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| 1 | Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis显示文摘AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes. | Mehdi Mohamadnejad Mehrnaz Namiri Mohamad Bagheri Seyed Masiha Hashemi Hossein Ghanaati Narges Zare Mehrjardi Saeed Kazemi Ashtiani Reza Malekzadeh Hossein Baharvand | 2007 | World Journal of Gastroenterology2007，13，24： | 74 |
| 2 | Osteoarticular manifestations of human brucellosis:A review显示文摘Brucellosis is a common global zoonotic disease, which is responsible for a range of clinical manifestations. Fever, sweating and musculoskeletal pains are observed in most patients. The most frequent complication of brucellosis is osteoarticular involvement, with 10% to 85% of patients affected. The sacroiliac(up to 80%) and spinal joints(up to 54%) are the most common affected sites.Spondylitis and spondylodiscitis are the most frequent complications of brucellar spinal involvement. Peripheral arthritis, osteomyelitis, discitis, bursitis and tenosynovitis are other osteoarticular manifestations, but with a lower prevalence. Spinal brucellosis has two forms: focal and diffuse. Epidural abscess is a rare complication of spinal brucellosis but can lead to permanent neurological deficits or even death if not treated promptly. Spondylodiscitis is the most severe form of osteoarticular involvement by brucellosis, and can have single-or multifocal involvement. Early and appropriate diagnosis and treatment of the disease is important in order to have a successful management of the patients with osteoarticular brucellosis. Brucellosis should be considered as a differential diagnosis for sciatic and back pain, especially in endemic regions. Patients with septic arthritis living in endemic areas also need to be evaluated in terms of brucellosis. Physical examination, laboratory tests and imaging techniques are needed to diagnose the disease. Radiography, computed tomography, magnetic resonance imaging(MRI) and bone scintigraphy are imaging techniques for the diagnosis of osteoarticular brucellosis. MRI is helpful to differentiate between pyogenic spondylitis and brucellar spondylitis. Drug medications(antibiotics)and surgery are the only two options for the treatment and cure of osteoarticular brucellosis. | Seyed Mokhtar Esmaeilnejad-Ganji Seyed Mohammad Reza Esmaeilnejad-Ganji | 2019 | World Journal of Orthopedics2019，10，2： | 52 |
| 3 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 4 | Amino acids and mammary gland development:nutritional implications for milk production and neonatal growth显示文摘Milk is synthesized by mammary epithelial cel s of lactating mammals. The synthetic capacity of the mammary gland depends largely on the number and efficiency of functional mammary epithelial cel s. Structural development of the mammary gland occurs during fetal growth, prepubertal and post-pubertal periods, pregnancy, and lactation under the control of various hormones(particularly estrogen, growth hormone, insulin-like growth factor-I, progesterone, placental lactogen, and prolactin) in a species- and stage-dependent manner. Milk is essential for the growth, development, and health of neonates. Amino acids(AA), present in both free and peptide-bound forms, are the most abundant organic nutrients in the milk of farm animals. Uptake of AA from the arterial blood of the lactating dam is the ultimate source of proteins(primarily β-casein and α-lactalbumin) and bioactive nitrogenous metabolites in milk. Results of recent studies indicate extensive catabolism of branched-chain AA(leucine, isoleucine and valine) and arginine to synthesize glutamate,glutamine, alanine, aspartate, asparagine, proline, and polyamines. The formation of polypeptides from AA is regulated not only by hormones(e.g., prolactin, insulin and glucocorticoids) and the rate of blood flow across the lactating mammary gland, but also by concentrations of AA, lipids, glucose, vitamins and minerals in the maternal plasma, as well as the activation of the mechanistic(mammalian) target rapamycin signaling by certain AA(e.g.,arginine, branched-chain AA, and glutamine). Knowledge of AA utilization(including metabolism) by mammary epithelial cells will enhance our fundamental understanding of lactation biology and has important implications for improving the efficiency of livestock production worldwide. | Reza Rezaei Zhenlong Wu Yongqing Hou Fuller W.Bazer Guoyao Wu | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 36 |
| 5 | Adipose-derived stromal cell in regenerative medicine:A review显示文摘The application of appropriate cell origin for utilizing inregenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells(ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years. As medical options, both the stromal vascular and ADSC suggests good opportunity as marvelous cell-based therapeutics. The some biological features are the main factors that impact the regenerative activity of ADSCs, including the modulation of the cellular immune system properties and secretion of bioactive proteins such as cytokines, chemokines and growth factors, as well as their intrinsic anti-ulcer and anti-inflammatory potential. A variety of diseases have been treated by ADSCs, and it is not surprising that there has been great interest in the possibility that ADSCs might be used as therapeutic strategy to improve a wider range of diseases. This is especially important when it is remembered that routine therapeutic methods are not completely effective in treat of diseases. Here, it was discuss about applications of ADSC to colitis, liver failure, diabetes mellitus, multiple sclerosis, orthopaedic disorders, hair loss, fertility problems, and salivary gland damage. | Reza Tabatabaei Qomi Mohsen Sheykhhasan | 2017 | World Journal of Stem Cells2017，9，8： | 33 |
| 6 | Hepatocellular carcinoma in Asia: Prevention strategy and planning显示文摘AIM: To review all of epidemiological and etiological aspects of hepatocellular carcinoma(HCC) and examined the prevention of this disease in Asia.METHODS: We conducted a systematic review according to the PRISMA guidelines. We were chosen articles that published previously, from Pub Med(MEDLINE), the Cochrane database and Scopus. The key words used in this research were as follows: HCC in Asia and the way of prevention of this disease, with no language limitations. We selected those papers published before 2014 that we considered to be most important and appropriate. All relevant articles were accessed in full text and all relevant materials was evaluated and reviewed.RESULTS: More than 70% of all new cases of liver cancer were diagnosed in Asia, a region that 75% of all those chronically infected with hepatitis B virus(HBV) in the world. Chronic HBV infection is the main cause of HCC in Asia, where the virus is endemic and vertical transmission is common. Japan, Saudi Arabia, Egypt and Pakistan are exception because of high prevalence of HCV infection in these regions. The prevalence of this cancer is high in Eastern and South-Eastern Asia, But Middle Eastern countries are characterized as moderate prevalence rate of HCC region and Central Asia and some part of Middle Eastern countries are known as low prevalence rate of HCC. In addition of HBV and HCV the other factors such as aflatoxin, alcohol, obesity, diabetes and non-alcoholic fatty liver disease(NAFLD) might be responsible for a low prevalence of HCC in Asian countries. Currently available HCC therapies, chemotherapy, surgical are inefficient, mainly due to usually late diagnosis and high recurrence rates after surgical resection, and usually end with treatment failure. Liver transplantation also remains as a difficult strategy in patients with HCC. Thus prevention of HCC by treating and prevention HBV and HCV infection, the major causative agents of HCC, and the other riskfactors such as aflatoxin, alcohol, obesity, diabetes and NAFLD is of a great medical importance. CONCLUSION: The main challenge which still present in Asia, is the high prevalence of chronic hepatitis.So, prevention of HBV and HCV is the key strategy to reduce the incidence of HCC in Asia. | Sara Ashtari Mohamad Amin Pourhoseingholi Afsaneh Sharifian Mohamad Reza Zali | 2015 | World Journal of Hepatology2015，7，12： | 25 |
| 7 | 西藏谢通门县雄村铜(金)矿矿石物质成分研究及其意义显示文摘西藏谢通门县雄村铜(金)矿是新发现的超大型细脉浸染型铜(金)矿。通过详细的岩石学、矿石学研究,表明矿石类型主要分为氧化矿石、次生硫化物矿石和细脉浸染状硫化物矿石三大类型。矿石主要为细脉浸染状。主要金属矿物为黄铜矿、黄铁矿、磁铁矿、磁黄铁矿,其次是辉铜矿等。主要非金属矿物为石英,约占矿物总量的60%~70%;其次是红柱石、钾长石、斜长石、黑云母、白云母、绢云母、绿帘石、石榴子石等。矿石主成矿元素以Cu为主,伴生有用组分为Au,Ag,Zn和Pb等。 | 张丽 唐菊兴 邓起 黄勇 郎兴海 Jim LANG Reza TAFITI | 2007 | 成都理工大学学报(自然科学版)2007，34，3： | 23 |
| 8 | Biochemical and physiological bases for utilization of dietary amino acids by young Pigs显示文摘Protein is quantitatively the most expensive nutrient in swine diets. Hence it is imperative to understand the physiological roles played by amino acids in growth, development, lactation, reproduction, and health of pigs to improve their protein nutrition and reduce the costs of pork production. Due to incomplete knowledge of amino acid biochemistry and nutrition, it was traditionally assumed that neonatal, post-weaning, growing-finishing, and gestating pigs could synthesize sufficient amounts of all 'nutritionally nonessential amino acids' (NEAA) to support maximum production performance. Therefore, over the past 50 years, much emphasis has been placed on dietary requirements of nutritionally essential amino acids as building blocks for tissue proteins. However, a large body of literature shows that NEAA, particularly glutamine, glutamate, arginine and proline regulate physiological functions via cell signaling pathways, such as mammalian target of rapamycin, AMP-activated protein kinase, extracellular signal-related kinase, Jun kinase, mitogen-activated protein kinase, and NEAA-derived gaseous molecules (e.g., nitric oxide, carbon monoxide, and hydrogen sulfide). Available evidence shows that under current feeding programs, only 70% and 55% of dietary amino acids are deposited as tissue proteins in 14-day-old sow-reared piglets and in 30-day-old pigs weaned at 21 days of age, respectively. Therefore, there is an urgent need to understand the roles and dietary requirements of NEAA in swine nutrition. This review highlights the basic biochemistry and physiology of absorption and utilization of amino acids in young pigs to enhance the efficacy of utilization of dietary protein and to minimize excretion of nitrogenous wastes from the body. | Reza Rezaei Weiwei Wang Zhenlong Wu Zhaolai Dai Junjun Wang Guoyao Wu | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 22 |
| 9 | Validation of nutritional risk index method against patientgenerated subjective global assessment in screening malnutrition in colorectal cancer patients显示文摘Objective:To validate malnutrition screening tool of nutrition risk index(NRI)against patient-generated subjective global assessment(PG-SGA)as a gold standard tool in colorectal cancer patients before radiotherapy.Methods:Nutritional status of 52 volunteer colorectal cancer patients with a mean age of 54.1±16.8 years who referred to radiotherapy center were assessed by PG-SGA(gold standard method)and NRI.Serum albumin levels of patients were determined by colorimetric method.A contingency table was used to determine the sensitivity,specificity,and predictive value of the NRI in screening patients at risk of malnutrition,in comparison with the PG-SGA in patients before radiotherapy.Results:The findings of PG-SGA and NRI showed that 52%and 45%of patients in our study were moderately or severely malnourished respectively.The NRI had a sensitivity of 66%and a specificity of 60%against PG-SGA.The positive predictive value was 64%and the negative predicative value was 62%.The agreement between NRI and PG-SGA was statistically insignificant(kappa=0.267;P>0.05).Conclusions:The findings of present study showed that the prevalence of malnutrition was high in patients with colorectal cancer.Moreover,NRI method had low sensitivity and specificity in assessing nutritional status of patients with cancer.It seems that the combination of anthropometric,laboratory parameters and a subjective scoring system may be helpful tools in screening of malnutrition in cancer patients. | Elnaz Faramarzi Reza Mahdavi Mohammad Mohammad-Zadeh Behnam Nasirimotlagh | 2013 | Chinese Journal of Cancer Research2013，25，5： | 23 |
| 10 | Diabetes mellitus and cognitive impairments显示文摘There is strong evidence that diabetes mellitus increases the risk of cognitive impairment and dementia. Insulin signaling dysregulation and small vessel disease in the base of diabetes may be important contributing factors in Alzheimer's disease and vascular dementia pathogenesis, respectively. Optimal glycemic control in type 1 diabetes and identification of diabetic risk factors and prophylactic approach in type 2 diabetes are very important in the prevention of cognitive complications. In addition, hypoglycemic attacks in children and elderly should be avoided. Anti-diabetic medications especially Insulin may have a role in the management of cognitive dysfunction and dementia but further investigation is needed to validate these findings. | Elham Saedi Mohammad Reza Gheini Firoozeh Faiz Mohammad Ali Arami | 2016 | World Journal of Diabetes2016，7，17： | 23 |
| 11 | 二氧化硅纳米流体在储集层微粒运移控制中的应用显示文摘利用SiO_2纳米流体开展岩心驱替实验,通过注入SiO_2纳米流体改变孔壁的表面性质,加强颗粒与孔壁间的吸引力,克服水动力排斥力,以提高临界流速,控制储集层中微粒运移、提高注液速度。在注水过程中注入SiO_2纳米颗粒控制微粒的运移,有助于设计更高的产/注液速度。驱替实验结果表明质量分数为0.1%的SiO_2纳米流体控制微粒运移的性能最好,可将微粒运移量降低80%。增加注入流体的盐度并不能改善纳米流体控制微粒运移的性能。通过测量岩心表面的Zeta电位,得知SiO_2纳米颗粒由于带负电荷不能改变孔壁上的Zeta电位。原子力显微镜(AFM)分析证明,控制微粒运移的主要机理是SiO_2纳米流体增加了孔壁的粗糙度,需要更大的水动力才能使多孔介质中的微粒开始移动。对于所有实验都计算了微粒上的总作用力和扭矩,理论结果与实验结果吻合,计算结果表明微粒主要以滚动机理从孔壁脱落。 | HASANNEJADA Reza POURAFSHARY Peyman VATANI Ali SAMENI Abdolhamid | 2017 | 石油勘探与开发2017，44，5： | 21 |
| 12 | 柑橘黄龙病热处理防治技术研究进展显示文摘柑橘黄龙病正在中国、巴西和美国等地广泛传播,急需快速、有效的田间防治技术。热水和湿热空气处理对柑橘病苗和嫁接枝条有脱毒作用,在温室环境中对病苗木进行光照热疗,可以减少黄龙病病菌数量,促进其健康生长并有效延长产果寿命。该文针对柑橘黄龙病防治技术的研究现状,综述了基因改良育种、苗木脱毒、化学防治、物理防治和生物防治等方法,结合热疗法在微生物和昆虫杀灭中的广泛应用,分析了田间热处理防治技术研究中存在的主要问题,提出了研究柑橘黄龙病病菌热处理温度阈值和对应时间、建立田间黄龙病病情快速诊断和热处理防治效果评价体系、研究热处理对黄龙病病菌抑制和消杀机理以及不同传热介质在柑橘树体的传热过程和特性、建立黄龙病田间快速热处理系统、研究黄龙病综合防治方法等建议,可为进一步研究柑橘黄龙病田间防治技术提供参考。 | 贾志成 郑加强 黄雅杰 周宏平 Ehsani Reza | 2015 | 农业工程学报2015，31，23： | 21 |
| 13 | 柑桔黄龙病的可见-近红外光谱特征显示文摘柑桔黄龙病是一种以木虱为载体的细菌病原,目前还没有行之有效的治疗方法,对世界柑桔产业构成了严重的威胁。探索快速检测柑桔黄龙病的方法,对该病的诊断、评估及进一步的控制都具有重要意义。该研究采用了快速、无损的光谱方法对该病害特征进行初步探索。实验针对健康及染病植株的叶片及冠层,分别在实验室条件及田间环境下测量了其可见-近红外光谱反射率,以分析寻找二者的光谱差异。对原始光谱数据进行了平滑、聚类平均等预处理,并求取了一阶微分以确定其红边位置(red edge position,REP)。为了应对一阶微分在REP处的多个波峰现象,采用了线性外插值法及拉格朗日插值法量化REP。研究结果显示,健康及染病样本的反射率在可见光、近红外具有明显的差异。相比于健康样本,染病样本因其呈现的黄化现象,使其反射率在可见光区较高;又因黄龙病菌会明显阻碍叶片对水分的吸收而使其反射率在近红外较低。REP同样显示了潜在的区分能力,其明显随着染病程度的加深逐渐向红波段移动。在染病程度差异较大的数据集中,REP平均值相差达20nm;而在染病程度差异较小的数据集中,阈值分割法的分类精度也高达90%以上,且线性外插值法的分类精度略高于拉格朗日插值法。本研究成果为利用光谱技术快速无损检测柑桔黄龙病提供了可靠的理论依据。 | 李修华 李民赞 Won Suk Lee Reza Ehsani Ashish Ratn Mishra | 2014 | 光谱学与光谱分析2014，34，6： | 20 |
| 14 | Vascular complications following liver transplantation:Aliterature review of advances in 2015显示文摘Although vascular complications(VCs) following orthotopic liver transplantation(OLT) seldom occur, they are the most feared complications with a high incidence of both graft loss and mortality, as they compromise the blood flow of the transplant(either inflow or outflow). Diagnosis and therapeutic management of VCs constitute a major challenge in terms of increasing the success rate of liver transplantation. While surgical treatment used to be considered the first choice for management, advances in endovascular intervention have increased to make this a viable therapeutic option. Considering VC as a rare but a major and dreadful issue in OLT history, and in view of the continuing and rapid progress in recent years, an update on these uncommon conditions seemed necessary. In this sense, this review comprehensively discusses the important features(epidemiological, clinical, paraclinical, prognostic and therapeutic) of VCs following OLT. | Tullio Piardi Martin Lhuaire Onorina Bruno Riccardo Memeo Patrick Pessaux Reza Kianmanesh DanieleSommacale | 2016 | World Journal of Hepatology2016，8，1： | 20 |
| 15 | Global elimination of hepatitis C virus infection:Progresses and the remaining challenges显示文摘Today, with the introduction of interferon-free direct-acting antivirals and outstanding progresses in the prevention, diagnosis and treatment of hepatitis C virus(HCV) infection, the elimination of HCV infection seems more achievable. A further challenge is continued transmission of HCV infection in high-risk population specially injecting drug users(IDUs) as the major reservoir of HCV infection. Considering the fact that most of these infections remain undiagnosed, unidentified HCVinfected IDUs are potential sources for the rapid spread of HCV in the community. The continuous increase in the number of IDUs along with the rising prevalence of HCV infection among young IDUs is harbinger of a forthcoming public health dilemma, presenting a serious challenge to control transmission of HCV infection. Even the changes in HCV genotype distribution attributed to injecting drug use confirm this issue. These circumstances create a strong demand for timely diagnosis and proper treatment of HCV-infected patients through risk-based screening to mitigate the risk of HCV transmission in the IDUs community and, consequently, in the society. Meanwhile, raising general awareness of HCV infection, diagnosis and treatment through public education should be the core activity of any harm reduction intervention, as the root cause of failure in control of HCV infection has been lack of awareness among young drug takers. In addition, effective prevention, comprehensive screening programs with a specific focus on high-risk population, accessibility to the new anti-HCV treatment regimens and public education should be considered as the top priorities of any health policy decision to eliminate HCV infection. | Reza Taherkhani Fatemeh Farshadpour | 2017 | World Journal of Hepatology2017，9，33： | 20 |
| 16 | Molecular identification of hepatitis B virus genotypes/subgenotypes:Revised classification hurdles and updated resolutions显示文摘The clinical course of infections with the hepatitis B virus(HBV)substantially varies between individuals,as a consequence of a complex interplay between viral,host,environmental and other factors.Due to the high genetic variability of HBV,the virus can be categorized into different HBV genotypes and subgenotypes,which considerably differ with respect to geographical distribution,transmission routes,disease progression,responses to antiviral therapy or vaccination,and clinical outcome measures such as cirrhosis or hepatocellular carcinoma.However,HBV(sub)genotyping has caused some controversies in the past due to misclassifications and incorrect interpretations of different genotyping methods.Thus,an accurate,holistic and dynamic classification system is essential.In this review article,we aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification.Analyzing fulllength genome sequences when classifying genotypes and subgenotypes is the foremost prerequisite of this classification system.Careful attention must be paid to all aspects of phylogenetic analysis,such as bootstrapping values and meeting the necessary thresholds for(sub)genotyping.Quasi-subgenotype refers to subgenotypes that were incorrectly suggested to be novel.As many of these strains were misclassified due to genetic differences resulting from recombination,we propose the term'recombino-subgenotype'.Moreover,immigration is an important confounding facet of global HBV distribution and substantially changes the geographic pattern of HBV(sub)genotypes.We therefore suggest the term'immigro-subgenotype'to distinguish exotic(sub)genotypes from native ones.We are strongly convinced that applying these two proposed terms in HBV classification will help harmonize this rapidly progressing field and allow for improved prophylaxis,diagnosis and treatment. | Mahmoud Reza Pourkarim Samad Amini-Bavil-Olyaee Fuat Kurbanov Marc Van Ranst Frank Tacke | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 17 | 雄村式斑岩型-浅成低温热液型铜金矿地质特征显示文摘 1 概 况
雄村铜(金矿)是新近发现的超大型铜(金)矿,由作者负责勘探工作的实施,迄今完成近7万米钻探工作量.Ⅰ号矿体勘探报告已经通过评审,Ⅰ号矿体于2007年10月完成勘探,正在编写报告.'雄村式'铜金矿主要分布在日喀则弧前盆地的谢通门县-日喀则市一线.该区是西藏特提斯-喜马拉雅构造域南部,属冈底斯-念青唐古拉陆壳地体基础上发育的冈底斯南缘燕山期-早喜马拉雅期陆缘岩浆弧与昂仁-日喀则中-新生代弧前盆地转换部位.地层以一套早侏罗统一始新世的沉积-火山岩建造为主,主要为一套含火山物质的陆内碎屑岩夹碳酸盐岩、火山碎屑岩.由于受早期板块俯冲和后期板块碰撞作用的影响,岩浆活动强烈,早中晚侏罗世、白垩世、第三纪均有岩浆活动,其中与成矿有关的主要为中晚侏罗世和白垩世的岩浆活动,形成与以上岩浆活动有关的铜金矿(如雄村铜金矿、洞嘎金多金属矿、洞嘎普-普钦木铜金矿、则莫多拉铜金矿).…… | 唐菊兴 李志军 张丽 黄勇 邓起 郎兴海 Jim Lang Reza Tafiti | 2007 | 矿物学报2007，，z1： | 19 |
| 18 | FREE VIBRATION ANALYSIS OF SIMPLY SUPPORTED BEAM WITH BREATHING CRACK USING PERTURBATION METHOD显示文摘In this paper,a new analytical method for vibration analysis of a cracked simply supported beam is investigated.By considering a nonlinear model for the fatigue crack,the governing equation of motion of the cracked beam is solved using perturbation method.The solution of the governing equation reveals the superharmonics of the fundamental frequency due to the nonlinear effects in the dynamic response of the cracked beam.Furthermore,considering such a solution,an explicit expression is also derived for the system damping changes due to the changes in the crack parameters,geometric dimensions and mechanical properties of the cracked beam.The results show that an increase in the crack severity and approaching the crack location to the middle of the beam increase the system damping.In order to validate the results,changes in the fundamental frequency ratios against the fatigue crack severities are compared with those of experimental results available in the literature.Also,a comparison is made between the free response of the cracked beam with a given crack depth and location obtained by the proposed analytical solution and that of the numerical method.The results of the proposed method agree with the experimental and numerical results. | Mousa Rezaee Reza Hassannejad | 2010 | Acta Mechanica Solida Sinica2010，23，5： | 19 |
| 19 | Sublethal effects of imidacloprid and pymetrozine on population growth parameters of cabbage aphid, Brevicoryne brassicae on rapeseed, Brassica napus L.显示文摘菜蚜的人口生长参数上的 imidacloprid 和 pymetrozine 的效率, Brevicoryne brassicae L。( Homoptera:Aphididae ) 被叶剧降方法用人口统计的毒物学决定。起初,生物鉴定测试被执行。为 imidacloprid 和 pymetrozine 的 LC_(50 ) 价值和置信界限是 1.61 x 10 ^(-5) mol/L (0.74 x 10 ^(-5)-2.66 x10^(-5)) 和 2.14 x 10 ^(-4) mol/L (1.24 x 10 ^(-4)-3.40 x 10 ^(-4)), 分别地。在菜蚜的人口生长参数上评估二杀虫药剂的尚不致命的效果, imidacloprid 和 pymetrozine 的 LC_(30 ) 集中在 5 mol/L 和 30 mol/L 被使用。实验在 20 ±在一个孵卵器被执行 1 ℃, 60% ± 5% RH 并且 16:8 (L:D ) canolaseedlings 上的光周期, Brassica 马来麝 L。var。“ PF ”。网肥沃率在两 insecticide-treatedpopulations 减少了。增加(r_m ) 的内在的率比在控制在 imidacloprid 和 pymetrozine 处理是更低的。内在的出生率也在对待的人口减少了。处于对待的人口的内在的死亡率有相对增加。吝啬的产生时间和倍增时间在比在控制与杀虫药剂对待的人口也是更低的。在作为与控制相比每女性复制的美女的平均数字有可观的减小。在控制的女成年人的平均长寿与与 imidacloprid 和 pymetrozine 对待的那些显著地不同。然而,在在二张对待杀虫药剂的人口之间的蚜虫生活桌子参数没有重要差别(P >
0.01 ) 。 | MOHAMMAD REZA LASHKARI AHAD SAHRAGARD MOHAMMAD GHADAMYARI | 2007 | Insect Science2007，14，3： | 18 |
| 20 | Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance显示文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. | Kamran Ghaffarzadehgan Mostafa Jafarzadeh Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani | 2008 | World Journal of Gastroenterology2008，14，41： | 18 |
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