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| 1 | Cancer statistics, 2015显示文摘 | Rebecca L. Siegel Kimberly D. Miller Ahmedin Jemal | 2015 | CA: A Cancer Journal for Clinicians2015，，1： | 41 |
| 2 | 美国临床药学教育与实践显示文摘目的:介绍美国临床药学教育的概况,探讨其发展方向。方法:总结近50年美国临床药学的发展史,介绍其教学和培训模式、临床药师工作内容及相关认证情况。结果与结论:美国的药学教育和临床实践经历了重大的变化与发展。2000年开始设立的临床药学博士学位项目是变革核心,其是目前美国药学院校提供的唯一药学学位。坚实的临床教育是培养临床药学从业者的基础,这些课程主要由资深的临床药学博士授课。患者监护是临床药学博士生教育的中心,而以技能展现所学知识的课堂活动正逐步取代传统的授课式教学模式。药学院校需要证明其学生掌握了评审标准中所要求的技能。为了将学生培养为专业的临床药师,在完成临床药学博士项目后,一般需要1~2年的住院药师培训。大多数临床药师还需要通过一项临床委员会考试以取得临床药学执业执照。此外,临床药师也可成为药学院校的临床教师。中国临床药师的发展,可以此为借鉴,通过院校和医疗机构的协同努力,以加强药师的临床培训。 | Keith M.Olsen Sylvia A.Dang Olivia V.Nguyen Kimberly K.Scarsi 张伶俐 曾力楠 归舸 | 2016 | 中国药房2016，27，2： | 29 |
| 3 | Non-viral causes of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy and represents an international public health concern as one of the most deadly cancers worldwide.The main etiology of HCC is chronic infection with hepatitis B and hepatitis C viruses.However,there are other important factors that contribute to the international burden of HCC.Among these are obesity,diabetes,non-alcoholic steatohepatitis and dietary exposures.Emerging evidence suggests that the etiology of many cases of HCC is in fact multifactorial,encompassing infectious etiologies,comorbid conditions and environmental exposures.Clarification of relevant non-viral causes of HCC will aid in preventative efforts to curb the rising incidence of this disease. | Wojciech Blonski David S Kotlyar Kimberly A Forde | 2010 | World Journal of Gastroenterology2010，16，29： | 25 |
| 4 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 5 | 美国临床药学的发展与实践显示文摘目的:介绍美国临床药学的发展史及其实践领域的拓展。方法:简要总结20世纪美国临床药学发展史及其临床实践领域从住院部拓展到门诊,并描述临床药师的主要职责。结果与结论:美国临床药学的重心已从用药和药物调剂向'以患者为中心'、以提高用药安全和有效为目标的临床实践上倾斜。20世纪初,在大多数医院尚无雇佣药师时,一些药师中的有识之士就已开始参加患者监护查房。此后,出现了更多开创性临床实践模式,昭示着药学职业的巨大潜力。这一系列改变也催生了药学博士项目发展,将药师更好地培养为临床人员,运用其药学专长优化患者监护。虽然临床药学的进步并非一蹴而就和一帆风顺,但经过药师和专业组织的努力,临床药学发展方向发生转变,药师已成为多学科团队中不可或缺的一员。 | Kimberly K.Scarsi Emily A.Prinz Hannah K.Snyder Keith M.Olsen 张伶俐 曾力楠 归舸 | 2015 | 中国药房2015，26，26： | 14 |
| 6 | Venous thromboembolism in inflammatory bowel disease显示文摘Patients with inflammatory bowel disease(IBD)are at an increased risk for venous thromboembolism(VTE).VTE events carry significant morbidity and mortality,and have been associated with worse outcomes in patients with IBD.Studies have suggested that the hypercoagulable nature of the disease stems from a complex interplay of systems that include the coagulation cascade,natural coagulation inhibitors,fibrinolytic system,endothelium,immune system,and platelets.Additionally,clinical factors that increase the likelihood of a VTE event among IBD patients include older age(though some studies suggest younger patients have a higher relative risk of VTE,the incidence in this population is much lower as compared to the older IBD patient population),pregnancy,active disease,more extensive disease,hospitalization,the use of certain medications such as corticosteroids or tofacitinb,and IBD-related surgeries.Despite the increased risk of VTE among IBD patients and the safety of pharmacologic prophylaxis,adherence rates among hospitalized IBD patients appear to be low.Furthermore,recent data suggests that there is a population of high risk IBD patients who may benefit from post-discharge prophylaxis.This review will provide an overview of patient specific factors that affect VTE risk,elucidate reasons for lack of VTE prophylaxis among hospitalized IBD patients,and focus on recent data describing those at highest risk for recurrent VTE post-hospital discharge. | Kimberly Cheng Adam S Faye | 2020 | World Journal of Gastroenterology2020，26，12： | 14 |
| 7 | POLYMER CHARGE AND MOLECULAR WEIGHT EFFECTS ON TREATED IRRIGATION FURROW PROCESSES显示文摘Application of 5-10 mg L-1 water soluble anionic polyacrylamide (PAM) to furrow irrigation water during flow advance substantially reduces sediment loss and increases net infiltration. We hypothesized that PAM_s solvated molecular conformation influences its irrigation-management efficacy. The study was conducted in Kimberly, Idaho, on Portneuf silt loam (Durinodic Xeric Haplocalcids), under furrowirrigated beans (Phaseolus vulgaris ) at a 1.5% slope. Polyacrylamides with contrasting molecular weight (anionic; 4-7, 12- 15 and 14-17 MDa, i.e. Mg mol-1 ), charge type (neutral, anionic, cationic), and charge density (8, 19, 35 mol %) were tested in two studies. Inflow rate was 23 L min-1 during furrow advance, and 15 L min-1 for the remaining set. Anionic and neutral PAMs were twice as effective as cationic PAMs for controlling sediment loss in new furrows. The order of effectiveness for overall soilloss control was : anionic >neutral >cationic PAM, and efficacy increased with increasing charge density and/or molecular weight. Net furrow infiltration increased by 14 to 19% when PAM treatment molecular weight was reduced from 17 to 4 MDa. General trends suggested that medium and high charge density anionic and neutral PAM produced the greatest increase in infiltration compared with controls.Compared with untreated furrows, neutral PAM gave the greatest season-long net infiltration gains (5%),while charged PAMs tended to increase net infiltration early in the season on new furrows but decreased infiltration on repeat-irrigated furrows later in the season. | R. D. Lentz(USDA-ARS, Northwest Irrigation and Soils Research Laboratory, Kimberly, ID)R. E. Sojka (Landcare Research, New Zealand, Ltd, Palmerston North, New ZealandNote: The manucript of this paper was received in March 1999, Discussion open until March | 2000 | International Journal of Sediment Research2000，15，1： | 13 |
| 8 | The p75 neurotrophin receptor:at the crossroad of neural repair and death显示文摘The strong repair and pro-survival functions of neurotrophins at their primary receptors,Trk A,Trk B and Trk C,have made them attractive candidates for treatment of nervous system injury and disease.However,difficulties with the clinical implementation of neurotrophin therapies have prompted the search for treatments that are stable,easier to deliver and allow more precise regulation of neurotrophin actions.Recently,the p75 neurotrophin receptor(p75NTR) has emerged as a potential target for pharmacological control of neurotrophin activity,supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system,2) promotion of adult neurogenesis and 3) increased expression in neurons,macrophages,microglia,astrocytes and/or Schwann cells in response to injury and neurodegenerative diseases.Although the receptor has no intrinsic catalytic activity it interacts with and modulates the function of Trk A,Trk B,and Trk C,as well as sortilin and the Nogo receptor.This provides substantial cellular and molecular diversity for regulation of neuron survival,neurogenesis,immune responses and processes that support neural function.Upregulation of the p75 NTR under pathological conditions places the receptor in a key position to control numerous processes necessary for nervous system recovery.Support for this possibility has come from recent studies showing that small,non-peptide p75 NTR ligands can selectively modify pro-survival and repair functions.While a great deal remains to be discovered about the wide ranging functions of the p75 NTR,studies summarized in this review highlight the immense potential for development of novel neuroprotective and neurorestorative therapies. | Rick B.Meeker Kimberly S.Williams | 2015 | Neural Regeneration Research2015，10，5： | 12 |
| 9 | 伴有脑肿胀的大脑和小脑梗死的管理推荐意见美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景和目的关于缺血性卒中后脑肿胀患者的最佳管理方案,仍有许多尚未确定的问题。需要制定相关指南来指导如何处理这种严重并发症,如何提供最佳的综合性神经科和内科治疗,以及在患者病情恶化时如何与面临外科干预复杂决策的家属进行良好的沟通。本科学声明为大脑或小脑半球缺血性卒中伴脑肿胀的患者提供了早期的管理方案。方法写作组利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有证据进行总结并指出与当前知识水平的差距。写作组通过对MEDLINE、EMBASE和Web of Science数据库进行医学文献计算机检索(最后检索时间为2013年3月,研究对象为成年人)回顾最相关的文献。在美国心脏协会(American Heart Association,ARIA)框架背景下对证据进行组织,根据AHA/美国心脏病学学会基金会以及AHA卒中委员会的证据强度分级方案进行分类。这份声明经过AHA内部的广泛同行评议。结果已有适用于由缺血性梗死引起的半球(累及整个大脑中动脉供血区或更大范围)和小脑(累及小脑后下动脉或小脑上动脉供血区)肿胀的临床标准。幕上半球缺血性卒中伴脑肿胀发生恶化的临床表现包括新发意识障碍或意识障碍加重、脑性上睑下垂以及瞳孔大小变化。在小脑梗死伴肿胀患者中,意识水平下降是脑干受压的结果,因此可能出现早期角膜反射丧失和瞳孔缩小。应制定标准化定义以促进多中心和基于人群的发病率、患病率、危险因素和转归研究。脑肿胀高危患者的识别应包括临床和神经影像学资料。如果大面积卒中患者有必要进入全面复苏状态,则需要收入具备神经监护功能的病房。这些患者最好被收入由技术熟练和经验丰富的医生(如神经重症监护医生或神经血管科医生)负责的重症监护室或卒中单元。综合性医疗管理包括气道管理和机械通气、血压控制、液体管理以及血糖和体温控制。在幕上半球缺血性卒中伴肿胀患者中,不需行常规颅内压监测或脑脊液引流,但神经功能继续恶化的患者应考虑行去骨瓣减压和硬脑膜切开术。去骨瓣减压术在≥60岁的患者中的疗效尚不确定。在神经功能恶化的小脑卒中伴肿胀患者中,应行枕骨下颅骨切除和硬脑膜切开术。当应用脑室造瘘术缓解小脑梗死后梗阻性脑积水时,应同时行枕骨下颅骨切除术以防小脑向上移位导致的病情恶化。幕上半球梗死伴肿胀患者可获得令人满意的转归,但即使行去骨瓣减压术,仍有1/3的患者会遗留严重残疾和完全生活依赖。多数小脑梗死患者在术后能获得可接受的功能转归。结论大脑和小脑梗死伴肿胀是需要立即给予专业神经重症监护、并常需要进行神经外科干预的危重情况。去骨瓣减压术是很多患者的必然治疗选择,经过选择的患者能从中受益匪浅,尽管他们可能会遗留残疾,但仍可生活自理。 | Eelco F. M. Wijdicks Kevin N. Sheth Bob S. Carter David M. Greer Scott E. Kasner W. Taylor Kimberly Stefan Schwab Eric E. Smith Rafael J. Tamargo Max Wintermark 王玉琴 牛牧 柯开富 | 2014 | 国际脑血管病杂志2014，22，4： | 11 |
| 10 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 11 | An automated dispensing system for improving medication timing in the emergency department显示文摘BACKGROUND:Numerous medical conditions require timely medication administration in the emergency department(ED).Automated dispensing systems(ADSs)store premixed common doses at the point-of-care to minimize time to administration,but the use of such automation to improved time to medication administration has not been studied.Since vancomycin is a commonly used empiric antimicrobial,we sought to quantify the effect of using an ADS on time to drug delivery in patients presenting to the ED.The study aimed to determine the efficacy of utilizing an ADS to improve time to administration of vancomycin and determine any negative effects on dosing appropriateness.METHODS:The institional review board approved the retrospective quality improvement study took place in a single,urban academic tertiary care ED with an annual census of 80 000.Study subjects were all patients receiving vancomycin for the management of sepsis between March 1 to September 30,2008 and the same time period in 2009.The primary outcome was the proportion of patients who received vancomycin within one hour of bed placement and the secondary outcome was dosing appropriateness.RESULTS:Sixty-three patients had weight and dosing information available(29 before and 34after intervention)and were included in the study.Before intervention,no patient received vancomycin in less than 60 minutes,while after intervention 14.7%of the patients received it in less than 60minutes(difference in proportions 14.7%,95%CI 0.39%-30.0%,P=0.04).A similar proportion of the patients received correct dosing before and after intervention(44.8%vs.41.2%,difference in proportions 3.7%,95%CI-20.0%-26.7%,P=0.770).CONCLUSION:The use of an ADS may improve the timing of medication administration in patients presenting to the ED without affecting dosing appropriateness. | Michael J.Ward Jeremy S.Boyd Nicole J.Harger John M.Deledda Carol L.Smith Susan M.Walker Jeffrey D.Hice Kimberly W.Hart Christopher J.Lindsell Stewart W.Wright | 2012 | World Journal of Emergency Medicine2012，3，2： | 6 |
| 12 | Spatiotemporal microRNA profile in peripheral nerve regeneration:miR-138 targets vimentin and inhibits Schwann cell migration and proliferation显示文摘While the peripheral nervous system has regenerative ability,restoration of sufficient function remains a challenge.Vimentin has been shown to be localized in axonal growth fronts and associated with nerve regeneration,including myelination,neuroplasticity,kinase signaling in nerve axoplasm,and cell migration;however,the mechanisms regulating its expression within Schwann cell(SC) remain unexplored.The aim of this study was to profile the spatial and temporal expression profile of micro RNA(mi RNA) in a regenerating rat sciatic nerve after transection,and explore the potential role of mi R-138-5 p targeting vimentin in SC proliferation and migration.A rat sciatic nerve transection model,utilizing a polyethylene nerve guide,was used to investigate mi RNA expression at 7,14,30,60,and 90 days during nerve regeneration.Relative levels of mi RNA expression were determined using microarray analysis and subsequently validated with quantitative real-time polymerase chain reaction.In vitro assays were conducted with cultured Schwann cells transfected with mi RNA mimics and assessed for migratory and proliferative potential.The top seven dysregulated mi RNAs reported in this study have been implicated in cell migration elsewhere,and GO and KEGG analyses predicted activities essential to wound healing.Transfection of one of these,mi RNA-138-5 p,into SCs reduced cell migration and proliferation.mi R-138-5 p has been shown to directly target vimentin in cancer cells,and the luciferase assay performed here in rat Schwann cells confirmed it.These results detail a role of mi R-138-5 p in rat peripheral nerve regeneration and expand on reports of it as an important regulator in the peripheral nervous system. | Travis B.Sullivan Litchfield C.Robert Patrick A.Teebagy Shannon E.Morgan Evan W.Beatty Bryan J.Cicuto Peter K.Nowd Kimberly M.Rieger-Christ David J.Bryan | 2018 | Neural Regeneration Research2018，13，7： | 6 |
| 13 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 14 | RECENT ADVANCES IN RESEARCH AND FORECASTING OF TROPICAL CYCLONE TRACK, INTENSITY, AND STRUCTURE AT LANDFALL显示文摘This review prepared for the fourth International Workshop on Tropical Cyclone Landfall Processes(IWTCLP-4) summarizes the most recent(2015-2017) theoretical and practical knowledge in the field of tropical cyclone(TC) track, intensity, and structure rapid changes at or near landfall. Although the focus of IWTCLPIV was on landfall, this summary necessarily embraces the characteristics of storms during their course over the ocean prior to and leading up to landfall. In the past few years, extremely valuable observational datasets have been collected for TC forecasting guidance and research studies using both aircraft reconnaissance and new geostationary or low-earth orbiting satellites at high temporal and spatial resolution. Track deflections for systems near complex topography such as that of Taiwan and La Réunion have been further investigated, and advanced numerical models with high spatial resolution necessary to predict the interaction of the TC circulation with steep island topography have been developed. An analog technique has been designed to meet the need for longer range landfall intensity forecast guidance that will provide more time for emergency preparedness. Probabilistic track and intensity forecasts have also been developed to better communicate on forecast uncertainty. Operational practices of several TC forecast centers are described herein and some challenges regarding forecasts and warnings for TCs making landfall are identified. This review concludes with insights from both researchers and forecasters regarding future directions to improve predictions of TC track, intensity, and structure at landfall. | MARIE-DOMINIQUE LEROUX KIMBERLY WOOD RUSSELL L.ELSBERRY ESPERANZA O.CAYANAN ERIC HENDRICKS MATTHEW KUCAS PETER OTTO ROBERT ROGERS BUCK SAMPSON ZIFENG YU | 2018 | Tropical Cyclone Research and Review2018，7，2： | 4 |
| 15 | Regulator of myeloid differentiation and function:The secret life of Ikaros显示文摘Ikaros (also known as Lyf-1) was initially described as a lymphoid-specific transcription factor.Although Ikaros has been shown to regulate hematopoietic stem cell renewal,as well as the development and function of cells from multiple hematopoietic lineages,including the myeloid lineage,Ikaros has primarily been studied in context of lymphoid development and malignancy.This review focuses on the role of Ikaros in myeloid cells.We address the importance of post-transcriptional regulation of Ikaros function;the emerging role of Ikaros in myeloid malignancy;Ikaros as a regulator of myeloid differentiation and function;and the selective expression of Ikaros isoform-x in cells with myeloid potential.We highlight the challenges of dissecting Ikaros function in lineage commitment decisions among lymphoidmyeloid progenitors that have emerged as a major myeloid differentiation pathway in recent studies,which leads to reconstruction of the traditional map of murine and human hematopoiesis. | Olivia L Francis Jonathon L Payne Kimberly J Payne | 2011 | World Journal of Biological Chemistry2011，2，6： | 4 |
| 16 | A matter of time: Temporal variation in the introduction history and population genetic structuring of an invasive lizard显示文摘 | HalmahMOULE Kirilee CHAPLIN Rebecca D. BRAY Kimberly A. MILLER Michael B. THOMSON David G. CHAPPLE | 2015 | Current Zoology2015，61，3： | 4 |
| 17 | Short-Root1 Plays a Role in the Development of Vascular Tissue and Kranz Anatomy in Maize Leaves显示文摘 | Thomas L. Slewinski Alyssa A. Anderson Simara Price Jacob R. Withee Kimberly Gallagher Robert Turgeon | 2014 | Molecular Plant2014，7，8： | 4 |
| 18 | Accuracy of abdominal ultrasound for the diagnosis of small bowel obstruction in the emergency department显示文摘BACKGROUND: Emergency physicians frequently encounter patients with acute small bowel obstructions(SBO). Although computed tomography(CT) imaging is the current gold standard in the assessment of patients with suspected SBO in the emergency department, a few studies have examined the use of ultrasound as an alternative imaging technique. METHODS: We evaluated the accuracy of ultrasound performed in the ED by a variety of providers(physicians with various levels of training, physician assistants) compared to CT imaging in 47 patients with suspected SBOs. RESULTS: Our data demonstrated a sensitivity of 93.8% and a specificity of 93.3% when compared to abdominal CT, and a sensitivity of 94.3% and specificity of 95.2% using a composite endpoint of abdominal CT and discharge diagnosis. CONCLUSION: Ultrasound can play an important role in the identification of small bowel obstructions in ED patients. | Sarah E. Frasure Amy F. Hildrcth Raghu Seethala Heidi H. Kimberly | 2018 | World Journal of Emergency Medicine2018，9，4： | 4 |
| 19 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 20 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
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