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| 1 | Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding显示文摘AIM:To identify optimum timing to maximize diagnostic yield by capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB).METHODS:We identified patients who underwent CE at our institution from August 2003 to December 2009.Patient medical records were reviewed to determine type of OGIB (occult,overt),CE results and complications,and timing of CE with respect to onset of bleeding.RESULTS:Out of 385 patients investigated for OGIB,284 (74%) had some lesion detected by CE.In 222 patients (58%),definite lesions were detected that could unequivocally explain OGIB.Small bowel ulcer/erosions secondary to Crohn's disease,tuberculosis or non-steroidal anti-inflammatory agent use were the commonest lesions detected.Patients with overt GI bleeding for < 48 h before CE had the highest diagnostic yield (87%).This was significantly greater (P < 0.05) compared to that in patients with overt bleeding prior to 48 h (68%),as well as those with occult OGIB (59%).CONCLUSION:We established the importance of early CE in management of OGIB.CE within 48 h of overt bleeding has the greatest potential for lesion detection. | Mahesh Kumar Goenka Shounak Majumder Sanjeev Kumar Pradeepta Kumar Sethy Usha Goenka | 2011 | World Journal of Gastroenterology2011，17，6： | 39 |
| 2 | Palliation:Hilar cholangiocarcinoma显示文摘Hilar cholangiocarcinomas are common tumors of the bile duct that are often unresectable at presentation. Palliation, therefore, remains the goal in the majority of these patients. Palliative treatment is particularly indicated in the presence of cholangitis and pruritus but is often also offered for high-grade jaundice and abdominal pain. Endoscopic drainage by placing stents at endoscopic retrograde cholangio-pancreatography(ERCP) is usually the preferred modality of palliation. However, for advanced disease, percutaneous stenting has been shown to be superior to endoscopic stenting. Endosonography-guided biliary drainage is emerging as an alternative technique, particularly when ERCP is not possible or fails. Metal stents are usually preferred over plastic stents, both for ERCP and for percutaneous bili-ary drainage. There is no consensus as to whether it is necessary to place multiple stents within advanced hi-lar blocks or whether unilateral stenting would suffice. However, recent data have suggested that, contrary to previous belief, it is useful to drain more than 50% of the liver volume for favorable long-term results. In the presence of cholangitis, it is beneficial to drain all of the obstructed biliary segments. Surgical bypass plays a limited role in palliation and is offered primarily as asegment Ⅲ bypass if, during a laparotomy for resec-tion, the tumor is found to be unresectable. Photody-namic therapy and, more recently, radiofrequency abla-tion have been used as adjuvant therapies to improve the results of biliary stenting. The exact technique to be used for palliation is guided by the extent of the bili-ary involvement(Bismuth class) and the availability of local expertise. | Mahesh Kr Goenka Usha Goenka | 2014 | World Journal of Hepatology2014，6，8： | 16 |
| 3 | 不同人工泪液对体外培养的人角结膜上皮细胞的毒性作用比较显示文摘干眼是泪液分泌量不足、泪膜稳定性受损所致的眼部疾病[1-2].流行病学研究表明,在世界范围内,干眼发病率很高,与老龄、妇女围绝经期、配戴隐形眼镜及自身免疫性疾病等有关[3-5],其中亚洲人群中发病率约为17% ~ 33% [6-9],而白种人发病率相对较低,约为7%~14.6%[3,10].目前,干眼最常用的治疗方法是眼表滴用人工泪液,由于干眼是慢性疾患,大部分患者需长期用药,因此其长期疗效和安全性值得关注.本研究比较了不同成分的人工泪液对体外培养的人角膜和结膜上皮细胞的毒性作用,以期为临床用药提供试验依据. | Malik Kahook Cullen T. Vogelson Usha Sivaprasad David A. Ammar | 2012 | 中华眼科杂志2012，48，2： | 11 |
| 4 | Capsule endoscopy:Present status and future expectation显示文摘Video capsule endoscopy(CE)since its introduction 13years back,has revolutionized our approach to small intestinal diseases.Obscure gastrointestinal bleed(OGIB)continues to be the most important indication for CE with a high sensitivity,specificity as well as positive and negative predictive values.It is best performed during ongoing bleed or immediately thereafter.Overt OGIB has a higher diagnostic yield than occult OGIB.However,even in iron deficiency anemia,CE is emerging as important investigation after initial negative work up.In suspected Crohn’s disease(CD),CE has been shown superior to traditional imaging and endoscopic technique and should be considered after a negative ileocolonoscopy.Although CE has also been used for evaluating established CD,a high capsule retention rate precludes its use ahead of cross-sectional imaging.Celiac disease,particularly where gastro-duodenoscopy cannot be performed or is normal,can also be investigated by CE.Small bowel tumor,hereditary polyposis syndrome,and non-steroidal anti-inflammatory drugs induced intestinal damage are other indications for CE.Capsule retention is the only significant adverse outcome of CE and occurs mostly in presence of intestinal obstruction.This can be prevented by use of Patency capsule prior to CE examination.Presence of cardiac pacemaker and intracardiac devices continue to be relative contraindications for CE,though data do not suggest interference of CE with these devices.Major limitations of CE today include failure to control its movement from outside,inability of CE to acquire tissue for diagnosis,and lack of therapeutic help.With ongoing interesting and exciting developments taking place in these areas,these issues would be solved in all probability in near future.CE has the potential to become one of the most important tools in diagnostic and possibly in the therapeutic field of gastrointestinal disorder. | Mahesh K Goenka Shounak Majumder Usha Goenka | 2014 | World Journal of Gastroenterology2014，20，29： | 9 |
| 5 | Perfusion computed tomography in renal cell carcinoma显示文摘Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs. | Chandan J Das Usha Thingujam Ananya Panda Sanjay Sharma Arun Kumar Gupta | 2015 | World Journal of Radiology2015，7，7： | 8 |
| 6 | 结膜滤过泡组织病理学特性显示文摘目的:描述并比较在修复小梁切除术和由于疏忽造成的滤过泡时得到的的结膜的组织学特征并评价抗纤维变性药物的作用。方法:我们对经过晚期滤过泡修复的28只眼的结膜标本采用常规石蜡制作的方法和光学显微镜下检查进行仔细观察:19只眼为渗漏的小梁切除术滤过泡,5只眼为无渗漏的小梁切除术滤过泡,4只眼为由于疏忽造成的滤过泡。定量分析的组织学特征包括结膜上皮的厚度,基质血管供应,鳞状组织化生,基质炎症细胞浸润和杯状细胞的密度。并且分析了手术类型,存在渗漏,先前的局部用药,应用抗纤维化药物都与组织学检查所见并置对比。结果:与由于疏忽造成的滤过泡的对照组相比,小梁切除术的滤过泡(渗漏的和无渗漏的)显示上皮的厚度(P〈0.02),杯状细胞的密度(P〈0.001)和血管供应(P〈0.001)全部降低。接受过抗纤维化药物的结膜比先前未受抗纤维化药物影响的结膜的上皮细胞层数更少(P〈0.05)。结论:小梁切除术后切除的薄的滤过泡的组织学分析证明上皮的厚度和杯状细胞的密度与由于疏忽造成的滤过泡相比均降低。与正常结膜相比。 | Brian A. Francis Lee T. Du Kathryn Najafi Raghu Murthy Usha Kurumety Narsing Rao Don S. Minckler 李航(译) 申敏如(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 8 |
| 7 | 环鸟苷酸依赖的蛋白激酶对心血管功能的调节作用显示文摘环鸟苷酸(cGMP)依赖的蛋白激酶(PKG)是一氧化氮-cGMP的主要细胞内受体,在哺乳动物细胞中分为PKG-I和PKG-II两型。在PKG介导的血管平滑肌舒张作用中,其主要通过活化细胞膜上的钙活化的钾通道(BK通道),磷酸化肌质网上的受磷蛋白(phospholamban,PLB)和三磷酸肌醇受体相关的PKG-I底物(IP3receptor-associated PKG-I substrate,IRAG),降低细胞内Ca2+浓度。PKG还可通过活化肌球蛋白轻链磷酸酶及抑制Rho激酶降低肌球蛋白对Ca2+敏感性。PKG调节血管平滑肌细胞的基因表达和表型调变,调节细胞增生。PKG活化以后还具有抑制血小板聚集,抑制心肌细胞肥大等功能。最近的研究证明,PKG的表达水平和活性改变与动脉粥样硬化和再狭窄、高血压、糖尿病心血管病变以及硝酸盐耐受等的发病机制有密切关系。 | 王晓华 童梅 窦豆 Usha J Raj 高远生 | 2005 | 生理科学进展2005，36，4： | 7 |
| 8 | Multimodality imaging of ovarian cystic lesions: Review with an imaging based algorithmic approach显示文摘Ovarian cystic masses include a spectrum of benign, borderline and high grade malignant neoplasms. Imaging plays a crucial role in characterization and pretreatment planning of incidentally detected or suspected adnexal masses, as diagnosis of ovarian malignancy at an early stage is correlated with a better prognosis. Knowledge of differential diagnosis, imaging features, management trends and an algorithmic approach of such lesions is important for optimal clinical management. This article illustrates a multi-modality approach in the diagnosis of a spectrum of ovarian cystic masses and also proposes an algorithmic approach for the diagnosis of these lesions. | Ashish P Wasnik Christine O Menias Joel F Platt Usha R Lalchandani Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 7 |
| 9 | Endoscopic ultrasound guided thrombin injection of angiographically occult pancreatitis associated visceral artery pseudoaneurysms:Case series显示文摘Pseudoaneurysm is a known complication of pancreatitis associated with significant mortality and morbidity. Imaging plays an important role in the diagnosis and management. Computed tomography(CT) helps localize the lesion and the severity of the background pancreatitis but digital subtraction angiography with coil embolization is recommended to avoid bleeding and inadvertent surgery. However, in cases where angiographic coil embolization is not feasible due to technical reasons, thrombin injection via CT or ultrasound guidance remains a viable option and often described in literature. In this series, effort has been made to highlight the role of endoscopic ultrasound guided thrombin instillation especially in patients with poorly visualized pseudoaneurysm on ultrasound thereby avoiding surgery and the associated mortality and morbidity. | Shivanand Gamanagatti Usha Thingujam Pramod Garg Surajkumar Nongthombam Nihar Ranjan Dash | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，13： | 6 |
| 10 | 铁鞣新方法显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上呈的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，9： | 4 |
| 11 | Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products显示文摘Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration from the remaining neurons(Schwab and Strittmatter,2014).However,the local environment in the central nervous | Tiffany K.Fan Usha Gundimeda William J.Mack Rayudu Gopalakrishna | 2016 | Neural Regeneration Research2016，11，4： | 3 |
| 12 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 13 | Endotherapy of leaks and fistula显示文摘Perforations, leaks and fistula involving gastrointestinal(GI) tract are increasing encountered in clinical practice. There is a changing paradigm for their management with surgical approach being replaced by conservative approach including endoscopic therapy. Clips(through the scope and over the scope) and covered stent are front runners for endotherapy for GI leaks and fistula.Over the scope clips introduced recently, can treat larger defects compared to through the scope clips. Covered stents are suited for larger defects and those associated with luminal narrowing. However cervical esophagus, gastro-esophageal junction, stomach and right colonic lesions may be better for clip therapy rather than stenting. Recent developments in this field include use of endovac therapy which consists of a sponge with suction device, biodegradable stent, use of fibrin glue and some endo-suturing device. Conservative therapy with no surgical or endoscopic intervention, may be suitable for a small subset of patients. An algorithm based on location, size of defect, associated stricture, infection and available expertise needs to be developed to reduce the mortality and morbidity of this difficult clinical problem. | Mahesh Kumar Goenka Usha Goenka | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 3 |
| 14 | Imaging-based algorithmic approach to gallbladder wall thickening显示文摘Gallbladder(GB) wall thickening is a frequent finding caused by a spectrum of conditions. It is observed in many extracholecystic as well as intrinsic GB conditions. GB wall thickening can either be diffuse or focal. Diffuse wall thickening is a secondary occurrence in both extrinsic and intrinsic pathologies of GB, whereas, focal wall thickening is mostly associated with intrinsic GB pathologies. In the absence of specific clinical features, accurate etiological diagnosis can be challenging. The survival rate in GB carcinoma(GBC) can be improved if it is diagnosed at an early stage, especially when the tumor is confined to the wall. The pattern of wall thickening in GBC is often confused with benign diseases, especially chronic cholecystitis, xanthogranulomatous cholecystitis, and adenomyomatosis. Early recognition and differentiation of these conditions can improve the prognosis. In this minireview, the authors describe the patterns of abnormalities on various imaging modalities(conventional as well as advanced) for the diagnosis of GB wall thickening. This paper also illustrates an algorithmic approach for the etiological diagnosis of GB wall thickening and suggests a formatted reporting for GB wall abnormalities. | Pankaj Gupta Yashi Marodia Akash Bansal Naveen Kalra Praveen Kumar-M Vishal Sharma Usha Dutta Manavjit Singh Sandhu | 2020 | World Journal of Gastroenterology2020，26，40： | 3 |
| 15 | Energy feedback and synchronous dynamics of Hindmarsh–Rose neuron model with memristor显示文摘We analyze the energy aspects of single and coupled Hindmarsh–Rose(HR) neuron models with a quadratic flux controlled memristor. The energy function for HR neuron with memristor has been derived and the dynamics have been analyzed in the presence of various external stimuli. We found that the bursting mode of the system changes with external forcing. The negative feedback in Hamilton energy function effectively stabilizes the chaotic trajectories and controls the phase space. The Lyapunov exponents have been plotted to verify the stabilization of trajectories. The energy aspects during the synchronous dynamics of electrically coupled neurons have been analyzed. As the coupling strength increases, the average energy fluctuates and stabilizes at the point of synchronization. When the neurons are coupled via chemical synapse,the average energy variations show three important regimes: a fluctuating regime corresponding to the desynchronized, a stable region indicating synchronized and a linearly increasing regime corresponding to the amplitude death states have been observed. The synchronization transitions are verified by plotting the transverse Lyapunov exponents. The proposed method has a large number of applications in controlling coupled chaotic systems and in analyzing the energy change during various metabolic processes. | K Usha P A Subha | 2019 | Chinese Physics B2019，28，2： | 3 |
| 16 | 两平行板间非稳态Casson磁流体的辐射挤压流动(英文)显示文摘本文通过数值计算,研究了在均匀一阶化学反应条件下,受热辐射、内热产生或吸收以及焦耳耗散效应的影响,Casson流体在两平行板间的传热传质特性。建立流变Casson流体流动模型,将Casson流体的非牛顿行为与牛顿流体的非牛顿行为进行区分。Casson流体的非稳态二维挤压流动的控制偏微分方程具有高度非线性和耦合性质。对守恒定律进行相似变换,得到控制挤压流的非线性常微分方程。分别应用利用龙格-库塔四阶积分法和bvp4cMatlab求解法对所得方程进行求解,并将结果进行比较。此外,对于不同的物理参数集,得到其数值结果,并以图和表的形式给出计算结果。然而,考虑到工业应用,因压缩数为负值,平行板运动所需的功率大幅度减少。研究发现,由于存在较强的Lorentz力,Hartmann数的增强值最终会抑制温度场和速度场。此外,压缩数越大,流体的压缩力越小,热场越小。而且化学反应的破坏性放大了浓度场,而构造性化学反应降低了浓度场。本文给出的数值解与以往的计算结果进行了比较,显示出较好的一致性。 | N. B. NADUVINAMANI Usha SHANKAR | 2019 | Journal of Central South University2019，26，5： | 2 |
| 17 | 铁鞣新方法(续)显示文摘将铁鞣与铬鞣进行了优化结合,这种鞣制技术不仅可以加工出质量上乘的皮革制品,同时又可以满足废液中铬与铁的含量低于100mg/kg的标准。此工艺制造的皮革可耐沸水试验,阐述了其鞣制技术和鞣制机理。对铁鞣法在加工山羊绒面革和绵羊全粒面服装革中出现的问题进行了研究。用扫描电镜对鞣革的结构特性进行了研究,对成革的物理机械性能及染色特性也做了分析和阐述。 | N K Chandra Babu R Karthikeyan R Ramesh Usha Ramamurthi T Ramasami 范贵洋 李彦春 | 2007 | 中国皮革2007，36，11： | 2 |
| 18 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 19 | TNF inhibitors to treat ulcerative colitis in a metastatic breast cancer patient:A case report and literature review显示文摘Adalimumab(ADA)is a tumor necrosis factor(TNF)inhibitor,used for the treatment of inflammatory bowel disease.Previous studies have reported an increased risk of cancer following exposure to TNF inhibitors,but little has been reported for patients with cancer receiving TNF-inhibitor treatment.We present a female patient with metastatic breast cancer and ulcerative colitis(UC)who was treated with ADA.A 54-year-old African American female with a past history of left-sided breast cancer(BC)diagnosed at age 30 was initially treated with left-breast lumpectomy,axillary dissection,followed by chemotherapy and radiation therapy.Years after initial diagnosis,she developed recurrent,bilateral BC and had bilateral mastectomy.Subsequent restaging computed tomography(CT)scan demonstrated distant metastases to the bone and lymph nodes.Three years into her treatment of metastatic breast cancer,she was diagnosed with UC by colonoscopy.Her UC was not controlled for 5 mo with 5-aminosalicylates.Subcutaneous ADA was started and resulted in dramatic improvement of UC.Four months after starting ADA,along with ongoing chemotherapy,restaging CT scan showed resolution of the previously seen metastatic lymph nodes.Bone scan and follow-up positron emission tomography/CT scans performed every 6 mo indicated the stability of healed metastatic bone lesions for the past 3 years on ADA.While TNF-αinhibitors could theoretically promote further metastases in patients with prior cancer,this is the first report of a patient with metastatic breast cancer in whom the cancer has remained stable for 3 years after ADA initiation for UC. | Ruwaida Ben Musa Lydia Usha John Hibbeln Ece A Mutlu | 2014 | World Journal of Gastroenterology2014，20，19： | 2 |
| 20 | Positive Surgical Margin and Perioperative Complication Rates of Primary Surgical Treatments for Prostate Cancer: A Systematic Review and Meta-Analysis Comparing Retropubic, Laparoscopic, and Robotic Prostatectomy 显示文摘 | Ashutosh Tewari Prasanna Sooriakumaran Daniel A. Bloch Usha Seshadri-Kreaden April E. Hebert Peter Wiklund | 2012 | European Urology2012，，1： | 2 |
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