|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 海洋放线菌——新活性代谢物的重要来源(英文)显示文摘放线菌是一类产生活性代谢物最多的微生物资源。目前人类认识的活性代谢物有22000余种,其中10100多种由放线菌产生。海洋覆盖了75%的地表面积,为发现新活性化合物和新用途提供了巨大的潜在资源。本文简要评述了海洋放线菌的多样性及其产生的活性物质的种类与功能(包括:酶抑制剂、抗肿瘤化合物、抗菌物质和其他活性代谢物),讨论了新放线菌活性代谢物开发中值得重视的几个问题以及研究前景。 | 姜怡 Jutta Wiese 徐丽华 Johannes F.Imhoff 姜成林 | 2007 | 中国抗生素杂志2007，32，12： | 12 |
| 2 | 徐州矿区充填复垦土壤特性实验研究显示文摘为了研究矿区复垦土壤的特性、环境质量状况,探寻矿区特殊生态环境中污染物料的时间路径、人工土壤的质量品质,为煤矿塌陷区的充填复垦、环境治理提供依据,采用对复垦场地进行实验研究和数据分析的方法,对不同物料充填复垦场地的土壤特性进行比较分析。结果发现:(1)土壤环境:从渗透性来说,矸石复垦场地的保水性高于粉煤灰复垦场地,土层的保水性高于充填物料层的保水性;从土壤紧实度来说,粉煤灰充填复垦场地充填物料层的紧实度低于土层的紧实度,但都在适宜作物生长的范围内;对照地的土壤紧实度偏高;粉煤灰充填场地的土壤偏碱性;(2)土壤品质:粉煤灰充填土壤能够正常种植小麦、稻、草本的植物、蔬菜等;粉煤灰充填场地的土层虽然是沙土,但比较容易板结,不利于水分的渗透,而底层的粉煤灰保水性比较差;煤矸石充填复垦场地表层覆土厚度不均匀,且煤矸石保水保肥性比较差;(3)充填土壤的适种性和产量分析:粉煤灰回填的土壤适合草本蔬菜类植物的种植,单产与正常产量相当;对于种植稻的田块,保持正常的单产水平;种植小麦的产量受到影响。 | 董霁红 卞正富 雷少刚 BEXTEN Jutta | 2008 | 水土保持研究2008，15，1： | 10 |
| 3 | 中国城市社会空间转型解读--以单位空间向社区空间转型为例显示文摘在新中国成立后的城市发展过程中,单位是计划经济时代社会空间最基本的细胞单元,承载着社会主义的意识形态和履行国家制度政策的职能。这一社会空间组织,保证了社会秩序的稳定和经济的正常运转,成为中国政治和社会叙事中不可分割的组成部分。改革开放后,随着管制放宽、市场经济以及快速城市化的发展,单位空间景观开始解体。随着个人主义泛滥、社会多元化的发展以及贫富差距的悬殊,社会结构中出现离心力加速的趋势,这对社会结构整合、社会凝聚力和政治稳定提出了严峻挑战。本文通过梳理单位空间的演变过程,试图理解与阐释中国当前城市社会空间转型的发展特征、地方政府的行动实践以及城市社区的建设。 | 冯革群 马仁锋 陈芳 Jutta Hebel | 2016 | 城市规划2016，40，1： | 8 |
| 4 | Rangelands of Central Asia:challenges and opportunities显示文摘Rangelands of Central Asia(referring to Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan in this study), the largest contiguous area of grazed land in the world, serve as an important source of livelihood for pastoral and agro-pastoral communities in this region. They also play an important role in absorbing CO2 as a global carbon sink. However, unsustainable management of rangelands has led to their degradation hugely by downgrading their potential agro-ecological, environmental and socio-economical roles. This paper reviewed the rangeland degradation in Central Asia, a topic which so far has received only scant coverage in the international scientific literature. It also provided examples of successful experiences and outlined possible options that land managers can adopt to enhance the sustainable management of these vast degraded rangelands. The experiences and lessons described in this paper may also be relevant for other degraded rangeland areas, especially in the developing countries. The causes of rangeland degradation within the Central Asian region are numerous, complex and inter-related. Therefore, while addressing the factors associated with improper rangeland management may shed some light on the causes of rangeland degradation, the scope of this paper would not be all-encompassing for the major causes of degradation. There is a need to develop and widely apply the viable and locally accepted and adapted packages of technical, institutional and policy options for sustainable rangeland management. Incentivizing the collective action of small-scale pastoralists who group together to facilitate access to remote pastures can reduce the degree of overgrazing within community pastures, such as those near the settlements. We also found that migratory grazing through pooling of resources among small-scale pastoralists can increase household income. After their independence, most Central Asian countries adopted various rangeland tenure arrangements. However, the building of enhanced capacities of pasture management and effective local rangeland governance structures can increase the likelihood, which will be sustainable and equitable. Finally, this paper presented several promising technical options, aiming at reversing the trend of rangeland degradation in Central Asia. | Alisher MIRZABAEV Mohamed AHMED Jutta WERNER John PENDER Mounir LOUHAICHI | 2016 | Journal of Arid Land2016，8，1： | 8 |
| 5 | Polycyclic aromatic hydrocarbon in rain and street runoff in Amman, Jordan显示文摘Concentrations of polycyclic aromatic hydrocarbons(PAHs) were determined in the rain and street runoff samples from two sites in the vicinity of Amman City during the pluvial period 1999—2000. The results showed that elevated levels of PAHs were detected in the city center(site 1) than the residential area(site 2) and that the levels were higher in street runoff than rain samples of the same sites. The highest concentration of PAHs in both street runoff and rain samples were observed in the first rainy month(November 1999) which indicated a wash out effect of PAHs originating from vehicular emission accumulated during the long dry summer season before sampling. Within the investigated cold winter seasons, fluctuations in PAHs concentration were observed. The variation was attributed to the fossil combustion for heating purposes and to intervals between rainfalls: as the longer the intervals between rains were, the higher the PAH concentration were. Removal of PAHs from the atmosphere through precipitation over the investigated period varied with time and places depending on the amount of rainfall where higher rainfall removed higher amount of PAHs from the atmosphere. The amount of PAHs washed out through precipitation was estimated to be around 14.8 mg/m 2 and 21.1 mg/m 2 for sites 1 and 2 respectively. | Anwar. G. Jiries Helmi. H. Hussein Jutta Lintelmann | 2003 | Journal of Environmental Sciences2003，15，6： | 6 |
| 6 | The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting显示文摘Background Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT)_n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods Candidates who underwent coronary stent implantation were genotyped for the HO-1 promoter polymorphism using polymerase chain reaction (PCR) and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein (CRP) were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis (QCA). Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of whom 27.8% showed ≥50% restenosis after 6 months. The distribution of (GT)_n repeats of all patients in the promoter region of HO-1 genotype ranged from 22 to 42, with (GT)_ 25 and (GT)_ 32 being the two most common alleles. The allelic repeats were divided into the short class (S) with 29 (GT)_n, the middle class (M) with 30-37 (GT)_n and the long class (L) with 38 (GT)_n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele (n=120) had 33.3% lower baseline IL-6 compared with non-S carriers (n=67, P=0.0008). Conclusions Although no association was observed between the HO-1 promoter polymorphism aod coronary in-stent restenosis following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process. | LI Ping Mohamed A. Elrayess Abuzeid H. Gomma Jutta Palmen Emma Hawe Kim M. Fox Steve E. Humphries | 2005 | Chinese Medical Journal2005，，18： | 6 |
| 7 | Identification of Tissue-Specific MicroRNAs from Mouse显示文摘 | Mariana Lagos-Quintana Reinhard Rauhut Abdullah Yalcin Jutta Meyer Winfried Lendeckel Thomas Tuschl | 2002 | Current Biology2002，，9： | 4 |
| 8 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 9 | Isolated subcutaneous implantation of a borderline ovarian tumor:A case report and review of the literature显示文摘Laparoscopy-related tumor implantations of gynecological malignancies into the subcutaneous tissue are rarely diagnosed.We report an interesting case of a 46-year-old female who presented with an abdominal subcutaneous metastasis of a borderline ovarian tumor.The patient received a laparoscopic unilateral adnexectomy for a solid-cystic tumor of the right ovary.Histopathological workup showed a papillary borderline tumor of mucinous type.Nine days later she underwent a hysterectomy,left adnexectomy,appendectomy and omentectomy.Exploration of the peritoneum revealed no intraperitoneal implants.Further exploration showed a non-invasive implant of a borderline tumor in the subcutaneous tissue above the fascia that had no contact to the peritoneum.It is hypothesized that tumor cells may have been implanted during a previous laparoscopy,the most recent of which had been fourteen years prior to her current presentation.Various risk factors for port-site malignancies have been identified.Tumor manipulation and extraction of tumor tissue without a protective bag may contribute to development of trocarsite metastasis. | Malgorzata Banys-Paluchowski Borsu Yeganeh Jutta Luettges Achim Maibach Ruediger Langenberg Natalia Krawczyk Peter Paluchowski Holger Maul Gerhard Gebauer | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 10 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 11 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 12 | 接头连接PCR步行法鉴定转基因烟草显示文摘应用接头连接PCR步行法,建立了分子水平鉴定不同转基因事件的方法和体系;并利用不同转基因事件外源基因与植物基因组DNA整合位点处核酸序列的差异,设计了不同转基因烟草事件的标签引物,成功地对几个转TMV-CP材料进行了鉴定。 | 万秀清 JUTTA TUERCK MARTIN WARD 郭兆奎 李丽杰 颜培强 徐香玲 | 2007 | 烟草科技2007，40，4： | 3 |
| 13 | Hepatotoxicity of NONI juice: Report of two cases显示文摘NONI juice (Morinda citrifolia) is an increasingly popular wellness drink claimed to be beneficial for many illnesses.No overt toxicity has been reported to date. We present two cases of novel hepatotoxicity of NONI juice. Causality of liver injury by NONI juice was asses-sed. Routine laboratory tests and transjugular or percutaneous liver biopsy were performed. The first patient underwent successful liver transplantation while the second patient recovered spontaneously after cessation of NONI juice.A 29-year-old man with previous toxic hepatitis associated with small doses of paracetamol developed sub-acute hepatic failure following consumption of 1.5 L NONI juice over 3 wk necessitating urgent liver transplantation. A 62-year-old woman without evidence of previous liver disease developed an episode of self-limited acutehepatitis following consumption of 2 L NONI juice for over 3 mo. The most likely hepatotoxic components of Morinda citrifolia were anthraquinones. Physicians should be aware of potential hepatotoxicity of NONI juice. | Vanessa Stadlbauer Peter Fickert Carolin Lackner Jutta Schmerlaib Peter Krisper Michael Trauner Rudolf E Stauber | 2005 | World Journal of Gastroenterology2005，11，30： | 3 |
| 14 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 2 |
| 15 | SYFPEITHI: database for MHC ligands and peptide motifs显示文摘 | Hans-Georg R Jutta B Oskar AB | 1999 | Immunogenetics1999，50，： | 2 |
| 16 | Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos)显示文摘 | Jutta Keller Christiane Fibbe Frank Volke Jeremy Gerber Alexander C. Mosse Meike Reimann-Zawadzki Elisha Rabinovitz Peter Layer Daniel Schmitt Viola Andresen Ulrich Rosien Paul Swain | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 17 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 18 | Homocysteine as a Risk Factor for Cardiovascular Disease in Patients Treated by Dialysis: A Meta–analysis显示文摘 | Judith Heinz Siegfried Kropf Claus Luley Jutta Dierkes | 2009 | American Journal of Kidney Diseases2009，，： | 2 |
| 19 | The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh ( Cimicifuga or Actaea racemosa )显示文摘 | Wolfgang Wuttke Hubertus Jarry Jutta Haunschild Guenter Stecher Markus Schuh Dana Seidlova-Wuttke | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 2 |
| 20 | MACBETH与PROMETHEE在废弃物再生利用系统评价中的应用显示文摘利用特尔菲法确定废弃物再生利用系统评价指标体系,综合考虑经济、技术和环境等属性,应用MACBETH(Measuring Attractiveness by Categorical Based Evaluation Technique)确定属性权重,再借助于PROMETHEE(Preference Ranking Organization Method for Enrichment Evaluation)对再生利用系统的绩效进行综合评价,并应用多元统计方法建立GAIA(Geometric Analysis for Interactive Aid)平面,分析决策结果的灵敏度.最后给出MACBETH和PROMETHEE多属性决策方法在废弃物再生利用系统绩效评价中的具体应用. | 张科静 仓平 GELDERMANN Jutta | 2010 | 东华大学学报(自然科学版)2010，36，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员