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| 1 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 2 | Probiotics for the treatment of Clostridium difficile associated disease显示文摘The purpose of this review paper is to update the current and potential future role of probiotics for Clostridium difficile-associated disease (CDAD). Included in this review, is an update on the testing of newer probiotics (e.g. , Bacillus coagulans GBI-30, 6086) in animal models of CDAD. There is a focus on the modulation of signal transduction pathways (i.e. , transcription factors like cAMP response element-binding, activator protein 1, and nuclear factor kappa B), as well as the inhibition of certain kinases (e.g. , p38 mitogen activated protein kinases) by probiotics. Inhibition of signal transduction by probiotics, such as Saccharomyces boulardii , result in multiple effects on intestinal fluid secretion, neutrophil influx into the colon, inflammation, and colonocyte apoptosis that may positively impact CDAD. Recent clinical approaches with probiotics, for the prevention of primary and recurrent CDAD, are also summarized in this review paper. Future directions for the treatment of CDAD by probiotics are also mentioned in this review. In particular, the use of multi-strain probiotic formulations such as Ecologic AAD and VSL #3 may represent a rationale pharmacological approach, particularly as adjunctive therapies for CDAD. Understanding the mechanistic basis of CDAD, and how probiotics interfere at ceratin steps in the pathogenic process, may also present the opportunity to design other multi-strain probiotics that could have a future impact on CDAD. | Leo R Fitzpatrick | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，3： | 7 |
| 3 | Noninvasive biomarkers in non-alcoholic fatty liver disease:Current status and a glimpse of the future显示文摘The development of non invasive biomarkers of disease has become a major focus of interest in nonalcoholic fatty liver disease(NAFLD). The large prevalence of the disease and the invasive nature of the investigation means that screening with liver biopsy is impractical.In addition to screening, the differentiation of those with simple steatosis vs steatohepatitis and fibrosis is clinically important as the prognosis of each differs.Serum biomarkers may be a combination of simple markers derived from large data sets or direct markers of disease activity. Serum markers of inflammation,apoptosis and oxidative stress in addition to fibrosis have been extensively studied in patients with NAFLD.Other techniques such as transient elastography,magnetic resonance elastography and acoustic radiation force imaging are becoming more established as noninvasive methods of detecting fibrosis in a variety of chronic liver conditions in addition to NAFLD. Newer high throughput methods such as proteomics and glycomics allow the nonhypothesis-driven identification of novel markers and may also potentially contribute to our understanding of the pathogenesis of the condition.This review addresses some of the methodological issues which need to be considered in the search for the ideal biomarker. It is likely that a combination of serum biomarkers and techniques such as transient elastography may provide the optimal diagnostic discrimination however this remains to be proven in large studies. | Emer Fitzpatrick Anil Dhawan | 2014 | World Journal of Gastroenterology2014，20，31： | 6 |
| 4 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 5 | The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development goals显示文摘The Sustainable Development Goals(SDGs)call for an integrated response,the kind that has defined Neglected Tropical Diseases(NTDs)efforts in the past decade.NTD interventions have the greatest relevance for SDG3,the health goal,where the focus on equity,and its commitment to reaching people in need of health services,wherever they may live and whatever their circumstances,is fundamentally aligned with the target of Universal Health Coverage.NTD interventions,however,also affect and are affected by many of the other development areas covered under the 2030 Agenda.Strategies such as mass drug administration or the programmatic integration of NTD and WASH activities(SDG6)are driven by effective global partnerships(SDG17).Intervention against the NTDs can also have an impact on poverty(SDG1)and hunger(SDG2),can improve education(SDG4),work and economic growth(SDG8),thereby reducing inequalities(SDG10).The community-led distribution of donated medicines to more than 1 billion people reinforces women’s empowerment(SDG5),logistics infrastructure(SDG9)and non-discrimination against disability(SDG16).Interventions to curb mosquito-borne NTDs contribute to the goals of urban sustainability(SDG11)and resilience to climate change(SDG13),while the safe use of insecticides supports the goal of sustainable ecosystems(SDG15).Although indirectly,interventions to control waterand animal-related NTDs can facilitate the goals of small-scale fishing(SDG14)and sustainable hydroelectricity and biofuels(SDG7).NTDs proliferate in less developed areas in countries across the income spectrum,areas where large numbers of people have little or no access to adequate health care,clean water,sanitation,housing,education,transport and information.This scoping review assesses how in this context,ending the epidemic of the NTDs can impact and improve our prospects of attaining the SDGs. | Mathieu Bangert David H.Molyneux Steve W.Lindsay Christopher Fitzpatrick Dirk Engels | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 6 | The evolution of male mate choice and female ornamentation: a review of mathematical models显示文摘 | Courtney L. FITZPATRICK Maria R. SERVEDIO | 2018 | Current Zoology2018，64，3： | 3 |
| 7 | A bright future for the tree shrew in neuroscience research:Summary from the inaugural Tree Shrew Users Meeting显示文摘Tree shrews(Tupaia spp.)have been used in neuroscience research since the 1960s due to their evolutionary proximity to primates.The use of and interest in this animal model have recently increased,in part due to the adaptation of modern neuroscience tools in this species.These tools include quantitative behavioral assays,calcium imaging,optogenetics and transgenics.To facilitate the exchange and development of these new technologies and associated research findings,we organized the inaugural“Tree Shrew Users Meeting”which was held online due to the COVID-19 pandemic.Here,we review this meeting and discuss the history of tree shrews as an animal model in neuroscience research and summarize the current themes being investigated using this animal,as well as future directions. | Elise Savier Madineh Sedigh-Sarvestani Ralf Wimmer David Fitzpatrick | 2021 | Zoological Research2021，42，4： | 3 |
| 8 | Kinematic and Contact Stress Analysis of Posterior Malleolus Fractures of the Ankle显示文摘 | Daniel C. Fitzpatrick Jason K. Otto Todd O. McKinley J. Lawrence Marsh Thomas D. Brown | 2004 | Journal of Orthopaedic Trauma2004，，5： | 3 |
| 9 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 10 | A Systematic Review of the Cost and Cost Effectiveness of Treatment for Multidrug-Resistant Tuberculosis显示文摘 | Christopher Fitzpatrick Katherine Floyd | 2012 | PharmacoEconomics2012，，1： | 2 |
| 11 | Comparison and evaluation of retrospective intermodality brain image registration techniques显示文摘 | West J Fitzpatrick JM Wang MY | 1997 | Journal of Computer Assisted Tomography1997，21，4： | 2 |
| 12 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Paul Gissen Louise Tee Colin A. Johnson Emmanuelle Genin Almuth Caliebe David Chitayat Carol Clericuzio Jonas Denecke Maja Rocco Bj?rn Fischler David FitzPatrick Angeles García-Cazorla Delphine Guyot Sebastien Jacquemont Sibylle Koletzko Bruno Leheup Hann | 2006 | Human Genetics2006，，3： | 2 |
| 13 | Phosphate Glass Fibre Composites for Bone Repair显示文摘We investigate high-modulus degradable materials intended to replace metals in biomedical applications.These are typicallycomposites comprising a polylactide(PLA)matrix reinforced with phosphate glass fibres,which provide reinforcementsimilar to E-glass but are entirely degradable in water to produce,principally,calcium phosphate.We have made compositesusing a variety of fibre architectures,from non-woven random mats to unidirectional fibre tapes.Flexural properties in theregion of 30 GPa modulus and 350 MPa strength have been achieved-directly comparable to quoted values for human corticalbone.In collaboration with other groups we have begun to consider the development of foamed systems with structures mimickingcancellous bone and this has shown significant promise.The fibres in these foamed structures provide improved creepresistance and reinforcement of the pore walls.To date the materials have exhibited excellent cellular responses in vitro andfurther studies are due to include consideration of the surface character of the materials and the influence of this on cell interaction,both with the composites and the glass fibres themselves,which show promise as a standalone porous scaffold. | Andrew J.Parsons Ifty Ahmed Papia Haque Ben Fitzpatrick Muhammad I.K.Niazi Gavin S.Walker Chris D.Rudd | 2009 | Journal of Bionic Engineering2009，6，4： | 2 |
| 14 | 海河低平原盐渍区土壤磁化率研究初报显示文摘利用英国巴廷敦(Bartington)MS2型双频率感应磁化率仪测定分析了海河低平原盐渍区4个剖面土壤磁学性质。结果表明,该区土壤具有明显的磁化率空间分布差异,盐渍涝洼地段磁化率低(<34×10^(-8)m^3/kg),已脱盐地段磁化率高(>50×10^(-8)m^3/kg);同一剖面表土层较底土层土壤磁化率高。位于剖面中下部的河湖沉积胶泥层磁化率高,且频率依赖性系数甚高,指示粘层存在粒径<0.01μm左右的超顺磁铁磁态矿物。土壤磁化率测量适用于冲积性平原土壤磁学性质空间分布趋势的检测,亦作为土壤与生态环境演变指示特征之一。 | 毛任钊 Fitzpatrick R.W. | 1999 | 生态农业研究1999，7，3： | 2 |
| 15 | Transient Elastography Is a Useful Noninvasive Tool for the Evaluation of Fibrosis in Paediatric Chronic Liver Disease显示文摘 | Emer Fitzpatrick Alberto Quaglia Sunitha Vimalesvaran Maria Sole Basso Anil Dhawan | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，1： | 2 |
| 16 | Testing of biological aerated filter (BAF) media 显示文摘 | Kent T D Fitzpatrick C S B Williams S C | 1996 | Wat Sci Tech1996，34，34： | 2 |
| 17 | Endoscopic management of colonic perforations: clips versus suturing closure (with videos)显示文摘 | Sergey V. Kantsevoy Marianne Bitner Gulara Hajiyeva Paulina M. Mirovski Michael E. Cox Thomas Swope Kelly Alexander Nora Meenaghan J. Lawrence Fitzpatrick Vadim Gushchin | 2015 | Gastrointestinal Endoscopy2015，，： | 2 |
| 18 | 煤焦油的加氢反应性显示文摘本研究采用电磁拖动搅拌高压反应釜对两种煤焦油进行了催化加氢反应。反应结果表明、两种煤焦油在氢压17MPa;反应温度450℃;反应时间90min的反应条件下,都具有一定的加氢反应活性。中低温煤焦油的加氢反应活性明显高于高温煤焦油,催化加氢反应使中低温煤焦油中200℃前的馏分量由6.44%增加到41.57%,增加了约6.5倍。加氢反应使煤焦油得到了较高的提质。 | 凌开成 Roger Lott Edward G. Fitzpatrick | 1993 | 太原工业大学学报1993，24，2： | 2 |
| 19 | A computational grammar of discourse-neutral prosodic phrasing in English显示文摘 | Bachenko J Fitzpatrick E | 1990 | Computational Linguistics1990，16，3： | 2 |
| 20 | Coronary artery calcium areas by electron beam computed tomography and coronary atherosclerotic plaque area: A histopathologic corrlative study 显示文摘 | Simons DB Fitzpatrick LA Sheedy PF Schwartz RS | 1995 | Circulatiom1995，92，： | 1 |
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