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| 1 | 培养耐盐的杜氏藻的生物技术显示文摘单胞藻杜氏藻(Dunaliella)在分类上属于团藻目(Volvocales),包括各种没有定名的单胞种。杜氏藻属的藻都是细胞体积为50~1000μm^3、具双鞭毛的卵园形细胞。杜氏藻横截面的电子显微镜图片表明了细胞器具有其它绿藻细胞器的特征。然而,与其它藻不同的是杜氏藻缺少坚硬的多糖细胞壁,细胞由一种粘液外衣覆盖的薄层弹性原生质膜所包围。缺乏这种坚硬的细胞壁可以使细胞的体积随着胞外渗透压的改变而迅速改变。杜氏藻存在于各种海水环境中如海洋、盐湖、盐滩和近海的盐水湖,主要在含10%以上盐分的水中。 | Ami Ben-Amotz 吴南君 | 1992 | 生物技术通报1992，8，1： | 12 |
| 2 | Synovial sarcoma:a rare presentation of parapharyngeal mass显示文摘Synovial sarcoma is a rare soft tissue sarcoma of the head and neck region involving the parapharyngeal space.The diagnosis of synovial sarcoma can be very challenging to the pathologists.We present a rare case of parapharyngeal synovial sarcoma in a young female patient who had a two-month history of left cervical intumescent mass at level II.The fine needle aspiration cytology of the mass was proved inconclusive.Transcervical excision of the mass was performed and the first case of parapharyngeal sarcoma was identified in our center by fluorescence in situ hybridization(FISH) technique.Repeat imaging revealed residual tumor.The patient successfully underwent a second excision of the residual tumor and received adjuvant radiotherapy. | Mohd Mokhtar Shaariyah Ami Mazita Mansor Masaany Mohd Yunus Razif Mohamed Rose Isa Abdullah Asma1 | 2010 | Chinese Journal of Cancer2010，29，6： | 7 |
| 3 | Gastric stimulation for weight loss显示文摘The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity. | Meir Mizrahi Ami Ben Ya'acov Yaron Ilan | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 4 | Antimicrobial Profile of Lactic Acid Bacteria Isolated from Vegetables and Indigenous Fermented Foods of India against Clinical Pathogens Using Microdilution Method显示文摘In dairy and food industries lactic acid bacteria(LAB)have been used in form of starter culture that plays vital role in fermentation;as flavouring and texturizing or as preservative agents.There is increasing evidence that lactobacilli which inhabit the gastrointestinal tract develop antimicrobial activities and participatein the host’s defence system[1].During fermentation,most of the LAB produces a number of different compounds like organic acids,hydrogen peroxide,diacetyl,acetaldehyde,carbon dioxide,polysaccharides,and proteinaceous compounds called bacteriocins or bacteriocinogenic peptides[2-3].Such metabolites exert antimicrobial activity and | Ami PATEL Nihir SHAH Padma AMBALAM J. B. PRAJAPATI Olle HOLST Asa LJUNGH | 2013 | Biomedical and Environmental Sciences2013，26，9： | 4 |
| 5 | The use of psychotropic drugs in irritable bowel syndrome显示文摘 | Roy Dekel Douglas A Drossman Ami D Sperber | 2013 | Expert Opinion on Investigational Drugs2013，，3： | 4 |
| 6 | High on food: the interaction between the neural circuits for feeding and for reward显示文摘饥饿,主要在精力由缺乏开始了,导致寻求的食物和吸入。然而,向食物的开车是不仅由生理的需要调整了,而且被从食物的摄取导出的快乐激发,特别地好吃的食物。因此,喂被看作包含在喂电路和报酬电路的 homeostatic 之间的综合通讯的适应激发的行为。一个喂的事件的开始和结束被许多 neuronal 信号,和不适应的粘性在几乎任何东西指示网络的部件可以导致病理学的吃的混乱的开发。在这评论,我们将总结在大脑的喂的电路和报酬电路怎么交往的最近的理解。我们将强调在视下丘和 mesolimbic 多巴胺系统之间的通讯并且为这块地加亮复杂性,差异,待研究的问题和未来方向。 | Jing-Jing Liu Diptendu Mukherjee Doron Haritan Bogna Ignatowska-Jankowska Ji Liu Ami Citri Zhiping P. Pang | 2015 | Frontiers in Biology2015，10，2： | 3 |
| 7 | Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis显示文摘AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet model.METHODS For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic FACS.RESULTS The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice.CONCLUSION Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis. | Yaron Ilan Ami Ben Ya'acov Yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel | 2016 | World Journal of Gastroenterology2016，22，39： | 3 |
| 8 | Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity显示文摘 | Corbin Amie S Agarwal Anupriya Loriaux Marc Cortes Jorge Deininger Michael W Druker Brian J | 2011 | Journal of Clinical Investigation2011，，1： | 3 |
| 9 | Clinical appliance of probiotics in the treatment of Helicobacter pylori infection—A brief review显示文摘 | Ami Patel Nihir Shah J.B. Prajapati | 2013 | Journal of Microbiology Immunology and Infection2013，，： | 2 |
| 10 | Combined Thermo-Chemotherapy for Recurrent Bladder Cancer After Bacillus Calmette-Guerin显示文摘 | Ofer Nativ J. Alfred Witjes Kees Hendricksen Michael Cohen Daniel Kedar Ami Sidi Renzo Colombo Ilan Leibovitch | 2009 | The Journal of Urology2009，，4： | 2 |
| 11 | Hyaluronic acid-based hydrogels with tobacco mosaic virus containing cell adhesive peptide induce bone repair in normal and osteoporotic rats显示文摘Tobacco mosaic virus(TMV)has been studied as a multi-functional agent for bone tissue engineering.An osteo-inductive effect of wild-type TMV has been reported,as it can significantly enhance the bone differentiation potential of bone marrow stromal cells both on a two-dimensional substrate and in a three-dimensional(3D)hydrogel system.A TMV mutant(TMV-RGD1)was created which featured the adhesion peptide arginyl-glycyl-aspartic acid(RGD),the most common peptide motif responsible for cell adhesion to the extracellular matrix,on the surface of the virus particle to enhance the bio-functionality of the scaffold material.We hypothesised that the incorporation of either wild-type TMV or TMV-RGD1 in the 3D hydrogel scaffold would induce bone healing in critical size defects of the cranial segmental bone.We have previously tested the virus-functionalised scaffolds,in vitro,with a hyaluronic acid-based system as an in-situ hydrogel platform for 3D cell encapsulation,culture,and differentiation.The results of these experiments suggested the potential of the virus-functionalised hydrogel to promote in vitro stem cell differentiation.The hydrogel-forming system we employed was shown to be safe and biocompatible in vivo.Here,we further explored the physiological responses regarding bone regeneration of a calvarial defect in both normal and osteoporotic ovariectomized rat models.Our results,based on histological analysis in both animal models,suggested that both wild-type TMV and TMV-RGD1 functionalised hydrogels could accelerate bone regeneration,without systemic toxicity,evaluated by blood counts.New bone formation was intensified by the incorporation of the RGD-mutant viral particles.This finding increased the potential for use of the rodshaped plant virus as a platform for the addition of powerful biofunctionality for tissue engineering applications.This study was approved by the Ethics Committee on Animal Use of the Zhenjiang Affiliated First People’s Hospital affiliated to Jiangsu University. | Jishan Yuan Panita Maturavongsadit Zhihui Zhou Bin Lv Yuan Lin Jia Yang Jittima Amie Luckanagul | 2020 | Biomaterials Translational2020，1，1： | 2 |
| 12 | Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor Cells显示文摘 | Ami N. Shah Justin M. Summy Jing Zhang Serk In Park Nila U. Parikh Gary E. Gallick | 2007 | Annals of Surgical Oncology2007，，12： | 2 |
| 13 | Clinical application of probiotics in the treatment of Helicobacter pylori infection—A brief review显示文摘 | Ami Patel Nihir Shah J.B. Prajapati | 2014 | Journal of Microbiology, Immunology and Infection2014，，： | 2 |
| 14 | Decrease of CD56 + T Cells and Natural Killer Cells in Cirrhotic Livers With Hepatitis C May Be Involved in Their Susceptibility to Hepatocellular Carcinoma显示文摘 | Nobuaki Kawarabayashi Shuhji Seki Kazuo Hatsuse Takashi Ohkawa Yuji Koike Tsukasa Aihara Yoshiko Habu Ryusuke Nakagawa Katsunori Ami Hoshio Hiraide Hidetaka Mochizuki | 2000 | Hepatology2000，，5： | 2 |
| 15 | Relationship Formation on the Internet: What’s the Big Attraction?显示文摘 | Katelyn Y. A.McKenna Amie S.Green Marci E. J.Gleason | 2002 | Journal of Social Issues2002，，1： | 2 |
| 16 | Patients with type 2 diabetes demonstrate proprioceptive deficit in the knee显示文摘AIM To investigate proprioceptive discrepancies in the lower extremity in persons with type 2 diabetes mellitus(T2DM). METHODS In this cross-sectional study, a total of 46 older persons were divided into a T2DM group(n = 23) and a control group who did not have T2 DM(n = 23). Participants were given a brief warm up with stretching exercises. Diabetic neuropathy scores were collected prior to proprioceptive testing. For proprioceptive testing, participants performed leg extensions to randomized target positions of 15°, 30°, 45, 60° degrees of elevation in the sagittal plane, each target was repeated a total of four times. Subjects were guided to target positions in the absence of visual feedback via auditory cues from a custom JPS application. When the participant entered the target position, they memorized the location of their limb in space and subsequently attempted to relocate this position in space. Proprioceptive errors were measured from the target positioned, target remembered, target repositioned protocol. RESULTS Proprioceptive accuracy was lower in the diabetic groupat all levels of target angle than the control group(P < 0.05). The diabetic group had 46% greater inaccuracy than the control group at all levels of target position. Diabetics also reported greater neuropathy scores than controls in the past 12 mo P < 0.01. CONCLUSION Deficits in lower limb localization and greater diabetic neuropathy scores were identified in this study. Our findings may be associated with deafferentation as peripheral neuropathy is a common complication with the disease. These findings may help to explain the declining balance function in the older persons with T2DM which is also commonly reported. | Lucas Richard Ettinger Ami Boucher Elisabeth Simonovich | 2018 | World Journal of Diabetes2018，9，3： | 2 |
| 17 | Effect of nonionic surfactants in release media on accelerated in-vitro release profile of sirolimus eluting stents with biodegradable polymeric coating显示文摘It is a well-known fact that sirolimus(SRL) undergoes degradation process via hydrolysis in aqueous media, leading to incorrect assessment of drug amount and thus release characteristics of formulations.The main objective of the present study was to evaluate the effect of nonionic surfactants in media on invitro release profiles for sirolimus eluting stents(SES) coated with biodegradable polymeric matrix.Phosphate buffer and acetate buffer incorporating nonionic surfactants with varying concentrations were examined for adequate solubility and stability(by RP-HPLC). Good sink condition was achieved in phosphate buffer(at pH 4.0) with 1.0% Tween 20, 1.0% Brij 35% and 0.5% Brij 58. Hydrodynamic size(by DLS) and the micelle-water partition coefficient(P) with standard free energy of solubilization(ΔGs°) of drug were evaluated to get some understanding about the solubilization phenomena. About 80% of drug release during the period of 48 h was achieved in optimized drug release media which was 1.0% Tween20 in phosphate buffer pH 4.0. The obtained accelerated SRL release profile in optimized medium correlated well with the real time in-vitro release in phosphate buffer(pH 7.4). Surface morphology changes(by SEM), changes in gravimetric weights and molecular weight change(by GPC) were examined before and after drug release to understand the drug release mechanism which explains that the polymer did not undergo degradation during the drug release. | Ami Raval Pratap Bahadur Ankur Raval | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 2 |
| 18 | 运用循证医学手段评价整形外科患者报告的结果显示文摘因为外科手术会对患者的外观和机体功能形成较大改变,所以理解患者对术后效果的看法及生活质量的改变,在整形外科中显得尤其重要。患者报告效果的评价(patient-reported outcome measures)是以患者主观的方式,在针对术后生活健康质量方面特制的量化问卷上作评价。本研究旨在对患者主观效果解读作以概述,并为整形外科医师提供一些必要的、严格的评估技能,使其在临床研究中能更好地应用和评价从患者主观效果评价方面获取的证据,以更好地指导临床工作。 | Andrea L.Pusic Valerie Lemaine Anne F.Klassen Amie M.Scott Stefan J.Cano | 2011 | 中国美容整形外科杂志2011，22，5： | 2 |
| 19 | Expression of cytokeratin 20 in urinary cytology of patients with bladder carcinoma显示文摘 | Ruth Zemer Victor Buchumensky | 1998 | American Cancer1998，82，2： | 1 |
| 20 | Iatrogened Kyphosis:A complication of Harrington instrumentation in Marfan syndrome 显示文摘 | Herring JA | 1984 | J Bone J Surg Am1984，66，： | 1 |
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