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| 1 | Biliary cast syndrome:literature review and a single centre experience in liver transplant recipients显示文摘BACKGROUND:Biliary cast syndrome(BCS)is an unusual complication of orthotopic liver transplantation (OLTx),and its management is difficult.Limited success using endoscopic retrograde cholangiopancreatography (ERCP)or open exploration to clear casts has been reported, but failure usually results in re-transplantation.We aimed to review our experience with BCS and highlight a novel combined percutaneous and endoscopic approach for duct clearance.A brief review of the literature is given. METHODS:We retrospectively reviewed our experience of managing BCS using case notes review.Details were also gathered from radiology,where interventional procedures were carried out. RESULTS:We had a total of three cases of BCS reported between 2002 and 2005.Multiple attempts were made to remove these casts.All three were treated in a variety of ways.Management is discussed along with highlighting a novel combined percutaneous and endoscopic approach for duct clearance. CONCLUSIONS:BCS is a potential complication of OLTx. Surgical and endoscopic methods of removing casts are used.However,in circumstances where these methods are technically difficult,a percutaneous endoscopic approach with serial dilatation of the cutaneous port and surgical removal of casts can be done. | Narasimhaiah Srinivasaiah Mettu Srinivas Reddy Schlok Balupuri David Talbot Bryon Jaques Derek Manas | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 8 |
| 2 | Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence显示文摘AIM: To study the correlation between the patterns of subcellular expression of p16 and CDK4 in colorectal epithelia in the normal-adenoma-carcinoma sequence. METHODS: Paraffin sections of 43 cases of normal colorectal epithelia and corresponding adenomas as well as carcinomas were analysed immunocytochemically for subcellular expression of p16 and CDK4 proteins. RESULTS: Most carcinomas showed more cytoplasmic overexpression for p16 and CDK4 than the adenomas from which they arised or the adjacent normal mucosa. Most normal or non-neoplastic epithelia showed more p16 and CDK4 expression in the nucleus than their adjacent adenomas and carcinomas. There was a significant difference between the subcellular expression pattern of p16 and CDK4 in normal-adenoma-carcinoma sequence epithelia (P < 0.001). Neither p16 nor CDK4 subcellular patterns correlated with histological grade or Dukes’ stage. CONCLUSION: Interaction of expression of p16 and CDK4 plays an important role in the Rb/p16 pathway. Overexpression of p16 and CDK4 in the cytoplasm, as well as loss expression of p16 in the nucleus might be important in the evolution of colorectal carcinoma from adenoma and, of adenoma from normal epithelia. | PO Zhao Xin Mao Ian C Talbot | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 3 | 砾性土液化评价方法的通用性和可靠性研究显示文摘以2008年汶川地震液化震害调查资料为背景,基于操作性和经济性上具有显著优势的中国动力触探试验(DPT)而提出的砾性土液化评价方法,包括砾性土层液化触发条件以及判别公式(CYY公式),理论上已经得到国内外同行的认可,但其通用性和可靠性尚需检验。以5个国家29个历史地震砾性土场地中美联合勘测为基础,研究DPT技术、砾性土层液化触发条件和CYY公式在不同国家、不同地震和不同场地的适用性和可靠性问题,其中,成都平原14个砾性土场地的勘测与数据处理由中方完成,美国、意大利、新西兰、厄瓜多尔等15个砾性土场地的勘测与数据处理由美方Rollins教授主导完成,均为新的测试检验点。结果表明:中国动力触探标准探头在不同国家、不同砾性土场地上测试具有可行性,可以有效穿透20 m的砾性土场地,动探击数可作为砾性土液化评价的核心指标,同时亦可扩展到砾性土层的力学性能评价;不同国家、不同砾性土液化场地上,均存在不排水或排水不畅的埋藏条件,符合砾性土层液化触发条件要求;对动力触探击数进行锤击能量、有效上覆压力等修正后,CYY公式在不同国家、不同地震、不同砾性土液化场地的判别成功率约96%,具有较高可靠性。以2008年汶川地震砾性土液化为背景、以动力触探锤击数为基本指标的砾性土液化评价方法,具有国际通用的可行性。 | 曹振中 Kyle M.Rollins 袁晓铭 T.Leslie Youd Michael Talbot Jashod Roy Sara Amoroso | 2019 | 岩土工程学报2019，41，9： | 5 |
| 4 | ON THE TRAIL OF A CEREAL KILLER: Exploring the Biology of Magnaporthe grisea显示文摘 | Nicholas J. Talbot | 2003 | Annual Review of Microbiology2003，，： | 3 |
| 5 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 6 | Retinal vascular changes associated with transpupillary thermotherapy for choroidal melanomas显示文摘 | Currie ZI Rennie IF Talbot JF | 2000 | Retina2000，20，： | 2 |
| 7 | Number of COVID-19 cases required in a population to detect SARS-CoV-2 RNA in wastewater in the province of Alberta, Canada:Sensitivity assessment显示文摘With a unique and large size of testing results of 1,842 samples collected from 12 wastewater treatment plants (WWTP) for 14 months through from low to high prevalence of COVID-19,the sensitivity of RT-qPCR detection of SARS-CoV-2 RNA in wastewater that correspond to the communities was computed by using Probit analysis.This study determined the number of new COVID-19 cases per 100,000 population required to detect SARS-CoV-2RNA in wastewater at defined probabilities and provided an evidence-based framework of wastewater-based epidemiology surveillance (WBE).Input data were positive and negative test results of SARS-CoV-2 RNA in wastewater samples and the corresponding new COVID-19 case rates per 100,000 population served by each WWTP.The analyses determined that RT-qPCR-based SARS-CoV-2 RNA detection threshold at 50%,80%and 99%probability required a median of 8 (range:4-19),18 (9-43),and 38 (17-97) of new COVID-19 cases/100,000,respectively.Namely,the positive detection rate at 50%,80%and 99%probability were 0.01%,0.02%,and 0.04%averagely for new cases in the population.This study improves understanding of the performance of WBE SARS-CoV-2 RNA detection using the large datasets and prolonged study period.Estimated COVID-19 burden at a community level that would result in a positive detection of SARS-CoV-2 in wastewater is critical to support WBE application as a supplementary warning/monitoring system for COVID-19 prevention and control. | Qiaozhi Li Bonita E.Lee Tiejun Gao Yuanyuan Qiu Erik Ellehoj Jiaao Yu Mathew Diggle Graham Tipples Rasha Maal-Bared Deena Hinshaw Christopher Sikora Nicholas J.Ashbolt James Talbot Steve E.Hrudey Xiaoli Pang | 2023 | Journal of Environmental Sciences2023，，3： | 2 |
| 8 | Dangers of adding insulin to intravenous infusion bags with fixed needle syringes显示文摘 | Talbot EM | 1984 | Br Med J1984，28，9： | 2 |
| 9 | Evidence for the Role Evolutionary Increase Yield in Cotton of Transfer Cells in the in Seed and Fiber Biomass显示文摘 | Deborah A. Pugh Christina E. Offler Mark J. Talbot Yong-Ling Ruan | 2010 | Molecular Plant2010，3，6： | 2 |
| 10 | Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis显示文摘 | Matthew Rutter Brian Saunders Kay Wilkinson Steve Rumbles Gillian Schofield Michael Kamm Christopher Williams Ashley Price Ian Talbot Alastair Forbes | 2004 | Gastroenterology2004，，： | 2 |
| 11 | Thirty-Year Analysis of a Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis显示文摘 | Matthew D. Rutter Brian P. Saunders Kay H. Wilkinson Steve Rumbles Gillian Schofield Michael A. Kamm Christopher B. Williams Ashley B. Price Ian C. Talbot Alastair Forbes | 2006 | Gastroenterology2006，，： | 2 |
| 12 | FM-dyes as experimental probes for dissecting vesicle trafficking in living plant cells 显示文摘 | Bolte S Talbot C Boutte Y | 2004 | Journal of Microscopy2004，214，2： | 1 |
| 13 | MMP-2 and MMP-9 type Ⅳ collagenases in colorectal cancer显示文摘 | Talbot I Smith RA | 1996 | Cancer Res1996，56，1： | 1 |
| 14 | Feline islands of Calleja complex:Cytoarchitectural organization and comparative anatomy显示文摘 | Talbot K Woolf NJ Butcher LL | 1988 | J Comp Neurol1988，275，4： | 1 |
| 15 | Pressure and Velocity Distribution for Air Flow Through Fruits Packed in Shipping Containers Using Porous Media Flow Analysis 显示文摘 | Talbot M T Oliver C C Gaffney P E | 1990 | ASHARE Transactions1990，9，： | 1 |
| 16 | Matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 ( MMP9 ),type ⅣV collagenase in colorectal cancer显示文摘 | Liabakk NB Talbot Ⅰ Smith RA | 1996 | Cancer Res1996，56，： | 1 |
| 17 | Randomised,phase Ⅱ trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines显示文摘 | Talbot DC Moiseyenko V van Belle S | 2002 | Br J Cancer2002，86，： | 1 |
| 18 | Uptake of Streptococcus pneumoniae by respiratory epithelial eells 显示文摘 | TALBOT U M PATON A W PATON J C | 1996 | Infeet Immun1996，64，： | 1 |
| 19 | A phase Ⅱ trial of docetaxel and estramustine in patients with refractory metastatic breast carcinoma 显示文摘 | TIERSTEN AD NELSEN C TALBOT SL | 2003 | Cancer2003，97，3： | 1 |
| 20 | Posterolateral ap- proach for open reduction and internal fixation of tri- malleolar ankle fractures显示文摘 | Talbot M Steenblock TR Cole PA | 2005 | Can J Surg2005，48，6： | 1 |
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