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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 美国罗德岛医院临床药师培训见闻及体会显示文摘随着临床药学的发展,国内医院药学的工作模式正逐渐从"以物为中心的保障供应型"向"以人为本的技术服务型"转变,医院药师的工作也正逐渐从简单的药品调剂转向技术要求较高的为临床医护人员和患者提供专业的药学服务。这些转变主要参照的是美国的医院药学模式。美国的医院药学经过近半个世纪的发展,已建立了成熟的药学服务体系,药师作为临床治疗团队的一员,在保证药物使用的安全、有效、经济方面发挥着重要作用。今年5月,我有幸赴美国罗德岛医院参加了为期近一个月的临床药师培训。 | 沈健 James E. Beaulieu | 2013 | 药学与临床研究2013，21，6： | 6 |
| 3 | Droplet digital PCR for quantification of ITGA6 in a stool mRNA assay for the detection of colorectal cancers显示文摘AIM To investigate the use of droplet digital polymerase chain reaction(dd PCR) for detecting host m RNA markers in stools as a non-invasive test for colorectal cancer screening.METHODS dd PCR and quantitative PCR were compared side by side for their performance in the detection of ITGA6 and ITGA6 A transcripts in stool samples obtained from patients with various types of colorectal lesions(advanced adenomas and stage Ⅱ-Ⅳ colorectal cancers) and control(patients displaying no pathological findings) using duplex Taq Man reactions for both methods. ITGA6 and ITGA6 A were chosen for this proof-of-concept study based on their relative medium and low abundance in stool samples, respectively, as established in a previous study.RESULTS We found that the dd PCR and q PCR methods per-formed equally well in this Taq Man duplex assay for the detection of ITGA6 and ITGA6 A transcripts in stools of patients with colorectal lesions. For ITGA6, receiver operating characteristic(ROC) curve analysis showed comparable areas under the curve of 0.91(P < 0.0001) and 0.89-0.90(P < 0.0001) for the prediction of advanced adenomas and colorectal cancers, respectively. ITGA6 A, which was detected at very low levels in control patients, was found to be significantly elevated(over 40 times) in stage Ⅱ and Ⅲ colorectal cancers(P < 0.0002). Comparison of the two sets of data revealed a strong correlation of the copy numbers obtained by dd PCR and q PCR for both ITGA6 and ITGA6 A.CONCLUSION We found that ITGA6 and ITGA6 A detection in stools of patients with colorectal cancers with dd PCR is comparable to that of q PCR using Taq Man assays. | Elizabeth Herring Shigeru Kanaoka éric Tremblay Jean-Francois Beaulieu | 2017 | World Journal of Gastroenterology2017，23，16： | 2 |
| 4 | 日粮成分对生长猪饮水量的影响显示文摘1 前言
历史上,人们一直把水看成是充裕而廉价的资源,所以缺乏确定猪需水量或对影响水利用情况因素进行研究(Fraser等,1990)的积极性。现在,人类社会正越来越意识到水是有限的资源,而家畜生产行业却又是一个主要的耗水行业之一。对肉猪生产者来说,过度用水会产生过多的厩粪,而厩粪储存和田间施用的费用都很高。因此,肉猪生产者日益有兴趣于既能减少用水量又不危害猪生长性能的管理方法。日粮调整不失为一个可能解决问题的策略。 | M. I. Shaw A. D. Beaulieu J. F. Patience 陈春月(译) 覃矜(校) 樊薛安(摘) | 2007 | 国外畜牧学(猪与禽)2007，，6： | 2 |
| 5 | Characterization of Actinomycetes isolated from common scab lesions on potato tubers显示文摘 | FAUCHER E SAVARD T BEAULIEU C | 1992 | Canadian Journal of Plant Pathology1992，14，： | 2 |
| 6 | Estimating the Distribution of A Sum of Independent Lognormal Random Variables 显示文摘 | Beaulieu N C Abu-Dayya A A McLane P J | 1995 | IEEE Transactions on Communications1995，43，12： | 1 |
| 7 | P-order metric UWB receiver structures with superior performance显示文摘 | BEAULIEU N C SHAO H FIORINA J | 2008 | IEEE Transactions on Communications2008，56，10： | 1 |
| 8 | The basic of Anisotrophic Water Diffusion in the Nervous Systerm : a Technical Review 显示文摘 | Beaulieu C | 2002 | NMR Biomed2002，15，78： | 1 |
| 9 | SP analysis may beused to identify cancer stem cell population显示文摘 | Hadnagy A Gaboury L Beaulieu R | 2006 | Exp Cell Res2006，312，19： | 1 |
| 10 | Neonatal sensory deprivation induces selective changes in the quantitative distribution of GABA-immunoreactive neurons in the rat barrel field cortex显示文摘 | Michcva KD Beaulieu C | 1995 | J Comp Neurol1995，361，4： | 1 |
| 11 | Expression of multidrugresistance P-glycoprotein(MDRl) in human brain tumors 显示文摘 | Demeule M Shedid D Beaulieu E | 2001 | Int J Cancer2001，93，1： | 1 |
| 12 | P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain显示文摘 | BEAULIEU E DEMEULE M GHITESCU L | 1997 | Biochem J1997，326，2： | 1 |
| 13 | Accurate error- rate performance analysis of OFDM on frequency-se- lective Nakagami-m fading channels显示文摘 | DU Z CHENG J L BEAULIEU N C | 2006 | IEEE Trans Commun2006，54，2： | 1 |
| 14 | White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis显示文摘 | Concha L Beaulieu C Collins DL | 2009 | J Neurol Neurosurg Psychiatry2009，80，： | 1 |
| 15 | Correction of CT artifacts and its influence on Monte Carlo dose calculations 显示文摘 | Bazalova M Beaulieu L Palefsky S | 2007 | Medical Physics2007，34，： | 1 |
| 16 | Modern pollen vegetation relationships in the Champsaur valley (French Alps) and their potential in the interpretation of fossil pollen records of past cultural landseapes显示文摘 | COURT PICONA M BUTTLER A BEAULIEU J L | 2005 | Review of Palaeobotany and Palynology2005，135，： | 1 |
| 17 | From co-location to co-presence: Shifts in the use of ethnography for the study of knowledge 显示文摘 | Beaulieu A | 2010 | Social Studies of Sci-ence2010，40，3： | 1 |
| 18 | Genome size evolu- tion in relation to leaf strategy and metabolic rates revisited 显示文摘 | Beaulieu J M Leitch I J Knight C A | 2007 | Annals of Botany2007，99，： | 1 |
| 19 | Bedside ultrasonography in the ICU:part 1显示文摘 | Beaulieu Y Marik PE | 2005 | Chest2005，128，： | 1 |
| 20 | Clinical pathways: unique contribution of family medicine显示文摘 | Beaulieu MD | 2013 | Can Fam Physician2013，59，6： | 1 |
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