉的 ecto 间充质的干细胞(OE-MSCs ) 。然而,它仍然保持不清楚是否 OE-MSCs 拥有任何 immunoregulatory 功能。在这研究,我们发现老鼠 OE-MSCs 比骨头表示了更高转变的生长因素贝它和 interleukin-10 层次导出髓的 MSC。在文化, OE-MSCs 经由直接压制受动器 T 房间增长并且增加规章的 T (Treg ) 房间扩大施加了他们的抑制免疫力的能力。在有导致骨胶原的关节炎的老鼠, OE-MSCs 的采纳转移显著地压制了关节炎发作和疾病严厉,它被增加的 Treg 房间伴随并且在 vivo 减少了 Th1/Th17 房间回答。一起拿,我们的调查结果在调整 T 房间回答识别了 OE-MSCs 的新奇功能,显示那 OE-MSCs 可以为风湿性关节炎和另外的自体免疫的疾病的处理代表新房间治疗。 | Ke Rui Zhijiang Zhang Jie Tian Xiang Lin Xiaohui Wang Jie Ma Xinyi Tang Huaxi Xu Liwei Lu Shengjun Wang | 2016 | Cellular & Molecular Immunology2016，13，3： | 8 |
| 7 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 8 | Photo-induced transformations of Hg(Ⅱ) species in the presence of Nitzschia hantzschiana,ferric ion,and humic acid显示文摘Effects of algae Nitzschia hantzschiana, Fe(Ⅲ) ions, humic acid, and pH on the photochemical reduction of Hg(Ⅱ) using the irradiation of metal halide lamps (λ 365 nm, 250 W) were investigated. The photoreduction rate of Hg(Ⅱ) was found to increase with increasing concentrations of algae, Fe(Ⅲ) ions, and humic acid. Alteration of pH value affected the photoreduction of Hg(Ⅱ) in aqueous solution with or without algae. The photoreduction rate of Hg(II) decreased with increasing initial Hg(Ⅱ) concentration in aqueous solution in the presence of algae. The photochemical kinetics of initial Hg(Ⅱ) and algae concentrations on the photoreduction of Hg(Ⅱ) were studied at pH 7.0. The study on the total Hg mass balance in terms of photochemical process revealed that more than 42% of Hg(Ⅱ) from the algal suspension was reduced to volatile metallic Hg under the conditions investigated. | Lin Deng Nansheng Deng Liwei Mou Fangtong Zhu | 2010 | Journal of Environmental Sciences2010，22，1： | 7 |
| 9 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 10 | Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome显示文摘Immunoproteasome activation in immune cells is involved in the modulation of immune responses.Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases,but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren’s syndrome(SS).Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS(ESS)in mice.In this study,we detected high levels of low-molecular-weight protein 7(LMP7),a key subunit of the immunoproteasome,in Th17 cells from ESS mice.Moreover,treatment with bortezomib(BTZ),a proteasome inhibitor,markedly suppressed Th17 differentiation in both murine and human naive T cells in culture.Furthermore,ESS mice treated with BTZ displayed significantly higher saliva flow rates and a reduction in tissue destruction in the salivary glands compared with vehicle-treated ESS mice.Notably,BTZ-treated ESS mice showed markedly decreased Th17 cells,germinal center B cells and plasma cells in the peripheral lymphoid organs.In addition,adoptively transferred wild type naive CD4+T cells rapidly differentiated into Th17 cells and induced salivary dysfunction in IL-17-deficient mice immunized for ESS induction.However,BTZ treatment profoundly suppressed the donor T-cell-derived Th17 response and ameliorated the reduction in salivary secretion in IL-17-deficient recipient mice.Taken together,our findings demonstrate that proteasome inhibition can effectively ameliorate ESS by suppressing the Th17 response,which may contribute to the development of a novel therapeutic strategy for the treatment of SS. | Fan Xiao Xiang Lin Jie Tian Xiaohui Wang Qian Chen Ke Rui Jie Ma Shengjun Wang Qingwen Wang Xiaoqi Wang Dongzhou Liu Lingyun Sun Liwei Lu | 2017 | Cellular & Molecular Immunology2017，14，11： | 6 |
| 11 | Kirigami-inspired,highly stretchable microsupercapacitor patches fabricated by laser conversion and cutting显示文摘The recent developments in material sciences and rational structural designs have advanced the field of compliant and deformable electronics systems.However,many of these systems are limited in either overall stretchability or areal coverage of functional components.Here,we design a construct inspired by Kirigami for highly deformable microsupercapacitor patches with high areal coverages of electrode and electrolyte materials.These patches can be fabricated in simple and efficient steps by laser-assisted graphitic conversion and cutting.Because the Kirigami cuts significantly increase structural compliance,segments in the patches can buckle,rotate,bend and twist to accommodate large overall deformations with only a small strain(<3%)in active electrode areas.Electrochemical testing results have proved that electrical and electrochemical performances are preserved under large deformation,with less than 2%change in capacitance when the patch is elongated to 382.5%of its initial length.The high design flexibility can enable various types of electrical connections among an array of supercapacitors residing in one patch,by using different Kirigami designs. | Renxiao Xu Anton Zverev Aaron Hung Caiwei Shen Lauren Irie Geoffrey Ding Michael Whitmeyer Liangjie Ren Brandon Griffin Jack Melcher Lily Zheng Xining Zang Mohan Sanghadasa Liwei Lin | 2018 | Microsystems & Nanoengineering2018，4，1： | 6 |
| 12 | 3D-printed microelectronics for integrated circuitry and passive wireless sensors显示文摘Three-dimensional(3D)additive manufacturing techniques have been utilized to make 3D electrical components,such as resistors,capacitors,and inductors,as well as circuits and passive wireless sensors.Using the fused deposition modeling technology and a multiple-nozzle system with a printing resolution of 30μm,3D structures with both supporting and sacrificial structures are constructed.After removing the sacrificial materials,suspensions with silver particles are injected subsequently solidified to form metallic elements/interconnects.The prototype results show good characteristics of fabricated 3D microelectronics components,including an inductor–capacitor-resonant tank circuitry with a resonance frequency at 0.53 GHz.A 3D“smart cap”with an embedded inductor–capacitor tank as the wireless passive sensor was demonstrated to monitor the quality of liquid food(e.g.,milk and juice)wirelessly.The result shows a 4.3%resonance frequency shift from milk stored in the room temperature environment for 36 h.This work establishes an innovative approach to construct arbitrary 3D systems with embedded electrical structures as integrated circuitry for various applications,including the demonstrated passive wireless sensors. | Sung-Yueh Wu Chen Yang Wensyang Hsu Liwei Lin | 2015 | Microsystems & Nanoengineering2015，1，1： | 5 |
| 13 | Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy显示文摘Extensive studies have demonstrated that mesenchymal stem cells(MSCs)are multipotent mesoderm-derived stromal cells that can differentiate into a variety of cell types,including adipocytes,osteoblasts,chondrocytes,myocytes and neuronal cells.1 MSCs are found in numerous organs and tissues,including bone marrow,heart,lung,muscle,peripheral blood,adipose tissue,cartilage,synovium,dental pulp,tonsil,umbilical cord,placenta,thymus and olfactory mucosa.1 MSCs have been shown to possess potent immunosuppressive functions and tissue repair capacities,which have facilitated the clinical applications of MSCs in treating a diverse range of disorders involving angiogenesis and fibrosis,including rheumatic diseases and graft-versus-host diseases.2,3 Here,we provide a brief commentary on newly emerging evidence of the immunoregulatory function and potential application of ecto-mesenchymal stem cells. | Ke Rui Xiang Lin Jie Tian Xiaohui Wang Lingyun Sun Xiaoping Hong Dongzhou Liu Shengjun Wang Liwei Lu | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 14 | Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding显示文摘A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes.Here,three-dimensional(3D)printed polymer molds are used to construct multilayer poly(dimethylsiloxane)(PDMS)devices by employing unique molding,bonding,alignment,and rapid assembly processes.Specifically,a novel single-layer,two-sided molding method is developed to realize two channel levels,non-planar membranes/valves,vertical interconnects(vias)between channel levels,and integrated inlet/outlet ports for fast linkages to external fluidic systems.As a demonstration,a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure,illustrating a high degree of flow rate control.In addition,multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels.Using integrated alignment marks to accurately position both stamps and individual layers,this technique is demonstrated by rapidly assembling a six-layer microfluidic device.By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS,this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems. | Casey C.Glick Mitchell T.Srimongkol Aaron J.Schwartz William S.Zhuang Joseph C.Lin Roseanne H.Warren Dennis R.Tekell Panitan A.Satamalee Liwei Lin | 2016 | Microsystems & Nanoengineering2016，2，1： | 4 |
| 15 | Fabrication of Si-based three-dimensional microbatteries: A review显示文摘 | Chuang YUE Jing LI ChuangYUE Liwei LIN | 2017 | Frontiers of Mechanical Engineering2017，12，4： | 2 |
| 16 | An electronic nose using a single graphene FET and machine learning for water, methanol, and ethanol显示文摘The poor gas selectivity problem has been a long-standing issue for miniaturized chemical-resistor gas sensors.The electronic nose(e-nose)was proposed in the 1980s to tackle the selectivity issue,but it required top-down chemical functionalization processes to deposit multiple functional materials.Here,we report a novel gas-sensing scheme using a single graphene field-effect transistor(GFET)and machine learning to realize gas selectivity under particular conditions by combining the unique properties of the GFET and e-nose concept.Instead of using multiple functional materials,the gas-sensing conductivity profiles of a GFET are recorded and decoupled into four distinctive physical properties and projected onto a feature space as 4D output vectors and classified to differentiated target gases by using machine-learning analyses.Our single-GFET approach coupled with trained pattern recognition algorithms was able to classify water,methanol,and ethanol vapors with high accuracy quantitatively when they were tested individually.Furthermore,the gas-sensing patterns of methanol were qualitatively distinguished from those of water vapor in a binary mixture condition,suggesting that the proposed scheme is capable of differentiating a gas from the realistic scenario of an ambient environment with background humidity.As such,this work offers a new class of gas-sensing schemes using a single GFET without multiple functional materials toward miniaturized e-noses. | Takeshi Hayasaka Albert Lin Vernalyn C.Copa Lorenzo P.Lopez Jr Regine A.Loberternos Laureen Ida M.Ballesteros Yoshihiro Kubota Yumeng Liu Arnel A.Salvador Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 17 | Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset:an in vitro study显示文摘Persistent hypotonic and inflammatory conditions in the joint cavity can lead to the loss of cartilage matrix and cell death,which are the important mechanisms of osteoarthritis(OA)onset.Previous studies have confirmed that the existence of a hypotonic environment is a red flag for inflammation,as hypotonic environment induces the opening of the chloride channel of the cell and promotes chloride ion efflux,which prompts the cell volume to increase.Chloride channels play an important role in the regulation of mineralization and chondrocyte death.Here,we reported that OA chondrocytes showed a significant increase of cell death rate and the imbalance of cartilage matrix catabolism.We found that the distribution of skeleton protein F-actin was disordered.In addition,the volume-sensitive chloride current of OA chondrocytes decreased significantly with the increase of the expression levels of inflammation-related proteins caspase-1,caspase-3,and NLRP3.Moreover,interleukin-1β(IL-1β)showed a potential to activate the chloride current of normal chondrocytes.These results indicate that IL-1β-induced chloride channel opening in chondrocytes may be closely related to the occurrence of OA.This chloride channel opening process may therefore be a potential target for the treatment of OA. | Zhiqin Deng Zicong Lin Qing Zhong Minqiang Lu Huankun Fang Jianquan Liu Li Duan Lixin Chen Liwei Wang Daping Wang Wencui Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 2 |
| 18 | The expanding functional diversity of plasma cells in immunity and inflammation显示文摘The generation and function of plasma cells have been well recognized as the central events in humoral immunity.In particular,long-lived plasma cells,characterized by a long lifespan and the lack of cell division,persistently secrete high-affinity antibodies to maintain serum antibody titers in the immune response and autoimmune inflammation.Although the significant expansion of plasma cells is observed during the aging process,autoimmune diseases and chronic infections,the expanding functional diversity and underlying mechanisms of plasma cells remain incompletely understood.Here,we describe recent advances in revealing new functional subsets and phenotypic features of plasma cells in aging and autoimmunity. | Kongyang Ma Xiaohui Wang Xiaofei Shi Xiang Lin Fan Xiao Xin Ma Dongzhou Liu Liwei Lu | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 19 | Deep learning for non-parameterized MEMS structural design显示文摘The geometric designs of MEMS devices can profoundly impact their physical properties and eventual performances.However,it is challenging for researchers to rationally consider a large number of possible designs,as it would be very time-and resource-consuming to study all these cases using numerical simulation.In this paper,we report the use of deep learning techniques to accelerate the MEMS design cycle by quickly and accurately predicting the physical properties of numerous design candidates with vastly different geometric features.Design candidates are represented in a nonparameterized,topologically unconstrained form using pixelated black-and-white images.After sufficient training,a deep neural network can quickly calculate the physical properties of interest with good accuracy without using conventional numerical tools such as finite element analysis.As an example,we apply our deep learning approach in the prediction of the modal frequency and quality factor of disk-shaped microscale resonators.With reasonable training,our deep learning neural network becomes a high-speed,high-accuracy calculator:it can identify the flexural mode frequency and the quality factor 4.6×10^(3)times and 2.6×10^(4)times faster,respectively,than conventional numerical simulation packages,with good accuracies of 98.8±1.6%and 96.8±3.1%,respectively.When simultaneously predicting the frequency and the quality factor,up to~96.0%of the total computation time can be saved during the design process.The proposed technique can rapidly screen over thousands of design candidates and promotes experience-free and data-driven MEMS structural designs. | Ruiqi Guo Fanping Sui Wei Yue Zekai Wang Sedat Pala Kunying Li Renxiao Xu Liwei Lin | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 20 | New insights into the significance of the BCR repertoire in B-1 cell development and function显示文摘As an important player of innate immunity,B-1 cells have been characterized by natural antibody production and rapid immune response.Based on their expression or lack of CD5,B-1 cells are further separated into B-1a and B-1b subsets.1 Although extensive studies have demonstrated a pivotal role of conventional B cells in adaptive immunity,there is increasing evidence indicating the close associations of B-1a cells with self-reactivity,autoimmunity,infection,and even leukemia.2–4 Here,we describe recent advances that lead to a clearer understanding of B-1 cell development with a focus on new insights into the significance of the B-cell receptor(BCR)repertoire in B-1a cell biology and discuss the potential strategies for specific targeting of B-1a cells under pathological settings. | Xiaohui Wang Cong Ye Xiang Lin Kongyang Ma Fan Xiao Lingli Dong Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，9： | 2 |
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