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| 1 | Passive technologies for future large-scale photonic integrated circuits on silicon: polarization handling, light non-reciprocity and loss reduction显示文摘Silicon-based large-scale photonic integrated circuits are becoming important,due to the need for higher complexity and lower cost for optical transmitters,receivers and optical buffers.In this paper,passive technologies for large-scale photonic integrated circuits are described,including polarization handling,light non-reciprocity and loss reduction.The design rule for polarization beam splitters based on asymmetrical directional couplers is summarized and several novel designs for ultra-short polarization beam splitters are reviewed.A novel concept for realizing a polarization splitter–rotator is presented with a very simple fabrication process.Realization of silicon-based light non-reciprocity devices(e.g.,optical isolator),which is very important for transmitters to avoid sensitivity to reflections,is also demonstrated with the help of magneto-optical material by the bonding technology.Low-loss waveguides are another important technology for large-scale photonic integrated circuits.Ultra-low loss optical waveguides are achieved by designing a Si3N4 core with a very high aspect ratio.The loss is reduced further to,0.1 dB m21 with an improved fabrication process incorporating a high-quality thermal oxide upper cladding by means of wafer bonding.With the developed ultra-low loss Si3N4 optical waveguides,some devices are also demonstrated,including ultra-high-Q ring resonators,low-loss arrayed-waveguide grating(de)multiplexers,and high-extinction-ratio polarizers. | Daoxin Dai Jared Bauters John E Bowers | 2012 | Light(Science & Applications)2012，1，1： | 28 |
| 2 | Seminal biomarkers for the evaluation of male infertility显示文摘为努力与他们的搭挡一起怀孕的男人,诊断工具被限制并且经常由仅仅标准精液分析组成。这基线测试用作男富饶的一个粗略的评价,离开需要另外的诊断 biomarkers 的病人和临床医生。精液从因此,这评论在某些男不孕情形在当前、新奇的精液的 biomarkers 上集中包括自然富饶,区分精子缺乏病原学,并且预言的繁殖的腺帮助了的男性包含分子的最高的集中繁殖技术成功。当前可得到的测试包括 antisperm 抗体试金, DNA 破碎索引,在 situ 杂交的精子荧光,和另外的历史的精子功能的测试。当前的试金的差的诊断能力导致了继续的努力发现更预兆的 biomarkers。genomics, epigenetics, proteomics, transcriptomics,和为新奇男不孕 biomarkers 的发展的 metabolomics 抓住诺言的地里的新兴的研究。TEX101, ECM1,和 ACRV1 的精液的基于蛋白质的试金已经是可得到的或在为临床的使用的最后的开发中。当我们试图理解男不孕的 pathophysiologic 过程, DNA, RNA,蛋白质,或代谢物的另外的面板正在被探索。未来冒险将需要继续数据集成和确认让临床上有用的不孕 biomarkers 的开发帮助男不孕诊断,处理,并且建议。 | Jared M Bieniek Andrei P Drabovich Kirk C Lo | 2016 | Asian Journal of Andrology2016，18，3： | 15 |
| 3 | Copper Delivery by the Copper Chaperone for Chloroplast and Cytosolic Copper/Zinc- Superoxide Dismutases: Regulation and Unexpected Phenotypes in an Arabidopsis Mutant显示文摘铜(Cu ) 是作为与 plastocyanin 和 Cu/Zn superoxide dismutase (Cu/ZnSOD ) 联系的一个余因子在叶绿体发现的重要矿物质营养素。Superoxide dismutases 是在减少氧化应力与建议角色在很氧的有机体发现的 metallo 酶。在 Arabidopsis 的几最近的研究显示出那 microRNAs 和一个 SQUAMOSA 倡导者绑定 protein-like7 (SPL7 ) 抄写因素函数到下面调整许多 Cu 蛋白质的表达式包括在质体和 cytosol 的 Cu/ZnSOD,在低 Cu 上的生长期间。植物为把 Cu 送到 Cu/ZnSODs 的草皮(CCS ) 包含 Cu 女伴,并且,在 Arabidopsis, cytosolic 和 plastidic CCS 版本被一基因编码。在这研究,我们证明 Arabidopsis CCS 抄本层次被 Cu 调整,由 microRNA 调停了 398 那以前没被预言指向 CCS。microRNA 目标地点在 Oryza sativa 的 CCS 被保存。数据建议那调整 Cu 的 microRNAs 可以有更多的 mRNA 目标比以前被预言。CCS 空异种不在叶绿体和 cytosol 举办可测量的草皮活动,显示为 CCS 的一个绝对要求。当 CCS 空异种在高 Cu 媒介上是成年的时,它缺乏两 Fe superoxide dismutase (FeSOD ) 和 Cu/ZnSOD 活动。然而,这没导致视觉显型,没有光合的缺乏被检测,甚至在高轻的应力以后。这些结果显示 Cu/ZnSOD 不在处于实验室条件的生长期间是光合的抗氧化剂系统的一个枢轴的部件。 | Christopher M. Cohu Salah E. Abdel-Ghany Kathryn A. Gogolin Reynolds Alexander M. Onofrio Jared R. Bodecker Jeffrey A. Kimbrel Krishna K. Niyogi Marinus Pilon | 2009 | Molecular Plant2009，2，6： | 9 |
| 4 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 5 | 钛网结合异体骨移植和人骨形成蛋白在上颌前牙种植前牙槽嵴骨增量中的应用研究(附1例报告)显示文摘萎缩的牙槽嵴对于种植牙而言是一个不利的因素,在植入种植体之前牙槽骨嵴增量手术能够使骨的体积增加。在上颌前牙区,牙槽嵴增量不仅有利于后期种植体的植入而且可以获得更好美学效果。本文详述用钛网结合异体骨移植和人骨形成蛋白治疗上前牙区部分牙缺失部位的颊舌向骨缺损。通过这种方法可获得一定的骨增量,8个月后植入种植体,在植入种植体后4个月行二期手术和临时修复,4个月后进行永久修复,追踪时间为2年。 | Bing-Yan Wang Robin Weltman Jared Abramian 李琛 潘亚萍 | 2014 | 中国实用口腔科杂志2014，7，1： | 6 |
| 6 | ICD-11精神与行为障碍(草案)关于人格障碍诊断标准的进展显示文摘人格障碍(personality disorder)是较为常见的一类精神障碍,调查显示其人群中的患病率高于5%。虽然目前临床常用的精神障碍分类系统DSM和ICD中对人格障碍的定义均比较明确和一致,但历史上其具体分类却一直处在变动之中。 | 郑毓鹳 张天宏 Jared Keeley 谢斌 | 2018 | 中华精神科杂志2018，51，1： | 5 |
| 7 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 8 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 9 | SURGICAL MANAGEMENT OF RENAL TUMORS 4 CM. OR LESS IN A CONTEMPORARY COHORT显示文摘 | CHERYL T. LEE JARED KATZ WEIJI SHI HOWARD T. THALER VICTOR E. REUTER PAUL RUSSO | 2000 | The Journal of Urology2000，，： | 3 |
| 10 | Molecular Characterization of the Calvin Cycle Enzyme Phosphoribulokinase in the Stramenopile Alga Vaucheria litorea and the Plastid Hosting Mollusc Elysia chlorotica显示文摘Phosphoribulokinase (PRK ) ,一个原子编码对光合的碳减小(加尔文) 唯一的质体局部性的酶周期,从 stramenopile 水藻 Vaucheria litorea 被克隆并且描绘。这水藻是为软体动物(海蛞蝓) 的质体的来源使动物能完全由 photoautotrophic CO2 幸存月的 Elysia chlorotica 固定。1633-bp V。litorea prk 基因被克隆并且编码区域,发现被四 introns 打断,编码 405-amino 酸蛋白质。这蛋白质包含被指导到建筑群的原子编码蛋白质期望的典型由两部组成的目标顺序(即四膜界限) 海藻的质体。PRK 和酶活动的 De novo 合成在 E 被检测。尽管有 V 被饿了的 chlorotica。为几个月的 litorea。不同于海藻的酶,在海蛞蝓的 PRK 没展出氧化还原作用规定。部分编码 PRK 基因的二个拷贝用 PCR 从两海蛞蝓和 aposymbiotic 海蛞蝓鸡蛋 DNA 被孤立。每个拷贝包含跨越 exon 的核苷酸区域 1 并且 exon 的部分 2 V。litorea prk,包括由两部组成的指向肽。然而,更大的 prk 碎片也包括 intron 1。在 E 的 prk 的 exon 和 intron 序列。chlorotica 和 V。litorea 是将近相同的。这些数据建议 PRK 是在 V 调整的差别。litorea 和 E。chlorotica 和 V 的至少部分。litorea 原子 PRK 基因在被饿几个月了的海蛞蝓是在场的。 | Mary E. Rumpho Sirisha Pochareddy Jared M. Worful Elizabeth J. Summer Debashish Bhattacharya Karen N. Pelletreau Mary S. Tyler Jungho Lee James R. Manhart Kara M. Soule | 2009 | Molecular Plant2009，2，6： | 3 |
| 11 | Differential expression of the CCN family member WISP-1, WISP-2 andWISP-3 in human colorectal cancer and the prognostic implications显示文摘 | Simon Davies Mansel Davies Andrew Sanders Chris Parr Jared Torkington Wen Jiang | 2010 | International Journal of Oncology2010，，5： | 3 |
| 12 | Smart-phone,paper-based fluorescent sensor for ultra-low inorganic phosphate detection in environmental samples显示文摘A major goal of environmental agencies today is to conduct point-of-collection monitoring of excess inorganic phosphate(Pi)in environmental water samples for tracking aquatic“dead zones”caused by algae blooms.However,there are no existing commercial devices which have been miniaturized and are suitable for the point-of-need-testing(“PONT”)that is required to fully map a large region,such as the Florida Everglades.To solve this challenge,a reflection-mode fluorescence-sensing apparatus was developed,leveraging an environmentally sensitive fluorophore(MDCC)bound to a bacterial phosphate-binding protein to generate a fluorescent optical signal proportional to the concentration of(Pi)present.The combined end-to-end integrated sensor system had a response time of only 4 s,with minimal effects of common interfering agents and a linear range spanning from 1.1 to 64 ppb.To support easeof-use during PONT,the platform incorporated disposable wax-printed paper strip sample pads and a smartphone camera detection system.Since the EPA threshold is currently 30 ppb to prevent eutrophication,this system serves as a rapid test of whether a region is compliant. | Mehenur Sarwar Jared Leichner Ghinwa MNaja Chen-Zhong Li | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 13 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 14 | Mechanical valve obstruction:Review of diagnostic and treatment strategies显示文摘Prosthetic valve obstruction(PVO) is a rare but feared complication of mechanical valve replacement. Diagno-stic evaluation should focus on differentiating prosthetic valve thrombosis(PVT) from pannus formation,as their treatment options differ. History of sub-optimal anti-coagulation and post-op time course to development of PVO are useful clinical characteristics in differentiating thrombus from pannus formation. Treatment of PVT is influenced by the patient's symptoms,valve location,degree of obstruction and thrombus size and may include thrombolysis or surgical intervention. Alternatively,pannus formation requires surgical intervention. The purpose of this article is to review the pathophysiology,epidemiology,diagnostic approach and treatment options for aortic and mitral valve PVO. | Jason Salamon Jerson Munoz--Mendoza Jared J Liebelt Cynthia C Taub | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 15 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 16 | The influence of time, storage temperature, and substrate age on potential soil enzyme activity in acidic forest soils using MUB-linked substrates and l -DOPA显示文摘 | Jared L. DeForest | 2009 | Soil Biology and Biochemistry2009，，6： | 2 |
| 17 | Fatigability during volitional walking in incomplete spinal cord injury: cardiorespiratory and motor performance considerations显示文摘Fatigability describes the decline in force production(i.e., performance fatigability) and/or changes in sensations regulating performance(i.e., perceived fatigability) during whole-body activity and poses a major challenge to those living with spinal cord injuries(SCI). After SCI, the inability to overcome disruptions to metabolic homeostasis due to cardiorespiratory limitations and physical deconditioning may contribute to increased fatigability severity. The increased susceptibility to fatigability may have implications for motor control strategies and motor learning. Locomotor training approaches designed to reduce fatigability and enhance aerobic capacity in combination with motor learning may be advantageous for promoting functional recovery after SCI. Future research is required to advance the understanding of the relationship between fatigability, cardiorespiratory function and motor performance following SCI. | Jared M.Gollie | 2018 | Neural Regeneration Research2018，13，5： | 2 |
| 18 | A simple scoring system to estimate perioperative mortality following liver resection for primary liver malignancy-the Hepatectomy Risk Score(HeRS)显示文摘Background:Selection of the optimal treatment modality for primary liver cancers remains complex,balancing patient condition,liver function,and extent of disease.In individuals with preserved liver function,liver resection remains the primary approach for treatment with curative intent but may be associated with significant mortality.The purpose of this study was to establish a simple scoring system based on Model for End-stage Liver Disease(MELD)and extent of resection to guide risk assessment for liver resections.Methods:The 2005-2015 NSQIP database was queried for patients undergoing liver resection for primary liver malignancy.We first developed a model that incorporated the extent of resection(1 point for major hepatectomy)and a MELD-Na score category of low(MELD-Na=6,1 point),medium(MELD-Na=7-10,2 points)or high(MELD-Na>10,3 points)with a score range of 1-4,called the Hepatic Resection Risk Score(HeRS).We tested the predictive value of this model on the dataset using logistic regression.We next developed an optimal multivariable model using backwards sequential selection of variables under logistic regression.We performed K-fold cross validation on both models.Receiver operating characteristics were plotted and the optimal sensitivity and specificity for each model were calculated to obtain positive and negative predictive values.Results:A total of 4,510 patients were included.HeRS was associated with increased odds of 30-day mortality[HeRS=2:OR=3.23(1.16-8.99),P=0.025;HeRS=3:OR=6.54(2.39-17.90),P<0.001;HeRS=4:OR=13.69(4.90-38.22),P<0.001].The AUC for this model was 0.66.The AUC for the optimal multivariable model was higher at 0.76.Under K-fold cross validation,the positive predictive value(PPV)and negative predictive value(NPV)of these two models were similar at PPV=6.4%and NPV=97.7%for the HeRS only model and PPV=8.4%and NPV=98.1%for the optimal multivariable model.Conclusions:The HeRS offers a simple heuristic for estimating 30-day mortality after resection of primary liver malignancy.More complicated models offer better performance but at the expense of being more difficult to integrate into clinical practice. | Dimitrios Moris Brian I.Shaw Cecilia Ong Ashton Connor Mariya L.Samoylova Samuel J.Kesseli Nader Abraham Jared Gloria Robin Schmitz Zachary W.Fitch Bryan M.Clary Andrew S.Barbas | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 19 | A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination显示文摘Ubiquitination 调整主人免疫的许多方面并且因此是为传染代理人的一个普通目标。最近的研究表明了细菌的病原体 Legionella pneumophila 的方面受动器家庭的成员攻击不要求主人 ubiquitination 机械的 E1 和 E2 酶的新奇 ubiquitination 机制与 endoplasmic 蜂窝胃联系的几小 GTPases。在这种情况中, ubiquitin 被一项 mono-ADP-ribosyltransferase 活动被 ADP-ribosylation 首先在 Arg 42 激活;中介然后被也住在 SdeA 以内的一项 phosphodiesterase 活动劈开,有到经由一个 phosphoribosyl 连接器的底层蛋白质的丝氨酸残余的 ubiquitin 的附件的伴随物。这里,我们证明方面的效果被 SidJ 反对,一个受动器由位于为方面家庭(SdeC, SdeB 和 SdeA ) 的三个成员编码的地点的基因编码了。SidJ 由劈开连接 phosphoribosylated ubiquitin 到蛋白质底层的 phosphodiester 契约颠倒修改方面的底层的 ubiquitination。SidJ 也显示古典 deubiquitinase 活动但是不要求催化半胱氨酸残余。进一步, SidJ 的这些 deubiquitinase 活动为它在 L 的角色是必要的。pneumophila 感染。最后, SidJ 的活动为高效地在细菌的举起以后在一些小时以内在感染的房间减少许多 ubiquitinated Rab33b 被要求。我们的结果作为工作在方面受动器的活动强加时间的规定的 ubiquitin-deconjugating 酶建立 SidJ。SidJ 可能在表明串联的未来研究是重要的由这唯一的 ubiquitination 调停了,潜在地也在真核细胞的房间调整细胞的过程的。 | Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo | 2017 | Cell Research2017，27，7： | 2 |
| 20 | Does obesity impact lymph node retrieval in colon cancer surgery?显示文摘 | Jared H. Linebarger Michelle A. Mathiason Kara J. Kallies Stephen B. Shapiro | 2010 | The American Journal of Surgery2010，，4： | 2 |
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