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| 1 | 为十二指肠的胃肠的 stromal 肿瘤的有限切除术:外科的管理和临床的结果显示文摘 AIM:To analyze our experience in patients with duodenal gastrointestinal stromal tumors(GIST) and review the appropriate surgical approach.METHODS:We retrospectively reviewed the medical records of all patients with duodenal GIST surgically treated at our medical institution between 2002 and 2011.Patient files,operative reports,radiological charts and pathology were analyzed.For surgical therapy open and laparoscopic wedge resections and segmental resections were performed for limited resection(LR).For extended resection pancreatoduodenectomy was performed.Age,gender,clinical symptoms of the tumor,anatomical localization,tumor size,mitotic count,type of resection resectional status,neoadjuvant therapy,adjuvant therapy,risk classification and follow-up details were investigated in this retrospective study.RESULTS:Nine patients(5 males/4 females) with a median age of 58 years were surgically treated.The median follow-up period was 45 mo(range 6-111 mo).The initial symptom in 6 of 9 patients was gastrointestinal bleeding(67%).Tumors were found in all four parts of the duodenum,but were predominantly located in the first and second part of the duodenum with each 3 of 9 patients(33%).Two patients received neoadjuvant medical treatment with 400 mg imatinib per day for 12 wk before resection.In one patient,the GIST resection was done by pancreatoduodenectomy.The 8 LRs included a segmental resection of pars 4 of the duodenum,5 wedge resections with primary closure and a wedge resection with luminal closure by Roux-Y duodeno-jejunostomy.One of these LRs was done minimally invasive;seven were done in open fashion.The median diameter of the tumors was 54 mm(14-110 mm).Using the Fletcher classification scheme,3/9(33%) tumors had high risk,1/9(11%) had intermediate risk,4/9(44%) had low risk,and 1/9(11%) had very low risk for aggressive behaviour.Seven resections showed microscopically negative transsection margins(R0),two showed positive margins(R1).No patient developed local recurrence during follow-up.The one patient who underwent pancreatoduodenectomy died due to progressive disease with hepatic metastasis but without evidence of local recurrence.Another patient died in complete remission due to cardiac disease.Seven of the nine patients are alive disease-free.CONCLUSION:In patients with duodenal GIST,limited surgical resection with microscopically negative margins,but also with microscopically positive margins,lead to very good local and systemic disease-free survival. | Jens Hoeppner Birte Kulemann Goran Marjanovic Peter Bronsert Ulrich Theodor Hopt | 2013 | World Journal of Gastrointestinal Surgery2013，5，2： | 11 |
| 2 | Postoperative adjunctive bevacizumab versus placebo in primary trabeculectomy surgery for glaucoma显示文摘AIM: To compare the effectiveness of postoperative adjunctive use of subconjunctival bevacizumab in altering the outcome of primary trabeculectomy in terms of sustained lowering of intraocular pressure(IOP) and reduction of postoperative bleb vascularization and fibrosis.METHODS: A prospective, one center, randomized, placebo-control study. Fifty-nine patients(59 eyes) with uncontrolled IOP under maximal tolerated medical treatment(MTMT) were recruited. A primary trabeculectomy with mitomycin C(MMC) was done and the patients were randomized to either postoperative subconjunctival injection of bevacizumab(1.25 mg/0.05 mL) or balanced salt solution(BSS). Forty-seven patients(47 eyes) completed at least one year of follow up and were included in the study. The main outcome measure was the IOP, and secondary outcome measures include bleb morphology, vascularization, and fibrosis, as well as the need for glaucoma medications and 5-fluorouracil(5-FU) needling.RESULTS: At 1-year follow up, there was no significant difference between groups for IOP(P=0.65), bleb morphology(P=0.65), and the need for glaucoma medications(P=0.65) or 5-FU needling requirements(P=0.11). However, the bevacizumab group had a higher rate of success results, lower use of glaucoma medications after surgery, and optimal bleb aspect in more patients, but more 5-FU needling procedures required. CONCLUSION: A bigger sample size is needed in order to determine whether the differences found in the bevacizumab group are statistically significant. | Sana’Muhsen Javiera Compan Tze Lai Christoph Kranemann Catherine Birt | 2019 | International Journal of Ophthalmology(English edition)2019，12，10： | 4 |
| 3 | Interventional strategies in infected necrotizing pancreatitis:Indications,timing,and outcomes显示文摘Acute pancreatitis(AP)is one of the most common gastrointestinal diseases and remains a life-threatening condition.Although AP resolves to restitutio ad integrum in approximately 80%of patients,it can progress to necrotizing pancreatitis(NP).NP is associated with superinfection in a third of patients,leading to an increase in mortality rate of up to 40%.Accurate and early diagnosis of NP and associated complications,as well as state-of-the-art therapy are essential to improve patient prognoses.The emerging role of endoscopy and recent trials on multidisciplinary management of NP established the“step-up approach”.This approach starts with endoscopic interventions and can be escalated to other interventional and ultimately surgical procedures if required.Studies showed that this approach decreases the incidence of new multiple-organ failure as well as the risk of interventional complications.However,the optimal interventional sequence and timing of interventional procedures remain controversial.This review aims to summarize the indications,timing,and treatment outcomes for infected NP and to provide guidance on multidisciplinary decision-making. | Birte Purschke Louisa Bolm Max Nikolaus Meyer Hiroki Sato | 2022 | World Journal of Gastroenterology2022，28，27： | 4 |
| 4 | From Proteomics to Structural Studies of Cytosolic/MitochondriaI-Type Thioredoxin Systems in Barley Seeds显示文摘 | Azar Shahpiri Birte Svensson Christine Finnie | 2009 | Molecular Plant2009，2，3： | 3 |
| 5 | Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses显示文摘AIM: To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS: Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline concentration, intra-abdominal adhesions, and a histological score concerning the mucosal ischemic injury were collected. The data are given as median (range).RESULTS: On postoperative day 4, median bursting pressure was 124 mmHg (60-146 mmHg) in the control group. The experimental groups did not show a statistically significant difference (P > 0.05). Regarding the hydroxyproline concentration, we did not find any significant variation in the experimental groups. We detected significantly less mucosal injury in the RIPC groups. Furthermore, we assessed more extensive intra-abdominal adhesions in the preconditioned groups than in the control group. CONCLUSION: RIPC directly before performing small bowel anastomosis does not affect anastomotic stability in the early period, as seen in ischemic preconditioning. | Philipp Anton Holzner Birte Kulemann Simon Kuesters Sylvia Timme Jens Hoeppner Ulrich Theodor Hopt Goran Marjanovic | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 6 | STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo显示文摘 | Melanie Spitzner Birte Roesler Christian Bielfeld Georg Emons Jochen Gaedcke Hendrik A. Wolff Margret Rave‐Fr?nk Frank Kramer Tim Beissbarth Julia Kitz Jürgen Wienands B. Michael Ghadimi Reinhard Ebner Thomas Ried Marian Grade | 2014 | Int J Cancer2014，，4： | 2 |
| 7 | Identification of Shewanella baltica as the most important H2S-producing species during iced storage of Danish marine fish显示文摘 | BIRTE F V KASTHURI V MASATAKA S | | 0，，11： | 1 |
| 8 | Cellular and molecular basis for endometriosis-associated infertility 显示文摘 | Stilley JA Birt JA Sharpe-Timms KL | 2012 | Cell Tissue Res2012，349，3： | 1 |
| 9 | Networks, clusters and innovation in tourism: AUK experience 显示文摘 | Marina Novelli Birte Schmitz Trisha Spencer | 2006 | Tourism Management2006，，27： | 1 |
| 10 | Human factors design guide (HFDG) for acquisition of commercial off-the-shelf subsystems, non-developmental iteoas, and developmental systems显示文摘 | WAGNER D BIRT J A SNYDER M D | 1996 | Design1996，，： | 1 |
| 11 | Elucidation of Listeria monocytogenes contamination routes in cold-smoked salmon processing plants detected by DNA-based typing methods显示文摘 | Birte Fonnesbech vogel Hans Henrik Huss Bente Ojeniyi | 2001 | Applied and Environmental Microbiology2001，67，6： | 1 |
| 12 | Loss of CD34 and high IGF2 are associated with malignant transformation in solitary fibrous tumors显示文摘 | Birte Schulz Annelore Altendorf-Hofmann | 2014 | Pathology-Research and Practice2014，210，： | 1 |
| 13 | A catalytically independent physiologi- cal function for human acute phase protein group IIA phospholipase A2:cellular uptake facilitates cell debris removal显示文摘 | Birts CN Barton CH Wihon DC | 2005 | J Biol Chem2005，283，8： | 1 |
| 14 | Explaining the diffusion of renewable energy technology in developing countries显示文摘 | Birte P Peter M | 2013 | Energy Economics2013，40，： | 1 |
| 15 | A review of NDE methods for porosity measurement in fibre-reinforced polymer composites显示文摘 | Birt E A Smith R A | 2004 | Non- Destructive Testing and Condition Monitoring2004，46，11： | 1 |
| 16 | Analysis of reliability indices from Humphrey visual field tests in an urban glaucoma population显示文摘 | Birt CM Shin DH Samudrala V | 1997 | Ophthalmology1997，104，： | 1 |
| 17 | Recovery charaeter-istics using single-breath 8% sevoflurane or propofolforindue-tion of anaesthesia in day-case arthroscopy patients显示文摘 | Dashfield AK Birt DJ Thurlow J | 1998 | Anaesthe -sia1998，53，： | 1 |
| 18 | A review of NDE methods for porosity measurement in fibre-reinforced polymer composites显示文摘 | Birt E A Smith R A | 2004 | NonDestructive Testing and Condition Monitoring2004，46，11： | 1 |
| 19 | Distal molar movement with Kloehn headgear:Isit stable显示文摘 | Birte M Michel D | 2003 | Am J Orthod Dentofacial Orthop2003，123，4： | 1 |
| 20 | Applicability of X - radiography to the inspection of Composites 显示文摘 | Anne Birt E | 2000 | Non - Destructive Testing and Condition Monitoring2000，42，3： | 1 |
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