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| 1 | 北祁连早古生代花岗质岩浆作用及构造演化显示文摘北祁连山中段花岗岩锆石SHRIMP定年结果表明,柯柯里岩体的斜长花岗岩和石英闪长岩的年龄分别为512Ma和501 Ma,野马咀和金佛寺花岗岩的年龄分别为508Ma和424Ma。结合区内其它花岗岩体的定年资料,根据花岗岩的岩石地球化学特征及岩体产出的构造位置、区域地质资料等,我们认为,早古生代北祁连洋板块向南俯冲,至少引发了两期花岗质岩浆作用,第一次岩浆作用形成柯柯里斜长花岗岩(512Ma)、野马咀花岗岩(508Ma)和柯柯里石英闪长岩(501 Ma),第二次花岗质岩浆作用形成牛心山花岗岩(477Ma)。由于往南俯冲的板块受到柴达木板块向北俯冲的影响,俯冲受阻,继而俯冲极性发生变化,转向北俯冲,形成了民乐窑沟(463Ma)等花岗岩侵入体。大约440Ma之后,洋盆闭合,柴达木陆块和阿拉善陆块对接碰撞,形成北祁连造山带。由于造山带根部岩石圈发生折沉作用,造山带上不同的块体伸展、滑塌,形成一系列碰撞后花岗岩如金佛寺花岗岩(424Ma)及牛心山岩体的石英闪长岩(435Ma)等。 | 吴才来 徐学义 高前明 李向民 雷敏 郜源红 Ronald B FROST Joseph L WOODEN | 2010 | 岩石学报2010，26，4： | 132 |
| 2 | 基础骨生物学新观显示文摘 | 黎小坚 Harold M Frost 朱绍舜 柯华珠 | 2001 | 中国骨质疏松杂志2001，7，2： | 73 |
| 3 | 南阿尔金茫崖地区花岗岩类锆石SHRIMP U-Pb定年、Lu-Hf同位素特征及岩石成因显示文摘南阿尔金茫崖地区早古生代花岗岩锆石SHRIMP U-Pb定年结果表明,阿克提山花岗岩为264±1Ma,柴水沟花岗岩分别为404±5Ma、406±4Ma,其中的辉绿岩为454±4Ma,常春沟花岗岩分别为411±5Ma、406±3Ma,茫崖镇北石英闪长岩为466±5Ma,阿卡龙山花岗岩为469±6Ma。锆石Lu-Hf同位素分析表明,εHf(t)值大多数为正值,少数继承性锆石为负值,反映了它们的源岩以新生地壳为主,同时,也混有少量的古大陆壳的成分。结合区域地质特征和各岩体的岩石地球化学特征,将南阿尔金茫崖地区早古生代花岗质岩浆活动划分为3期,第一期(465~469Ma)岩石组合为石英闪长岩+花岗闪长岩+花岗岩,具有岛弧火成岩的地球化学属性,其形成可能与洋壳的俯冲作用有关;第二期(404~411Ma)岩石组合为花岗闪长岩+二长花岗岩+正长花岗岩,具有A型花岗岩的地球化学特征,可能与板块碰撞后造山带块体均衡调整有关,第三期(264Ma)岩石组合为石英闪长岩+二长花岗岩+正长花岗岩,也具有I型花岗岩的特征,可能与阿尔金断裂的活动有关。 | 吴才来 郜源红 雷敏 秦海鹏 刘春花 李名则 B Ronald FROST Joseph L WOODEN | 2014 | 岩石学报2014，30，8： | 56 |
| 4 | Abstract from: Pharmacologic treatment of hypertension in adults aged 60 years or older to higher versus lower blood pressure targets: A clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians显示文摘Description: The American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) jointly developed this guideline to present the evidence and provide clinical recommendations based on the benefits and harms of higher versus lower blood pressure targets for the treatment of hypertension in adults aged 60 years or older. | Amir Qaseem Timothy J. Wilt Robert Rich Linda L. Humphrey Jennifer Frost Mary Ann Forciea | 2017 | Chinese Nursing Research2017，4，4： | 43 |
| 5 | 都兰花岗岩锆石SHRIMP定年及柴北缘超高压带花岗岩年代学格架显示文摘柴北缘超高压带东端都兰地区花岗岩锆石SHRIMP U-Pb定年结果表明,野马滩东岩体的年龄为(406.6±3.5)Ma,巴立给哈滩西岩体的年龄分别为(407.3±4.3)和(397±6)Ma,水文站北岩体的年龄分别为(404.5±4.0)和(397.0±3.7)Ma,水文站南岩体的年龄为(380.5±5.0)Ma,察察公麻岩体的年龄分别为(382.5±3.6)和(372.5±2.8)Ma.从年龄上看,这些花岗岩明显地分为两期:早期的为407-397 Ma,晚期的为383-373 Ma.它们主要为准铝质-弱过铝质的石英闪长岩、花岗闪长岩和二长花岗岩.岩石地球化学研究表明,大多数样品为钙碱性系列,少数样品为钙性或碱钙性系列,其中,早期花岗岩的87Sr/86Sr比值(0.7082-0.7110)和模式年龄(T2DM=1.41-1.90 Ga)高于晚期花岗岩(0.7072-0.7091,T2DM=1.07-1.38 Ga),但晚期花岗岩的εNd(t)值(0.6- -3.0)高于早期花岗岩(-3.2- -9.3),表明早期花岗岩可能起源于早中元古代的大陆壳;而晚期花岗岩起源于晚中元古代玄武质地壳.结合区域地质构造特征,可以认为,早期花岗岩的形成与俯冲板块的断离并折返有关,而晚期花岗岩的形成与造山带岩石圈地幔拆沉作用有关. | 吴才来 郜源红 李兆丽 雷敏 秦海鹏 李名则 刘春花 Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | 中国科学:地球科学2014，44，10： | 27 |
| 6 | Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China显示文摘Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for Chachagongma.These granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North Qaidam.Geochemically,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc series.The third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 Ga.Therefore,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model ages.On the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 to-9.3.Thus,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental material.Combined with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle. | WU CaiLai GAO YuanHong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | Science China Earth Sciences2014，57，12： | 21 |
| 7 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 8 | 美国信息学院理念及其延伸(英文)显示文摘信息学院(i-school)在当今美国图书情报学(LIS)教育史中具有重要作用。本文明确了信息学院的关键特征,并描述其如何帮助定位图书情报学教育长期面临的挑战。以'人、信息、技术'为中心,信息学院已经在科研和教学中建立了强大的多学科项目,结果获得学科地位提升、交叉学科伙伴、学生入学增多和较强的经费支持。在美国以外的地方也正在出现类似信息学院的模式,可见于中国、印度、日本、新加坡和德国。参考文献12。 | C. Olivia Frost | 2008 | 中国图书馆学报2008，34，6： | 10 |
| 9 | ≥60岁高血压病人控制血压在较高或较低水平的药物治疗--美国医师协会和美国家庭医师学会临床实践指南显示文摘目的:针对≥60岁的高血压病人治疗中较高和较低降压目标的利弊,美国医师协会(ACP)和美国家庭医师学会(AAFP)共同制订了这一指南,为临床治疗提供证据及治疗建议。方法:本指南依据于已发表的主要疗效指标的随机对照试验以及针对危害的观察性研究的系统性评价。资料来源于EMBASE、系统性综述Cochrane数据库、MEDLINE和Clinical Trials.gov,搜索时间为从数据库建立开始至2015年1月,其中MEDLINE数据更新到2016年9月。评估指标包括全因死亡率、与卒中相关的发病率和死亡率、主要心脏事件(包括致死和非致死性心肌梗死和心源性猝死)和危害。本指南采用GRADE法(Grading of Recommendations,Assessment,Development,and Evaluation)对证据和建议进行分级。目标使用者和病人人群:本指南的目标使用者为所有临床医师,目标病人人群包括所有年龄≥60岁的高血压病人。建议1:对≥60岁、收缩压持续≥150mmHg(1mmHg=0.133kPa)的病人治疗时,ACP和AAFP建议临床医师应启动降压治疗以控制收缩压<150mmHg,从而减少死亡、脑卒中和心脏事件的风险(等级:强烈推荐,高质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。建议2:对≥60岁的有脑卒中或短暂性脑缺血发作病史的病人,ACP和AAFP建议临床医生考虑启动或者加强药物治疗,以控制收缩压<140mmHg,降低脑卒中复发的风险(等级:弱推荐,中等质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。建议3:对一部分≥60岁有高度心血管风险的病人,ACP和AAFP建议临床医生根据个体评估情况考虑启动或者强化降压药物治疗,控制收缩压到140mmHg以下,从而减少脑卒中或心脏事件发生的风险(等级:弱推荐,低质量证据)。对≥60岁高血压病人进行治疗时,建议临床医生定期与病人具体讨论降压目标的利弊,根据讨论情况选择治疗目标。 | Amir Qaseem Timothy J.Wilt Robert Rich Linda L.Humphrey Jennifer Frost Mary Ann Forciea | 2017 | 护理研究(下旬版)2017，31，8： | 8 |
| 10 | MCM-41介孔材料的合成条件和特性对吸附镉离子的影响显示文摘以气相氧化硅为硅源,十六烷基三甲基溴化铵(cetyl trimethyl ammonium bromide,CTAB)为模板剂,分别在碱性[氢氧化钠(NaOH),四乙基氢氧化铵,tetraethyl ammonium hydroxide,(C2H5)4NOH(TEAOH)]和酸性介质条件[盐酸(HCl)]下水热合成了MCM-41有序介孔材料MCM-41-N,MCM-41-T和MCM-41-H。用X射线衍射、氮气吸附-脱附等手段对比分析了合成的3种MCM-41介孔材料的物相、比表面积、孔径、孔体积等,发现酸性介质中合成的介孔材料的孔径最大。在此基础上,利用MCM-41介孔材料对比研究了处理含镉离子(Cd2+)废水的效果和机理,确定了不同介孔材料用量、不同初始pH值条件下MCM-41介孔材料对水中Cd2+的吸附率和吸附量。结果表明:介孔材料用量相同时,溶液pH值的增大有利于提高3种MCM-41介孔材料对水中Cd2+的处理效果。在pH值从7.0到8.0的过程中,其吸附率有1个突变,MCM-41-T的Cd2+吸附率从35.65%提高到62.15%;MCM-41-N的从38.80%提高到69.40%;MCM-41-H的从50.22%提高到73.47%。孔径最大的MCM-41-H对Cd2+的吸附效果最佳,最大吸附率为89.56%,最大吸附容量为8.57mg/g。吸附溶液pH值的大小和介孔材料的孔径尺寸是决定吸附量大小的关键因素,因此,重点应通过优化合成工艺提高介孔材料的孔径。 | 杨静 麻晓光 FROST Ray L | 2007 | 硅酸盐学报2007，35，6： | 7 |
| 11 | Cyclic load testing of pre-stressed rock anchors for slope stabilization显示文摘The objective of this research was to assess the characteristics of seismic induced damage and the deformation patterns of pre-stressed cement-grouted cables that are used for rock slope stabilization projects subjected to quasi-static cyclic loading.The experimental configuration includes the installation of 15 pre-stressed cables in a slope model made of concrete blocks(theoretically rigid rock mass) on top of a pre-existing sliding surface.The study showed that:(i) The pre-stressed cables exhibited great seismic performance.Rapid displacement of the model blocks was observed after the complete loss of the initial pre-stress load under continued applied cyclic loads and exceedance of the state of equilibrium,which implies the higher the initial pre-stress load,the better the seismic performance of the rock anchor;(ii) The failure of the pre-stressed cables was due to fracture at the connection of the tendons and cable heads under cyclic loading.The sequence of failure had a distinct pattern.Failure was first observed at the upper row of cables,which experienced the most severe damage,including the ejection of cable heads.No evidence of de-bonding was observed during the cyclic loading;(iii) The stress distribution of the bond length for pre-stressed cables was highly non-uniform.High stress concentrations were observed at both the fixed end and the free end of the bond length both before and immediately after the state of equilibrium is exceeded.The results obtained can be used to evaluate the overall performance of pre-stressed rock anchors subject to seismic loading and their potential as rockfall prevention and stabilization measures. | ZHENG Da LIU Fang-zhou JU Neng-pan FROST J.David HUANG Run-qiu | 2016 | Journal of Mountain Science2016，13，1： | 5 |
| 12 | 鸽子丘脑圆核细胞的视觉反应显示文摘鸟类离顶盖通路由视顶盖、圆核和外侧纹状体组成。用Ketanine/Rompun麻醉鸽子后进行标准的细胞外引导。由计算机产生的图形投射到一个正切的屏幕上,在屏幕上事先描上眼的标记和感受野边界。根据219个单位的记录,区分出下列不同的类型:1)亮度单位;2)色觉拮抗单位;3)运动/色觉单位;4)轴向运动单位;5)覆盖边反应单位;6)运动抑制单位。 | 姜世英 王永昌 Frost B J | 1991 | 广西师范大学学报(自然科学版)1991，9，2： | 4 |
| 13 | The presence of a cytopathologist increases the diagnostic accuracy of endoscopic ultrasound‐guided fine needle aspiration cytology for pancreatic adenocarcinoma: a meta‐analysis显示文摘 | S. Hébert‐Magee S. Bae S. Varadarajulu J. Ramesh A. R. Frost M. A. Eloubeidi I. A. Eltoum | 2013 | Cytopathology2013，，3： | 4 |
| 14 | 对明串珠菌及其他细菌的抑制效果显示文摘在从压榨间直到蔗汁澄清的蔗糖生产过程中,蔗汁中微生物活动是破坏蔗糖品质的一个重要因素。蔗糖损失和葡聚糖的形成通常与蔗汁中微生物引起的变质有关。多年来,这一直成为糖厂试图改善蔗糖品质时所面临的问题。本文以直接影响得糖率的微生物减少和相对纯度为指标,研究了不同杀菌方法在蔗汁中的效果。浓度为0.007%的S抑制剂显示了对某糖厂初压汁和混合汁中的微生物菌群的抗菌效应。在对照组中,12h后观察到4.8单位的纯度降低。加入S抑制剂后,只降低2个单位。且蔗汁的稳定性在3个样品中几乎完全一致。以S抑制剂处理的蔗汁保持深褐色和清新的气味,且pH与初始相比无显著变化,而未处理的蔗汁变浅褐色,产生很强的酒味,pH和纯度显著降低。这种稳定效应尚未被其他常用的糖用杀菌剂所报导。同样,本文证明了有可能通过使用S抑制剂来稳定混合汁。经S抑制剂处理后,游离的还原物质和多聚糖比不经处理的样品低6倍。这些结果表明,形成的葡聚糖以及随之形成的游离果糖减少。 | Georgina Michelena Aidin Martinez Graciela Cerutti Monica Coronel Antonio Bell Emilia Carrera Agustin Lopez-Murguia Roberto Portuondo Lazaro Mergarejo Frost M Steele 李宜海 | 2006 | 广西轻工业2006，22，4： | 3 |
| 15 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 16 | Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘 | Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin | 2008 | Circulation2008，，23： | 2 |
| 17 | Language processing is strongly left lateralized in both sexes显示文摘 | Frost JA Binder JR Springer JA | 1999 | Brain1999，122，1： | 2 |
| 18 | Photochemical ozone production in the rural southeastern United States during the 1990 Rural Oxidants in the Southern Environment (ROSE) program显示文摘 | Frost G Trainer M Allwine G | 1998 | J Geophy Res1998，103，22： | 2 |
| 19 | Infrared spectroscopic study of potassium and cesium acetate-intercalated kaolinites显示文摘 | Ray L Frost Oliver B Locos Janos Kristof J.Theo Kloprogge | 2001 | Vibrational Spectroscopy2001，，1： | 2 |
| 20 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 2 |
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