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| 1 | The future of computer-aided sperm analysis显示文摘电脑辅助的精子分析(房屋) 技术为分析精子运动特征或 kinematics 在 1980 年代末被开发并且在启用研究的这个领域是高度成功的。房屋也与大成功被使用了在许多动物种测量象精子集中和进步活动性的比例那样的精液特征,包括在驯养的动物生产实验室和繁殖毒物学的宽申请。然而,为人的临床的精液分析使用房屋的尝试大部分由于精子 clumping 和直到现在,预防了的重背景碎片引起的许多人的精液样品介绍的固有的困难取得了差的成功精确数字图象分析。作者考察二个现代房屋平台(Hamilton Thorne CASA-II 和 Microptic SCA6 ) 的改进能力并且与向使用这种技术估计精子的功能而非简单的描述的特征指导我们的焦点的特别参考考虑他们的现在和将来的应用程序。为为人的精液分析作为一个自动化半的系统验证房屋技术的特定的要求也被提供,与为在根据现代认证标准操作的临床的实验室的实现的柔韧的医药实验室测试期望的测量的精确性和无常的特别参考。 | Sharon T Mortimer Gerhard van der Horst David Mortimer | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 2 | Targeting non-coding RNAs to overcome cancer therapy resistance显示文摘It is now well known that non-coding RNAs(ncRNAs),rather than protein-coding transcripts,are the preponderant RNA transcripts.NcRNAs,particularly microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),are widely appreciated as pervasive regulators of multiple cancer hallmarks such as proliferation,apoptosis,invasion,metastasis,and genomic instability.Despite recent discoveries in cancer therapy,resistance to chemotherapy,radiotherapy,targeted therapy. | BaoQing Chen Mihnea P.Dragomir Chen Yang Qiaoqiao Li David Horst George A.Calin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 3 |
| 3 | Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘 | Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin | 2008 | Circulation2008，，23： | 2 |
| 4 | Ineffective oesophageal motility:Manometric subsets exhibit different symptom profiles显示文摘AIM:To compare the demographic and clinical features of different manometric subsets of ineffective oesophageal motility(IOM;defined as ≥ 30% wet swallows with distal contractile amplitude < 30 mmHg) ,and to determine whether the prevalence of gastro-oesophageal reflux differs between IOM subsets. METHODS:Clinical characteristics of manometric subsets were determined in 100 IOM patients(73 female,median age 58 years) and compared to those of 100 age-and gender-matched patient controls with oesophageal symptoms,but normal manometry. Supine oesophageal manometry was performed with an eight-channel DentSleeve water-perfused catheter,and an ambulatory pH study assessed gastro-oesophageal reflux. RESULTS:Patients in the IOM subset featuring a majority of low-amplitude simultaneous contractions(LASC) experienced less heartburn(prevalence 26%) ,but more dysphagia(57%) than those in the IOM subset featuring low-amplitude propagated contractions(LAP;heartburn 70%,dysphagia 24%;both P ≤ 0.01) . LASC patients also experienced less heartburn and more dysphagia than patient controls(heartburn 68%,dysphagia 11%;both P < 0.001) . The prevalence of heartburn and dysphagia in IOM patients featuring a majority of non-transmitted sequences(NT) was 54%(P = 0.04 vs LASC) and 36%(P < 0.01 vs controls) ,respectively. No differences inage and gender distribution,chest pain prevalence,acid exposure time(AET) and symptom/reflux association existed between IOM subsets,or between subsets and controls. CONCLUSION:IOM patients with LASC exhibit a different symptom profile to those with LAP,but do not differ in gastro-oesophageal reflux prevalence. These findings raise the possibility of different pathophysiological mechanisms in IOM subsets,which warrants further investigation. | Horst Gunter Haack Ross David Hansen Allison Malcolm John Edward Kellow | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 5 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 6 | Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically显示文摘 | Tracy L. Putoczki Stefan Thiem Andrea Loving Rita A. Busuttil Nicholas J. Wilson Paul K. Ziegler Paul Nguyen Adele Preaudet Ryan Farid Kirsten Edwards Yeliz Boglev Rodney B. Luwor Andrew Jarnicki David Horst Alex Boussioutas Joan K. Heath Oliver M. Sieber | 2013 | Cancer Cell2013，，： | 2 |
| 7 | Updated Clinical Classification of Pulmonary Hypertension显示文摘 | Gerald Simonneau Michael A. Gatzoulis Ian Adatia David Celermajer Chris Denton Ardeschir Ghofrani Miguel Angel Gomez Sanchez R. Krishna Kumar Michael Landzberg Roberto F. Machado Horst Olschewski Ivan M. Robbins Rogiero Souza | 2013 | Journal of the American College of Cardiology2013，，25： | 2 |
| 8 | γ-Catenin is an independent prognostic marker in early stage colorectal cancer显示文摘 | Jutta Maria Nagel Lydia Kriegl David Horst Jutta Engel Shiva Gautam Christos S. Mantzoros Thomas Kirchner Burkhard G?ke Frank Thomas Kolligs | 2010 | International Journal of Colorectal Disease2010，，11： | 1 |
| 9 | CYSTIC RENAL CELL CARCINOMA IS CURED BY RESECTION: A STUDY OF 24 CASES WITH LONG-TERM FOLLOWUP显示文摘 | FEDERICO A. CORICA KENNETH A. ICZKOWSKI LIANG CHENG HORST ZINCKE MICHAEL L. BLUTE AMY WENDEL THOMAS J. SEBO ROXANN NEUMANN DAVID G. BOSTWICK | 1999 | The Journal of Urology1999，，2： | 1 |
| 10 | Patients with Refractory Crohn?s Disease Successfully Treated with Ustekinumab显示文摘 | Kimberly A. Harris Sara Horst Akash Gadani Anne Nohl Kim Annis Caroline Duley Dawn Beaulieu Leyla Ghazi David A. Schwartz | 2016 | Inflammatory Bowel Diseases2016，，2： | 1 |
| 11 | The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors显示文摘 | Tobias Vogler Lydia Kriegl David Horst Jutta Engel Sabine Sagebiel Achim J. Sch?ffauer Thomas Kirchner Andreas Jung | 2011 | Experimental and Molecular Pathology2011，，1： | 1 |
| 12 | RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA显示文摘 | CHRISTOPHER B. DECHET DAVID G. BOSTWICK MICHAEL L. BLUTE SANDRA C. BRYANT HORST ZINCKE | 1999 | The Journal of Urology1999，，1： | 1 |
| 13 | IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis显示文摘 | Rokavec Matjaz ?ner Meryem G?lfem Li Huihui Jackstadt Rene Jiang Longchang Lodygin Dmitri Kaller Markus Horst David Ziegler Paul K Schwitalla Sarah Slotta-Huspenina Julia Bader Franz G Greten Florian R Hermeking Heiko | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 14 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 1 |
| 15 | Renal Cell Carcinoma Metastatic to the Pancreas: Clinical and Radiological Features显示文摘 | Reza Ghavamian Katherine A. Klein David H. Stephens Timothy J. Welch Andrew J. Leroy Ronald L. Richardson Patrick A. Burch Horst Zincke | 2000 | Mayo Clinic Proceedings2000，，6： | 1 |
| 16 | Biodiesel from algae: challenges and prospects显示文摘 | Stuart A Scott Matthew P Davey John S Dennis Irmtraud Horst Christopher J Howe David J Lea-Smith Alison G Smith | 2010 | Current Opinion in Biotechnology2010，，3： | 1 |
| 17 | Left atrial appendage closure with amplatzer cardiac plug in atrial fibrillation: Initial European experience显示文摘 | Jai‐Wun Park Armando Bethencourt Horst Sievert Gennaro Santoro Bernhard Meier Kevin Walsh Jose Ramon Lopez‐Minquez David Meerkin Mariano Valdes Oliver Ormerod Boris Leithauser | 2014 | Cathet. Cardiovasc. Intervent2014，，6： | 1 |
| 18 | Biodiesel from algae: challenges and prospects显示文摘 | Stuart A Scott Matthew P Davey John S Dennis Irmtraud Horst Christopher J Howe David J Lea-Smith Alison G Smith | 2010 | Current Opinion in Biotechnology2010，，3： | 1 |
| 19 | Updated Clinical Classification of Pulmonary Hypertension显示文摘 | Gerald Simonneau Michael A. Gatzoulis Ian Adatia David Celermajer Chris Denton Ardeschir Ghofrani Miguel Angel Gomez Sanchez R. Krishna Kumar Michael Landzberg Roberto F. Machado Horst Olschewski Ivan M. Robbins Rogiero Souza | 2013 | Journal of the American College of Cardiology2013，，25： | 1 |
| 20 | RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA显示文摘 | CHRISTOPHER B. DECHET DAVID G. BOSTWICK MICHAEL L. BLUTE SANDRA C. BRYANT HORST ZINCKE | 1999 | The Journal of Urology1999，，： | 1 |
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