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| 1 | 美国高校实验室废弃物安全管理浅析显示文摘实验室废弃物的收集、管理不当会造成严重的环境污染甚至人员伤害,这已经引起国内外相关部门的高度重视。美国高校在实验室废弃物安全管理方面积累了科学、规范的管理经验:通过对实验室科研人员的专业培训保证废弃物的安全分类收集;通过专业环境健康安全管理部门人员的科学管理实现对废弃物的安全收集与存放;通过专业废弃物收集处置公司来实现废弃物的安全转移运输和最终无害化处理。为加强国内高校实验室废弃物的安全管理,在对美国高等院校实验室废弃物的收集、储藏、运输和处理等方面调查研究的基础上,结合国内实验室废弃物安全管理的现状,对国内外高校实验室废弃物的安全管理进行了对比分析,以期为国内高校实验室废弃物的安全管理工作提供有益的借鉴。 | 吕陈燕 Noel Nguyen 陈全 | 2010 | 中国安全生产科学技术2010，6，2： | 49 |
| 2 | 基于激光扫描技术的三维模型重建显示文摘通过分析三维激光扫描系统获取的点云数据,得到了利用点云数据构建三维模型的技术、方法和流程。介绍了利用地面三维激光扫描仪获取点云数据的过程以及结合RiSCAN PRO软件和Geomagic Studio软件进行建模的方法。对原始测量的点云数据进行处理(去除噪声,平滑,对多站点数据做拼接配准,提取目标建筑物等)得到正确和完整的目标建筑物的表面信息,然后构建三角网建立它的三维表面模型,最后通过所拍的照片进行纹理映射得到真实的三维模型。实验结果表明,利用上述方法可以有效地处理三维激光扫描获取的点云数据,实现对建筑物快速三维可视化建模。 | Nguyen Tien Thanh 刘修国 王红平 于明旭 周文浩 | 2011 | 激光与光电子学进展2011，48，8： | 48 |
| 3 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 4 | Relationship between types of urban forest and PM_(2.5) capture at three growth stages of leaves显示文摘Particulate matter diameter ≤ 2.5 μm(PM2.5) causes direct harm to human health. Finding forms of urban forest systems that with the ability to reduce the amount of particulate matter in air effectively is the aim of this study. Five commonly cultivated kinds of urban forest types were studied in Beijing city at three stages of leaf growth. Results show that the urban forest system is capable of storing and capturing dust from the air. The types of shrubs and broadleaf trees that have the ability to capture PM2.5from the air are most effective when leaves have fully developed. In the leafless season, the conifer and mixed tree types are the most effective in removing dust from the air. For all kinds of forest types and stages of leaf growth, the PM2.5concentration is highest in the morning but lower in the afternoon and evening. Grassland cannot control particles suspended in the air,but can reduce dust pollution caused by dust from the ground blown by the wind back into the air. | Thithanhthao Nguyen Xinxiao Yu Zhenming Zhang Mengmeng Liu Xuhui Liu | 2015 | Journal of Environmental Sciences2015，27，1： | 30 |
| 5 | Non-invasive diagnosis of advanced fibrosis and cirrhosis显示文摘Liver cirrhosis is a common and growing public health problem globally.The diagnosis of cirrhosis portends an increased risk of morbidity and mortality.Liver biopsy is considered the gold standard for diagnosis of cirrhosis and staging of fibrosis.However,despite its universal use,liver biopsy is an invasive and inaccurate gold standard with numerous drawbacks.In order to overcome the limitations of liver biopsy,a number of non-invasive techniques have been investigated for the assessment of cirrhosis.This review will focus on currently available non-invasive markers of cirrhosis.The evidence behind the use of these markers will be highlighted,along with an assessment of diagnostic accuracy and performance characteristics of each test.Non-invasive markers of cirrhosis can be radiologic or serum-based.Radiologic techniques based on ultrasound,magnetic resonance imaging and elastography have been used to assess liver fibrosis.Serum-based biomarkers of cirrhosis have also been developed.These are broadly classified into indirect and direct markers.Indirect biomarkers reflect liver function,which may decline with the onset of cirrhosis.Direct biomarkers,reflect extracellular matrix turnover,and include molecules involved in hepatic fibrogenesis.On the whole,radiologic and serum markers of fibrosis correlate well with biopsy scores,especially when excluding cirrhosis or excluding fibrosis.This feature is certainly clinically useful,and avoids liver biopsy in many cases. | Suraj Sharma Korosh Khalili Geoffrey Christopher Nguyen | 2014 | World Journal of Gastroenterology2014，20，45： | 28 |
| 6 | 干旱胁迫下不同甘蔗品种叶片抗氧化酶活性和渗透调节物质含量的变化显示文摘我国80%以上的甘蔗种植在旱地,干旱缺水是影响甘蔗生产的主要因子。研究不同甘蔗品种的抗旱生理生化特性对于抗旱甘蔗品种选育和抗旱栽培技术研发具有重要意义。本研究采用桶栽方式,对抗旱性有差异的F172(抗旱性强)和YL6(不抗旱)2个甘蔗品种在苗期及伸长期分别进行不同程度的干旱胁迫及复水处理,探讨了不同甘蔗品种抗旱性与叶片抗氧化酶活性和渗透调节物质含量的关系。结果表明:抗旱性较强的甘蔗品种F172在干旱胁迫条件下叶片中氧自由基清除酶系中的超氧化物歧化酶(SOD)、过氧化物酶(POD)和抗氧化保护酶过氧化氢酶(CAT)活性及非可溶性蛋白(ISP)、可溶性糖(SS)含量显著提高;与不抗旱甘蔗品种YL6相比,甘蔗品种F172叶片中丙二醛(MDA)、非可溶性糖(ISS)含量相对比较稳定;而不抗旱甘蔗品种YL6在干旱胁迫条件下叶片中氧自由基清除酶反应较迟钝,MDA和ISS含量上升幅度相对较大,而可溶性蛋白(SP)、ISP含量下降。说明甘蔗叶片抗氧化酶活性和渗透调节物质含量的差异是品种耐干旱胁迫存在差异的生理基础。 | Do Thanh Trung 李健 张风娟 邢永秀 杨丽涛 李杨瑞 Nguyen Thi Hanh | 2018 | 热带作物学报2018，39，5： | 22 |
| 7 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 8 | Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19显示文摘AIM:To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor(CTGF) or transforming growth factor-β (TGF-β) in a human retinal pigment epithelial cell line, ARPE-19. METHODS:The effect of Y27632 on the CTGF or TGF-β induced phenotype in ARPE-19 cells was measured with immunocytochemistry as the change in F-actin. ARPE-19 cells were treated with CTGF (1, 10, 100ng/mL)and TGF-β (10ng/mL) in serum free media, and analyzed for fibronectin, laminin, and MMP-2 and type I collagen by RT-qPCR and immunocytochemistry. Cells were also pretreated with an ROCK inhibitor, Y27632, to analyze the signaling contributing to ECM production. ·RESULTS:Treatment of ARPE-19 cells in culture with TGF-β or CTGF induced an ECM change from a cobblestone morphology to a more elongated swirl pattern indicating a mesenchymal phenotype. RT-qPCR analysis and different gene expression analysis demonstrated an upregulation in expression of genes associated with cytoskeletal structure and motility. CTGFor TGF-β significantly increased expression of fibronectin mRNA (P =0.006, P =0.003 respectively), laminin mRNA (P =0.006, P =0.005), MMP-2 mRNA (P =0.006, P =0.001), COL1A1 mRNA (P =0.001, P =0.001), COL1A2 mRNA (P = 0.001, P =0.001). Preincubation of ARPE-19 with Y27632 (10mmol/L) significantly prevented CTGF or TGF-β induced fibronectin (P=0.005, P=0.003 respectively), MMP-2 (P = 0.003, P =0.002), COL1A1 (P =0.006, P =0.003), and COL1A2 (P =0.006, P =0.004) gene expression, but not laminin (P =0.375, P =0.516). CONCLUSION:Our study demonstrated that both TGF-β and CTGF upregulate the expression of ECM components including fibronectin, laminin, MMP-2 and type I collagen by activating the RhoA/ROCK signaling pathway. During this process, ARPE-19 cells were shown to change from an epithelial to a mesenchymal phenotype in vitro. Y27632, a ROCK inhibitor, inhibited the transcription of fibronectin, MMP-2 and type I collagen, but not laminin. The data from our work suggest a role for CTGF as a profibrotic mediator. Inhibiting the RhoA/ROCK pathway represents a potential target to prevent the fibrosis of retinal pigment epithelial (RPE) cells. This might lead to a novel therapeutic approach to preventing the onset of early proliferative vitreoretinopathy(PVR). | Jing Zhu Duy Nguyen Hong Ouyang Xiao-Hui Zhang Xiao-Ming Chen Kang Zhang | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 21 |
| 9 | 黄芪多糖对丝裂霉素C(MMC)致骨髓抑制小鼠骨髓及脾脏造血祖细胞的生成作用的影响显示文摘目的 研究黄芪多糖 (APS)对MMC致骨髓抑制小鼠的骨髓和脾造血祖细胞生长的影响。方法 d 0腹腔注射丝裂霉素C(MMC) 7mg·kg- 1 ,APS皮下注射 1 0 0mg·kg- 1·d- 1 ,给药方案分 3种 :① 0~ 4d ,共 5d ;② 0~ 1 1d ,共 1 2d ;③ 1 2d给药 ,3wk内给完 ,用造血细胞集落培养法观察APS的药理作用。结果 在d 3时 ,APS治疗组对MMC致骨髓抑制小鼠骨髓CFU C数目增加了 3倍 ,分别为 1 870±40 /股骨和 62 4 0± 1 1 0 /股骨 ,从d 3~d 1 8,APS治疗组的骨髓CFU C均高于模型组。在给MMC后d 1 4之前APS对脾CFU C的生长没有影响 ,APS在d 1 4和d 1 8时APS有刺激脾造血祖细胞增殖作用 (分别高 3倍和 2倍 )。 | 夏星 Dao Nguyen | 2003 | 中国药理学通报2003，19，7： | 20 |
| 10 | 灭活肌筋膜疼痛触发点治疗膝骨性关节炎108例疗效观察显示文摘目的 :观察针刺和拉伸灭活膝关节周围肌的肌筋膜疼痛触发点治疗中老年膝骨性关节炎和缓解行走疼痛的疗效。方法:回顾性分析2010年至2014年在疼痛门诊治疗的108例中老年膝骨性关节炎的临床资料。男35例,女73例,利用针来回穿刺膝关节周围触发点,要求引出肌肉的局部抽搐反应。针刺治疗后对膝关节周围肌肉进行拉伸锻炼,拉伸的幅度以患者可耐受肌肉拉紧的酸痛为止,循序渐进逐渐增大。对治疗前后关节活动度测量和行走时疼痛的VAS评分进行统计分析。结果:所有患者获随访,1年后随访95例无疼痛。VAS评分,从治疗前重度7.6±0.5,中度4.9±0.7,下降至1年后随访的轻度1.9±0.6和无痛0.3±0.2。结论:对膝关节周围肌针刺和拉伸灭活其肌筋膜疼痛触发点可以缓解膝骨性关节炎造成的行走疼痛。 | 张辉 黄强民 Nguyen Thi Tham 刘庆广 袁志斌 张胜年 | 2016 | 中国骨伤2016，29，9： | 19 |
| 11 | Review of endoscopic techniques in the diagnosis and management of cholangiocarcinoma显示文摘Cholangiocarcinoma is a rare malignancy of the biliary tract. Key factors in determining therapeutic options include knowledge of tumor extent, anatomy and obtaining tissue diagnosis. Endoscopically, there are three modalities available to make the diagnosis of cholangiocarcinoma. These include endoscopic retrograde cholangiopancreatography, endoscopic ultrasound with fine needle aspiration and cholangioscopy. Management of cholangiocarcinoma endoscopically is typically confined to stent placement for palliative purposes or as a bridge to surgery. In this article, we will review the endoscopic techniques available for the diagnosis and management of cholangiocarcinoma. | Katherine Nguyen James T Sing Jr | 2008 | World Journal of Gastroenterology2008，14，19： | 18 |
| 12 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 13 | Mechanisms underlying feed intolerance in the critically ill: Implications for treatment显示文摘Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to improve mortality in non-malnourished critically ill patients, early enteral feeding is considered best practice. However, enteral feeding is often limited by delayed gastric emptying. The best method to clinically identify delayed gastric emptying and feed intolerance is unclear. Gastric residual volume (GRV) measured at the bedside is widely used as a surrogate marker for gastric emptying, but the value of GRV measurement has recently been disputed. While the mechanisms underlying delayed gastric emptying require further investigation, recent research has given a better appreciation of the pathophysiology. A number of pharmacological strategies are available to improve the success of feeding. Recent data suggest a combination of intravenous metoclopramide and erythromycin to be the most successful treatment, but novel drug therapies should be explored. Simpler methods to access the duodenum and more distal small bowel for feed delivery are also under investigation. This review summarises current understanding of the factors responsible for, and mechanisms underlying feed intolerance in critical illness, together with the evidence for current practices. Areas requiring further research are also highlighted. | Adam Deane Marianne J Chapman Robert J Fraser Laura K Bryant Carly Burgstad Nam Q Nguyen | 2007 | World Journal of Gastroenterology2007，13，29： | 18 |
| 14 | Design and Demonstration of a Locust-Like Jumping Mechanism for Small-Scale Robots显示文摘 | Quoc-Viet Nguyen Hoon Cheol Park | 2012 | Journal of Bionic Engineering2012，9，3： | 18 |
| 15 | 关中平原畜禽粪便重金属农用风险估算显示文摘通过在关中平原畜禽养殖集中的县区采集畜禽粪便和饲料样品,测定其中Cr、Cu、Pb、Zn等重金属元素含量,以评估施用畜禽粪便造成的土壤重金属累积速率和安全使用年限.结果表明,牛粪、鸡粪、猪粪样品中Cr超标率分别为7.69%,4.35%和8.00%,而猪粪中Cu、Zn超标率分别达到76.00%和8.00%.饲料样品中Cu、Zn含量高于Cr、Pb含量,且与畜禽粪便Cu、Zn含量呈极显著正相关关系结合主成分分析可知,畜禽粪便中Cu、Zn主要来源于饲料.形态分析结果显示,畜禽粪便中Cu,Zn的有效性很高,尤其是鸡粪中Cu、Zn的有效态含量最高若畜禽粪便施用量保持在当前水平,则施用畜禽粪便24.4~131.0年和69.7~91.9年后,大棚土壤中Cu、Zn含量即可从土壤背景值分别达到安全临界值,因此,畜禽粪便农用时不仅要控制其施用量,还应适当减少饲料中Cu、Zn添加量. | 庞妍 唐希望 吉普辉 杨莉莉 Nguyen Thanh Hung 同延安 | 2015 | 中国环境科学2015，35，12： | 18 |
| 16 | Role of microRNAs in the immune system,inflammation and cancer显示文摘MicroRNAs,a key class of gene expression regulators,have emerged as crucial players in various biological processes such as cellular proliferation and differentiation,development and apoptosis.In addition,microRNAs are coming to light as crucial regulators of innate and adaptive immune responses,and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders,such as inflammatory bowel disease,and cancers.In this review,we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. | Jennifer Raisch Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2013 | World Journal of Gastroenterology2013，19，20： | 17 |
| 17 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 18 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 19 | Stable Vertical Takeoff of an Insect-Mimicking Flapping-Wing System Without Guide Implementing Inherent Pitching Stability显示文摘 | Hoang Vu Phan Quoc Viet Nguyen Quang Tri Truong Tien Van Truong Hoon Cheol Park Nam Seo Goo Doyoung Byun Min Jun Kim | 2012 | Journal of Bionic Engineering2012，9，4： | 16 |
| 20 | 沸石咪唑酯骨架结构材料ZIF-8催化Friedel-Crafts酰基化反应(英文)显示文摘A zeolite imidazolate framework,ZIF-8,was synthesized and characterized by dynamic laser light scattering,X-ray powder diffraction,scanning electron microscopy,transmission electron microscopy,thermogravimetric analysis,Fourier transform infrared,atomic absorption spectrophotometry,and nitrogen adsorption measurements.The ZIF-8 was highly crystalline and porous with a surface area of over 1600 m2 /g.Friedel-Crafts acylation of anisole and benzoyl chloride proceeded well in the presence of ZIF-8(2-6 mol%) without the need for an inert atmosphere.The reaction afforded a selectivity of 93%-95% to the p-isomer.The solid catalyst can be separated from the reaction mixture by simple centrifugation and reused without significant degradation in catalytic activity.There was no leaching of active acid species into the reaction solution. | Lien T. L. NGUYEN Ky K. A. LE Nam T. S. PHAN | 2012 | 催化学报2012，33，4： | 15 |
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