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| 1 | Malnutrition affects quality of life in gastroenterology patients显示文摘瞄准:与良性的胃肠的疾病调查在在病人的生命的营养不良和质量之间的协会。方法:200 个病人(养育的 104 井并且 96 营养不良) 根据主观全球评价,人体测量的大小和简历被估计电的阻抗分析。生命的质量与短形式的一般健康调查的验证医药结果学习 36 条款(SF 36 ) 被决定。肌肉功能手工被估计掌握力量和山峰流动。结果:身体集体索引,身体细胞群,手臂肌肉区域和手握力法力量在营养不良的病人是显著地更低的。当时,生命的质量通常更低与标准价值相比。七从生活规模的八质量(排除身体疼痛) 显著地在营养不良的病人被减少。把病人与肝肝硬化和煽动性的肠疾病(IBD ) 作比较,有经历的 IBD 的病人显著地在感觉降低价值身体疼痛,社会工作和心理健康。营养不良的肝 cirrhotics 在更多的规模承受了减小(六从八) 比营养不良的 IBD,病人们做了(四从八) 。结论:生命的质量在良性的胃肠的疾病通常是低的并且进一步在作为营养不良被分类的病人被减少。看来,肝肝硬化病人比 IBD 病人做经历生命的高质量,但是营养不良的影响似乎比在 IBD 在肝肝硬化更大。 | Kristina Norman Henriette Kirchner Herbert Lochs Matthias Pirlich | 2006 | World Journal of Gastroenterology2006，12，21： | 10 |
| 2 | Risk factors for colonoscopic perforation: A population-based study of 80118 cases显示文摘AIM: To assess the incidence and risk factors associated with colonic perforation due to colonoscopy. METHODS: This was a retrospective cross-sectional study. Patients were retrospectively eligible for inclusion if they were 18 years and older and had an inpatient or outpatient colonoscopy procedure code in any facility within the Geisinger Health System during the period from January 1, 2002 to August 25, 2010. Data are presented as median and inter-quartile range, for continuous variables, and as frequency and percentage for categorical variables. Baseline comparisons across those with and without a perforation were made using the two-sample t -test and Pearson's χ2 test, as appropriate.RESULTS: A total of 50 perforations were diagnosed out of 80118 colonoscopies, which corresponded to an incidence of 0.06% (95%CI: 0.05-0.08) or a rate of 6.2 per 10000 colonoscopies. All possible risk factors associated with colonic perforation with a P -value < 0.1 were checked for inclusion in a multivariable logbinomial regression model predicting 7-d colonic perforation. The final model resulted in the following risk factors which were significantly associated with risk of colonic perforation: age, gender, body mass index, albumin level, intensive care unit (ICU) patients, inpatient setting, and abdominal pain and Crohn's disease as indications for colonoscopy. CONCLUSION: The cumulative 7 d incidence of colonic perforation in this cohort was 0.06%. Advanced age and female gender were significantly more likely to have perforation. Increasing albumin and BMI resulted in decreased risk of colonic perforation. Having a colonoscopy indication of abdominal pain or Crohn's disease resulted in a higher risk of colonic perforation. Colonoscopies performed in inpatients and particularly the ICU setting had substantially greater odds of perforation. Biopsy and polypectomy did not increase the risk of perforation and only three perforations occurred with screening colonoscopy. | Uzair Hamdani Raza Naeem Fyeza Haider Pardeep Bansal Michael Komar David L Diehl H Lester Kirchner | 2013 | World Journal of Gastroenterology2013，19，23： | 9 |
| 3 | Liver transplantation for malignancy:current treatment strategies and future perspectives显示文摘In 1967,Starzl et al performed the first successful liver transplantation for a patient diagnosed with hepatoblastoma.In the following,liver transplantation was considered ideal for complete tumor resection and potential cure from primary hepatic malignancies.Several reports of liver transplantation for primary and metastatic liver cancer however showed disappointing results and the strategy was soon dismissed.In1996,Mazzaferro et al introduced the Milan criteria,offering liver transplantation to patients diagnosed with limited hepatocellular carcinoma.Since then,liver transplantation for malignant disease is an ongoing subject of preclinical and clinical research.In this context,several aspects must be considered:(1)Given the shortage of deceased-donor organs,long-term overall and disease free survival should be comparable with results obtained in patients transplanted for nonmalignant disease;(2)In this regard,living-donor liver transplantation may in selected patients help to solve the ethical dilemma of optimal individual patient treatment vs organ allocation justice;and(3)Ongoing research focusing on perioperative therapy and antiproliferative immunosuppressive regimens may further reduce tumor recurrence in patients transplanted for malignant disease and thus improve overall survival.The present review gives an overview of current indications and future perspectives of liver transplantation for malignant disease. | Christina Hackl Hans J Schlitt Gabriele I Kirchner Birgit Knoppke Martin Loss | 2014 | World Journal of Gastroenterology2014，20，18： | 7 |
| 4 | 卫星激光测距中回波实时识别和预报轨道的实时修正显示文摘介绍了卫星激光测距中回波信号的实时识别和预报轨道实时修正的方法和应用情况。回波信号的实时识别和预报轨道的实时修正有助于测距系统自动化的提高、弱回波信号卫星 (如GPS)的探测以及白天测距能力的增强。 | 张忠平 Georg Kirchner 夏小海 | 2001 | 中国科学院上海天文台年刊2001，，1： | 4 |
| 5 | Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR显示文摘 | Volker Heinemann Sebastian Stintzing Thomas Kirchner Stefan Boeck Andreas Jung | 2008 | Cancer Treatment Reviews2008，，3： | 3 |
| 6 | KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer显示文摘 | Stefan Boeck Andreas Jung Rüdiger P. Laubender Jens Neumann Rosalind Egg Clara Goritschan Steffen Ormanns Michael Haas Dominik P. Modest Thomas Kirchner Volker Heinemann | 2013 | Journal of Gastroenterology2013，，4： | 2 |
| 7 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 8 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | Decision tree technique applied to pigfarming datasets显示文摘 | Kirchner H Tolle K K Krieter J | 2004 | Livestock Production Science2004，12，90： | 1 |
| 10 | Electrochemical micromachining 显示文摘 | SCHUSTER R KIRCHNER V ALLONGUE P | 2000 | Science2000，289，： | 1 |
| 11 | Inter leukin-2/interferon alpha2a /13-retinoie acid-based ehemoimmunotherapy in advanced renal cell earcino ma:results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)显示文摘 | Atzpodien J Kirchner H Rebmann U | 2006 | gr J Cancer2006，95，4： | 1 |
| 12 | IL-2 in combination with IFN-alpha and 5-FU versus tamoxifen in metastatic renal cell carcinoma long-term results of a controlled randomized clinical trial显示文摘 | Atzpodien J Kirchner H | 2001 | Br J Cancer2001，85，： | 1 |
| 13 | Effects of thidiazuron on cytokinin autonomy and the metabolism of N6-C2 isopenteny adenosine in callus tissues of Phaseolus lunatus显示文摘 | Capelle S C Mok D W S Kirchner S C | 1983 | Plant Physiol1983，73，： | 1 |
| 14 | Catchment-scale advection and dispersion as a mechanism for fractal scaling in stream tracer concentrations显示文摘 | Kirchner J W Feng X H Neal C | 2001 | Journal of hydrology2001，254，： | 1 |
| 15 | Longitudinal asse- ssment of neurocognitive function after coronary-artery bypass surge- ry显示文摘 | Newman MF Kirchner JL Phillips-Bute B | 2001 | N Engl J Med2001，344，6： | 1 |
| 16 | Age Differences in Short-term Retention of Rapidly Changing Information 显示文摘 | KIRCHNER W K | 1958 | Journal of Experimental Psychology1958，55，4： | 1 |
| 17 | Quaternary downcutting rate of the New River, Virginia, measured from differential decay of cosmogenic 26A1 and 1Be in cave-deposited alluvium 显示文摘 | Granger D E Kirchner J W Finkel R C | 1997 | Geology1997，25，2： | 1 |
| 18 | Strain Relaxation in A1GaN/GaN Superlattices Grown on GaN显示文摘 | Einfeldt S Heinke H Kirchner V | 2001 | Journal of Applied Physics2001，89，4： | 1 |
| 19 | Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure显示文摘 | Pfluger P T Kirchner H Günnel S | | 0，，03： | 1 |
| 20 | Molecular genetic aberrations of ovarian and uterine carcinosarcomas: a CGH and FISH study显示文摘 | Schipf A Mayr D Kirchner T | 2008 | Virchows Arch2008，452，3： | 1 |
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