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| 1 | Habitual rapid food intake and ineffective esophageal motility显示文摘AIM:To study non-cardiac chest pain(NCCP) in relation to ineffective esophageal motility(IEM) and rapid food intake.METHODS:NCCP patients with a self-reported habit of fast eating underwent esophageal manometry for the diagnosis of IEM.Telephone interviews identified eating habits of additional IEM patients.Comparison of manometric features was done among IEM patients with and without the habit of rapid food intake and healthy controls.A case study investigated the effect of 6-mo gum chewing on restoration of esophageal motility in an IEM patient.The Valsalva maneuver was performed in IEM patients and healthy controls to assess the compliance of the esophagus in response to abdominal pressureincrease.RESULTS:Although most patients diagnosed with NCCP do not exhibit IEM,remarkably,all 12 NCCP patients who were self-reporting fast eaters with a main complaint of chest pain(75.0%) had contraction amplitudes in the mid and distal esophagus that were significantly lower compared with healthy controls [(23.45 mmHg(95%CI:14.06-32.85)vs 58.80 mmHg(95%CI:42.56-75.04),P < 0.01 and 28.29 mmHg(95%CI:21.77-34.81) vs 50.75 mmHg(95%CI:38.44-63.05),P < 0.01,respectively)].In 7 normal-eating IEM patients with a main complaint of sensation of obstruction(42.9%),the mid amplitude was smaller than in the controls [30.09 mmHg(95%CI:19.48-40.70) vs 58.80 mmHg(95%CI:42.56-75.04),P < 0.05].There was no statistically significant difference in manometric features between the fast-eating and normal-eating groups.One NCCP patient who self-reported fast eating and was subsequently diagnosed with IEM did not improve with proton-pump inhibition but restored swallow-induced contractions upon 6-mo gum-chewing.The Valsalva maneuver caused a markedly reduced pressure rise in the mid and proximal esophagus in the IEM patients.CONCLUSION:Habitual rapid food intake may lead to IEM.A prospective study is needed to validate this hypothesis.Gum-chewing might strengthen weakened esophageal muscles. | Kong-Ling Li Ji-Hong Chen Qian Zhang Jan D Huizinga Shawn Vadakepeedika Yu-Rong Zhao Wen-Zhen Yu He-Sheng Luo | 2013 | World Journal of Gastroenterology2013，19，14： | 0 |
| 2 | 消化道液体灌注测压技术显示文摘消化道动力障碍性疾病是最常见的消化系统疾病,由于发病机制不明,症状无特异性,缺乏有效的诊疗手段。消化道灌注测压可反映消化道动力性疾病的生理病理改变情况,准确反映消化道腔内基础压力及其压力变化的频率、幅度、动力指数等,对胃肠运动功能疾病的诊治有较高的价值。该技术被广泛应用于各种消化道动力监测的临床及基础试验中,对消化系统疾病的诊疗及胃肠外科术后消化道运动功能的评价有很大帮助作用。 | 李楠 尤胜义 | 2013 | 中国中西医结合外科杂志2013，19，6： | 0 |
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