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| 1 | 丹参素对大鼠肝缺血再灌注损伤的保护作用显示文摘目的 观察丹参素对大鼠肝缺血再灌注损伤的保护作用.方法 60只SD大鼠随机分成3组(每组20只):假手术(Sham)组、缺血再灌注(I/R)组、丹参预处理(Sal+I/R)组.解剖出肝脏中叶、左叶的门静脉、肝动脉以及胆管,应用小血管夹钳夹后造成肝脏左、中叶缺血,1h后恢复血流,构建缺血再灌注模型.假手术(Sham)组按同样步骤解剖,但不阻断血流.丹参预处理(Sal+I/R)组于缺血前60 min经尾静脉注射丹参素40 mg/kg.再灌注6h后,各组随机各取10只大鼠,经下腔静脉收集血液标本及留取肝组织标本.再灌注12h后同样方法处理剩余大鼠.测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平.检测肝脏组织中谷胱甘肽过氧化物酶(GPX)和超氧化物歧化酶(SOD)的水平.苏木素-伊红(HE)染色,光镜观察肝脏组织病理学的变化.结果 Sal+ I/R组血清中ALT、AST、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平[6 h:(350.47 ±69.65) U/L、(500.25±76.12) U/L、(165.32±23.46) ng/L、(65.31±9.52) ng/L;12 h:(250.47±36.78) U/L、(355.25±59.12) U/L、(130.65±34.31) ng/L、(103.38±18.46) ng/L]均低于I/R组[6 h:(550.34±82.31) U/L、(702.28±106.48) U/L、(300.13±49.28) ng/L、(95.55 ±29.21) ng/L;12 h:(490.34 ±89.68) U/L、(550.28±64.23) U/L、(260.00±60.08) ng/L、(180.32±38.12) ng/L,P=0.019];Sal+ I/R组肝脏组织中GPX和SOD的水平[6 h:(52.34±11.59)、(63.00±19.23) pg/ml;12 h:(68.32±21.45)、(81.00±17.65) pg/ml]高于I/R组[6 h:(30.12±5.12)、(43.00 ±7.45) pg/ml;12 h:(39.58 ±3.16)、(54.00±8.46) pg/ml,P=0.029];光镜下Sal+ I/R组肝脏组织损伤较I/R组轻.结论 丹参素可降低大鼠肝脏缺血再灌注损伤后血清IL-6、TNF-α的水平,提高肝组织中GPX和SOD的水平,减轻缺血再灌注后肝脏的损伤程度. | 黄庆先 贾秀梅 闫博 王雪峰 刘小方 Akash Masaud | 2018 | 中华实验外科杂志2018，35，5： | 6 |
| 2 | Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis显示文摘Periodontitis 是 periodontium 的煽动性的疾病。在 neutrophils 和织物禁止者分泌的矩阵 metalloproteinases (MMP ) 之间的任何不平衡在口香糖织物开始骨胶原的破坏,导致长期的 periodontitis。这研究瞄准了 MMP-8 的唾液的层次和长期的 periodontitis 的牙齿周围的参数到相互关联为长期的 periodontitis 的早诊断作为一个 noninvasive 标记建立 MMP-8。学习包含了访问扎乌丁·阿赫马德博士的 periodontic OPD 的 40 个题目牙齿的学院和医院,在 Aligarh 定位了, U.P,印度,从 2011 ~ 2012。这些题目被划分成二个组:组当组 II 与长期的 periodontitis 由 20 个病人组成了时,我由 20 个牙齿周围地健康的题目(控制) 组成了。长期的 periodontitis 根据几个牙齿周围的参数被估计,包括探查深度(PPD ) 的衣袋,临床的附件水平(CAL ) ,齿龈的索引(官方补给) ,并且匾索引(PI ) 。为由用 Quantikine 人总数 MMP-8 免疫分析工具包的 ELISA 的 MMP-8 评价在 unstimulated 和整个吐的口水的 3ml 附近是镇定的。数据用 STATISTICA (Windows 版本 6 ) 软件被分析。组的唾液的 MMP-8 层次我和 II 是 190.91?? | Namita Gupta N.D. Gupta Akash Gupta Saif Khan Neha Bansa | 2015 | Frontiers of Medicine2015，9，1： | 5 |
| 3 | A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration显示文摘Age-related macular degeneration(AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040.Genetics,age,diabetes,gender,obesity,hypertension,race,hyperopia,iris-color,smoking,sun-light and pyroptosis have varying roles in AMD,but oxidative stress-induced inflammation remains a significant driver of pathobiology.Eye is a unique organ as it contains a remarkable oxygengradient that generates reactive oxygen species(ROS) which upregulates inflammatory pathways.ROS becomes a source of functional and morphological impairments in retinal pigment epithelium(RPE),endothelial cells and retinal ganglion cells.Reports demonstrated that hydrogen sulfide(H_2S) acts as a signaling molecule and that it may treat ailments.Therefore,we propose a novel hypothesis that H_2S may restore homeostasis in the eyes thereby reducing damage caused by oxidative injury and inflammation.Since H_2S has been shown to be a powerful antioxidant because of its free-radicals' inhibition properties in addition to its beneficial effects in age-relatedconditions,therefore,patients may benefit from H_2S salubrious effects not only by minimizing their oxidant and inflammatory injuries to retina but also by lowering retinal glutamate excitotoxicity. | Akash K George Mahavir Singh Rubens Petit Homme Avisek Majumder Harpal S SANDhu Suresh C Tyagi | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 3 |
| 4 | Chemical composition, antioxidant activity and GC-MS analysis of juice and peel oil of grapefruit varieties cultivated in India显示文摘Citrus family especially Grapefruit,has attained considerable attention due to the presence of a number of essential components that have cardiovascular and anti-hypertensive properties.The juice and essential oil extracted from eight recently released grapefruit cultivars were used to study physicochemical and antioxidant properties.The total soluble solids(TSS),titratable acidity(TA) and pH of juice samples extracted from various grapefruit varieties differed significantly.The refractive index,specific gravity and optical rotation values for the oil varied from 1.473 to 1.396,0.863 to 0.847 and +93 to +86,respectively.The percent 2,2-diphenyl-1-picrylhydrazyl radical activity(% DPPH activity) and ferric reducing antioxidant power(FRAP) values for grapefruit juice and peel oil varied from 24.06 to 18.79,2.91 to 1.44 mmol g^–1 and 84.87 to 74.73,7.76 to 5.73 mmol g^-1,respectively.There were significant differences in physicochemical,antioxidant properties and volatile profiles of extracted juice and oil.The oil exhibited higher DPPH and FRAP values than the juice.Among different components identified which accounted for over 99% of the volatile fraction,limonene,myrcene,and benzopyran were major components in all oil samples. | Shahnawaz Ahmed H S Rattanpal Khalid Gul Rouf Ahmad Dar Akash Sharma | 2019 | Journal of Integrative Agriculture2019，18，7： | 3 |
| 5 | Imaging-based algorithmic approach to gallbladder wall thickening显示文摘Gallbladder(GB) wall thickening is a frequent finding caused by a spectrum of conditions. It is observed in many extracholecystic as well as intrinsic GB conditions. GB wall thickening can either be diffuse or focal. Diffuse wall thickening is a secondary occurrence in both extrinsic and intrinsic pathologies of GB, whereas, focal wall thickening is mostly associated with intrinsic GB pathologies. In the absence of specific clinical features, accurate etiological diagnosis can be challenging. The survival rate in GB carcinoma(GBC) can be improved if it is diagnosed at an early stage, especially when the tumor is confined to the wall. The pattern of wall thickening in GBC is often confused with benign diseases, especially chronic cholecystitis, xanthogranulomatous cholecystitis, and adenomyomatosis. Early recognition and differentiation of these conditions can improve the prognosis. In this minireview, the authors describe the patterns of abnormalities on various imaging modalities(conventional as well as advanced) for the diagnosis of GB wall thickening. This paper also illustrates an algorithmic approach for the etiological diagnosis of GB wall thickening and suggests a formatted reporting for GB wall abnormalities. | Pankaj Gupta Yashi Marodia Akash Bansal Naveen Kalra Praveen Kumar-M Vishal Sharma Usha Dutta Manavjit Singh Sandhu | 2020 | World Journal of Gastroenterology2020，26，40： | 3 |
| 6 | Nanomaterials for sensing of formaldehyde in air: Principles, applications, and performance evaluation显示文摘Despite the improvement in sensing technologies, detection of small and highly reactive molecules like formaldehyde remains a highly challenging area of research. Applications of nanomaterials/nanostructures and their composites have increased as effective sensing platforms (e.g., reaction time, sensitivity, and selectivity) for the detection of aqueous or gaseous formaldehyde based on diverse sensing principles. In this review, the basic aspects of important nanomaterial-based sensing systems (e.g., electrochemical, electrical, biological, and mass variation sensors) were evaluated in relation to performance, cost, and practicality of sensing gas phase formaldehyde. Accordingly, existing knowledge gaps in such applications were assessed in various respects along with suitable recommendations for building a new roadmap for the expansion of chemical sensing technology of gas phase formaldehyde. | Deepak Kukkar Kowsalya Vellingiri Rajnish Kaur Sanjeev Kumar Bhardwaj Akash Deep Ki-Hyun Kim | 2019 | Nano Research2019，12，2： | 3 |
| 7 | Complementary roles of interventional radiology and therapeutic endoscopy in gastroenterology显示文摘Acute upper and lower gastrointestinal bleeding, enteral feeding, cecostomy tubes and luminal strictures are some of the common reasons for gastroenterology service. While surgery was initially considered the main treatment modality, the advent of both therapeutic endoscopy and interventional radiology have resulted in the paradigm shift in the management of these conditions. In this paper, we discuss the patient's work up, indications, and complementary roles of endoscopic and angiographic management in the settings of gastrointestinal bleeding, enteral feeding, cecostomy tube placement and luminal strictures. These conditions often require multidisciplinary approaches involving a team of interventional radiologists, gastroenterologists and surgeons. Further, the authors also aim to describe how the fields of interventional radiology and gastrointestinal endoscopy are overlapping and complementary in the management of these complex conditions. | David M Ray Indu Srinivasan Shou-jiang Tang Andreas S Vilmann Peter Vilmann Timothy C McCowan Akash M Patel | 2017 | World Journal of Radiology2017，9，3： | 2 |
| 8 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 9 | Radiation-induced in vitro mutagenesis system for salt tolerance and other agronomic characters in sugarcane(Saccharum officinarum L.)显示文摘Gamma ray-induced in vitro mutagenesis and selection for salt(NaC l) tolerance were investigated in sugarcane(Saccharum officinarum L.). Embryogenic callus cultures were irradiated(10 to 80 Gy) and subjected to in vitro selection by exposure of irradiated callus to NaC l(0, 50, 100,150, 200, and 250 mmol L-1). Increasing NaC l concentrations resulted in growth reduction and increased membrane damage. Salt-selected callus lines were characterized by the accumulation of proline, glycine betaine, and Na+and K+concentration. Higher accumulation of proline and glycine betaine was observed in NaC l stressed callus irradiated at 20 Gy. Na+concentration increased and K+concentration decreased with increasing salt level. Irradiated callus showed50–60% regeneration under NaC l stress, and in vitro-regenerated plants were acclimatized in the greenhouse, with 80–85% survival. A total of 138 irradiated and salt-selected selections were grown to maturity and their agronomic performance was evaluated under normal and saline conditions. Of these, 18 mutant clones were characterized for different agro-morphological characters and some of the mutant clones exhibited improved sugar yield with increased Brix%,number of millable canes, and yield. The result suggest that radiation-induced mutagenesis offers an effective way to enhance genetic variation in sugarcane. | Ashok A.Nikam Rachayya M. Devarumath Akash Ahuja Harinath Babu Mahadeo G.Shitole Penna Suprasanna | 2015 | The Crop Journal2015，3，1： | 2 |
| 10 | Where is the global in global mental health?A call for inclusive multicultural collaboration显示文摘To the editor:Common mental health disorders,like depression and anxiety,account for 45%of the global disease burden on youths aged 15-29.1 This challenge is particularly significant in low and middle-income countries(LMICs)where risk factors such as poverty,limited treatment options and stigma restrict access to care and exacerbate the burden and magnify the impact of mental disorders.23 Given these barriers,there is an urgent need for research dedicated to expanding mental healthcare for young people in LMICs. | Tom L Osborn Akash R Wasil John R Weisz Arthur Kleinman David M Ndetei | 2020 | General Psychiatry2020，33，6： | 2 |
| 11 | 简易转速测量系统设计显示文摘介绍了一种基于定时器的转速测量系统的设计与开发。使用直流电动机的转轴来测量其转速,定时器IC 555用于不稳定模式。使用数字存储示波器(DSO)测量的定时器输出波形的频率几乎与转轴的转速成线性比例,而这个转速又与外部输入电压水平的变化成线性关系,由此得到了定时器输出波形频率与转速之间的线性关系。该系统的主要优点是线性输入-输出,体积小,便于携带且成本低。 | Akash Kumar Anindya Debnath Antar Banik Kabirul Islam Mondal Partha Pratim Biswas Rik Bhattacharyya T K Maiti | 2020 | Journal of Measurement Science and Instrumentation2020，11，2： | 2 |
| 12 | T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report显示文摘BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of treatment.Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality.To date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation occurs.CASE SUMMARY A 67-year-old gentleman who presented with dysphagia and weight loss.Endoscopy and imaging revealed a T4N1M0 cervical esophageal squamous cell carcinoma.He received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was inserted.After discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 fractions.Three months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and dilatation.The patient remains cancer-free at two year on follow-up.Complete response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of TEF.CONCLUSION This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies. | Chia Ching Lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey | 2020 | World Journal of Clinical Cases2020，8，10： | 2 |
| 13 | Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis显示文摘AIM: To investigate the applications of hydrogen sulfide(H2 S) in eye-specific ailments in mice.METHODS: Heterozygous cystathionine-β-synthase(CBS+/-) and wild-type C57 BL/6 J(WT) mice fed with or without high methionine diet(HMD) were administered either phosphate buffered saline(PBS) or the slow-release H2 S donor: GYY4137. Several analyses were performed to study GYY4137 effects by examining retinal lysates for key protein expressions along with plasma glutamate and glutathione estimations. Intraocular pressure(IOP) was monitored during GYY4137 treatment; barium sulfate and bovine serum albumin conjugated fluorescein isothiocyanate(BSA-FITC) angiographies were performed for examining vasculature and its permeability post-treatment. Visionguided behavior was also tested employing novel object recognition test(NORT) and light-dark box test(LDBT) recordings.RESULTS: CBS deficiency(CBS+/-) coupled with HMD led disruption of methionine/homocysteine(Hcy) metabolism leading to hyperhomocysteinemia(HHcy) in CBS+/-mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase(SAHH) levels. Unlike CBS, cystathionine-γ lyase(CSE), methylenetetrahydrofolate reductase(MTHFR) levels which were reduced but compensated by GYY4137intervention. Heightened oxidative and endoplasmic reticulum(ER) stress responses were mitigated by GYY4137 effects along with enhanced glutathione(GSH) levels. Increased glutamate levels in CBS+/-strain were prominent than WT mice and these mice also exhibited higher IOP that was lowered by GYY4137 treatment. CBS deficiency also resulted in vision-guided behavioral impairment as revealed by NORT and LDBT findings. Interestingly, GYY4137 was able to improve CBS+/-mice behavior together with lowering their glutamate levels. Blood-retinal barrier(BRB) appeared compromised in CBS+/-with vessels' leakage that was mitigated in GYY4137 treated group. This corroborated the results for occludin(an integral plasma membrane protein of the cellular tight junctions) stabilization.CONCLUSION: Findings reveal that HHcy-induced glutamate excitotoxicity, oxidative damage, ER-stress and vascular permeability alone or together can compromise ocular health and that GYY4137 could serve as a potential therapeutic agent for treating HHcy induced ocular disorders. | Akash K.George Rubens P.Homme Avisek Majumder Anwesha Laha Naira Metreveli Harpal S.SANDhu Suresh C.Tyagi Mahavir Singh | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 14 | Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs 显示文摘 | SARANJIT S BHAGWAT P AKASH A | 2009 | Trends Anal Chem2009，28，1： | 1 |
| 15 | Synthesis of hollow silica fibers with porous walls by coaxial electrospinning method显示文摘 | Akash Katoch Sang Sub Kim | 2012 | J Am Ceram Soc2012，95，2： | 1 |
| 16 | Enzymatic modification of guar solutions 显示文摘 | Akash Tayal Robert M K | 2007 | Macromolecules2007，，5： | 1 |
| 17 | Liquid-liquid extraction and recovery of indium using Cyanex 923 显示文摘 | Gupta Bina Deep Akash Malik Poonma | 2004 | Analytica Chimica Acta2004，513，2： | 1 |
| 18 | Investigation of simultaneous coal and lignin liquefaction Kinetic studies显示文摘 | Akash B A Muchore C B Koropchak J A | 1992 | Energy & Fuel1992，6，5： | 1 |
| 19 | Association of antigen processing machinery and HLA class Ⅰ defects with clinicopathological outcome in cervical carcinoma显示文摘 | Akash M Ekaterina S | 2008 | Cancer Immunol Immunother2008，57，2： | 1 |
| 20 | The fertility of cryopre- served Deccan Mahseer, Torkhodree (Sykes) spermatozoa 显示文摘 | Basavaraja N Hegde S N Akash N | 2002 | Asian Fishedes Science2002，15，： | 1 |
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